DocumentsDate added
Original research article:-
Makwava Prakash V 1, Odedara Ram V 2, *Shah Harsh D 3
1MD Medicine, associate professor, Head of the unit,Department of medicine, 2MD Medicine, 3 Resident, MD , Department of community medicine , Guru Govind Singh Hospital, MP Shah Medical College, Jamnagar, Gujarat , India.
Abstract:- The wide spread use of organophosphorus compounds has increased incidence of its poisoning to the human kind by accidental or suicidal. Organophosphate (OP) insecticides inhibit both acetyl cholinesterase and pseudocholinesterase activities. This study helps to focus to make management protocols during morbidity at the time of presentation of poisoning. Method: A cross sectional descriptive study was done on fifty patients, by simple random sampling technique who came to emergency ward of Hospital, Jamnagar. After setting inclusion and exclusion criteria, Pre tested profoma was filled up. Analysis was done with primary information, clinical admission POP score, pseudo cholinesterase, hospital stay, atropinization requirements, need of ventilator support and mortality. Intravenous atropine and pralidoxime was administered as soon as possible. The diagnosis was performed from the history taken from the patient or the patient’s relatives after taking consent. Results: Amongst fifty patients, 78% were male and 22% were females. Mean age of the studied patients was 28 ± 10 years. In the study, inhalational poisoning (54%) had common occurrences than ingestion poisoning (46%) but mortality (6%) was found higher with ingestion. The compound that was exposed most commonly is monochrotophos (60%). Association of POP score came significant at p < 0.05 with above mentions factors. Conclusion: OP insecticide poisoning is a serious condition that requires rapid diagnosis and treatment. The patients with evidence of moderate and severe degrees of poisoning need close monitoring, as respiratory failure is the prime cause. Early management protocol will help to reduce mortality of poisoning.
Keywords:-Organophosphorus, poisoning.