DocumentsDate added
Research article:-
P.A. Subramanian1, Abraha Gebrekidan1, 2*, and Kebede Nigussie1, 3
1Department of Chemistry, College of Natural and Computational Sciences, Mekelle University, P.O.Box 231, Mekelle, Ethiopia.
2Department of Chemical Engineering, Laboratory of Applied Physical Chemistry and Environmental Technology, Katholieke Universiteit Leuven, Belgium.
3Department of Chemistry, Addis Ababa University, Addis Ababa, Ethiopia.
Abstract:- Eucalyptus trees are available abundantly in the Tigray Region, Ethiopia. The investigation has been carried out to find the feasibility for the extraction of medicinal quality eucalyptus oil in this area. A survey in this Region showed that Hagereselam, Korem and Maychew are the potential areas to collect the samples. The species has been identified as Eucalptus globulus in all the highlands of Tigray Region. Hydro-distillation method was employed for the extraction of oil. The oil extracted in the sample area has been analyzed to have 1.4602 - 1.4623 refractive index value, 0.918 - 0.919 specific gravity (sp.gr.), +9 - +10 optical rotation and negative for phellandrene test that satisfy the standards stipulated by British Pharmacopeia. The percentage oil content in the Eucalyptus globulus has been found to be in the range 0.8 - 2.0% w/w (% dry weight) depending upon the dryness of the leaves. The essential oils were analyzed by GC/MS where the composition of the ten commonly found compounds in the oils are as follows: 1,8-cineole (66.28 - 75.36%), cis-ocimen (15.92 - 21.33%), α-terpineol acetate (2.70 - 3.39%), α-terpineol (1.51 - 2.26%), aromadendrene (0.69 - 2.85%), globulol (0.82 - 1.43%), β-pinen (0.96 - 1.24%), β-myrcene (0.66 - 1.00%), 4-terpineol (0.46 - 0.52%) and camphene (0.16 - 0.27%) as the main leaf oil components. The oils could be used for medicinal purpose except in the case of Maychew it needs purification and enrichment so as to make its 1,8-cineole content greater than 70%.
Keywords:-Eucalyptus globules, Hydro-distillation, Eucalyptus oil, GC/MS, 1,8-Cineole,Tigray
Original article:-
Bhusari Vidhya K. 1, Dhaneshwar Sunil R. 2*
1Ph.D. Scholar, Department of Pharmaceutical Chemistry, Bharati Vidyapeeth University, Poona College of Pharmacy, Pune, Maharashtra, India 411038.
2Professor & Chairperson, Department of Pharm.Chemistry,RAK Medical & Health Sciences University, College of Pharmaceutical Sciences, Ras Al Khaimah Post Box No 11172,U.A.E.
Abstract:- HPLC method has been described for simultaneous determination of Amlodipine besylate, Atenolol and Aspirin in formulation. This method is based on HPLC separation of the three drugs on the Thermo Hypersil BDS–C18 (250 mm × 4.6 mm, 5.0 µ) from Germany with isocratic conditions and simple mobile phase containing methanol: 10 mM phosphate buffer with pH 7.0 adjusted with ortho phosphoric acid (70: 30) at flow rate of 1 mL/min using UV detection at 235 nm with Rt of 2.58 min for Amlodipine besylate, Rt of 3.40 min for Atenolol and 4.23 min for Aspirin. This method has been applied to formulation without interference of excipients of formulation. The linear regression analysis data for the calibration plots showed a good linear relationship over the concentration range of 2-12 µg/mL for Amlodipine besylate, Atenolol and 4-24 µg/mL for Aspirin, respectively. The mean values of the correlation coefficient, slope and intercept were 0.9993 ± 0.63, 2134.1 ± 0.54 and 1676 ± 0.89 for Amlodipine besylate, 0.9994 ± 0.91, 21326 ± 1.02 and 42960 ± 0.74 for Atenolol and 0.9993 ± 1.02, 15182 ± 0.48 and 64910 ± 0.64 for Aspirin, respectively. The method was validated for precision, robustness and recovery. The limit of detection (LOD) and limit of quantitation (LOQ) was 0.5 μg/mL and 1 μg/mL for Amlodipine besylate and Atenolol and 1 μg/mL and 2 μg/mL for Aspirin, respectively. Statistical analysis showed that the method is repeatable and selective for the estimation of Amlodipine besylate, Atenolol and Aspirin.
Key Words:-Amlodipine besylate, Aspirin, Atenolol, HPLC, Method development, Validation.
Case Report
*Ankur Jhanwar. 1, Radheyshyam meena. 2, Neelam Sharma3, Priyanka Maheshwari4
1 MS, General Surgery, Senior Resident, 2 MS, General Surgery, Prof. & Head,Department of Surgery, Govt. Medical College, Kota (Rajasthan),India. Pin- 324001. 3 MS,Obs & Gyne,Assistant Prof,4 MS,Obs & Gyne ,Senior Resident, Department of Obstetrics and Gynecology,S.R.G. Hospital and Medical College, Jhalawar,Rajasthan,India. Pin- 326001.
Abstract:- Evisceration of small intestine through the anus has been reported to occur spontaneously and in association with trauma. We report a unique case of a 4 year old male child who sustained a penetrating injury through rectum with a traumatic evisceration of small bowel through anus while playing. There were no apparent abdominal injury on examination. Interesting photos pre and post operative are presented. He was managed successfully.
Key Words:- Penetrating injury, Transanal evisceration of small bowel, rectal tear
Original article:-
Jaspreet Kaur1, K.M.Prabhu2, L.C.Thakur3.
1Professor,H.O.D.,I.T.S. Centre for Dental Studies and Research, Delhi-Meerut Road, Murad Nagar, Ghaziabad- 201206,India.
2Professor , Department of Biochemistry, 3 Professor , Department of neurology ,UCMS & GTB Hospital, Shahdra, New Delhi, India.
Abstract:- Serum magnesium is an indispensable element for man .It is indispensable activator of over 300 enzymes in humans. Hypomagnesia (ionized form) leads to neuromuscular hyperirritability, tremors, increased vascular resistance ,coronary vasospasm and hypertension . Magnesium deficiency triggers vasoconstriction, enhances vascular endothelial injury and hence leads to atherosclerosis.The present study evaluated serum magnesium levels in transient ischaemic attack and stroke patients. Method: The study was carried on 50 diagnosed cases of acute ischaemic stroke,10 cases of TIA and 60 healthy controls(age and sex matched) Fasting blood samples were collected and assessed for serum magnesium levels. Statistical analysis was performed P value less than 0.05 were considered significant. Result: The value of serum magnesium is significantly lower in patient when compared with controls. Conclusion: Magnesium levels are significantly decreased in ischaemic stroke, though hemorrhagic stroke patients as well as patients of transient ischaemic attack also had magnesium deficiency. Magnesium deficiency predisposes atherosclerosis, the known modifiable risk factor of stroke.
Keywords:- Atherosclerosis, Diabetes mellitus, magnesium, transient ischemic attack, stroke.
Research article:-
R.H. Krishna Reddy, N. Naga Malleswara Rao, J. V. Suman Krishna , K. Ravindhranath*
Department of Engg. Chemistry and Post Graduate Chemistry, Bapatla Engineering College (Autonomous), BAPATLA-422101, Guntur Dt., A.P.India.
Abstract:- Leaves and their ashes of Tephrosia purpurea and Solanum nigrum have been found to have affinity towards Chromium(VI) at low pHs. The sorption abilities of these plant materials have been studied with respect to various physicochemical parameters such as pH, equilibration time and sorbent concentration in controlling the Chromium (VI) pollution in waste waters adopting batch system of extractions. Conditions for maximum extraction have been optimized. With synthetic waters, % of extractions of Chromium (VI) are found to be 84.0% and 88.0% with leaves powders and their ashes of Tephrosia purpurea respectively and 100.0% with both the leaves powders and their ashes of Solanum nigrum. Fivefold excess of common cation ions present in natural waters, viz., Ca2+, Mg2+ , Cu2, Zn2+, Ni2 + and Fe2+ are found to have synergistic effect in increasing the % removal of Chromium while anions like Phosphate, SO42- and Carbonate are interfering; monovalent ions: NO3- , Chloride, and Fluoride have marginal interference. The methodologies developed are successfully applied to some real samples of industrial effluents and polluted lakes
Keywords:-Chromium (VI), pollution control, bio-sorbents, Tephrosia purpurea, Solanum nigrum.