DocumentsDate added
Review article:-
*Peter I Aziba,
*Ph.D. Department of Pharmacology, Obafemi Awolowo College of Health Sciences, Olabisi Onabanjo University, Ago iwoye, NIGERIA.
Abstract:- This article intends to remind pharmacologists especially Researchers in developing countries on emphasis in pharmacological Research using intact animals and isolated tissues as a vital approach to drug development and inventions and call attention to IUPHAR initiatives to restore training in these principles and techniques in integrative organ systems pharmacology.
Keywords:-Bio-Assay, methods, drug, development, pharmacology.
Research article:-
*Kabnurkar R. B. *
Kabnurkar R. B., M.Pharm. Ph.D. Head, Dept.of Pharmacy P.V.Polytechnic, S.N.D.T.(W)University,Mumbai-400049,India.
Abstract:- Prepared,topical gel formulations containing active methanolic fraction of the fresh oil, of the seeds of Celastrus paniculatus Willd (Celastraceae), using Carbomer - 940, propylene glycol and glycerin. Studied the formulations, with their best compositions for physicochemical, rheological properties and stability over a period of one year. Developed a sensitive spectrophotometric method for the estimation of the active fraction ,at λ max =278 nm. Linearity studies, along with the reproducibility of the analytical method and its freedom from interference of excipients at λ max were found. Evaluation of the selected gel formulations indicated that the average content of the methanolic extract was well within ± 5%w/w limits of the labeled amount and their topical administration induced a dose dependent reduction in inflammation on carrageenan induced rat paw oedema.
Keywords:-Anti–inflammatory,Celastrus paniculatus Willd, Gel formulations.
Original article:-
S.C.Vijayvergiya1, Arvind K.Bohra1,*Purushottam Jhanwar1, Ankur Jhanwar2
1MS, Assistant Professor, Department of Orthopedics, S.R.G. Hospital and Medical College, Jhalawar, Rajasthan, India.
2MS, Senior Resident, Department of Surgery, Govt. Medical College, Kota , Rajasthan, India.
Abstract:- Background: Injuries related to agricultural equipment are a significant cause of morbidity and mortality both in high-income and low-income countries. Agricultural work is the most prevalent type of employment in the worlds. An estimated 1.3 billion workers are working in agricultural production worldwide. Agriculture related injuries are one of the common reason for hospitalization. Aim & Objective: To study the pattern of agriculture related injured patient hospitalized in S.R.G. Hospital, Jhalawar, and give a baseline for deriving effective preventive measures for the local community. Methodology: A retrospective study was done in Orthopedic unit of S.R.G. Hospital, Jhalawar over a period of three years from 2009-2011.All the data were taken from case record of patients and determined and charted in an excel sheet. Simple frequencies and percentages were derived for various variables. Result: Most cases involved males between ages of 20-39 yrs ,with a seasonal peak seen in month of October and July. There were 8.47% patients admitted in the age group of less than 20yrs and almost comparable percentage were of older age group (9.03%).Tractor was responsible for about 36% of agriculture related injuries followed by hand-operated tools and thrasher injuries (24% and 12% respectively).Most common injuries encountered were fractures (both simple and compound) about 60%.Amputation occurred in 2.02% cases.
Keywords:-Agriculture related injuries, machinery, Rollover Protective Structure (ROPS), tractors.
Original article:-
*Rudrama Devi K, Kusumlatha C, Dilip Reddy K, J. Karuna Kumari and Minny Jael.
Human Genetics and Molecular Biology Laboratory, Department of Zoology, Osmania University, Hyderabad-7, India.
Abstract:- Background: A number of antineoplatic drugs are used to combat with different types of cancer, and had been shown to cytotoxic. Adriamycin is one of most commonly used in malignant lymphomas. The antioxidants such as VitC inhibits the toxicity of mutagens/carcinogens in animals and Humans. Aim: The protective effects of ascorbic acid in adriamycin induced toxicity in swiss male mice was evaluated using sperm morphology assay. Material and Methods: Two experiments were conducted in germ cells of Swiss male mice. The cauda epidymis was collected from control and exposed group of animals after five weeks of treatment schedule and screened for presence of various types of sperm head abnormalities such as amorphous, banana hammer head etc., Results: The animals treated with 5, 10 and 20 mg/kg of ascorbic acid showed as non mutagenic where as the adriamycin induced significant increase in the percentage sperm head abnormalities but when primed with AA there is decrease in the percentages of abnormal sperms. Conclusion: VitC protects the adriamycin induced genotoxicity in germ cells of mice. Hence VitC supplementation is safer in chemotherapeutic strategy.
Keywords:- Ascorbic acid, genotoxicity, adriamycin, sperm morphology.
Research article:-
Rathod Nitin R1, Ghodasara Malay K 2, *Shah Harsh D 3
1MD, Associate professor, Department of internal medicine, 2Resident, MD , 3 Resident, MD , Department of community medicine , Guru Govind Singh Hospital, MP Shah Medical College, Jamnagar, Gujarat , India.
Abstract:- Aim and Objective: To assess the prevalence of systolic and diastolic dysfunction in patients of chronic kidney failure on conservative management. Methods: fifty patients with varying degree of chronic renal failure (CKD) were subjected to two-dimensional M mode echocardiography for determination of systolic and diastolic dysfunction. These included patients with mild to moderate CKD (n =27) and advanced CKD (n = 23). Fifty healthy controls were matched for age and sex. The left ventricular ejection fraction (EF) and fractional shortening (FS) were taken as measures of LV systolic function. Diastolic function was determined by measuring E/A ratio by spectral doppler LV inflow velocity. Results: The mean left ventricular ejection fraction (LVEF) in patients with mild/moderate CKD (56.18 ± 7.36%) and severe CKD (51.17 ± 10%) was significantly lower than the controls (62 ± 5.32%). The mean FS in the three groups was similar, 29.6% patients with mild/moderate CKD and 21.7% patients with severe CKD had FS ≤ 25%. In mild/moderate CKD 51.85% patients and in severe CKD group 82.6% patients had evidence of diastolic dysfunction. The prevalence of left ventricular hypertrophy (LVH) along with systolic dysfunction in severe CKD group was 30.4%, which was significantly higher than mild/moderate CKD group (3.7%). The prevalence of LVH along with diastolic dysfunction in severe CKD group was 56.52%, which was significantly higher than mild/moderate CKD group (11.1%). Conclusion: Patients with chronic kidney disease have higher prevalence of diastolic and systolic dysfunction and diastolic dysfunction appears to occur earlier than systolic dysfunction.
Keywords:-Chronic kidney disease, Cardiac dysfunction, Echocardiography