DocumentsDate added
Research article:-
*Kabnurkar R. B. *
Kabnurkar R. B., M.Pharm. Ph.D. Head, Dept.of Pharmacy P.V.Polytechnic, S.N.D.T.(W)University,Mumbai-400049,India.
Abstract:- Prepared,topical gel formulations containing active methanolic fraction of the fresh oil, of the seeds of Celastrus paniculatus Willd (Celastraceae), using Carbomer - 940, propylene glycol and glycerin. Studied the formulations, with their best compositions for physicochemical, rheological properties and stability over a period of one year. Developed a sensitive spectrophotometric method for the estimation of the active fraction ,at λ max =278 nm. Linearity studies, along with the reproducibility of the analytical method and its freedom from interference of excipients at λ max were found. Evaluation of the selected gel formulations indicated that the average content of the methanolic extract was well within ± 5%w/w limits of the labeled amount and their topical administration induced a dose dependent reduction in inflammation on carrageenan induced rat paw oedema.
Keywords:-Anti–inflammatory,Celastrus paniculatus Willd, Gel formulations.
Research article:-
R.H. Krishna Reddy, N. Naga Malleswara Rao, J. V. Suman Krishna , K. Ravindhranath*
Department of Engg. Chemistry and Post Graduate Chemistry, Bapatla Engineering College (Autonomous), BAPATLA-422101, Guntur Dt., A.P.India.
Abstract:- Leaves and their ashes of Tephrosia purpurea and Solanum nigrum have been found to have affinity towards Chromium(VI) at low pHs. The sorption abilities of these plant materials have been studied with respect to various physicochemical parameters such as pH, equilibration time and sorbent concentration in controlling the Chromium (VI) pollution in waste waters adopting batch system of extractions. Conditions for maximum extraction have been optimized. With synthetic waters, % of extractions of Chromium (VI) are found to be 84.0% and 88.0% with leaves powders and their ashes of Tephrosia purpurea respectively and 100.0% with both the leaves powders and their ashes of Solanum nigrum. Fivefold excess of common cation ions present in natural waters, viz., Ca2+, Mg2+ , Cu2, Zn2+, Ni2 + and Fe2+ are found to have synergistic effect in increasing the % removal of Chromium while anions like Phosphate, SO42- and Carbonate are interfering; monovalent ions: NO3- , Chloride, and Fluoride have marginal interference. The methodologies developed are successfully applied to some real samples of industrial effluents and polluted lakes
Keywords:-Chromium (VI), pollution control, bio-sorbents, Tephrosia purpurea, Solanum nigrum.
Original article:-
Jaspreet Kaur1, K.M.Prabhu2, L.C.Thakur3.
1Professor,H.O.D.,I.T.S. Centre for Dental Studies and Research, Delhi-Meerut Road, Murad Nagar, Ghaziabad- 201206,India.
2Professor , Department of Biochemistry, 3 Professor , Department of neurology ,UCMS & GTB Hospital, Shahdra, New Delhi, India.
Abstract:- Serum magnesium is an indispensable element for man .It is indispensable activator of over 300 enzymes in humans. Hypomagnesia (ionized form) leads to neuromuscular hyperirritability, tremors, increased vascular resistance ,coronary vasospasm and hypertension . Magnesium deficiency triggers vasoconstriction, enhances vascular endothelial injury and hence leads to atherosclerosis.The present study evaluated serum magnesium levels in transient ischaemic attack and stroke patients. Method: The study was carried on 50 diagnosed cases of acute ischaemic stroke,10 cases of TIA and 60 healthy controls(age and sex matched) Fasting blood samples were collected and assessed for serum magnesium levels. Statistical analysis was performed P value less than 0.05 were considered significant. Result: The value of serum magnesium is significantly lower in patient when compared with controls. Conclusion: Magnesium levels are significantly decreased in ischaemic stroke, though hemorrhagic stroke patients as well as patients of transient ischaemic attack also had magnesium deficiency. Magnesium deficiency predisposes atherosclerosis, the known modifiable risk factor of stroke.
Keywords:- Atherosclerosis, Diabetes mellitus, magnesium, transient ischemic attack, stroke.
Case Report
*Ankur Jhanwar. 1, Radheyshyam meena. 2, Neelam Sharma3, Priyanka Maheshwari4
1 MS, General Surgery, Senior Resident, 2 MS, General Surgery, Prof. & Head,Department of Surgery, Govt. Medical College, Kota (Rajasthan),India. Pin- 324001. 3 MS,Obs & Gyne,Assistant Prof,4 MS,Obs & Gyne ,Senior Resident, Department of Obstetrics and Gynecology,S.R.G. Hospital and Medical College, Jhalawar,Rajasthan,India. Pin- 326001.
Abstract:- Evisceration of small intestine through the anus has been reported to occur spontaneously and in association with trauma. We report a unique case of a 4 year old male child who sustained a penetrating injury through rectum with a traumatic evisceration of small bowel through anus while playing. There were no apparent abdominal injury on examination. Interesting photos pre and post operative are presented. He was managed successfully.
Key Words:- Penetrating injury, Transanal evisceration of small bowel, rectal tear
Original article:-
Bhusari Vidhya K. 1, Dhaneshwar Sunil R. 2*
1Ph.D. Scholar, Department of Pharmaceutical Chemistry, Bharati Vidyapeeth University, Poona College of Pharmacy, Pune, Maharashtra, India 411038.
2Professor & Chairperson, Department of Pharm.Chemistry,RAK Medical & Health Sciences University, College of Pharmaceutical Sciences, Ras Al Khaimah Post Box No 11172,U.A.E.
Abstract:- HPLC method has been described for simultaneous determination of Amlodipine besylate, Atenolol and Aspirin in formulation. This method is based on HPLC separation of the three drugs on the Thermo Hypersil BDS–C18 (250 mm × 4.6 mm, 5.0 µ) from Germany with isocratic conditions and simple mobile phase containing methanol: 10 mM phosphate buffer with pH 7.0 adjusted with ortho phosphoric acid (70: 30) at flow rate of 1 mL/min using UV detection at 235 nm with Rt of 2.58 min for Amlodipine besylate, Rt of 3.40 min for Atenolol and 4.23 min for Aspirin. This method has been applied to formulation without interference of excipients of formulation. The linear regression analysis data for the calibration plots showed a good linear relationship over the concentration range of 2-12 µg/mL for Amlodipine besylate, Atenolol and 4-24 µg/mL for Aspirin, respectively. The mean values of the correlation coefficient, slope and intercept were 0.9993 ± 0.63, 2134.1 ± 0.54 and 1676 ± 0.89 for Amlodipine besylate, 0.9994 ± 0.91, 21326 ± 1.02 and 42960 ± 0.74 for Atenolol and 0.9993 ± 1.02, 15182 ± 0.48 and 64910 ± 0.64 for Aspirin, respectively. The method was validated for precision, robustness and recovery. The limit of detection (LOD) and limit of quantitation (LOQ) was 0.5 μg/mL and 1 μg/mL for Amlodipine besylate and Atenolol and 1 μg/mL and 2 μg/mL for Aspirin, respectively. Statistical analysis showed that the method is repeatable and selective for the estimation of Amlodipine besylate, Atenolol and Aspirin.
Key Words:-Amlodipine besylate, Aspirin, Atenolol, HPLC, Method development, Validation.