DocumentsDate added
Original research article:- Dental Sciences
*Rizwan M Sanadi
Reader, Dept of Periodontics, Yerala Medical Trust & Research Centre’s ,Dental College & Hospital, PG Institution, Institutional Area, Sector – 4, Kharghar, Navi Mumbai- 410210 ,Maharashtra, India.
Abstract:- Aggressive periodontitis comprises a group of rare, severe, rapidly progressing forms of periodontitis characterized by an early age of clinical manifestation and a distinctive tendency for cases to aggregate in families. Aggressive periodontitis, typically results in severe, rapid destruction of the tooth supporting apparatus. The increased susceptibility of the host population with aggressive periodontitis may be caused by the combined effects of multiple genes and their interaction with various environmental factors. Co-enzyme Q10 (Co-Q10) is essentially a vitamin or vitamin-like substance present naturally in foods and every cell of the body. Co-Q10 appears to be helpful in gingivitis. Recent studies indicate a significant improvement in all the signs and symptoms of periodontal disease. Hence the present study was conducted to test the clinical efficacy of this substance incorporated in the tooth and gum gel (Co-Q Dent) in aggressive periodontitis patients.
Keywords:-Aggressive Periodontitis, Co-enzyme Q10, bleeding gums, periodontal pocket, gingival inflammation
Research article:-
*Kabnurkar R. B. *
Kabnurkar R. B., M.Pharm. Ph.D. Head, Dept.of Pharmacy P.V.Polytechnic, S.N.D.T.(W)University,Mumbai-400049,India.
Abstract:- Prepared,topical gel formulations containing active methanolic fraction of the fresh oil, of the seeds of Celastrus paniculatus Willd (Celastraceae), using Carbomer - 940, propylene glycol and glycerin. Studied the formulations, with their best compositions for physicochemical, rheological properties and stability over a period of one year. Developed a sensitive spectrophotometric method for the estimation of the active fraction ,at λ max =278 nm. Linearity studies, along with the reproducibility of the analytical method and its freedom from interference of excipients at λ max were found. Evaluation of the selected gel formulations indicated that the average content of the methanolic extract was well within ± 5%w/w limits of the labeled amount and their topical administration induced a dose dependent reduction in inflammation on carrageenan induced rat paw oedema.
Keywords:-Anti–inflammatory,Celastrus paniculatus Willd, Gel formulations.
Original article:-
Bhusari Vidhya K. 1, Dhaneshwar Sunil R. 2*
1Ph.D. Scholar, Department of Pharmaceutical Chemistry, Bharati Vidyapeeth University, Poona College of Pharmacy, Pune, Maharashtra, India 411038.
2Professor & Chairperson, Department of Pharm.Chemistry,RAK Medical & Health Sciences University, College of Pharmaceutical Sciences, Ras Al Khaimah Post Box No 11172,U.A.E.
Abstract:- HPLC method has been described for simultaneous determination of Amlodipine besylate, Atenolol and Aspirin in formulation. This method is based on HPLC separation of the three drugs on the Thermo Hypersil BDS–C18 (250 mm × 4.6 mm, 5.0 µ) from Germany with isocratic conditions and simple mobile phase containing methanol: 10 mM phosphate buffer with pH 7.0 adjusted with ortho phosphoric acid (70: 30) at flow rate of 1 mL/min using UV detection at 235 nm with Rt of 2.58 min for Amlodipine besylate, Rt of 3.40 min for Atenolol and 4.23 min for Aspirin. This method has been applied to formulation without interference of excipients of formulation. The linear regression analysis data for the calibration plots showed a good linear relationship over the concentration range of 2-12 µg/mL for Amlodipine besylate, Atenolol and 4-24 µg/mL for Aspirin, respectively. The mean values of the correlation coefficient, slope and intercept were 0.9993 ± 0.63, 2134.1 ± 0.54 and 1676 ± 0.89 for Amlodipine besylate, 0.9994 ± 0.91, 21326 ± 1.02 and 42960 ± 0.74 for Atenolol and 0.9993 ± 1.02, 15182 ± 0.48 and 64910 ± 0.64 for Aspirin, respectively. The method was validated for precision, robustness and recovery. The limit of detection (LOD) and limit of quantitation (LOQ) was 0.5 μg/mL and 1 μg/mL for Amlodipine besylate and Atenolol and 1 μg/mL and 2 μg/mL for Aspirin, respectively. Statistical analysis showed that the method is repeatable and selective for the estimation of Amlodipine besylate, Atenolol and Aspirin.
Key Words:-Amlodipine besylate, Aspirin, Atenolol, HPLC, Method development, Validation.
Original research article:-
Makwava Prakash V 1, Odedara Ram V 2, *Shah Harsh D 3
1MD Medicine, associate professor, Head of the unit,Department of medicine, 2MD Medicine, 3 Resident, MD , Department of community medicine , Guru Govind Singh Hospital, MP Shah Medical College, Jamnagar, Gujarat , India.
Abstract:- The wide spread use of organophosphorus compounds has increased incidence of its poisoning to the human kind by accidental or suicidal. Organophosphate (OP) insecticides inhibit both acetyl cholinesterase and pseudocholinesterase activities. This study helps to focus to make management protocols during morbidity at the time of presentation of poisoning. Method: A cross sectional descriptive study was done on fifty patients, by simple random sampling technique who came to emergency ward of Hospital, Jamnagar. After setting inclusion and exclusion criteria, Pre tested profoma was filled up. Analysis was done with primary information, clinical admission POP score, pseudo cholinesterase, hospital stay, atropinization requirements, need of ventilator support and mortality. Intravenous atropine and pralidoxime was administered as soon as possible. The diagnosis was performed from the history taken from the patient or the patient’s relatives after taking consent. Results: Amongst fifty patients, 78% were male and 22% were females. Mean age of the studied patients was 28 ± 10 years. In the study, inhalational poisoning (54%) had common occurrences than ingestion poisoning (46%) but mortality (6%) was found higher with ingestion. The compound that was exposed most commonly is monochrotophos (60%). Association of POP score came significant at p < 0.05 with above mentions factors. Conclusion: OP insecticide poisoning is a serious condition that requires rapid diagnosis and treatment. The patients with evidence of moderate and severe degrees of poisoning need close monitoring, as respiratory failure is the prime cause. Early management protocol will help to reduce mortality of poisoning.
Keywords:-Organophosphorus, poisoning.
Research article:-
Rathod Nitin R1, Ghodasara Malay K 2, *Shah Harsh D 3
1MD, Associate professor, Department of internal medicine, 2Resident, MD , 3 Resident, MD , Department of community medicine , Guru Govind Singh Hospital, MP Shah Medical College, Jamnagar, Gujarat , India.
Abstract:- Aim and Objective: To assess the prevalence of systolic and diastolic dysfunction in patients of chronic kidney failure on conservative management. Methods: fifty patients with varying degree of chronic renal failure (CKD) were subjected to two-dimensional M mode echocardiography for determination of systolic and diastolic dysfunction. These included patients with mild to moderate CKD (n =27) and advanced CKD (n = 23). Fifty healthy controls were matched for age and sex. The left ventricular ejection fraction (EF) and fractional shortening (FS) were taken as measures of LV systolic function. Diastolic function was determined by measuring E/A ratio by spectral doppler LV inflow velocity. Results: The mean left ventricular ejection fraction (LVEF) in patients with mild/moderate CKD (56.18 ± 7.36%) and severe CKD (51.17 ± 10%) was significantly lower than the controls (62 ± 5.32%). The mean FS in the three groups was similar, 29.6% patients with mild/moderate CKD and 21.7% patients with severe CKD had FS ≤ 25%. In mild/moderate CKD 51.85% patients and in severe CKD group 82.6% patients had evidence of diastolic dysfunction. The prevalence of left ventricular hypertrophy (LVH) along with systolic dysfunction in severe CKD group was 30.4%, which was significantly higher than mild/moderate CKD group (3.7%). The prevalence of LVH along with diastolic dysfunction in severe CKD group was 56.52%, which was significantly higher than mild/moderate CKD group (11.1%). Conclusion: Patients with chronic kidney disease have higher prevalence of diastolic and systolic dysfunction and diastolic dysfunction appears to occur earlier than systolic dysfunction.
Keywords:-Chronic kidney disease, Cardiac dysfunction, Echocardiography