DocumentsDate added
original research article:-
*K. Ashok Augustine Raj1, K.Langeswaran2, P. Krishnamoorthy3.
1Assistant Professor in Bioinformatics, 2Assistant Professor in Industrial Biotech, 3Dean-Bioengineering Bharath University, Chennai, TN,India.
Abstract:- The effects of lycopene supplementation on PCB induced endocrine interference caused by PCBs in rat Sertoli cells of PCBs exposed adult rats was investigated. The severity of the endocrine disruption was determined by measuring Traits of reproductive organs; sperm characteristics, testicular histological findings, plasma testosterone levels and the testicular tissue oxidative status were determined. Induction of PCB to rats decreased sperm concentration (p<0.05) and sperm motility (p<0.001), increased total abnormal spermrates (p<0.05) as compared with the control group. An increase in testes malondialdehyde concentrations (p<0.05) and glutathione peroxidase activities (p<0.001) were detected while significant decreases in glutathione levels (p<0.001) in PCB alone group when compared to control group. While pre-treatment with lycopene restoring only malondialdehyde concentrations, its post-treatment caused normalization in both malondialdehyde and glutathione levels when compared with the PCB alone group. On the other hand, significant increases were determined in GSH-Px activities in all experimental groups when compared with the control group. In conclusion, lycopene supplementation was found to be able to diminish the severity of PCB induced endocrine disruption.
Research article:-
*M. Srujan Kumar1, Binayak Das1, S.V.S.Rama Raju2
1Department of Pharmaceutics, Samskruti college of Pharmacy,Kondapur,R.R District,Hyderabad,India.
2Department of Pharmaceutics, C.L.Baid Metha College of pharmacy, Chennai, India.
Abstract:- Compaction of multiparticulate, commonly called MUPS, is one of the more recent and challenging technologies that combine the advantages of both tablets and pellet-filled capsules in one dosage form. Venlafaxine is an anti depressant, having an elimination half-life of 5±2 hrs and its maximum daily dose is 300mg. Since the drug belongs to BCS class I, it is necessary to retard dissolution to ensure extended release of drug. The objective of the study is to prepare venlafaxine extended release pellets by extrusion spheronization technology, coating them with mixture of rate controlling polymers Ethyl cellulose and different grades of (Hydroxy propyl methyl cellulose (HPMC) using Wurster process to achieve the desired dissolution pattern and compressing the pellets into tablets. The pellets were analyzed for the parameters such as bulk density, tapped density, compressibility index, Hausner’s ratio and the results were found to be within the limits. Drug release rate was more when compared with the innovator sample. The Venlafaxine hydrochloride extended release pellets were compressed into the tablets. The dissolution profile of the prepared Venlafaxine hydrochloride extended release tablets were compared with that of Innovator (VENLAR). Finally conclude like extended release pellets in tablets of formulation (F9) have more drug release rate rather than innovator (VENLAR) and it have better Bioavailability.
Keywords:- Extrusion and Spheronization, HPMC, MUPS, multiparticulate, wurster process.
Case report:-
Sunita Gajbhiye, 1 , Gopal Agrawal 1, S. N. Shrikhande 2
1 MD, Assistant Professor,2 MD, Associate Professor, Department of Microbiology, Indira Gandhi Government Medical College, Nagpur 440018,India.
Abstract:-Nocardia is an uncommon pathogen in immunocompetent patients; however, it has been increasingly recognized as a significant opportunistic pathogen in immunocompromised individuals. A 35 year old male patient presented with fever and multiple erythematous swellings over right supraclavicular and post auricular region. The swellings were with multiple discharging sinuses. Patient is a known case of miliary tuberculosis and is HIV seropositive. Gram stain of pus showed presence of slender, gram positive, branching, filamentous bacilli. Modified Ziehl Neelsen stain revealed numerous acid fast branching filamentous organisms with beaded appearance. On culture the isolate was identified as Nocardia asteroides.
Keywords:-Nocardia asteroids, generalized nocardiosis, infection in immunocompromised.
Original article:- Gautam Nagori 1 , Rajendra K. Gupta1, Poonam Nagori 2
1 MD, Assistant Professor, Department of Paediatrics,2 MSc Resident, Department of physiology, Jhalawar Medical College, Jhalawar, Rajasthan, India-326001.
Abstract:-
Aim: To identify and co-relate various factors affecting the outcome in children with Scorpion sting envenomation and treatment done by standard protocol using prazosin. Method: This is a prospective study of scorpion sting affected cases in children ( 1-15yrs of age) admitted and treated in dept. of pediatrics , Jhalawar medical college, Rajasthan during the period of January 2010 to December 2011.Permission was taken from Ethical committee of the college before starting the study. Consent was taken from the close relative of the patient. General characteristics of the prazosin. children, anatomic site of the sting, seasonal pattern, clinical and laboratory findings, treatment approaches, complications and outcomes recorded. Result: A total of 61 children of Scorpion sting envenomation admitted in that period. Prevelance of male child’s were found to be 57.3%. Out of them 83.6% cases belongs to rural areas. Extremities were most common site of sting (95%).62% of sting cases occurred in summer months. Local pain, perspiration and cold extremities were seen in almost all cases. The standard treatment followed with the use of prazosin after admission. Mortality seen in only 4.91% of cases. Conclusion: Early hospitalization and administration of accurate dose of prazosin and closely monitoring vitals of the patients in intensive care unit will save many lives.
Keywords:- Scorpion sting envenomation, prazosin, myocarditis, peripheral circulatory failure, pediatric intensive care unit.
Original article:-
* OMOLE, Moses Kayode Pharm. D ADEYEMI, Morenike Titilola B. Pharm.
Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, University of Ibadan.
Abstract:- The requirement for rational use of drug (RUD) is that the right drug be used with the right dose, at the right interval and at the right duration. This study was carried out to determine the rational use of anti-asthmatic drugs and to investigate various factors that influence the selection of such drugs at the University College Hospital (UCH). The study was conducted between the period of two months of May 1st and June 30th, 2010. Four case notes of two male adults and two female adults from the medical out-patient records department were randomly selected and thoroughly studied. Patient A was prescribed 8 drugs including salbutamol and prednisolone as anti-asthmatic drugs. Patient B was prescribed 7 drugs including salbutamol and aminophylline as anti-asthmatic drugs. Patient C was prescribed 4 drugs including salbutamol as anti-asthmatic drug and patient D was prescribed 6 drugs including salbutamol, aminophylline and prednisolone as anti-asthmatic drugs. There was no potential drug interaction or adverse drug reaction documented for the patients. Other complications documented were hypertension and zeazure for patient A, diabetes mellitus for patient B, and chest infection in patient D. Although the patients were discharged and pharmacotherapy individualized, anti-asthmatics which were rationally used in the studies could be implicated by irrational use of drugs in the treatment of other complications.
Key Words:- Asthma, Rational, Prescriptions, Drugs.