DocumentsDate added
Research article:-
*1Obi HI, 1Ilodigwe EE, 1Ajaghaku DE, 2Okonta JM.
1Department of Pharmacology and Toxicology, Nnamdi Azikiwe University, Agulu campus, Anambra state, Nigeria.
2Department of Clinical Pharmacy, Nnamdi Azikiwe University, Agulu Campus, Anambra state, Nigeria.
Abstract:- The antidiabetic efficacy of combined aqueous extract of Gongronema latifolium and Allium cepa a popular polyherbal therapy in treatment of diabetes mellitus in South Eastern Nigeria was assessed. Alloxan induced diabetic rats were used for the study. Surviving diabetic rats were divided into treatment and control groups. Treatment groups received the combined extracts (1:1, 1:2 and 2:1) orally at three different doses (100, 200 and 400mg/kg). Control groups received Glibenclamide (5mg/kg, oral) and normal saline. After oral administration of the combined extracts/drug, invivo measurement of blood glucose was taken hourly for 6 hours. Thereafter, oral administration was continued for 28days and blood glucose measurement was taken every 7 days. Single dose treatment and 28days treatment caused blood glucose reduction over the intervals monitored with different doses and ratios of the combined extracts. Increasing dosages of 1:1 and 2:1 of combined aqueous extracts produced a dose-dependent significant (p < 0.05) reductions in the blood glucose levels. These effects were comparable with antidiabetic effect of glibenclamide. This study showed that the combination of Gongronema latifolium and Allium cepa as a polyherbal antidiabetic remedy expressed good actions in reducing blood glucose when combined in the ratio of 1:1 or 2:1 than 1:2. b.
Keywords:- Polyherbal therapy, diabetes mellitus, alloxan, Gongronema latifolium, Allium cepa, blood glucose, positive synergy, hypoglycemic effect.
Short communication:-
*Razieh Hassankhani, Maede Ghane.
*Law Department, Bu Ali Sina University of Hamedan, Islamic Republic of Iran.
Abstract:- Today with the help of genetics we have achieved to improvement of many diseases including polio, AIDS (HIV), and tuberculosis (TB), and many biological and genetic disorders are now preventable and ultimately curable. Biological crimes are included within the two last paragraphs of article 6 of the Statute, which contain the actions are done against the bearing in a specified group, or compulsory movement of children from a group to another one. This article can be extended to the levels of genetic diversity. In this case, as mentioned in the convention on genocide, deliberate destruction of genetic characteristics of a group and deployment of some tools to prevent bearing within it, can be considered as genocide.
Keywords:- Gen, genetics, genocide.
Short communication:-
*Razieh Hassankhani.
* Law Department, Bu Ali Sina University of Hamedan, Islamic Republic of Iran.
Abstract:- Genetics is a fundamental science that discusses the transmission of hereditary information from parents to children and from generation to the next generation. The nature of genetic information, as determined in the major jurisdictions, is reviewed. The most distinctive feature of genetic information is its predictive power for individuals and for their close relatives. It has to be interpreted with care as it is generally probabilistic in nature. Biotechnology, despite fine and useful effects, such as relief and reformation of congenital abnormalities, improvement of some disease, e.g. rickets has many uncomplimentary effects in simulation sphere. If these detrimental and harmful effects come to existences, there would be wretched destiny for the next generation. Such as descending human dignity, decreasing marriage statistics, satisfaction of sexual willing in absurd ways, smuggling of organs of new borne humans .
Keywords:- Freedom, Gen, genetic, simulation.
Research article:-
*R P Mishra1, Sarita Yadav2 and Anjali3 1R&D Division,MRD LifeSciences, Lucknow, India.
2M. G. Institute of Applied Sciences, Jaipur, India.
3Lachoo Memorial College of Science and Technology, Jodhpur, India.
Abstract:- The Methanolic extract of Citrus limetta screened against various bacterial and fungal pathogens and showed significant antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus and zero or no antifungal activity against Candida albicans, Trychophyton rubrum, Microsporum and Aspergillus niger. It is seen that methanol column has maximum antibacterial activity in E. coli JH-2 (17mm) among all solvents and minimum in S. aureus (12mm) in case of peel and juice whereas in pomace methanol suspension maximum (14mm) and no antimicrobial activity seen some extracts and in seeds cold water extract had shown partial inhibition. Among all extracts Citrus limetta juice cold water has lowest MIC i.e.22.85 mg/ml in S. aureus and maximum in pomace column extract 42.42 mg/ml in E. coli but no MIC seen in seeds.
Keywords:- Antimicrobial activity, Disc diffusion method, Phytochemicals, MIC, Citrus peel, juice, pomace and seed extract.
Research article:-
*Bhosale Suryakant D.1, Dr. (Mrs.) Rajput Sadhana J.2
1Research Scolar, Quality Assurance Laboratory, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda. Vadodara-390 001, Gujarat, India.
2Professor, Pharmacy Department, Faculty of Technology and Engineering, The Maharaja Sayajirao University of Baroda.Vadodara-390 001, Gujarat, India.
Abstract:- RP-HPLC Method For Simultaneous Estimation of Escitalopram Oxalate And Etizolam In A Tablet Formulation. An isocratic reversed phase HPLC method has been developed for the simultaneous determination of escitalopram oxalate and etizolam on a HiQ-silC18HS (250 x 4.6 mm) column using a mobile phase consisting of methanol:phosphate buffer pH-5 (70:30,v/v) at a flow rate of 1 mL/min and the detection was carried out at 254 nm. Retention times of escitalopram oxalate and etizolam were found to be 4.85 (± 0.31) min and 7.65 (± 0.56) min respectively. The method was validated with respect to specificity, linearity, accuracy, precision, ruggedness and robustness. This method is simple, precise, and sensitive and is applicable for simultaneous quantification of escitalopram oxalate and etizolam in a tablet formulation.
Keywords:- Isocratic, reverse phase, validation.