DocumentsDate added
Short communication
Manoj G Tyagi.
Department of Pharmacology, Christian Medical College, Vellore 632002, Tamilnadu, India.
Abstract:- Nattokinase is an enzyme found in Nattô, a popular Japanese cheese made from fermented soyabeans. This enzyme has been found to dissolve blood clots. Clots that form inside a blood vessel in the absence of a wound may restrict the blood flow and lead to heart attack or stroke. Nattokinase can diminish this risk. On the other hand, because of its powerful vasoconstrictor properties, and its effects on intracellular calcium, ET-1 has been implicated in the pathogenesis of hypertension, coronary vasospasm, and heart failure. A number of studies suggest a role for ET-1 in pulmonary hypertension, as well as in systemic hypertension. ET-1 has been shown to be released by the failing myocardium where it can contribute to cardiac calcium overload and hypertrophy. In this study, I propose that a combination of nattokinase enzyme and endothelin-1 receptor antagonist can ameliorate the cardiovascular ailments like the hypertension and cardiac failure.
Key Words :- Nattokinase, endothelin, hypertension, cardiac, fibrin.