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Research article:-Anatomy
* A.Mary Antony Praba¹, C.Venkatramaniah². ¹Assistant Professor, Department of Anatomy, Tagore Medical College, Chennai, India.
²Assistant Professor, Department of Anatomy, Sri Lakshmi Narayana Institute of Medical Sciences, Pondy, India.
Abstract:- Pterion is a region in the anterior part of the floor of the temporal fossa where the greater wing of the sphenoid, the parietal, frontal and the squamous temporal bones meet and form a H shaped suture. Alternatively it is the meeting region of these 4 bones(1,2). It is an commonly used landmark to find the place of anterior division of middle meningeal artery inside. There are four different types of pterions they are the spenoparietal, frontotemporal, stellate and the epipteric varieties(3,2,4). Because the anatomical variation is been so much cared by the forensic anthropologists, neurosurgeons and the forensic pathologists, we find it necessary to study the occurrence of different types of pterion in the skulls of Tamil Nadu regions. So as to full fill the criteria the different types of pterion and it’s occurrence in relation with the middle meningeal artery is been studied. The most occurring type of pterion among tamil nadu skulls are found to be the spenoparietal variety and the frontotemporal the least. Each pterion has a little difference their association with the middle meningeal artery and is important for neurosurgeons and forensic anthropologists.
Key Words :- Pterion, frontozygomatic suture, meningeal.
Research article:-
Maninder Karan1, Prerna Sarup2, Vandana Suneja3, *Karan Vasisht1.
1M. Pharm., Ph. D.2 M. Pharm.3 BAMS. University Institute of Pharmaceutical Sciences–UGC Centre for Advanced Studies , Panjab University, Chandigarh 160014, India.
Abstract:- Guggulu is an esteemed product of Ayurveda, used for over thousands of years and enjoy high status for its versatile use in several ailments. The two most important pharmacological properties of guggulu are its anti-inflammatory and hypolipidaemic actions. Ayurvedic texts describe at least seven purification processes of raw guggulu before incorporating it into different formulations to overcome the side effects. The present study was undertaken to find out the effect of seven different methods of purification of raw guggulu on inflammation. The anti-inflammatory activity of guggulu purified by different methods was found to be quiet variable and the activity of different guggulu’s was in the order: nirgundi swaras with haldi curna > vasa kasaya > cow milk > vasa swarasa > water/cow urine > triphla kasaya. The maximum activity shown by guggulu purified in nirgundi swaras with haldi curna was 50.16 percent at 3 h, while guggulu purified in triphla kasaya exhibited 36.72 percent protection at same time interval.
Keywords:-Guggulu, Ayurvedic purification methods (sodhanvidhi), anti-inflammatory activity.
Review article:-Periodontology and Oral Implantology
1*Sonakshi Gupta and 2 Vidya Dodwad.
1*Postgraduate student (III Yr), Department of Periodontology and Oral Implantology, I.T.S.-CDSR, Muradnagar, Ghaziabad,U.P,India.
2MDS, Professor and Head, Department of Periodontology and Oral Implantology, I.T.S.-CDSR, Muradnagar, Ghaziabad, U.P,India.
Abstract:- Tetracyclines belong to a notable class of biologically active and commercially valuable compounds. Chemically modified tetracyclines are one such group of drugs which have been viewed as potential host modulating agents. A major advantage of CMTs (unlike tetracyclines) is the lack of antimicrobial activity and development of antibiotic resistant microbial flora in vivo in long term therapy. The non-anti-microbial properties of chemically modified tetracyclines (CMTs) have shown a great promise in their therapeutic value in field of dentistry. Among them CMT-1, CMT-3 and CMT-8 have been tested for periodontal applications. Recent studies have shown that CMT-3 and CMT-8 inhibit tumor metastasis and arthritis affected synoviocyte invasion in animal models.
Keywords:- Chemically modified Tetracyclines, Host Modulating agents.
Review article:-Periodontology & oral implantology
Sweta Kumari Singh1* , Vidya Dodwad2 & Garima Dhariwal3
1Post graduate Student, 2Professor and HOD, 3Post graduate Student, Department of Periodontology & oral implantology, I.T.S. Centre for Dental Studies and Research, Delhi-Meerut Road, Murad Nagar, Ghaziabad- 201206, India.
Abstract:- Periodontitis is an “infectious disease resulting in inflammation within the supporting tissues of the teeth, progressive attachment loss and bone loss”. Periodontal therapy is aimed at the restoration of tissues destroyed by disease. However, achieving greater predictability with regenerative therapy requires the introduction of an agent which not only hampers tissue destruction but also enhances the regenerative capabilities of the periodontal tissues. Simvastatin is a hypolipidemic drug used to control elevated cholesterol, or hypercholesterolemia. It is a member of the statin class of pharmaceuticals. The primary uses of simvastatin are for the treatment of dyslipidemia and the prevention of cardiovascular disease. Simvastatin has been reported to promote osteoblastic activity and inhibit osteoclastic activity by inhibiting a rate-limiting enzyme of the cholesterol synthesis pathway. Locally applied simvastatin induces osteogenesis and bone growth by upregulation of BMP-Various animal and human studies showed that SMV assists in bone regeneration and has an anti-inflammatory effect when delivered or applied locally.
Key words:- Simvastatin, periodontal therapy, bone regeneration, BMP-2.
Review article:-Engineering chemistry
*Chandak Shilpa1, Sharma Dipak2, Sharma Vimukta3 and Dubey Arti.
1Department of Engineering Chemistry, VITS, Indore, MP, India.
2Department of Chemical Sciences, Maharaja Ranjit Singh College of Professional Sciences,Indore, MP, India.
3Principal, B.M. College of Pharmacy, Indore, MP, India.
Abstract:- Pyrimidines have been reported to possess various biological activities. Review indicates that compounds having pyrimidine nucleus have wide range of therapeutic uses that includes antimicrobial, antiviral, antioxidant, antitumer, antilukemia, antileishmanial and anti-inflammatory. Due to interesting activity of various substituted pyrimidines as biological agents considerable attentions have focused on this class. The pharmaceutical importance of these compounds lies in the fact that they can be effectively used as analgesics, anti-inflammatory, anticonvulsant, insecticidal, herbicidal, antitubercular anticancer and antidiabetic agents. The ability of thiazine to exhibit antitubercular, antibacterial which is inactivate HIV in biological fluids and used as cannabinoid receptor agonists. In the light of these interesting biological activities, it appeared of interest to synthesize some new pyrimidine derivatives. Pyrimidine is the most important member of all the diazines as this ring system occurs widely in living organisms. Purines, uric acid, alloxan, barbituric acid and a number of antimalarial and antibacterial drugs also contain the pyrimidine ring. Various derivatives like 4-(Morpholin-4-yl)-5,6,7,8-tetrahydro[1]benzothieno[2,3-d]pyrimidine(1), 4-(3-Methyl-5-phenyl-1H-pyrazol-1-yl)-5, 6, 7, 8-tetrahydro [1] benzothieno [2, 3-d] pyrimidine(9), 4-Benzoyl-3-(4-fluorophenyl)-1-(4-nitrophenyl)-5-phenylpyrazole (11). -been thoroughly studied and it was found that they are synthesized by conventional method of synthesis with different solvents and conditions similarly while1-Methyl-2-methylthio-4-(anisyl)-5-cyano-1,6-dihydropyrimidine-6-one.(24), 5-Cyano-1-(2,4-dimethyl-phenyl)-6-(4-methoxyphenyl)-2-thiouracil(40) were studied and they were found to have an advantage over the conventional once as their method was by microwave synthesis. Furthermore all these compound posses’ good pharmacological activities. Hence the review of pyrimidine derivatives gives a vast scope for further research in this area.
Key Words:- Pyrimidine derivatives, pharmacological activities, conventional method and microwave synthesis, benzothieno, antimicrobial activity, heterocyclic compound.