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Research article
Verma S.,Thakur B and *Das S.
G. D. Rungta College Of Science And Technology, Kohka Kurud Road, Bhilai, Durg, Chhattisgarh,India.
Abstract:- Water is important component of all living beings. It also performs unique and indispensible activities in earth ecosystem, biosphere and biogeochemical cycles. Physiochemical parameters were conducted to gain knowledge on the ponds. This study was carried out in the month of May -June (2012).the results showed that in the pond water The hardness, calcium, magnesium content was found to be high. The Dissolved Oxygen was found to be ~ 24.2mg/l while BOD remained ~7.28mg/l . Presence of NO3, PO4, and NH3 were also recorded. TDS values were ~1970mg/L.
Key Words:-Water sample, physico-chemical parameters.
Research article:-
Sanjeev Dole1, Amit D. Kandhare2, Pinaki Ghosh2, Tejas P. Gosavi1*, Subhash L. Bodhankar2 1Sanjeeven Homeo Clinic and Research Centre, Pune-411004, Maharashtra, India 2Department of Pharmacology, Poona College of Pharmacy, Bharati Vidyapeeth Deemed University, Pune-411038, Maharashtra, India
Abstract:- Introduction: Benign Prostatic Hyperplasia (BPH) and Lower Urinary Tract Symptoms (LUTS) are the uprising disease maladies troubling most of the old age population with much distress and irritability. Major surgical procedures without much adverse events gain a popularity of treatment choice. Nevertheless complementary medicine also ranks better in offering the non invasive solution with safety and efficacy. Homeopathy is also one of them frequently prescribed and accepted by the community for relief and cure. Material and Methods: Total 66 men above 40 years were enrolled in this study. All the patients were examined and screened with I-PSS score chart at base line. Three patients with very low and three with very high I-PSS score were excluded from the study. All the patients were followed up for a single time after 15 days from baseline visit. For the same visit the I-PSS score was taken again to compare from initial visit. The homeopathic medicine was prescribed in oral dosage form on 4 globules for a single time. Medicines prescribed on the basis of principle of individualization according to homeopathic philosophy. Result: The I-PSS score and Quality of Life both were found to be improved significantly (P < 0.001) with homeopathic treatment. Conclusion: From the present study it could be concluded that homeopathic treatment is effective therapeutic modality to improve the quality of life and symptomatic relief in men with BPH and LUTS.
Keywords:- Benign prostatic hyperplasia, Homeopathic medicine, International Prostate Symptom Score, Lower urinary tract symptoms, Quality of Life, Questionnaires, Urinary bladder.
Abbreviations:- BPH: Benign Prostatic Hyperplasia, I-PSS: International Prostate Symptom Score, LUTS: Lower Urinary Tract Symptoms, QOL: Quality Of Life.
Research article:-
*Soumendra Sahoo1, Rashmirekha Sahoo2, Yogesh Panditrao Palve 3 and Padmalochan Nayak 3
1Melaka Manipal Medical College, Melaka, Malaysia.
2Nilai University , Nilai, Malaysia.
3P.L.Nayak Research Foundation and Center for Nanoscience and Nanotechnology, Synergy Institute and Technology, Bhubaneswar, Odisha, India.
Abstract:-In the present research program, polymer nanocomposites have been used as the drug carrier for delivery systems of ocular drugs. Tamarind and Polyvinyl Alcohol (PVA) with different ratios were blended with different wt% of Cloisite 30B solution by solvent casting method. Cloisite 30B was incorporated in the formulation as a matrix material component which also plays the role of a co-emulsifier in the nanocomposite preparation. Timolol maleate in different concentrations was loaded with Tamarind-PVA/C 30B nanocomposites for studying the in-vitro drug delivery systems. Morphology and structure characterization of nanocomposites were investigated by fourier transmission infra red spectroscopy (FTIR), scanning electron microscope (SEM), tensile strength and water uptake capacity. The drug release was studied by changing time, pH and drug concentrations. The kinetics of the drug release was studied in order to ascertain the type of release mechanism. Based on the diffusion as well as the kinetics, the mechanism of the drug release from the composite matrix has been reported.
Keywords:-Tamarind, PVA, C 30B, Timolol maleate, Ocular film, Drug Delivery.
Research article:-
K. Karunambigai*, C. Saravanan, C. A. Sureshkumar, K. Kaveri, M. Thamizhmozhi.
Aadhibhagawan College of Pharmacy, Rantham, Cheyyar-604407, Thiruvannamalai, Tamil Nadu, India.
Abstract:- The present work describe a reverse phase HPLC method for line quantification of carbandazim in raw and cooked Indian Cereals as pulses the retention time of carbandazim is 2.85minutes in RP HPLC using 10%V/V phosphate butter in acetonitrile water in ratio 17.37:46 as mobile phase and c18 (5u 250X4.6mm)by hypersil column as stationary phase . The effluent was monitored by UV detection at 230nm the method was validated for accuracy, precision, specificity in this study 15 samples of cereals by pulses of different varieties were analyzed for residues of carbandazim in raw as well as cooked forms. The maximum residual limit for cerbandazim residues in cereals and pulses is 0.5 mg/kg. The analyzed amount of carbandazim residues in raw sample of cereals and pulses was 0.0320-18.8171 mg/kg by collected samples 0.003-0.6776 mg/kg. The carbandazin plots were within range of 0.1 to 100 mg /ml (R.0.9995), the observed percentage recovery of carbandazim was found to be 90.09-102-82% which indicated good accuracy and reproducibility of the method.
Key words:- RP-HPLC, Carbendazim, Cereals, Pulses, Determination.
Research article:-Biochemistry
*Renu Nagar Department of Biochemistry, Dr. RP Govt. Medical College, Kangra, Himachal Pradesh, India.
Abstract:-Prostate Specific Antigen (PSA) has long been used as a biological marker for prostatic cancer. Recent studies have demonstrated that PSA synthesis can be induced in both sexes by steroid hormones including Progesterone. PSA is present in the breast milk and other body fluids and tissues of women in health and in various disease conditions. The massive amounts of steroid hormones produced by the placenta during pregnancy stimulate PSA synthesis in the breast tissue. PSA in breast milk probably plays an important role in post-natal growth and development of the infant by virtue of its IGFBP 3 protease activity liberating IGF-I, its very cationic nature, the inactivation of the Protein C inhibitors and extensive homology of PSA with Tissue kallikrein, gamma Nerve growth factor and Epidermal growth factor binding protein. In this study, PSA levels in breast milk were found to decrease with increasing time post-partum. The milk PSA levels were higher in case of lesser gestation at delivery, smaller birth weight of the baby and for a male baby.
Key Words:-Prostate Specific Antigen, PSA, Serine protease, Kallikrein, Breast milk, Insulin like growth factor binding protein, Insulin like growth factor.