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Research article:-Clinical pharmacy
OMOLE, Moses Kayode Pharm. D *1, RAWAS Kehinde Bukola. M. Pharm1
1Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, University of Ibadan,Ibadan,Nigeria.
Abstract:- This is a retrospective study in which 254 case notes of diabetes inpatients and outpatients were randomly selected from the medical record department of the University College Hospital (UCH) Ibadan and thoroughly studied. The study which was conducted between the 3 months period of June and October 2007 consisted of 156(61.4%) males and 98 (38.6%) females diabetic patients. Forty eight (18.9%) patients were aged below 30 years, 28 (11.0%) aged between 30-39 years, 27(10.6%) between 40-49 years, 59 (23.2%) between 50-59 years, 56 (22.0%) aged 60-69 years while 36 (14.2%) aged 70 years and above. Ninety (35.4%) patients had type 1 DM, 162 (63.8%) had type 2 DM, while 2 (0.8%) had gestational DM. One hundred and thirty (52.0%) were on antidiabetic monotherapy, while 120 (48.0%) were on antidiabetic combination therapy. Other concomitant drugs prescribed were 103 (53.9%) ACEIs, 98 (40.7%) calcium channel blockers, 101 (41.9%) diuretics, 91 (37.8%) aspirin, 7 (2.9%) lipid lowering drugs, and 197 (81.7%) antibiotics. Diabetic complications documented include 4 (2.2%) hyperglycemic coma, 13 (7.1%) peripheral neuropathy, 36 (19.8%) diabetic foot ulcer, 47 (25.8%) diabetic neuropathy, 48 (26.4%) diabetic nephropathy, and 23 (12.6%) diabetic retinopathy. The study showed that optimal therapy for diabetes mellitus required aggressive management that involves all health care professionals beginning from when diabetes is diagnosed.
Keywords:-Type 1 diabetes Mellitus,Type 2 diabetes mellitus, Gestational diabetes,Management, Diabetic complications, Concomitant drugs.
Research article:-Biotechnology
*1Singh Mukesh (Ph.D), 2Majumdar Anurima (Ph.D), 3Momi Navneet (M.S, Ph.D pursuing) 4Bhattacharjee Aishwarya (M.Tech), 4Majumdar Kaustav (Ph.D pursuing), 4Kundu Soumyabrata (M.Tech), 4 Paul Rituparna (B.Tech), 4 Maity Dipanjana (B.Tech), 1Sasmal Kankaayan (B.Tech pursuing) and 1Sarkar Ankita (B.Tech pursuing).
*1Department of Biotechnology, Haldia Institute of Technology, Purba Medinipur, Haldia, India.
2University of Florida, Gainesville, FL.
3University of Nebraska, Omaha, Nebraska.
4Department of Biotechnology, Bengal College of Engg. & Technology, Durgapur, India.
Abstract:- Free radicals can cause damage to biomolecules and thus alter biological metabolism leading to dreadful diseases like cancer, diabetics, and age related disorder. From ancient times, plants have been known to possess medicinal properties and hence they have immense therapeutic potential. Tea (Camellia sinensis L.) is one of the most common beverages and people all over the world consume it on daily basis. Tea has many bioactive components like polyphenols, catechins, flavonoids etc. that have the intrinsic power to scavenge reactive oxygen species. The present research was undertaken to measure the effects of tea leaves’ extracts in reducing the oxidative stress induced by Mohr’s salt (Fe 2+) ions and H2O2 (Fenton system) in Calf thymus (CT) DNA. In addition, superoxide scavenging activity of the same extracts was also measured by auto-oxidation of hematoxilin. Boiled aqueous extracts of fresh green leaves and semi-fermented leaves were used for the above said study. This study showed that there was a dose-dependent protection of Fe 2+ ions and H2O2 stressed CT DNA and inhibition of superoxide radicals. Both gel electrophoresis and superoxide assay results correlated each other. These results suggested that tea leaves have the potential to serve as a beverage as well as a medicine against free-radical-associated oxidative damage and related degenerative diseases involving metabolic stress, genotoxicity and cytotoxicity.
Key words:- Antioxidant activity, Camellia sinensis, DNA strand, reactive oxygen species (ROS).