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Research article:-
K. Karunambigai*, C. Saravanan, C. A. Sureshkumar, K. Kaveri, M. Thamizhmozhi.
Aadhibhagawan College of Pharmacy, Rantham, Cheyyar-604407, Thiruvannamalai, Tamil Nadu, India.
Abstract:- The present work describe a reverse phase HPLC method for line quantification of carbandazim in raw and cooked Indian Cereals as pulses the retention time of carbandazim is 2.85minutes in RP HPLC using 10%V/V phosphate butter in acetonitrile water in ratio 17.37:46 as mobile phase and c18 (5u 250X4.6mm)by hypersil column as stationary phase . The effluent was monitored by UV detection at 230nm the method was validated for accuracy, precision, specificity in this study 15 samples of cereals by pulses of different varieties were analyzed for residues of carbandazim in raw as well as cooked forms. The maximum residual limit for cerbandazim residues in cereals and pulses is 0.5 mg/kg. The analyzed amount of carbandazim residues in raw sample of cereals and pulses was 0.0320-18.8171 mg/kg by collected samples 0.003-0.6776 mg/kg. The carbandazin plots were within range of 0.1 to 100 mg /ml (R.0.9995), the observed percentage recovery of carbandazim was found to be 90.09-102-82% which indicated good accuracy and reproducibility of the method.
Key words:- RP-HPLC, Carbendazim, Cereals, Pulses, Determination.
Research article:- Pharmacy
Dr. Srisombat Nawanopparatsakul1,Dr.Patamawan Phuagphong2 and Nudchanart Kitcharoen 2
1Associate.Prof, 2,3Assistant .Prof. Faculty of Pharmacy, Silpakorn University, Nakornpathom, Thailand.
Abstract:- The objective of this study was to screen inhibitory effects of selected herbs on plant growth. The peels of three species of Citrus, Citrus maxima (Burm.f) Merr., Citrus reticulata Blanco and Citrus aurantifolia (Christm.), were selected for various extractions. Three extraction solvents: methanol, 80% methanol and water were used in this study. The test methods were seed germination bioassay which focused on percent inhibition of seed germination, and seedling length bioassay that reflected the inhibitory effects on root elongation of seedling plants of lettuce seeds, Lactuca sativa L with suitable germination and growth rate as the representative for weeds in the test such as sensitivity, simplicity, low cost and suitability. The result showed that the 1 mg/ml of 80% methanol extracts of Citrus aurantifolia had significant inhibitory effects on germination of lettuce seeds. For the seedling length bioassay, three extracts of Citrus aurantifolia had inhibitory effects on root elongation of lettuce seeds with EC10 of 0.01 µg/ml, 0.11 µg/ml, 0.01 µg/ml for MeOH, 80% MeOH and aqueous extracts, respectively. The study is worthy of further investigation since this could provide potential bioherbicide and may lead to the discovery of new effective and applicable bioherbicide.
Keywords:- Citrus spp, seed germination bioassay, seedling length bioassay, bioherbicide.
Review article:-Periodontology & oral implantology.
Garima Dhariwal 1*, Vidya Dodwad2 & Sweta Kumari Singh3
1Post graduate Student, 2Professor and HOD, 3Post graduate Student, Department of Periodontology & oral implantology, I.T.S. Centre for Dental Studies and Research, Delhi-Meerut Road, Murad Nagar, Ghaziabad- 201206, India.
Abstract:- Chronic inflammatory periodontal disease is caused by host immune responses to periodontal microorganisms. In the past decade, our understanding of the pathogenesis of periodontal disease has improved. As more is learned about the role of the host response, new strategies for periodontal disease management have been emerging.. This development underscores the importance of exploring inflammatory pathways and mediators, thus setting the stage for the development of new prevention and treatment strategies of a widespread disease. So, this review paper discusses components of periodontal disease pathogenesis and their modulation.
Keywords:- Periodontal, Modulation therapies, Host Modulatory therapies.
Original article:-Medical microbiology
*Adenike A.O. Ogunshe,1 Mary T. Niemogha,2 Gabriel N. Azum3 & Anthony N. Odikagbue4
1Applied Microbiology and Infectious Diseases, Department of Microbiology, Faculty of Science, University of Ibadan, Nigeria.
2 Nigerian Institute of Medical Research, 6 Edmond Crescent, PMB 2013. Yaba, Lagos, Nigeria.
3Department of Botany & Microbiology, Faculty of Science, University of Ibadan, Nigeria.
4Department of Medical Microbiology & Parasitology, University College Hospital, Ibadan,Nigeria.
Abstract:-
Phenotypic antibiotic resistance profiles of 172 human wound-borne bacterial strains of (Bacillus, Staphylococcus, Streptococcus, Clostridium, Aeromonas, Enterobacter, E. coli, Klebsiella, Morganella, Proteus, Pseudomonas, Shigella and Yersinia) species, isolated from ≤ 75-year female and ≤ 85-year old male patients, including neonates and children, at two General hospitals and two tertiary health care institutions in Lagos and Oyo States of Nigeria were determined. High resistance and multiple antibiotic resistance (MAR)- Lagos: (Gram-positive = 62.3-100%; MAR = 25.0-100% / Gram-negative = 75.0-100%; MAR = 50.0-100%) and Ibadan: (Gram-positive = 57.9-97.4%; MAR = 40.0-100% / Gram-negative = 51.0-93.9%; MAR = 50.0-100%) against antibiotics (discs) were exhibited by the bacteria respectively. Gram-positive bacteria from Lagos were totally resistant to cloxacillin, while Gram-negative bacteria were totally resistant to cotrimoxazole but strains from Ibadan were mostly resistant to gentamicin / tetracycline (81.6%), erythromycin (89.5%), cloxacillin (97.4%) and augmentin (93.9%). Overall susceptibility rates to antibiotic drugs commonly used in self-medication for topical and systemic wound treatments in Nigeria were- penicillin, ampicillin (73.9%), erythrocin, tetracycline (78.3%) and erythromycin (82.6%). In conclusion, relatively high resistance and MAR to antibiotic discs but very high susceptibility to certain antibiotic drugs were exhibited by wound-borne bacteria, indicating that potent antibiotic drugs can serve as topical therapeutic agents in skin wound treatment.
Key Words- Antibiotics, septic wounds, topical skin treatments, wound cultures, wound care.
Clinical study:-Orthopaedics
1Ranganatha Babu Kurupati, MS , 2*YP Raghavendra Babu, MD, and 3O.B.Pattana Shetty, MS.
1Assistant Professor, Department of Orthopaedics, MVJ Medical College, Bangalore,India. 2Associate Professor, Department of Forensic Médicine & toxicology, Kasturba Médical Collège, Mangalore, Manipal University,India.
3 Professor and Head, Department of orthopedics, Shri B.M. Patil Medical College, Hospital & Research Centre, Bijapur,India.
Abstract: Tibial fractures are one of the commonest fracture involving the human skeletal system which has a high level of morbidity due to various reasons. The present study was conducted to evaluate the functional outcome in fracture shaft of tibia treated with intramedullary interlocking nail.
Keywords:-Tibial fracture, Skeletal system, Intramedullary interlocking, morbidity.