DocumentsDate added
Review article:-Pharmacology
Manoj G Tyagi and K Arumugasamy
Department of Pharmacology, Christian Medical College, Vellore 632002, Tamilnadu, India.
Abstract:-Serine protease inhibitors contribute in patho-physiological conditions.An important Serine protease enzyme inhibitor like the Protease nexin-1 (PN-1) is a 43 kDa protein of the serpin superfamily secreted in the extracellular space, where it binds and inhibits several serine proteases, including thrombin, trypsin, plasmin, tPA, and uPA. Its expression is finely regulated both spatially and temporally during development and in adulthood. In vivo, PN-1 regulates proteolytic activity in both the central nervous system (CNS) and peripheral nervous system (PNS). Mechanistically, PN-1 has been shown to promote neurite outgrowth and regulate survival or death of injured neurons. Injury of the rat sciatic nerve triggers PN-1 production in Schwann cells localized at the distal site of the lesion, possibly to protect structures from prolonged and extensive proteolytic attacks.This review reflects on their roles in nervous system disorders.
Key Words:- Protease inhibitor, Protease nexin-1, nerve, skeletal, thrombin.
Research article:-Pathology
*1Deshpande Rangrao H and 2S.K.Wadde. 1,2M.D. Pathology , Department of Pathology, MIMSR Medical College, Latur, India.
Abstract:- Aims & Objectives: Safety of blood is very important. Blood transfusion can cause the transmission of infections to recipients. This is an important mode of infection. The aim of study to assess HCV infection among blood donors. Retrospective study of five years from Jan.2007 to Dec.2011 was done. This study was conducted at Blood bank, MIMSR Medical College Latur, Govt. Medical College, Latur and Bhalchandra Blood bank, Latur. Materials & Methods: Total 10, 4925 donors were tested. Donors were screened for seroprevalence of HCV along with other necessary tests. Screening of HCV was done by Elisa method. Results: The Seroprevalence of HCV was 0.22% in total donors. Conclusion: The Seroprevalence is decreasing from 2007 to 2011 in this study in this type of infection. But it should be noted that maximum donors are voluntary (79.33%) who have donated blood in big blood donation camps. To reduce the seroprevalence still low, the selection of voluntary donors should be of high quality.
Key words:- Seroprevalence, Blood donation, HCV, blood transfusion infections.
Research article:-Pharmacology
Rajeev Kumar, Vasudevan Prabhakaran and Manoj G.Tyagi*
Department of Pharmacology Christian Medical College, Vellore 632002,Tamilnadu,India.
Abstract:- Rheumatoid arthritis (RA) is a chronic inflammatory disease which mainly affects synovial joints and leads to damage of articular cartilage and ankylosis of joints. In this study, the effect of atorvastatin, an inhibitor of 3 hydroxyl -3-methyl glutaryl coenzyme reductase alone and in combination with netilmicin a phospholipase C inhibitor on RA were studied. RA was induced with the help of Freund ’s adjuvant (0.3ml/200gms wistar rat) in three separate Wistar rat groups. Freund ’s adjuvant is the combination of mineral oil, an emulsifier mannide monooleate with 1mg/ml heat killed dry mycobacterium tuberculosis H37Ra. During these studies, plethysmography, TNF-α levels, weight and age of animals were analyzed. After arthritis induction in group 1 (6 rats) the animals were treated with 5 mg/kg of Atorvastatin injection i.p and it was found to reduce 32.41 % of RA in 8 days as determined by paw edema and a reduction in TNF- α levels. While 42.22% reduction was found after 8 days treatment with the combination of 10 mg/kg of Netilmicin and Atorvastatin i.p injection in case of group 2 (6 rats) there was also a concomitant reduction in the levels of TNF-α in the arthritic paw. These studies suggest the interaction of these two drugs in reducing arthritic inflammation.
Key Words:- Freund’s adjuvant, atorvastatin, netilmicin, plethysmograph, arthritis, TNF-α.
Original article:-Anesthesiology
1Banu Baran, MD , *2Tuba Berra Saritas, MD , 3Cigdem Sizer, MD , 4Hale Borazan , MD , 5Gamze Sarkılar, MD , 6Seref Otelcioglu, MD.
1Banu Baran , MD, Sarayönü Government Hospital, Anesthesiology And Reanimation DPT, Konya, Turkey.
*2Tuba Berra Saritas, MD, Assistant Prof. , Necmettin Erbakan Uni. Meram Medical School, Anesthesiology And Reanimation DPT. Konya, Turkey.
3Cigdem Sizer , MD, Konya Government Hospital, Anesthesiology And Reanimation DPT Konya, Turkey.
4Hale Borazan, MD,Assistant Prof.,Necmettin Erbakan Uni. Meram Medical School Anesthesiology And Reanimation DPT. Konya, Turkey.
5Gamze Sarkılar, MD, Assistant Prof . , Necmettin Erbakan Uni. Meram Medical School Anesthesiology And Reanimation DPT Konya, Turkey.
6Şeref Otelcioğlu, MD, Prof. Dr. Necmettin Erbakan Uni. Meram Medical School Anesthesiology And Reanimation DPT Konya, Turkey.
Abstract:- Background & objectives: It is aimed to evaluate the effect of intraarticular levobupivacaine and sufentanil on postoperative pain and tramadol consumption in arthroscopic knee surgeries. Methods: The patients were and divided into three groups randomly. 10 mg levobupivacaine to Group I, 10 mg levobupivacaine with 10 mcg sufentanil to Group II and saline to Group III in equal volumes was applied before tournement deflation intraarticularly. VAS, sedation scores, tramadol consumption at 1, 2, 3, 6, 12, and 24 hours, side effects and additional analgesic requirements reported. Results: Demographics, sedation scores, additional analgesic need and haemodynamics weren't statistically different (p>0,05). VAS scores of rest and movement were statistically significant between Group I -III and Group II-III at 1, 2, 3, 6, 12.and 24 hours (p<0,05). Group I and II VAS scores were approximate but not statistically significant at rest (p>0,05) 1. and 2. hours VAS scores at movement was statistically significant (p<0,05). Postoperative tramadol consumption of Group I postoperative 1,2,3 and 6 hours results were lower than Group III(p<0,05). There was no statistically significance between all of the groups at postoperative 12 and 24 hours (p>0,05). Interpretation & Conclusions: It's thought that intraarticular levobupivacaine and sufentanil + levobupivacaine provided effective postoperative analgesia in arthroscopic knee surgery however sufentanil addition to levobupivacaine provided better pain control at early postoperative hours and reduce additional analgesic consumption.
Keywords:-Arthroscopy,Sufentanil,Tramadol,Pain.
Review article:-
R. Narasimha Raghavan. R, BDS., MSc., (PhD) *1, Philip Jacob Mathew, MDS2, Abraham Helen Mary, BDS., (MDS) 3.
1Department of Biomaterials, Saveetha Dental College, Chennai, 2Senior Lecturer, Tagore Dental College, Chennai,3 Post graduate student, Coorg Institute of Dental Sciences, Coorg.
Abstract:- Substituting bone or joint by a strong biomaterial is quite common. There is a never ending need for bone biomaterials. Recently, focus has shifted to tissue engineering and regenerative medicine. Biomaterials science has a major role to play in this field. The scaffolds selected for tissue engineering has to have its own prerequisites. Engineering these materials to suit bone biology has resulted in an entire plethora of materials and their novel modifications. This paper attempts to review the trends in bone biomaterials.
Key words:-Bone, Biomaterials, Bone scaffolds, Bone substitutes, Alloplasts.