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Research article:-Pathology
*1Deshpande Rangrao H and 2S.K.Wadde. 1,2M.D. Pathology , Department of Pathology, MIMSR Medical College, Latur, India.
Abstract:- Aims & Objectives: Safety of blood is very important. Blood transfusion can cause the transmission of infections to recipients. This is an important mode of infection. The aim of study to assess HCV infection among blood donors. Retrospective study of five years from Jan.2007 to Dec.2011 was done. This study was conducted at Blood bank, MIMSR Medical College Latur, Govt. Medical College, Latur and Bhalchandra Blood bank, Latur. Materials & Methods: Total 10, 4925 donors were tested. Donors were screened for seroprevalence of HCV along with other necessary tests. Screening of HCV was done by Elisa method. Results: The Seroprevalence of HCV was 0.22% in total donors. Conclusion: The Seroprevalence is decreasing from 2007 to 2011 in this study in this type of infection. But it should be noted that maximum donors are voluntary (79.33%) who have donated blood in big blood donation camps. To reduce the seroprevalence still low, the selection of voluntary donors should be of high quality.
Key words:- Seroprevalence, Blood donation, HCV, blood transfusion infections.
Research article:-Pathology
Khanna Vinay1*, Bairy Indira2 , Maradi Ravindra3, Khanna Ruchee4, Vishwanath Shashidhar5, Sathyanarayanachar Manjunath6
1Assistant Professor, 2Professor, 5Associate Professor, Department of Microbiology, 3Associate Professor, Department of Biochemistry, 4Associate Professor, Department of Pathology, 6Associate Professor, Department of Forensic Medicine, Kasturba Medical College, Manipal, Manipal University.
Abstract:- Recent HIV infection (<6 months) represents the initial stage of the disease, when viral replication is associated with dissemination in lymphoid tissue and a distinct immunologic response. Patients with recent infection have symptoms, including flu like symptoms, fever, skin rash, headache, diarrhea, malaise, and lethargy. Recent HIV infections also include seroconversion with positive HIV serology generally takes place at 3 to 12 weeks following the viral transmission and clinical latent period which extends beyond 6 months in which most of the patients remained asymptomatic. In this study Established HIV-1 infection (>6 months) includes clinical latent period, symptomatic HIV-1 infection, AIDS and advanced HIV-1 infection, characterized by a CD4 cell count <50/mm3. This study was conducted in 261 HIV seropositive patients with recent and established HIV-1 infection. Data analyzed using SPSS 16.0 and variables are compared by using chi square test. There were total 33 cases identified as recent cases and 228 cases as established cases. Among recent and established infection fever was the commonest presentation. Flu like symptoms were commonly seen in all cases of recent infection. Majority of established cases of HIV showed generalized lymphadenopathy with weight loss.
Key words:-Human Immune deficiency Virus, Detuned ELISA, CD4 cells, AIDS.