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Research article:-Quality assurance
1Swapnil W. Tekade, 1Shweta S. Havele, 2*Sunil R. Dhaneshwar.
1Department of Quality Assurance, Bharati Vidyapeeth University, Poona College of Pharmacy, Erandwane, Pune – 411038, Maharashtra, India.
2Department of Pharmaceutical Chemistry, RAK Medical & Health Sciences University College of Pharmaceutical Sciences Ras Al Khaimah Post Box No 11172, U.A.E.
Abstract:- This paper describes a new, simple, precise, and accurate HPTLC method for simultaneous estimation of etodolac and thiocolchicoside as the bulk drug and in tablet dosage form. Chromatographic separation of the drugs was performed on aluminum plates precoated with silica gel 60 F254 as the stationary phase and the solvent system consisted of chloroform : methanol : toluene (6 : 2 : 3 v/v/v/v). Densitometric evaluation of the separated zones was performed at 238 nm. The two drugs were satisfactorily resolved with RF values of 0.20 and 0.50 for thiocolchicoside and etodolac, respectively.
Key Words:- Etodolac, thiocolchicoside,HPTLC.
Research article:-Cardiology
Dr.T.Rajini Samuel*
Cardiology Department, Venkataeswara Hospitals, 36-A Chamiers road, Nandanam, Chennai, India.
*Presently doing M.D. Biochemistry in Sree Balaji Medical College and Hospital, Chromepet, Chennai. India.
Abstract:- Aims: To make people understand what Einthoven was really talking about.
Methods and results: In the hex axial reference system of ecg, plot the net voltages of bipolar limb leads and connect them. Similarly, plot the net voltages of unipolar limb leads and connect them. Each forms equilateral triangles. Convert the equilateral triangles into circles. Each circle have same origin, same orientation, but different radii because the bipolar and unipolar limb leads have different resistance. The ratio of their resistance is 4/3. Hence the ratio of the area of the two circles is always constant and equal to 4/3. The square root of 4/3 is 1.154. The ratio of their radii is 1.154 .Multiply each unipolar limb lead voltages by 1.154 and then plot. The two equilateral triangles are on the same circle. The correction factor 1.154 is used because bipolar and unipolar limb leads have different resistance and the ratio of their resistance is 4/3. Thus heart is situated in the centre of the electric field which it generates. The two upper limbs and the left lower limb are the extensions of its electrical field. Voltage recorded in a particular lead is the result of dot product between the lead vector (measured in metre) and the cardiac vector measured in volt/metre. Hence voltage is a scalar quantity. The angle (α) determination from the ecg:
Tan α= (1.154*avF)/ Lead 1
Conclusion: Einthoven triangle is an absolute electrical equilateral triangle. Each cardiac wave can be represented in the form of circles.
Keywords:-Cardiac vector, Shifted Einthoven triangle.