DocumentsDate added
Research article:- Biochemistry
Yagana S. A., Sodipo O.A., Yagana K. and Modu S.
Department of Biochemistry, University of Maiduguri – Nigeria.
Abstract:- The methanolic / aqueous, ethylacetate, n-butanol and residual extracts of the root of G. senegalensis were subjected to preliminary phytochemcial screening and in vitro antimicrobial tests. The extracts revealed the presence of flavonoids, tannins, saponins, carbohydrates and cardiac glycosides. Anthraquinones were not detected. The antimicrobial activities of the extracts were assayed by the agar disc diffusion and nutrient broth dilution techniques. Test microorganisms were Streptococcus Pyogene, Staphylococcus aureus, Pseudomonas aeruginosa, Proteus mirabilis, Escherichia coli, Salmonella typhimirium and Klebsiella penumoniae; all the organisms were laboratory isolates. The ethylacetate extract inhibited the growth of Streptococcus pyogene with a mean range of (16.86±0.32 t 20.03±0.55)mm at the concentrations used ranging from (200 – 1000) mg/ml, Staphylococcus with a mean range of (13.16±0.28 to 16.865.51) and Pseudomonas aeruginosa with a mean range of 10.03±14.86±0.32)mm. There was no inhibition by the ethylaceatte extract against Proteus mirabilis, Escherichia coli, Salmonella typhimirium and Klebsiella Penumoniae. The results showed minimum inhibitory concentration (MIC) of 25mg/ml against Streptococcus Pyogene and Staphylococcus aureus while for Pseudomonas aeruginosa was 100mg/ml. The minimum bacteriocidal concentration (MBC) against S. Pyogene and S. aureus was 50mg/ml while that of P. aeruginosa was 100mg/ml. The methanolic / aqueous extract inhibited the growth of S. pyogene with a mean range of (16.09 ± 0.50 to 22.83 ±0.28)mm, S. aureus was inhibited with a mean range of (15.0±0.50 to 21.83±0.28)mm P. aeruginosa was inhibited with a mean range of (9.0±0.50 to 16.0±0.05) mm and P. mirabilis was with a mean range of (12.0±0.50 to 18.0±0.05)mm. There was no inhibition exhibited by the methanolic / water extract against E. Coli, S. typhimirium and K. pneumoniae. The minimum inhibitory concentration (MIC) against S. pyogene was 25mg/ml, for S. aureus was 50mg/ml and that of P. mirabilis and P. aerugonosa were 100mg/ml respectively. The minimum bacteriocidal concentration (MBC) against S. Pyogene and S. aureus were 50mg/dl and that of P. mirabilis was 100mg/dl of P. aeruginosa was 200mg/dl. The n-butanol extract inhibited the growth of S. Pyogene, S. aureus and P. aeruginosa with means ranging from (17.0±0.50 to 18.0±0.50, 18.0±0.50 to 19.0±0.50 and 8.0±0.50 to 17.0±0.50)mm respectively. The minimum inhibitory concentration of S. pyogene and S. aureus was 25mg/ml while that of P. aeruginosa was 100mg/ml. The (MBC) for both S. pyogene and S. aureus was 50mg/ml while that of P. aeruginosa was 200mg/ml. However, even the residual extract inhibited the growth of the test organisms with S. pyogene having mean ranging from (14.66±0.50 to 18.0±0.50)mm, S. aureus having (11.0±0.50 to 16.0±0.50)mm and P. mirabilis with mean ranging from (15.33±0.76 to 17.0±0.50)mm. The results of the (MIC) revealed that S. pyogene and P. mirabilis have (MIC) of 25mg/ml while that of S. aureus was 100mg/ml. The (MBC) for both S. pyogene and P. mirabilis was 50mg/ml while that of S. aureus was 100mg/ml. This study has justified the traditional use of this plant for the treatment of stomach discomfort, diarrhoea, dysentery and as a remedy for wound healing, boils and other infections whose causative agents are some of the organisms used in this study.
Key words:- Minimum inhibitory concentration, G. Senegalensis.
Research article:-Physiotherapy
Sethi Vanshika1* and Pragyadeep2
1Phd. Physiotherapy, Section in-charge physiotherapy department, 2Student BPT 4th year, Saaii College of medical science and technology, Kanpur,India.
Abstract:- Introduction: Chronic pain is that pain which lasts for more than three months. Depression is the most common emotion associated with chronic low back pain. The type of depression that often accompanies chronic low back pain is referred to as major depression or clinical depression. Methodology: A sample of 30 chronic low back pain patient of 20 to 40 year of age were taken by convenient sample method.pre treatment assessment of depression, anxiety and stress status on DASS scale were taken. Patients were given core stability training session of 4 week which included bridging, curl up exercises, pelvic bridging exercises, spinal extension exercise and side bridging exercises. These training treatment duration was of 30 min with 10 repetition for 4 weeks including 6 days a week for each exercises.post treatment assessment were done by using same outcome measures. Results: DASS(Depression, anxiety ,stress scale) score before giving the treatment were as 18.83±5.12, 11.06 ± 2.9 ,17.5 ± 3.7, whereas the score after exercises were as 16.6±4.30, 9.7 ± 2.6, 15.9 ± 3.3 with t-value of 6.299, 5.25, 3.1 with p-value of 0.000* , 0.000* ,0.004* ,which shows significant difference in scores. Conclusion: Exercise programs can be carried out safely in patient with chronic low back pain and there by their level of depression, anxiety and stress can be decreased by short duration core stability exercises as it is economical in time and money.
Key Words:- Core stability exercises, depression, anxiety, stress, low back pain.
Research article:-Physiotherapy
J. Lavanya1*,P.Saraswathi2 , J.Vijayakumar3 and S. Prathap4.
1BPT ,M.Sc, tutor, ACS Medical college, Chennai, India 2MBBS, M.Sc., Ph.D., Head of department, 3M.Sc.,Ph.D., Professor, Dept of Anatomy, Saveetha Medical College, Chennai, India,4MPT,PhD., Associate professor, college of physiotherapy, Saveetha Medical College, Chennai, India.
Abstract:- Aim: To analyze the quantitative and qualitative dermatoglyphic traits in patients with breast cancer. Objective: To determine whether dermatoglyphics can represent a non-invasive anatomical marker of Breast Cancer. Methodology: 60 individuals are selected in two groups. GI–30 Female patients with diagnosed breast cancer. G II – 30 Normal Females (control group).The finger ridge patterns of both hands are photographed using digital camera and were analyzed using Adobe Photoshop editor by visual observation. Outcome Measure: Quantitative parameters: Finger ridge count, Total finger ridge count, A-B ridge count, palmar angle (AtD), and pattern intensity index. Qualitative parameters: % of subjects with ≥ 6 whorls, % of total number of whorls in all digits. Result: From the statistical analysis made, the data’s revealed statistically significant difference between both the groups. Quantitative parameters- Finger ridge count Rt (P = 0.0450) Lt (P = 0.0431), total finger ridge count (P = 0.0400), A-B ridge count Rt (P = 0.0015) Lt (P = 0.0003), palmar angle (AtD) Rt (P = 0.0208) Lt (P = 0.0365), pattern intensity index (P = 0.0464) and qualitative parameters - % of subjects with ≥ 6 whorls. (P = 0.0337), % of total number of whorls in all digits (P = 0.0124), which proves breast cancer patients exhibited significant changes in their dermatoglyphic patterns compared to normal. Conclusion: The present study concludes that there is a possible genetic influence on the digital ridge patterns in carcinoma of breast patients in whom the digital ridge patterns are otherwise significantly affected.
Key words:-Dermatoglyphics, breast cancer, dermal ridge patterns.
Research article:-Pharmacology
Rajeev Kumar, Vasudevan Prabhakaran and Manoj G.Tyagi*
Department of Pharmacology Christian Medical College, Vellore 632002,Tamilnadu,India.
Abstract:- Rheumatoid arthritis (RA) is a chronic inflammatory disease which mainly affects synovial joints and leads to damage of articular cartilage and ankylosis of joints. In this study, the effect of atorvastatin, an inhibitor of 3 hydroxyl -3-methyl glutaryl coenzyme reductase alone and in combination with netilmicin a phospholipase C inhibitor on RA were studied. RA was induced with the help of Freund ’s adjuvant (0.3ml/200gms wistar rat) in three separate Wistar rat groups. Freund ’s adjuvant is the combination of mineral oil, an emulsifier mannide monooleate with 1mg/ml heat killed dry mycobacterium tuberculosis H37Ra. During these studies, plethysmography, TNF-α levels, weight and age of animals were analyzed. After arthritis induction in group 1 (6 rats) the animals were treated with 5 mg/kg of Atorvastatin injection i.p and it was found to reduce 32.41 % of RA in 8 days as determined by paw edema and a reduction in TNF- α levels. While 42.22% reduction was found after 8 days treatment with the combination of 10 mg/kg of Netilmicin and Atorvastatin i.p injection in case of group 2 (6 rats) there was also a concomitant reduction in the levels of TNF-α in the arthritic paw. These studies suggest the interaction of these two drugs in reducing arthritic inflammation.
Key Words:- Freund’s adjuvant, atorvastatin, netilmicin, plethysmograph, arthritis, TNF-α.
Case Report:-Anesthesiology
Alper Yosunkaya, Prof, MD; Şule Arıcan, MD; Hale Borazan, Assistant Prof, MD; Tuba Berra Sarıtaş, Assistant Prof, MD; Betül Olcay, MD.
Necmettin Erbakan University, Meram Medical Faculty, Department of Anesthesiology and Reanimation, Konya, Turkey.
Abstract:-Acute isoniazid intoxication is relatively uncommon but potentially life-threateningcondition in which the anesthesiologists may become involved when respiratory deficiency and refractory seizures could be accompanied with metabolic acidosis. In this report, we describe the management of such a case of INH intoxication in a suicide attempt; we also discuss the specific antidote, pyridoxine, route we have to use and other accompanied adjuncts for the treatment in the light of the literatures.
Key Words:-Isoniasid intoxication, pyridoxine, seizure, benzodiazepine