DocumentsDate added
Original article:-Community Medicine
Rituja Kaushal1, Neeraj Gour2*,Sanjay Kumar Gupta3, Arvind V Athawale4,M S Pathak5, P Tripathi6 and K Kaushal7.
1Post Graduate Resident,2Assistant Professor,3Associate Professor,4Professor and Head,5Associate Professor ,Department of Community Medicine, Peoples College of Medical Sciences & Research Centre Bhopal, M.P ,India.
6District Malaria Officer,Bhopal,M.P,India.
7Ex Superintendent,PMC, Bhopal,M.P ,India.
Abstract:- After years of fight against Malaria-a major public health problem, various states of India have started achieving success in controlling & preventing malaria transmission by implementing a broader mix of interventions. This observational secondary data based study was undertaken to assess the success achieved by District Malaria Centre, Bhopal in terms of various epidemiological surveillance parameters like API,ABER,SPR,SFR, Pf% etc. Overall a declining trend was found more or less among all epidemiological parameters which itself somehow by far reflect the quality of efforts put by district health officials and health workers. This study also demands a multicentre qualitative research in this aspect to explore what efforts and reasons have been responsible for this decline in various malariomatric parameters.
Key words:- Bhopal; malariomatric parameters; trend.
Original article:-Community Medicine
Nitheshkumar1* and B.Kiranmai2.
1Assistant Professor, Department of Community Medicine, Deccan College of Medical Sciences, Kanchanbagh, Hyderabad, India.
2Professor, Department of Community Medicine, Gandhi Medical college, Hyderabad, India.
Abstract- Background Rabies, present on all continents and endemic in most African and Asian countries, is a 100% fatal zoonotic viral disease, transmitted to humans through contact, mainly bites and scratches with infected animals, both domestic and wild. According to the World Health Organization, about 35,000 people die of rabies in India every year – accounting for about 81 percent of global deaths. Even today with no cure anywhere in the world, Rabies is only preventable with wound care, vaccines and immunoglobulins. Objectives: To assess the knowledge, attitudes, beliefs and practices (KAP) about animal bites and rabies among rural women Hyderabad. Materials & Methods:- Cross sectional community based study was conducted in randomly selected urban slum, Hassannagar, Hyderabad. The sample size of 100 woman between 20-55 years of age depending up on prevalence of rabies in this particular area. Study variables are age, education, socioeconomic status, diet, cultural activities, vaccine, and supernatural methods. Study done in a period of one month during May 2012 and data was analyzed using software Epi info, percentages and chi square test was done to know the significance of variables. Results: Out of 100 sample 37 % are literates and 63 % illiterates and the mean age was 24years. Majority of the people heard about rabies and transmitted by dog bite. . Knowledge about appropriate wound toilet was found to be inadequate. Only 33.4% of the respondents knew rabies could be prevented by vaccination, while 38.7% believed that the infection could be treated with herbs and other indigenous applications. KAP study suggests that there is need to create awareness amongst the masses regarding epidemiology of the disease and merits of prompt and appropriate post exposure treatment through enhanced IEC activities.
Key words:- Rabies, Supernatural methods, Herbal application, Wound toilet, Vaccination.
Research article:- General Surgery,
Basavaraj G. Veerapur1, I.V. Uppin2 and YP Raghavendra Babu3*.
1Assistant Professor, Department of General Surgery, Kasturba Medical College, Mangalore, Manipal University, India.
2Retired Professor, Department of General Surgey, J.N. Medical College, Belgaum, India.
3*Associate Professor, Department of Forensic Medicine and Toxicology, Kasturba Medical College, Mangalore, Manipal University, India.
Abstract:- The incidence of diabetes and its complications are on the rise with risk of lower extremity amputations being fifteen fold higher as compared to non-diabetics due to chronic diabetic foot ulcer. Diabetic ulcers are known to be resistant to conventional treatment and may herald severe complications if not treated wisely. A series of study has shown that application of PDGF to wound enhances the process of wound healing. In view of this a study on efficacy of rh-PDGF in chronic diabetic ulcers versus normal saline dressings was undertaken. Our study revealed that rh-PDGF therapy could act as an adjuvant to the conventional mode of treatment.
Key words:- rh-PDGF, diabetic foot ulcer, saline dressing, chronic ulcer.
Original article:-Pharmacology
Chandel Nitibhushansingh R1, Phadke Anant G2 and Goyal Chhaya A3
1M.D. (Pharmacology), Assistant Professor, 3M.D( Pharmacology), Professor, Department of Pharmacology, SAIMS Medical College & PG Institute, Indore, Madhya Pradesh, India. 2M.D.(Pharmacology), Professor, Department of Pharmacology, JNMC, Sawangi (Meghe), Wardha, India.
Abstract:- Aim: To study the interaction of calcium channel blocker (verapamil) with Antipsychotic drug (Haloperidol) in CAR and catalepsy models in rats.
Methods and Results: Every group consisted of 10 healthy albino rats of either sex. Different groups received Verapamil (5, 10 &20 mg/kg, i.p.), Haloperidol (ED50 -0.2mg/kg) alone and combined doses of both drugs. The Antipsychotic effect of drugs was measured by Conditioned avoidance response (CAR) using Cook’s Pole climbing apparatus and Adverse drug effect (Extra pyramidal syndrome) was measured by Catalepsy. 5 mg/kg i.p. of Verapamil inhibited CAR in 50 % of Rats (compared to control, p<0.001). 10mg/kg i.p. of verapamil inhibited CAR in 70% of Rats (p<0.001) & 20 mg/kg i.p. inhibited CAR in 80% of Rats (p<0.001). When verapamil (5 mg/kg i.p) was combined with Haloperidol ED50-0.2mg/kg the CAR was inhibited in 80% of the rats (p<0.001) and after combining verapamil (10mg/kg) with Haloperidol ED50-0.2mg/kg the CAR was inhibited in 100% Rats. (p<0.001) Verapamil at the dose of 5 mg/kg and 10 mg/kg (i.p.) did not induce catalepsy in the rats at any testing time interval. At 20 mg/kg i.p., it produced catalepsy in 3 rats at half hour and in 5 rats at 1 hour and 2 hour testing interval each.(p<0.01). Verapamil pretreatment in the dose of 5 mg/kg did not affect the haloperidol (ED50 -0.4 mg/kg) induced catalepsy. In the dose of 10 and 20 mg/kg, pretreatment with verapamil significantly increased cataleptic scores at all testing intervals (P<0.05).Conclusion: Verapamil blocked CAR. Its higher doses induced catalepsy and it is synergistic with haloperidol in blockade of CAR and catalepsy.
Key words:- Verapamil, Haloperidol, Conditioned avoidance response (CAR), Catalepsy.
Original article:-Pharmaceutical sciences
Jain Nilesh *, Sharma Bhupendra Kumar, Jain Ruchi, Jain Deepak Kumar & Jain Surendra. *Sagar Institute of Research & Technology-Pharmacy,Ayodhya Bypass Road, Bhopal, M.P-462041, India.
Abstract:- A simple, precise, rapid and reproducible reversed-phase high performance liquid chromatography (RP-HPLC) method is developed for the simultaneous estimation of Metoprolol Succinate (METO) and Telmisartan (TELM) present in multicomponent dosage forms. Chromatography is carried out isocratically at 25°C ± 0.5°C on an Prontosil C18 Column (5 µm,250mm x 4.60mm) with a mobile phase composed of acetonitrile: methanol: phosphate buffer pH-5 (35:35:30 % v/v/v) at a flow rate of 1.0 mL/min. Detection is carried out using a UV-PDA detector at 225 nm. Parameters such as linearity, precision, accuracy, recovery, specificity and ruggedness are studied as reported in the International Conference on Harmonization guidelines. The retention times for METO and TELM are 2.57 ± 0.5 min.and 4.68 ± 0.5 min. respectively. The linearity range for METO and TELM are 5-25g/ml & 8-40µg/ml and the recovery of added standards (80%, 100% and 120%) was in ranging from 98.24 to 99.35% for METO and 98.21 to 99.74% for TELM. The correlation coefficients for all components are close to 1. The relative standard deviations for three replicate measurements in three concentrations of samples in tablets are always less than 2%. The result obtained shows the developed method to be new (no method available for combination these drugs), rapid (Short retention time), simple, accurate (the value of SD and % RSD less then 2), precise and can be successfully employed in the routine analysis of these drugs in bulk drug as well as in tablet dosage form.
Key words:- RP-HPLC, Metoprolol succinate, Telmisartan, Simultaneous estimation.