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Research article:-Forensic Medicine and Toxicology
Shankar M Bakkannavar, MD DCL1, YP Raghavendra Babu, MD2*, Ashwinikumar, MD3, Vinod C Nayak, MD4, Manjunath S, MD DCL5, Pradeep Kumar G, MD, Dip. Cr.L6.
1Assistant Professor, Department of Forensic Medicine and Toxicology, Kasturba Medical College, Manipal University, Manipal, India.
2Associate Professor, Department of Forensic Medicine and Toxicology, Kasturba Medical College, Manipal University, Mangalore, India, 3 Assistant Professor, 4,5 Associate Professor, 6 Professor & Head, Department of Forensic Medicine and Toxicology, Kasturba Medical College, Manipal University, Manipal, India.
Abstract:- Subendocardial haemorrhage (SEH) is an atypical feature in many forensic autopsies, especially in victims of severe trauma. These haemorrhages are not only accompanied with blood loss due to trauma but also seen in non traumatic conditions such as poisoning and following transfusion of infected blood. In this retrospective study, we have analysed 1778 autopsy cases and investigated for the incidence of subendocardial haemorrhages in relation to their causes.
Key words:-Subendocardial haemorrhage; heart; autopsy; incidence.
References:
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Copyright © 2013 YP Raghavendra Babu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review article:-
Pai Keshava K1 & Nayak Sangeeta U2*
1Associate Professor, Department of Psychiatry, Kasturba Medical College, Mangalore, Manipal University, India.
2Assistant Professor, Department of Periodontology, Manipal College of Dental Sciences, Mangalore, Manipal University, India.
Abstract:- Stress has long been considered to be a major contributor to the clinical manifestation of many diseases. The relationship between stress and any disease is explained by hormonal modifications and behavioural changes induced by the stress. Research has suggested that stress and depression are two factors that play a role in the development and progression of periodontal disease. It is not clear, however, whether these factors lead to periodontal disease through physiological or behavioural changes, or by some combination of the two. This article reviews the current literature, with highlighting on the potential role of psychological stress in periodontal disease progression as well as on wound healing.
Keywords:- Cortisol, Periodontal disease, Stress, Wound healing.
References:-
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22.Rozlog LA, Kiecolt-Glaser JK, Marucha PT, Sheridan JF, Glaser R. Stress and immunity: Implications for viral disease and wound healing. J Periodontol 1999; 70 : 786-92.
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Competent interest:- The authors declare that they have no competing interests.
Source of funding: - None .
Copyright © 2013 Pai Keshava K & Nayak Sangeeta U. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review article:- Biochemistry
Ranganathan Lakshmi 1* &. Swaminathan S2.
*1Research Intern Krishnamacharya Yoga Mandiram, New No. 31, Old No. 13, 4th Cross Street, R K Nagar, Mandaveli, Chennai, Tamil Nadu 600028, India.
2Chief of Biochemistry, SRM Institute of Medical Sciences No: 1, Jawaharlal Nehru Salai, (100 feet Road), Vadapalni Chennai – 600 026, India.
Abstract:- Depression is a multi-dimensional disorder. It is neither purely a biochemical, nor a psychological phenomenon. Biological factors, genetic factors, personality traits and life events may all contribute to depression. Depression has biological components based in genetics, neurochemistry and physical health; it has psychological components that involve many individual factors such as cognitive style, coping style, and qualities of personal behaviour. And, it has social components, factors that are mediated by the quality of one’s relationships, including such variables as the family and the culture one is socialized into, and one’s range of social skills. Beyond all existing theories of depression, the greatest areas of agreement about depression are 1. The condition is complex (heterogeneous) 2. There is no ‘one’ explanation of its cause 3. There has been no single treatment known that will be effective in all cases. Several studies have proved that biochemical changes occur in depression and that these can be prompted or further modified by psychosocial factors. The balance of such factors in an individual may provide the clues to successful management with a combination of drugs and psychosocial therapy. This review article on the role of Biochemistry in depression in humans will enable researchers to understand in detail, the works already done and will give awareness about further works to be carried out in this field. Almost all biochemical disorders related to depression have been covered in this paper. This paper highlights the role of various biochemical analytes in inducing /reversing the symptoms of depression. Only key biochemical analytes are considered.
Key words:- Depression, Vitamin, CVD, ANS, WBC, CRP,HbA1C,Renal Profile, TSH, Cortisol, LH, FSH,PCOS, Acetyl choline, Endorphins, Prolactin, Oxidative Stress.
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Competent interest:- The authors declare that they have no competing interests. Source of funding: - None
Copyright © 2013 Ranganathan Lakshmi & Swaminathan S. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article:- Biochemistry
Ms. Revathy.K M.Sc., M.Phil1., Ms.G.Nithya M.Sc2., Dr.Mitra Ghosh M.D3, Dr.S.Swaminathan Ph.D.,FACBI4.
1Technical Supervisor, Department of Biochemistry, 3Director of Medical Sciences, 4Chief of Biochemistry, SRM Institute for Medical Sciences, Vadapalani, Chennai-600 026.India.
2Research Scholar, Department of Medical Biochemistry, Dr.ALM PG IBMS, Tharamani Campus, University of Madras, Chennai-600 113,India.
Abstract:- Laboratory assessment of renal function is one of the most commonly performed tasks in medical practice. A significant number of patients admitted in hospitals have compromised renal function, and the incidence of end stage renal disease (ESRD) is increasing at the rate of 7.5 % each year. The evaluation of renal function should be performed with an understanding of the advantages and shortcomings of available tests. Laboratory tests are useful to guide treatment in patients with established renal insufficiency and to detect subtle renal dysfunction in otherwise healthy individuals. The aim of the study is to find out the association between any two of the six parameters in a group of patients (normal male and female) as well as in some mild renal failure patients, then to pin point which of the two parameter or set of tests most suitable to correctly confirm renal dysfunction. This study also aims to reduce the number of biochemical tests there by reducing the financial burden of renal failure patients. The overall aim is to find out cost effect tests to be used in such cases. A highly significant correlation [p<0.0001] is observed for both serum urea & creatinine with the ratio of urine proteins to creatinine, suggesting that the clinical laboratory needs to measure only 4 analytes, viz serum urea, creatinine and urine proteins & creatinine in a random sample of urine.
Key words:- ARF, CRF, ESRD, Creatinine, Total Protein, Albumin, Calcium, Urine Protein, Urine Creatinine.
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Copyright © 2013 Swaminathan S et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
An original study-Oral Medicine and Radiology
Dr. Shashi Rani*
Professor, Department of Oral Medicine and Radiology, Institute of Dental Sciences(IDS), Siksha O Anusandhan University,Khandagiri Square,Bhubaneswar-751030,Orissa,India.
Abstract:- Background: Wide spectrum of bone disease can occur in renal failure patients ranging from states of markedly impaired bone formation and mineralization (such as low turnover bone disease, osteomalacia) to states of markedly increased bone turnover (hyperparathyroidism. Unique types of metabolic bone disease may also occur in patients with renal disease but with a normal glomerular filtration rate, as exemplified by the postrenal transplant state and renal tubular acidosis. Radiographic examinations were carried out on 40 patients to study the changes in the teeth and bones. Aim: To study the various Radiological manifestations in patients with chronic renal failure (CRF), hemodialysis patients and those with renal transplants. Methods: A radiographic study of the teeth, jaws & skeletal system in 40 cases of chronic renal Insufficiency patients was undertaken. These patients were divided into three groups(on conservative care, hemodialysis and post transplant) based on the treatment modality. Results: Changes in the lamina dura, Trabecular pattern and bone density were recorded. Pulpal alterations were also noticed. A significant relation between skeletal changes and changes in lamina dura was observed (t = 2.13) but, skeletal changes had become more evident with reduction in trabecular pattern and radiographic density (t = 3.24). No significant relation was found between the changes in pulp and the skeletal changes. Conclusion: An alert diagnostician if aware of the signs and symptoms seen in these patients along with the help of radiological data can caution a patient of the insidious condition as the changes in lamina dura though not a marker for this individual entity is the earliest manifestation.
Key words:- Manifestations, Renal insufficiency, Renal Osteodystrophy, Transplants.
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Copyright © 2013 Shashi Rani . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.