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Research article:-Forensic Medicine and Toxicology
Shankar M Bakkannavar, MD DCL1, YP Raghavendra Babu, MD2*, Ashwinikumar, MD3, Vinod C Nayak, MD4, Manjunath S, MD DCL5, Pradeep Kumar G, MD, Dip. Cr.L6.
1Assistant Professor, Department of Forensic Medicine and Toxicology, Kasturba Medical College, Manipal University, Manipal, India.
2Associate Professor, Department of Forensic Medicine and Toxicology, Kasturba Medical College, Manipal University, Mangalore, India, 3 Assistant Professor, 4,5 Associate Professor, 6 Professor & Head, Department of Forensic Medicine and Toxicology, Kasturba Medical College, Manipal University, Manipal, India.
Abstract:- Subendocardial haemorrhage (SEH) is an atypical feature in many forensic autopsies, especially in victims of severe trauma. These haemorrhages are not only accompanied with blood loss due to trauma but also seen in non traumatic conditions such as poisoning and following transfusion of infected blood. In this retrospective study, we have analysed 1778 autopsy cases and investigated for the incidence of subendocardial haemorrhages in relation to their causes.
Key words:-Subendocardial haemorrhage; heart; autopsy; incidence.
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Copyright © 2013 YP Raghavendra Babu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
An informed View:-Periodontology
K.David1, Shetty Neetha J2* & Pralhad Swati3
1Reader, 2Associate professor,3Assistant professor, Department of Periodontology, Manipal College of Dental Sciences, Mangalore, Manipal University,India.
Abstract:- Wounds in the oral cavity feature extremely good self-healing characteristics. However, some situations require the isolation of the oral wound from the oral milieu. These indications range from extractions to flap surgery and coverage of sutured wound borders. The American Academy of Periodontology in 1986 advocated the term periodontal dressing and defined it as a surgical dressing applied over and protecting the surgical wounds produced by periodontal surgical procedures. There are certain situations where the use of periodontal dressings may be advantageous. Based on current evidence, the use of periodontal dressing following surgery maybe a matter of individual preference related to the discretion and judgment of the clinician.
Key words:- Cyanoacrylates, periodontal dressing, zinc oxide non eugenol dressing.
References:-
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Original article:- Biochemistry
Ms. Revathy.K M.Sc., M.Phil1., Ms.G.Nithya M.Sc2., Dr.Mitra Ghosh M.D3, Dr.S.Swaminathan Ph.D.,FACBI4.
1Technical Supervisor, Department of Biochemistry, 3Director of Medical Sciences, 4Chief of Biochemistry, SRM Institute for Medical Sciences, Vadapalani, Chennai-600 026.India.
2Research Scholar, Department of Medical Biochemistry, Dr.ALM PG IBMS, Tharamani Campus, University of Madras, Chennai-600 113,India.
Abstract:- Laboratory assessment of renal function is one of the most commonly performed tasks in medical practice. A significant number of patients admitted in hospitals have compromised renal function, and the incidence of end stage renal disease (ESRD) is increasing at the rate of 7.5 % each year. The evaluation of renal function should be performed with an understanding of the advantages and shortcomings of available tests. Laboratory tests are useful to guide treatment in patients with established renal insufficiency and to detect subtle renal dysfunction in otherwise healthy individuals. The aim of the study is to find out the association between any two of the six parameters in a group of patients (normal male and female) as well as in some mild renal failure patients, then to pin point which of the two parameter or set of tests most suitable to correctly confirm renal dysfunction. This study also aims to reduce the number of biochemical tests there by reducing the financial burden of renal failure patients. The overall aim is to find out cost effect tests to be used in such cases. A highly significant correlation [p<0.0001] is observed for both serum urea & creatinine with the ratio of urine proteins to creatinine, suggesting that the clinical laboratory needs to measure only 4 analytes, viz serum urea, creatinine and urine proteins & creatinine in a random sample of urine.
Key words:- ARF, CRF, ESRD, Creatinine, Total Protein, Albumin, Calcium, Urine Protein, Urine Creatinine.
References:
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Copyright © 2013 Swaminathan S et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:-Physiology
Ashish Goel1*, Desh Deepak2, Kranthi Kumar G3, Sanjay Kumar Jha4 & Tripura Lakshmi J5.
1Assistant Professor, 3Demonstrator, Department of Physiology, SRMS Institute of Medical Sciences, Bareilly, UP, India.
2Professor, Department of Physiology, VCSG Government Medical Sciences and Research Institute, Srinagar, Uttarakhand, India.
4Assistant Professor, Department of Community Medicine, Government Medical College, Haldwani, Nainital, Uttarakhand,India.
5Demonstrator, Department of Physiology, Karpagam Faculty of Medical Sciences & Research, Coimbatore, Tamil Nadu, India.
Abstract: Objective: The chronic exposure at high altitude represents an ideal model for evaluating the effects of hypobaric hypoxia. This study was designed to evaluate the effects of chronic hypoxia on immune response. Material and methods: In this study 300 healthy adults (150 of plains and 150 of high altitude) were taken. The white blood cell parameters were evaluated by blood samples using MS-9 automated hematology cell counter. Observations and results: The total white blood cell count of high altitude individuals were significantly higher as compared to people residing in plains. The monocyte count was significantly higher as compared to people residing in plains. There was a statistically significant difference in total leukocyte count between males of plains and high altitude, while the difference was not statistically significant between females of plains and high altitude respectively which indicated that haemopoietic response to altitude is markedly less in women than that usually observed in men. Conclusion: It can be concluded that the chronic altitude exposure might activate the immune response, which is indicated by high WBC count in the permanent residents of high altitude.
Key words:- High altitude, Chronic hypoxia, White blood cell count, Immune response.
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Copyright © 2013 Goel Ashish et al., This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review article:- Biochemistry
Ranganathan Lakshmi 1* &. Swaminathan S2.
*1Research Intern Krishnamacharya Yoga Mandiram, New No. 31, Old No. 13, 4th Cross Street, R K Nagar, Mandaveli, Chennai, Tamil Nadu 600028, India.
2Chief of Biochemistry, SRM Institute of Medical Sciences No: 1, Jawaharlal Nehru Salai, (100 feet Road), Vadapalni Chennai – 600 026, India.
Abstract:- Depression is a multi-dimensional disorder. It is neither purely a biochemical, nor a psychological phenomenon. Biological factors, genetic factors, personality traits and life events may all contribute to depression. Depression has biological components based in genetics, neurochemistry and physical health; it has psychological components that involve many individual factors such as cognitive style, coping style, and qualities of personal behaviour. And, it has social components, factors that are mediated by the quality of one’s relationships, including such variables as the family and the culture one is socialized into, and one’s range of social skills. Beyond all existing theories of depression, the greatest areas of agreement about depression are 1. The condition is complex (heterogeneous) 2. There is no ‘one’ explanation of its cause 3. There has been no single treatment known that will be effective in all cases. Several studies have proved that biochemical changes occur in depression and that these can be prompted or further modified by psychosocial factors. The balance of such factors in an individual may provide the clues to successful management with a combination of drugs and psychosocial therapy. This review article on the role of Biochemistry in depression in humans will enable researchers to understand in detail, the works already done and will give awareness about further works to be carried out in this field. Almost all biochemical disorders related to depression have been covered in this paper. This paper highlights the role of various biochemical analytes in inducing /reversing the symptoms of depression. Only key biochemical analytes are considered.
Key words:- Depression, Vitamin, CVD, ANS, WBC, CRP,HbA1C,Renal Profile, TSH, Cortisol, LH, FSH,PCOS, Acetyl choline, Endorphins, Prolactin, Oxidative Stress.
References:-
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7.Willem J. Kop, PhD, Phyllis K. Stein, PhD, Russell P. Tracy, PhD, Joshua I. Barzilay, MD, Richard Schulz, PhD, and John S. Gottdiener, MD. “Autonomic Nervous System Dysfunction and Inflammation Contribute to the Increased Cardiovascular Mortality Risk Associated With Depression”. Psychosom Med. 2010 September; 72(7): 626–35.
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16.Angelina R. Sutin, Antonio Terracciano,1 Barbara Deiana, Manuela Uda, David Schlessinger, Edward G. Lakatta, and Paul T. Costa, Jr. “Cholesterol, Triglycerides, and the Five-Factor Model of Personality”. Biol Psychol. 2010 May; 84(2): 186–91.
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Competent interest:- The authors declare that they have no competing interests. Source of funding: - None
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