DocumentsDate added
Original article:-
A. J. Manjula Devi1 and S.Birundha2*
1Head of the Department & Professor, 2*Post Graduate, Department of Biochemistry, Sree Balaji Medical College, Chennai, India.
Abstract:- Background: Diabetes Mellitus (DM) is a metabolic disorder. Microalbuminuria is the main cause of morbidity and mortality in patients with DM. It is characterized by increased prevalence of arterial hypertension, proliferative retinopathy, and peripheral neuropathy. The present study was undertaken to determine the incidence of Microalbuminuria (Albumin/creatinine ratio) in type 2 diabetic patients. Materials & Methods: 25 patients with diagnosed diabetic subjects were selected for the study. Blood samples were collected for the estimation of FBS (Fasting Blood Sample), serum creatinine and 2 hours post meal for PPBS (Post Prandial Blood Sample). Urine samples were collected in sterilised containers.25 healthy age and sex matched control subjects were chosen. Results: Significant increase in the levels of urine microalbumin was observed in type 2 diabetes compared to healthy controls. Conclusion: Microalbuminuria is the diagnostic marker of nephropathy in diabetes mellitus and is an indicator of microvascular damage affecting renal functions. This study emphasizes the importance of microalbuminuria as an early marker of microvascular morbidity involved in type 2 diabetes and helps in better handling of this pandemic disease, diabetes mellitus. Key words:- Diabetes Mellitus (DM), Microalbuminuria, Diabetic nephropathy.
References:-
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Copyright © 2013 A.J.Manjula Devi and S.Birundha. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:-Pharmacology
M.Muniappan*
*Department of Pharmacology, Sree Balaji Medical College & Hospital (Deemed University), Chrompet, Chennai 600044, India.
Abstract: The extracts of Bambusa arundinacea have been used in folk medicine in bronchitis and asthma[1&2]. The anti-hypersensitivity action of methanol extract of Bambusa arundinacea have been studied on mast cell degranulation in albino rats, and found to be significant when compared to control and standard drug. Key words: anti-hypersensitivity, bronchitis, degranulation.
Key Words: Bambusa arundinacea, Methanol extracts, flavanoids.
References:
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2.Masiungan et al . Phillip J. Sci, 1959, 88 , p-245
3.Muniappan.M “Anti-inflammatory and antiulcer activities of Bambusa arundinacea” – Journal of Ethnopharmacolgy.2003: 88 161-7.
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Copyright © 2013 Muniappan M., This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:- Pharmacology
M.Muniappan*
*Department of Pharmacology, Sree Balaji Medical College & Hospital (Deemed University), Chrompet, Chennai – 600044, India.
Abstract: The extracts of Bambusa arundinacea have been used in Indian folk medicine in ptosis and paralytic complaints. Ptosis is one of the symptoms of myasthenia gravis, which is an autoimmune disease. The immunosuppressant effect of Methanol extract of the leaves of Bambusa arundinacea on relative weights of Thymus, Lymphnodes and Spleen and also on gamma glutamyl transpeptidase (γGT) activity have been studied in male albino rats and found to be significant when compared to the standard drug.
Key words: Immunosuppressant, gamma glutamyl transpeptidase, ptosis, autoimmune disease.
References:
1.Kirtikar K.R & .Basu. B.D. Indian Medicinal plats. II edition. Paras publication ,Calcutta, 1990.Vol IV, p-2724-2727.
2.Oscar Prof Dr. Aman. Medicinal secrets of your food. Paras publication ,Calcutta,1985, p-320-325
3.Muniappan. M, Sundararaj. T. Anti-inflammatory and antiulcer activities of Bambusa arundinacea. Journal of Ethno pharmacology. 2003; 88: 161-7.
4.R.Raghubir, S.Gupta and A.K.Srivastava. Evaluation of immunomodulatory effect of enkephalin analogs, using gamma glutamyl transpeptidase (Vgt) activity in lymphoid tissues .Ind.J .Pharmacology. 1991;23 (1): 43-44.
Copyright © 2013 Muniappan M., This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review article:-Pharmacology
Vasantha M N, S Kannan, Ayesha Sulthana, Nidhi Tyagi & Manoj G Tyagi*
Department of Pharmacology, Christian Medical College, Vellore 632002, India
Abstract:-
Histone deacetylases (HDACs) enzymes modify the acetylation status of histone proteins and other critical cellular proteins and are recognized as potentially useful therapeutic targets for a broad range of human disorders. Pharmacological interventions using small-molecule HDAC inhibitors may restore transcriptional balance to neurons, modulate cytoskeletal function, and affect immune responses and enhance protein degradation pathways. These have been found to beneficial in various experimental models of disease. In this review article we elaborate on the mechanism of HDAC enzymes in modifying various disease states and reflect on some new prototype drugs introduced for the treatment of some clinical manifestations.
Key words:- HDAC, enzymes, DNA, cell cycle, acetyl transferases, T cells.
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Copyright © 2013 Tyagi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report & Literature review:-Anesthesiology and Reanimation
Tuba Berra Saritas1* , Hasan Salcan2 , Remziye Gül Sivaci2
1Necmettin Erbakan University, Meram Medical School, Anesthesiology and Reanimation Department, Konya-Turkey.
2Afyonkocatepe University, Medical School, Anesthesiology and Reanimation Department, Afyonkarahisar-Turkey.
Abstract:- Congenital contractural arachnoductyly is a very rare autosomal dominantly inherited connective tissue disorder. It is caused by a fibrillin gene (FBN2) mutation in 5q23. It affects many of the body parts. Contractures, scoliosis, pectus carinatum, camptodactyly, crumpled external ears, micrognathia, highly arched palate, pseudotrismus and cranial abnormalities found. These are high risk people for anesthesia. Detailed physical examination and preparation for anesthetic procedures required.
Key Words:-Arachnodactyly, Crumpled Ear, Anaesthesia.
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