DocumentsDate added
Research article:-
Lalita Jayaram Thambiah1* & Satish Kumaran P2.
1Professor,Oral and Maxillofacial Pathology,2Consultant Oral and Maxillofacial Surgeon, Annasamy Mudaliar General Hospital, Fraser town, Bangalore, India.
Abstract:- Malignant or premalignant lesions are prone to develop in the mucosal surfaces of the upper aerodigestive tract exposed to topical carcinogens. Their development is a multistep process within the mucosa. Over ninety percent of malignancies arising from the oral cavity are epithelial in origin and can therefore be regarded more number of times than not as oral squamous cell carcinoma. An immunohistochemical study was done to compare the expression of laminin and β1 integrin in biopsy specimens.
Key Words:- Biopsy specimens, tumour progression, laminin and integrin.
References:-
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2.Hall, T.E., Robert J. Bryson-Richardson, Silke Berger, Arie S. Jacoby, Nicholas J. Cole, Georgina E. Hollway. “The Zebrafish Candyfloss Mutant Implicates Extracellular Matrix Adhesion Failure in Laminin α2-Deficient Congenital Muscular Dystrophy”. Proc Natl Acad Sci U S A. 2007 April 24; 104(17): 7092–97.
3.Haralson, M.A. and John R. Hassell (1995). Extracellular Matrix: a Practical Approach. Ithaca, N.Y: IRL Press. ISBN 0-19-963220-0.
4.Colognato, H., Yurchenko P. “Form and Function: the Laminin Family of Heterotrimers”. Dev. Dyn 2000;218 (2): 213-34.
5.Driemel, O., R. Dahse, S.G.Kim, Tsioutsias, H. Pistner, T.E.Reichert et al. “Laminin-5 Immunocytochemistry: A New Tool for Identifying Dysplastic Cells in Oral Brush Biopsies”. Cytopathology 2007; 18: 345-55.
6.Givant-Horwitz, Vered., Ben Davidson, Reuben Reich. “Laminin-induced Signaling in Tumour Cells”. Cancer Letters 2005;223: 1-10.
7.Patel, Vyomesh., Kay Alridge, John F. Ensley, Edward Odel, Andrea Boyd, Judith Jones et al. Laminin-γ2 “Overexpression in Head-and-Neck Squamous Cell Carcinoma”. Int. J. Cancer 2002; 99:583-8.
8.Carol A. Vandenburg. Integrins Step up the Pace of Cell Migration Through Polyamines and Potassium Channels. PNAS 2008; 105(20): 7109-10.
9.Akelia Bellachène, et al. Small Integrin-Binding Llgand N-linked Glycoproteins (SIBLINGs): Multifunctional Proteins in Cancer. Nat rev Cancer 2008 ; 8(3): 212-26.
10.Wei Yu et al. β1-Integrin Orients Epithelial Polarity via Rac 1 and LamininD. Molecular Biology of the Cell 2005;16, February: 433-45. 11.Cord Brakebusch et al. Integrins in Invasive Growth. The Journal of Clinical Investigation 2002;109(8): 999-1006.
Copyright © 2013 Lalita Jayaram Thambiah & Satish Kumaran P., This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report:-Orthodontics
Prabhuraj B. Kambalyal1, Ronak Maniar2*, Promod Shetty3 & Sudhanshu Sanadhya4.
1Professor,2Post graduate student, 3Head,Department of Orthodontics,4Post graduate student, Department of community Dentistry, Pacific Dental College and Hospital, Udaipur, Rajasthan, India.
Abstract:-
A 12 year old male with Class II div 1 subdivision and increased overjet and overbite was treated with modified nance appliance and implant supported niti coil spring distalization . Treatment resulted in Class I occlusion , ideal overjet , overbite , incisor andualation and matching midlines, total treatment duration was 1 year 4 months. Modified nance design with aniti coilspring and implants is an effective method to correct a Class II occlusion with minimal mandibular crowding.
Key Words:- Modified nance , Unilateral Molar distalization, Implant, Class II malocclusion.
References:
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2.Blechman AM. Magnetic force systems in orthodontics. Clinical results of a pilot study.Am J Orthod 1985; 87:201–10.
3.Basdra EK, Huber H, Komposch G. A clinical report for distalizing maxillary molars by usingsuper-elastic wire. Orofac Orthop/Fortschritte der Keieferorthopadie 1996; 57:118–23.
4.Gianelly AA, Bednar J, Dietz VS. Japanese NiTi coils used to move molars distally. Am J OrthodDentofacial Orthop 1991; 99:564–6.
5.Jeckel N, Rakosi T. Molar distalization by intraoral force application. Eur J Orthod 1991;13: 43–6.
6.Jones RD, White JM. Rapid Class II molar correction with an open-coil jig. J Clin Orthod 1992; 26:661–4.
7.Hilgers JJ. The pendulum appliance for Class II noncompliance therapy. J Clin Orthod 1992; 26:706–14.
8.Carano A, Testa M. The distal jet for upper molar distalization. J Clin Orthod 1996; 30: 374–80.
9.Kalra V. The K-loop molar distalizing appliance. J Clin Orthod 1995;29:298–301.
10.Fortini A, Lupoli M, Parri M. The First Class Appliance for rapid molar distalization. J ClinOrthod 1999; 33:322–8.
11.Ghosh J, Nanda RS. Evaluation of an intraoral maxillary molar distalization technique. Am J Orthod Dentofacial Orthop 1996; 110:639–46.
12.Wilson WL. Modular orthodontic systems. Part1. J Clin Orthod 1978;12:259–78.
13.Locatelli R, Bednar J, Dietz VS, Gianelly AA.Molar distalization with superelastic NiTi wire. J Clin Orthod 1992; 26:277–9.
14.Gianelly AA, Vaıtas AS, Thomas WM. The use of magnets to move molars distally. Am J OrthodDentofacial Orthop 1989; 96:161–7.
15.Itoh T, Tokuda T, Kiyosue S, Hirose T, Matsumoto M, Chaconas SJ. Molar distalization with repelling magnets. J Clin Orthod 1991;25: 611–17.
16.Erverdi N, Koyuturk O, Kucukkeless N. Nickeltitanium coil springs and repelling magnets: A comparison of two different intra-oral molar distalization techniques. Br J Orthod 1997; 24: 47–53.
17.Byloff FK, Darendeliler MA. Distal molar movement using the pendulum appliance. Part I: Clinical and radiological evaluation. Angle Orthod 1997; 67:249–60.
18.Bussick TJ, McNamara JA Jr. Dentoalveolar and skeletal changes associated with the pendulum appliance. Am J Orthod Dentofacial Orthop2000; 117:333–43.
19.Torog˘lu M, Uzel I, Cam O, Hanciog˘lu Z. Cephalometric evaluation of the effects of pendulumappliance on various vertical growth patternsand of the changes during short-term stabilization. Clin Orthod Res 2001; 4:15–27.
20.Gulati S, Kharbanda OP, Parkash H. Dental andskeletal changes after intraoral molar distalization with sectional jig assembly. Am J OrthodDentofacial Orthop 1998; 114:319–27.
21.Brickman CD, Sinha PK, Nanda RS. Evaluationof the Jones Jig appliance for distal molarmovement. Am J OrthodDentofacial Orthop 2000; 118:526–34.
22.Haydar S, Uner O. Comparison of Jones jigmolar distalization appliance with extraoral traction. Am J Orthod Dentofacial Orthop 2000; 117:49–53.
23.Bolla E, Muratore F, Carano A, Bowman SJ. Evaluation of maxillary molar distalization with the distal jet: A comparison with other contemporary methods. AngleOrthod 2002; 72: 481–94.
24.Aras K. 3D Cephalometric evaluation of 3Dmaxillary distalization arches effects on dentofacial system . Hacettepe University: Ankara, 1993.
25.Muse DS, Fillman MJ, Emmerson WJ, Mitchell RD. Molar and incisor changes with Wilson rapid molar distalization. Am J Orthod Dentofacial Orthop 1993; 104:556–5.
26.Yuksel S, Guls,en A, Ucem TT. Molar distalization with modified 3D bimetric distalizationarches. Turkish J Orthod 1996; 9:229-35.
27.Ucem TT, Yuksel S, Okay C, Guls,en A. Effects of a three-dimensional bimetric maxillary distalizing arch. Eur J Orthod 2000; 22:293–8.
28.Altug AT. A comparative investigation of 3D bimetric maxillary distalization arches and servical headgear on dentofacial structures.Ankara University: Ankara, 2002.
29.Altug-Atac AT, Erdem D, Arat ZM. Three-dimensional bimetric maxillary distalization arches compared with a modified Begg intraoral distalzation system.Eur J Ortho 2008;30:73-9.
Copyright © 2013 Maniar Ronak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review article:-Periodontics,
Sandeep A. Lawande MDS, FICOI(USA), FICD, FPFA.
Assistant Professor,Department of Periodontics, Goa Dental College & Hospital, Bambolim, Goa, India – 403202.
Abstract:- Turmeric (Curcuma longa) is a dietary spice with curcumin as its most active ingredient, widely used as a traditional medicine in Asian countries. Curcumin has been demonstrated to possess many beneficial properties including anti-inflammatory, antioxidant, chemopreventive and chemotherapeutic activities, which have paved the way for ongoing human clinical trials. Curcumin shows great promise as a therapeutic agent. This article explores its therapeutic applications in the field of dentistry.
Key words:- Turmeric, Curcuma longa, Curcumin, dentistry.
Copyright © 2013 Sandeep A. Lawande. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:-Medical Biochemistry
Oseni, O. A1* & Okoye, V. I2.
1Department of Medical Biochemistry, College of Medicine, Ekiti State University, Ado-Ekiti, Nigeria.
2Department of Chemical Sciences, Achievers University, Owo, Ondo State, Nigeria.
Abstract: The present study was undertaken to investigate the medicinal effect of the fruit of watermelon (Citrullus lanatus, family Cucurbitaceae). The fruit was obtained from Owo market in Ondo State and analyzed qualitatively and quantitatively for some basic phytochemicals of antioxidant importance in the various parts of the fruit using standard methods. The results of the antioxidant properties showed that the highest dose of 200µL possessed higher concentrations of flavonoids and total phenol in all extracts of the various parts investigated while lower dose of 50µL produced the highest percentage of iron chelation ability in all the parts investigated. Similarly, in this study it was also confirmed that the fruit possess the ability to scavenge free radicals and reactive oxygen species with the seed possessing the highest ability against DPPH at the least concentration of 150µL from the range of (150 – 500) µL investigated. The results obtained from this study however indicate the possibility of utilizing the fruit as neutraceutics or functional food to prevent or manage some critical diseases of man through scavenging or inhibition of some destructive species or radicals.
Key words: Diseases, antioxidant, concentration, consequence, medicine.
Copyright © 2013 Oseni, O. A & Okoye, V. I. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report:- Microbiology
B.Kiran Madhusudhan1* & B.Madhusudhan2
1MD (Microbiology), Associate Professor in Microbiology, Barath University, Shree Balaji Medical College and Hospital, Chrompet, Chennai-600 044, India.
2MS.,M.Ch(Plastic)-Consultant Plastic Surgeon BRS Hospital Pvt Ltd, Nungambakkam, Chennai-34, India.
Abstract: Protein C deficiency is a common cause for hypercoagulable state and can be inherited or acquired. Early in warfarin treatment, serum levels of vitamin K dependent antithrombotic protein C falls, even before other clotting factors. This causes a temporary prothrombic state, leading to venous thrombosis in subcutaneous and dermal vessels causing haemorrhagic infarction and skin necrosis. We report here a post aortic valve replacement patient who presented with a painful necrotic skin lesion of 2 weeks duration on the medial aspect of his right thigh .Patient was on anticoagulant treatment (T.Acitrom-5mg od) and his protein C level was well below normal limits, which helped in the diagnosis of warfarin induced skin necrosis in this case. Reversal of warfarin therapy was adopted, followed by surgical debridement and skin grafting.
Key words:- Skin necrosis, Warfarin, Hypercoagulable state, Protein C deficiency.
References:-
1.Schafer. Al. Thrombotic Disorders:hypercoagulable states.In Goldman.L,Ausiello D.eds Cecil Medicine .,23rd Edition Philadelphiala ,Pa Saunders Elsevier; 2007, Chapter 182.
2.Andrew’s Disease of Skin by Sauders Jane;10th Edition Pg122-123.
3.Mcknight JT,Maxwell AJ,Anderson RL(1992).”Warfarin necrosis”,Arch Fam Med (1);105-8,PMID 141581
4.James,William Berger,Timothy,Elston Drik(2005).Andrew’s Diseases of the skin; Clinical Dermatology 1oth Ed Saunders ISBN 0-7216-2921-0.
5.Schleicher SM,Fricker MP(April 1980). “Courmarin necrosis”.Arch Dermatol 116 (4); 444-5.PMID 7369776.
6.Chan YC,Valeti D, Mansfield AO ,standsby G (March 2000).”Warfarin induced skin necrosis” Br.J surg 87(3);266-72.
7.Chan YC,Valeti D, Mansfield AO ,standsby G (March 2000).”Warfarin induced skin necrosis” Br.J surg 87(3);266-72.
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Copyright © 2013 B.Kiran Madhusudhan & B.Madhusudhan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.