DocumentsDate added
Case report:-
Prakash M*1,2, Sambandhan A P2.
1Sree Balaji Medical College & Hospital, Chromepet, Chennai, India (Bharath University). 2Department of ENT, Institute of Child Health & Hospital for Children, Egmore, Tamil Nadu, India.
Abstract: Carcinoma of oesophagus in young is a rare clinical entity. A case of carcinoma oesophagus in young is presented here. A high index of suspicion was required for its diagnosis.
Key Words: Carcinoma of oesophagus, Rare, Systemic.
References:
1.Aryya NC, Lahiry TK, Gangopadhyay AN, Asthana AK. Carcinoma of the esophagus in childhood. Pediatr Surg Int 1993; 8: 251–2.
2.Allam AR, Fiaz M, Fazili FM, Khawaja FI, Sultan A. Esophageal carcinoma in a 15-year-old girl: A case report and review of the literature. Ann Saudi Med 2000; 20: 261–5.
3.Shahi UP, Sudarsan, Dattagupta S, Singhal S, Kumar L, Bahadur S, et al. Carcinoma esophagus in a 14-year-old child: Report of a case and review of literature. Trop Gastroenterol 1989; 10: 225–8.
4.Soni NK, Chatterji P. Carcinoma of the oesophagus in an eight-year old child. J Laryngol Otol 1980; 94: 327–9.
5.Tampi C, Pai S, Doctor VM, Plumber S, Jagannath P. HPV- associated carcinoma of esophagus in young. Int J Gastrointest Cancer 2005; 35: 135–42.
6.J. B. Hedawoo, N. G. Nagdeve, and G. N. Sarve. Squamous cell carcinoma of esophagus in a 15-year-old boy. J Indian Assoc Pediatr Surg 2010 Apr-Jun; 15(2): 59–61.
Copyright © 2013 Prakash M & Sambandhan A P., This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original research article:-Orthodontics
Prabhuraj Kambalyal1 , Promod Shetty2 , Ronak Maniar3* & Sudhanshu Sanadhya4
1Professor,2Professor and Head, 3Postgraduate student, Department of Orthodontics, 4 Postgraduate student, Department of Community dentistry , Pacific Dental College and Hospital, Airport Road, Debari, Udaipur – 313024, Rajasthan, India.
Abstract:- Aims: To correlate and evaluate the changes in the shape and size of the cervical vertebrae with the obese patients and normal patients. Settings and design: A cross sectional radiographic study was carried out among 240 subjects , 8-14 years further divided into 120 normal BMI( body mass index) and 120 obese(increased BMI) visiting Department of Orthodontics, Pacific Dental College and Hospital, Udaipur, India. Methods and Material: The lateral cephalogram were taken and traced for all subjects The system developed by Farman and Hassel modification of Lamparski’s criteria was used to determine skeletal maturation using cervical vertebrae. Results: The obese subjects (3.23±1.2) exhibited a significantly higher mean cervical vertebral maturation score than did the normal subjects (2.6±1.4). Conclusion: Obese subjects showed a higher mean discrepancy between skeletal and chronologic ages compared with normal-weight subjects. Furthermore, obese subjects had a significantly higher cervical vertebral maturation score than did normal-weight subjects. Thus, to account for the earlier growth in obese patients with skeletal discrepancies, it might be necessary to perform earlier examinations and treatments than in normal-weight subjects.
Key words:- Skeletal maturation, cervical vertebrae, obesity.
Copyright © 2013 Maniar Ronak et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:-
Abhijeet Shroff1,Subhash Puri2*, (COL) S. K. Biswas3, Sahil Sanghi4, Sandeep C4& Pranav Patel4.
1Assistant Professor,2Professor,3Professor and head,4Resident, Dept of Orthopaedics, Dr. D. Y. Patil Medical College, Pune, Maharashtra, India.
Abstract: Background: The Scaphoid bone is the commonest carpal bone to be fractured in the wrist injuries. The actual number of scaphoid fractures amongst all cases diagnosed clinically is small. For making the definitive diagnosis of scaphoid fracture, along with clinical suspicion , patient has to undergo intial and follow up radiographs. In view of this picture, patient should be clinically assessed and confirmed radiologically. Aim: To improve this situation, this study was undertaken at Dr. Dy Patil hospital, pimpiri, Pune,India. The objective was to rule out to how much extent the clinical signs help to make the definitive diagnosis in scaphoid fractures. Material & Methods: 82 patients were followed up to assess for how much extent the clinically suspected patients were diagnosed radiographically. Result: Out of 82, 21 patients were diagnosed with scaphoid fracture by clinical evaluation and by day1 & day 14 radiographs. Conclusion: The efficacy of clinical signs in diagnosing fracture scaphoid can be improved followed by serial radiographical evaluation for 2 weeks. Thus We conclude, with the high clinical suspicion by evaluating all the three clinical signs [Anatomical Snuffbox Tenderness(ASBT), Scaphoid Compression Tenderness(SCT),Scaphoid Tubercle Tenderness(STT)]following initial & day 14 radiographs ,helps in diagnosing scaphoid fractures for a better extent.
Key Words:- Scaphoid fracture, Clinical signs, Clinical & radiological diagnosis.
References:-
1.Tai C.C. et al.: Management of suspected scaphoid fractures in accident and emergency departments - time for new guidelines. Annals of the Royal College of Surgeons of England2005; 87 (5): 353-7.
2.T. Grant Phillips, Andrew M. Reibach , W. Paul Slomiany: Diagnosis and Management of Scaphoid Fractures.American academy of family physicians. 2004 Sep 1;70(5):879-84.
3.Schubert HE. Scaphoid fracture. Review of diagnostic tests and treatment. Can Fam Physician 2000;46:1825–32.
4.Freeland P. Scaphoid tubercle tenderness: a better indicator of scaphoid fractures? Arch Emerg Med. 1989;6:46–50.
5.ChenSC.The Scaphoid Compression Test. J Hand Surg Br1989;14B:3235.
6.Dias JJ, Thompson J, Barton NJ et al.: Suspected scaphoid fractures. The value of radiographs. Journal of Bone and Joint Surgery (Br). 1990; 72: 98-101.
7.Greene WB. Essentials of musculoskeletal care. 2d ed. Rosemont, Ill.: American Academy of Orthopaedic Surgeons 2001:252–4.
8.Waizenegger M, Barton N.J., Davis T.R.C. et al.: Clinical signs in scaphoid fractures. Journal of Hand Surgery (Br) 1994; 19: 743-7.
9.Fractures of the carpal scaphoid [editorial]. BMJ 1981;283:571-2.
10.Tiel-van Buul MM, van Beek EJ, Borm JJ, Gubler FM, Broekhuizen AH, van Royen EA. The value of radiographs and bone scintigraphy in suspected scaphoid fracture. A statistical analysis. J Hand Surg [Br]. 1993;18:403–6.
11.Grover R: Clinical assessment of scaphoid injuriesand the detection of fractures. Journal of Hand Surgery (Br): 21B 1996; 3: 341-3.
Copyright © 2013 Puri Subhash et al., This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:-
Potluri. Sushmitha1*, M.Lakshmi Narasu2 & M.V.Suryanarayana1
1Mylan Laboratories Limited, Hyderabad, India.
2Department of Biotechnology, Jawaharlal Nehru technological university, Kukatpally, Hyderabad-5000 072, India.
Abstract:-
A new, simple chiral HPLC method was developed for the enantiomeric separation of 1-(3-Methoxyphenyl) ethyl acetate, and 1-(3-Methoxyphenyl ethanol) (enzymatically synthesized key intermediate for Rivastigmine tartarate). Good resolution viz. Rs > 3.5 between R-and S-forms of 1-(3-Methoxyphenyl) ethyl acetate, and 1-(3-Methoxyphenyl ethanol) was achieved with Chiralcel OD-H (250x4.6 mm;5.0µm) column using n-Hexane, Isopropyl alcohol and Trifluoro acetic acid in the ratio of 95:05:0.2 %v/v/v as mobile phase at 30°C. Flow rate was kept as 1.0 mL/min and elution was monitored at 220 nm. The method was validated as per International Conference on Harmonization (ICH) guidelines in terms of limit of detection (LOD), limit of quantitation (LOQ), linearity, precision, accuracy, specificity.
Key words: Chiral HPLC, Validation, 1-(3-Methoxyphenyl)ethyl acetate, 1-(3-Methoxyphenyl ethanol).
References:-
1.Ariens EJ, Sodijn W. Timmermans PBMWM. Stereochemistry and Biological Activity of Drugs. Blackwell Scientific Publications: Oxford, 1983.
2. Mehta AC. Chiral high performance liquid chromatography of drug molecules. J Clin Pharm Therapeut 2008; 15: 313-23.
3. T.E. Beesley, R.P.W. Scott, Chiral Chromatography. Wiley, New York, 1998; 23-26 .
4.G. Subramanian , A Practical approach to chiral separations by liquid Chromatography.VCH Publishers, Wienheim; 1994.
5.H.Y. Aboul-Enein, I.W. Wainer, The impact of stereo chemistry in drug development and use. Wiley, New York; 1997. 6.
S. Allenmark, Chromatographic enantioseparation: methods and applications, 2nd edn. Ellis Horwood, New York; 1991.
7. Rosler, M.; Anand, R.; Cicin-Sain, A.; Gauthier, S.; Agid, Y.; Dal-Bianco, P.; Stahelin, H. B.; Hartman, R.; Gharabawi, M.; Brit. Med. J. 1999;318,:633-8.
8. Reading, P. J.; Luce, A. K.; Mckeith, I. G. Movement Discord. 2001; 16, 1171-1174
9. Mckeith, I.; Del Ser, T.; Spano, P.; Emre, M,; Wesnes, K.; Anand, R.; Cicin-Sain, A.; Ferrara, R.;Spiegel, R. Lancet 2000; 356: 2031-6.
10. Draft ICH guidelines on Validation of Analytical Procedures , Definitions and terminology. Federal Register, 1995; 60, IFPMA, Switzerland 11260.
11.Validation of Compendial methods, The United States Pharmacopeia, 30th. edn.USP30; 2007.
Copyright © 2013 Potluri. Sushmitha,M.Lakshmi narasu & M.V.Suryanarayana. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report:- Oral medicine and radiology.
Shekhar Kapoor1*, Kumud Mittal2, Bhushan Sharma3 & Kirat Anand4
1MDS, Senior Lecturer,4BDS, Demonstrator, Department of oral medicine and radiology,3MDS, Senior Lecturer, Department of oral pathology and microbiology, Christian Dental College and Hospital, Ludhiana, Punjab,India.
2MDS, Senior Lecturer, Department of Oral Medicine and Radiology, Sarabha Dental College and Hospital, Ludhiana, Punjab,India.
Abstract:- Amelogenesis imperfecta (AI) is a diverse collection of inherited diseases that exhibit quantitative or qualitative tooth enamel defects in the absence of systemic manifestations. Also known by varied names such as hereditary enamel dysplasia, Hereditary brown enamel, Hereditary brown opalescent teeth. This defect is entirely ectodermal, since mesodermal components of the teeth are basically normal. The AI trait can be transmitted by either autosomal dominant, autosomal recessive, or X-linked modes of inheritance. It is necessary to diagnose the case and provide durable functional and esthetic management of these patients, where the unaesthetic appearance has a definite negative psychological impact. Key words:- Amelogenesis imperfecta, enamel, genetic, brown.
References:-
1.Neville BW, Douglass DD, Allen CM, Bouquot JE. Abnormalities of teeth. In, Oral and Maxillofacial Pathology. 2nd ed. Pennsylvania: Elsevier, 2004; 89-94.
2.Paine ML, White SN, Luo W, Fong H, Sarikaya M, Snead ML. Regulated expression dictates enamel structure and tooth function (review). Matrix Biol 2001;20:273-92.
3.Rajendran R. Developmental disturbances of oral and paraoral structures. In, Rajendran R, Sivapathasundhram B, (ed). Shafer’s Textbook of Oral Pathology. 5th Ed. Elsevier; 2007; 67 -68.
4.Seow WK. Dental development in amelogenesis imperfecta: a controlled study. Pediatr Dent 1995; 17(1):26-30.
5.Aldred MJ, Savarirayan R, Crawford PJ. Amelogenesis imperfecta: a classification and catalogue for the 21st century. Oral Diseases 2003; 9(1):19-23.
6.Poulsen S, Gjqrup H, Haubek D, Haukali G, Hintze H, Lqvschall H, et al.. Amelogenesis imperfecta - a systematic literature review of associated dental and oro-facial abnormalities and their impact on patients. Acta Odontol Scand 2008; 66(4):193-9.
7.Crawford PJ, Aldred MJ. Amelogenesis imperfecta: autosomal dominant hypomaturation –hypoplasia type with taurodontism. Br Dent J 1988; 164:71-3.
8.Kida M, Ariga T, Shrakawa T, Oguchi H, Sakiyama Y. Autosomal dominant hypoplastic form of amelogenesis imperfecta caused by an enamelin gene mutation at the exon-intron boundary.J Dent Res 2002; 81:738-42.
9.Backman B. Amelogenesis imperfecta - clinical manifestations in 51 families in a Northern Swedish Country. Scand J Dent Res 1988; 96:505-16.
10.Aldred MJ, Crawford PJ. Amelogenesis imperfecta-towards a new classification. Oral Dis 1995;1:2-5. 11. 11.Cra
wford PJM, Aldred M, Bloch-Zupan A. Amelogenesis imperfecta. Orphanet J Rare Dis 2007; 2(1):17-22.
Copyright © 2013 Shekhar Kapoor et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.