DocumentsDate added
Research article:-
Potluri. Sushmitha1*, M.Lakshmi Narasu2 & M.V.Suryanarayana1
1Mylan Laboratories Limited, Hyderabad, India.
2Department of Biotechnology, Jawaharlal Nehru technological university, Kukatpally, Hyderabad-5000 072, India.
Abstract:-
A new, simple chiral HPLC method was developed for the enantiomeric separation of 1-(3-Methoxyphenyl) ethyl acetate, and 1-(3-Methoxyphenyl ethanol) (enzymatically synthesized key intermediate for Rivastigmine tartarate). Good resolution viz. Rs > 3.5 between R-and S-forms of 1-(3-Methoxyphenyl) ethyl acetate, and 1-(3-Methoxyphenyl ethanol) was achieved with Chiralcel OD-H (250x4.6 mm;5.0µm) column using n-Hexane, Isopropyl alcohol and Trifluoro acetic acid in the ratio of 95:05:0.2 %v/v/v as mobile phase at 30°C. Flow rate was kept as 1.0 mL/min and elution was monitored at 220 nm. The method was validated as per International Conference on Harmonization (ICH) guidelines in terms of limit of detection (LOD), limit of quantitation (LOQ), linearity, precision, accuracy, specificity.
Key words: Chiral HPLC, Validation, 1-(3-Methoxyphenyl)ethyl acetate, 1-(3-Methoxyphenyl ethanol).
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Copyright © 2013 Potluri. Sushmitha,M.Lakshmi narasu & M.V.Suryanarayana. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article:-Nursing
Radhamaniamma Jayasree(M Phil(N),MSN,RN/RM)
Senior Teacher, Salalah Nursing Institute, Sultanate of Oman.
Abstract:- Within nursing, the development and utilization of nursing model is an area of constant growth. The purpose of this article is to describe a detailed case application of Roy’s adaptation model (RAM) in the nursing care of patients with Rheumatoid arthritis (RA). The assessment and interventions are guided by RAM. An assessment tool for RA patient was prepared by the author and administered it to patients. A case study is presented to demonstrate how RAM can be used to guide nursing care of RA patients.
Key Words:- Adaptation, Assessment, Nursing Interventions, Rheumatoid arthritis, Roy’s adaptation model (RAM).
References:-
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Copyright © 2013 Radhamaniamma Jayasree et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article:- Physiotherapy
Jeganathan. A.1*, Suresh Kumar. T.2 ,Leo Rathinaraj. A.S3 & Nanthini Subbiah4.
1Associate Professor, MAEER’s Physiotherapy College, Talegaon, Pune, Maharashtra, India. 2Assistant Professor, 3Professor Maharashtra Institute of Physiotherapy, Latur, Maharashtra, India. 4Reader, National Institute of Health and Family Welfare, New Delhi, India.
Abstract:- Objective:- To compare the effectiveness of ACU treatments with analgesic alone in lateral ligament injured in ankle. Introduction:- The ankle joint is fairly unstable and largely depends on ligaments for its stability. Therefore it is highly susceptible for sprain. The sprains are a tearing of ligaments that connect bones and involve outer ligaments that support the ankle joint. The ankle sprains are two types’ pronation or eversion type and supination or inversion type. The most common mechanism of ankle sprain is inward twisting of the ankle. Generally it occurs in activities like running and jumping. In football and basketball the inversion sprain occurs when the player lands on other player’s foot. Supination type is a common capsule-ligamentous injury reported to be present in about 85% of all the ankle sprains. The injury occurs as a result of sudden adduction-inversion force on the ankle. The anterior and lateral ligaments are involved in these types of sprain. Materials & Methodology:- the sample of 30 subjects with lateral ligament injury who divided into two groups with 15 in each group. The experimental group exclusively treated with ACU treatment. The control group patients treated with analgesic only .The Materials used were, Table, inch tape and a chair ,Pain scale and swelling scale. Procedure: 30 subjects were selected with random sampling method and subjects were screened with inclusion criteria and exclusion criteria. The subjects are divided into two groups. Group A given with ACU treatment and group B given with analgesic only. The patients are assessed with pain scale and swelling scale pre and post study. Result & Conclusion:- In this study In ACU treatment, pre treatment pain score was 60 % in 0,40% in 1.after treatment 60% with the score 5, 33.3% with the score of 4, and 6.6% with the score 2. In 1st and 2nd degree ankle lateral ligament injury, treatment with analgesic, conservative and ultrasound (ACU) is found to be more effective in reducing pain and swelling.
Key words:- Ankle sprain, Pain, Swelling, Analgesics, Ultrasound, Lateral ligament injury.
Copyright © 2013 Jeganathan. A et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
An Informed view:- Periodontology
Kamath Deepa G1*& Nayak Sangeeta U2
1Additional Professor, 2Assistant Professor, Department of Periodontology, Manipal College of Dental Sciences ,Mangalore, Manipal University, India.
Abstract:- Dentinal hypersensitivity is characterized by a short, sharp pain in response to various stimuli. It is more commonly seen in adults in the 20- to 40-year-oldage group, has several etiological factors. Gingival recession and enamel loss both contribute to the prevalence of this condition, resulting in the exposure of dentin. Dentinal hypersensitivity is believed to occur due to the movement of fluid within the dentinal tubules occuring in response to thermal, chemical, tactile and evaporative stimuli, in accordance with Brännström’s Hydrodynamic Theory. Treatment options include in-office procedures and home use, self-applied products that are aimed at either occluding he dentinal tubules or preventing neural transmission and there by blocking the pain response.
Key words:- Dentinal Hypersensitivity, Recession, Pain, Potassium nitrate.
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Copyright © 2013 Kamath Deepa G & Nayak Sangeeta U. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:-Paediatrics
Caroline .A. Okoli1* & Gregory .E. Anekwe2
1Department of Paediatrics, University of Jos, Nigeria. 2Department of Biochemistry University of Jos, Nigeria.
Abstract: Background: In Nigeria, there is a very limited documentation on nutrient composition of fish species and the Africa catfish in particular. There is no documented data on identification of coenzyme Q10 in Africa catfish (Clarias gariepinus) liver oil. Africa catfish (Clarias gariepinus) is more common and cheaper than some other fishes rich in coenzyme Q10. Thus, identifying this nutrient in this fish could help in proper dietary planning, thereby ensuring better health. Method and Result The lipid fractions of the purified supernatant from centrifugation of 250g of 400 Africa catfish livers in 0.02M phosphate buffer pH7.0 were extracted using chloroform-methanol solution and purified by Folch wash giving a concentration of 100μg of lipids per μl. The lipid fraction was fractionated into neutral lipid and polar lipids by silicic acid chromatography and saponified using petroleum ether layer. Alumina column chromatography was used to fractionate and isolate the non-saponifiable parts including coenzyme fraction and their provisional identification was achieved by silica gel TLC and comparing of Rf values with that of reference standards after staining with iodine. The Rf of coenzyme fraction was 0.19.Confirmatory identification of coenzyme was by spectrophotometer. Coenzyme fraction and ubiquinone standard had peak absorption at 328nm and the concentration of ubiquinone in the coenzyme fraction was 0.6mg/ml Conclusion: Coenzyme Q10 is present in the liver oil of Africa catfish (Clarias gariepinus).
Key words: Co-enzyme Q10, ubiquinone Q10, Africa catfish (Clarias gariepinus), liver oil, Nigeria.
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Copyright © 2013 Caroline. A Okoli & Gregory. E Anekwe. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.