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Research article:-Biochemistry
Purnima Dey Sarkar1, Lincy K. Skaria2* & Gopinath Agnihotram 2
1Professor& HOD, 2 Research Scholar, Department. of Biochemistry, MGM Medical College, Indore, M.P, India.
Abstract:- Background: Thyroid disease results from a disruption of the endocrine and immune systems. Nutrition deficiencies cause a disruption of both the systems. The commonest thyroid disease is hypothyroidism with associated symptoms like fatigue, bradycardia, muscle hypotonia, female infertility, dry skin, etc. Methods: Total of 300 subjects were included in the study group of which 100 patients were hypothyroid, 50 patients were hypothyroid associated with women infertility along with 150 controls. Quantitative determination of thyrotropin (TSH), triiodothyroinine (T3) and tetraiodothyronine (T4) was analyzed along with nutritional analysis of dietary nutrients like carbohydrate, proteins, fat, vitamin A, B1, B2, C, niacin, etc. Biostatistical analysis and correlations were analyzed by using Graph pad prism software. Results:- The TSH levels in Hypothyroidism was 23.05 ± 13.05 and in hypothyroidism associated with infertility was 26.15 ± 13.36 and the difference between the two were significant (p<0.0001). The correlation between TSH and T4 in hypothyroidism was( r= -0.8447) and the correlation between TSH and T4 in hypothyroidism with infertility (r= -0.9137) are significant and is a negative correlation. Conclusion: The study concluded that the subjects in both the groups were deficient in almost all the dietary nutrients. Dietary zinc was found to be very low as suggested by ICMR, so there might be an interesting relationship between hypothyroidism and hypozincemia. Hence along with B-complex vitamins zinc also must be administered. Moreover fruits and vegetables must be included to meet the requirements of antioxidants such as β-carotene, Vitamin C and certain non-nutrients such as polyphenols and flavanoids.
Key words:- Hypothyroidism, Thyroid Stimulating Hormone(TSH), Triiodothyroinine (T3), Tetraiodothyronine(T4), Dietary Nutrients, Zinc.
Original article:- Physiotherapy
Jeganathan. A.1*, Suresh Kumar. T.2 ,Leo Rathinaraj. A.S3 & Nanthini Subbiah4.
1Associate Professor, MAEER’s Physiotherapy College, Talegaon, Pune, Maharashtra, India. 2Assistant Professor, 3Professor Maharashtra Institute of Physiotherapy, Latur, Maharashtra, India. 4Reader, National Institute of Health and Family Welfare, New Delhi, India.
Abstract:- Objective:- To compare the effectiveness of ACU treatments with analgesic alone in lateral ligament injured in ankle. Introduction:- The ankle joint is fairly unstable and largely depends on ligaments for its stability. Therefore it is highly susceptible for sprain. The sprains are a tearing of ligaments that connect bones and involve outer ligaments that support the ankle joint. The ankle sprains are two types’ pronation or eversion type and supination or inversion type. The most common mechanism of ankle sprain is inward twisting of the ankle. Generally it occurs in activities like running and jumping. In football and basketball the inversion sprain occurs when the player lands on other player’s foot. Supination type is a common capsule-ligamentous injury reported to be present in about 85% of all the ankle sprains. The injury occurs as a result of sudden adduction-inversion force on the ankle. The anterior and lateral ligaments are involved in these types of sprain. Materials & Methodology:- the sample of 30 subjects with lateral ligament injury who divided into two groups with 15 in each group. The experimental group exclusively treated with ACU treatment. The control group patients treated with analgesic only .The Materials used were, Table, inch tape and a chair ,Pain scale and swelling scale. Procedure: 30 subjects were selected with random sampling method and subjects were screened with inclusion criteria and exclusion criteria. The subjects are divided into two groups. Group A given with ACU treatment and group B given with analgesic only. The patients are assessed with pain scale and swelling scale pre and post study. Result & Conclusion:- In this study In ACU treatment, pre treatment pain score was 60 % in 0,40% in 1.after treatment 60% with the score 5, 33.3% with the score of 4, and 6.6% with the score 2. In 1st and 2nd degree ankle lateral ligament injury, treatment with analgesic, conservative and ultrasound (ACU) is found to be more effective in reducing pain and swelling.
Key words:- Ankle sprain, Pain, Swelling, Analgesics, Ultrasound, Lateral ligament injury.
Copyright © 2013 Jeganathan. A et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report:-
Agrawal C Alok1 & Sharma Saurabh2*
1Associate Professor,Orthopaedics, MAMS BMC,Sagar,Madhya Pradesh,India.
2Assistant Professor, Peoples Medical College ,Bhopal, Madhya Pradesh,India.
References:-
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Copyright © 2013 Agrawal C Alok & Sharma Saurabh., This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:-
Leila Ksiaa Cheikhrouhou (MD), Yousr Lakhoua Gorgi (phD), Salwa Jendoubi Ayed (MD), Houda Aouadi (MD) , Imen Sfar (MD), Mouna Makhlouf (MD), Taieb Ben Abdallah (phD), Khaled Ayed (phD).
Immunology Research Laboratory of Kidney Transplantation and Immunopathology (Laboratoire de Recherche: LR03SP01). University Tunis El Manar; Charles Nicolle Hospital. Tunisia.
Abstract:-
The aim of this study was to investigate the possibility of a significant relationship between the spontaneous clearance or the persistence of HCV infection and chemokines , chemokine receptors, cytokines and apoptosis genes polymorphisms in Tunisian hemodialysed patients. The polymorphisms of genes: CCR5 Δ32, CCR5 (-59029) A/G, CCR2 (64Ile), and MCP-1(-2518) A/G, (-889) IL-1α, (-511) and (+3954) IL-1β, IL-1-Ra, IL-18 (-137) and (-607), IL-12p40 (-1188) and Apo1/Fas (-670) were determined by PCR-RFLP, PCR-SSP and PCR-VNTR, at healthy blood donors (100 for cytokines and apo/fas gene polymorphisms and 170 for chemokine gene polymorphisms) and 100 hemodialysed patients infected by the HCV. Patients were classified in two groups: G1 included 76 active chronic hepatitis patients (positive RNA-HCV) and G2 included 24 having eliminated spontaneously virus (negative RNA-HCV). The univariate analyze of the genotypes and alleles frequencies of the cytokines polymorphisms studied does not reveal any positive or negative association statistically significant with the outcome of the HCV infection. Nevertheless, the frequency of genotype association [-37GC/-607CA] IL-18 is statistically higher among G2 patients (41,7%) compared to that at G1 hemodialysed (15,8%) (p=0,008, OR: 0.26, 95%CI: [0.10-0.73]). We found also, a significant increased frequency of AA genotype of Apo1/Fas gene in G2 patients (41,6%) than in G1 (17,5%) (p=0,026, OR=3,49, 95% CI [1,13-10,69]). Adjustment for known covariates factors (age, gender and genotypes) confirmed these univariate findings and revealed that the genotype association GC-CA of (-137and-607) IL-18 gene and AA genotype of Apo1/Fas gene were associated to the clearance of HCV (p=0.041 and p=0.017 respectively). Our results showed also a statistically increased frequencies of the CCR2 (64Ile) and the (-59029) CCR5 A alleles in total patients HCV infected (22,1% and 35,9%) and in G1 (24,3% and 40,6%) compared to controls (14,4% and 20%)[p=0.0086, p=0.03 and p=0.04, p=0.017 respectively]. Also, we observe a lower frequency of the MCP-1 G allele and a greater frequency of the CCR5 Δ32 variant in G2 (15,2% and 6,5%) compared to G1(22,6% and 1,4%)[p>0.05], but adjustment for known covariates factors didn’t confirmed these univariate findings. In conclusion, our study suggests a possible role of some of the chemokine and cytokine and apo/fas polymorphisms studied in the outcome of HCV infection in Tunisian population. These results should be further investigated by large population-based studies.
Key words:- Hepatitis C virus, Spontaneous clearance, Chemokines, Chemokines Receptors genes polymorphisms, cytokines, apo/fas polymorphisms.
Copyright © 2013 Leila K Cheikhrouho et al., This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report:- Oral medicine and radiology.
Shekhar Kapoor1*, Kumud Mittal2, Bhushan Sharma3 & Kirat Anand4
1MDS, Senior Lecturer,4BDS, Demonstrator, Department of oral medicine and radiology,3MDS, Senior Lecturer, Department of oral pathology and microbiology, Christian Dental College and Hospital, Ludhiana, Punjab,India.
2MDS, Senior Lecturer, Department of Oral Medicine and Radiology, Sarabha Dental College and Hospital, Ludhiana, Punjab,India.
Abstract:- Amelogenesis imperfecta (AI) is a diverse collection of inherited diseases that exhibit quantitative or qualitative tooth enamel defects in the absence of systemic manifestations. Also known by varied names such as hereditary enamel dysplasia, Hereditary brown enamel, Hereditary brown opalescent teeth. This defect is entirely ectodermal, since mesodermal components of the teeth are basically normal. The AI trait can be transmitted by either autosomal dominant, autosomal recessive, or X-linked modes of inheritance. It is necessary to diagnose the case and provide durable functional and esthetic management of these patients, where the unaesthetic appearance has a definite negative psychological impact. Key words:- Amelogenesis imperfecta, enamel, genetic, brown.
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Copyright © 2013 Shekhar Kapoor et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.