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Research article:-Pharmacology
1Associate professor, Department of Pharmacology, 2Associate professor, Department of Anatomy, Jhalawar medical college, Jhalawar, Rajasthan, India.
Abstract:- Background:- There is great controversy about role of male sex hormone, testosterone, in Psychotic mental disorders like schizophrenia. This study assessed the effectiveness of testosterone in schizophrenic patients and probes how it modulates the action of standard anti-psychotic medication Chlorpromazine which is commonly used in Clinical Psychiatric practice. Methods, a. Design and Setting:- -Randomized, Double-blind, Controlled Clinical study performed in collaboration with Department of Clinical Psychiatry from Feb 2003 to March 2004 in M.Y.H Hospital (Teaching hospital) associated with M.G.M. Medical College, Indore. b. Subjects - twelve patients aged 20 to 60 years diagnosed Schizophrenics according to ICD-10 Criteria who visited in outpatient department of psychiatry during study period. c. Interventions - Patients was treated with Oral Chlorpromazine 200 mg BD, half of the 12 patients also received single dose of testosterone esters 100mg intramuscularly with above-mentioned treatment .d. Outcome Measure - how symptomology in schizophrenic patients affected is measured by applying various valid psychiatric rating scales like Brief psychiatric Rating Score (BPRS) , Scale for assessment of positive symptom(SAPS), and Scale for Assessment of Negative Symptoms (SANS) . Basal reading is followed by treatment intervention and then scales are used to measure the effect every week for 3 weeks. Paired‘t’ test is used for determining level of significance (p value) of intervention. Results: - Single dose of Testosterone 100 mg administered initially by I.M. route potentiated the reduction level in negative symptoms of schizophrenia by 115% in patients receiving chlorpromazine 200 mg. Conclusion:- In this study, Testosterone potentiated the effects of Chlorpromazine 200 mg, on general psychotic manifestations, positive symptoms and negative symptoms of schizophrenia, assessed on BPRS, SAPS and SANS scoring scales. The most significant is the effect on negative symptoms as measured by SANS.
Keywords:- Testosterone, Schizophrenia, Chlorpromazine.
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Copyright © 2013 Vijaywargia Tarun & Sharma Gopal. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article:-
M. D. Dixit1, Kishore Bhat2*, Mohan D. Gan3 & Aruneshwari Dayal3
1Head of the Department & Professor,2Research Officer,3Professor,CVTS,Jawaharlal Nehru Medical College and Karnataka Lingayat Educational Society’s Dr.Prabhakar Kore Hospital & Medical Research Centre, Belgaum, Karnataka, India.
Abstract:- Background and Objectives: Several chronic microbial infections are being considered as newer risk factors for atherosclerosis and CAD. But the reports are conflicting and the published data from India is scarce. An attempt has been made in the present study to evaluate the role of pathogen burden in subjects with and without CAD in a Tertiary Care Hospital in Karnataka,India. Methods: Seropositivity to IgG antibodies specific for Chlamydia pneumoniae, Helicobacter pylori, Herpes simplex virus type 1 and 2 and Cytomegalovirus was investigated in 274 patients with CAD and 275 apparently healthy individuals by ELISA test. The presence of conventional risk factors including hyperlipidemia, hypertension, diabetes, smoking and BMI were recorded. Occurrence of angina and MI also were noted. Results: There was a significant difference in the incidence of CMV, H. pylori and C. pneumoniae between CAD patients and controls, but the association was weak after multivariate analysis. On the other hand, pathogen burden was significantly higher in study group. The presence of risk factors was very high in patients (73.82%) in contrast to controls (11.3%). The association between MI and pathogen burden was statistically significant. Interpretation and conclusion: our data provide strong evidence that pathogen burden may have direct bearing on the incidence of CAD and also on the occurrence of cardiac complications such as MI. On the other hand, the association of individual infections with CAD appears to be weak. More such studies, prospective in nature are needed before definite conclusions can be drawn.
Keywords:- Coronary Artery Disease, H. pylori, C. pneumonia, HSV, CMV, Risk factors, Myocardial infarction & Pathogen burden.
References:-
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Copyright © 2013 Bhat Kishore et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:- Pediatrics
Basavaraj M Patil1*, Sandeep V H2, Harish G3, Venaktesh M Patil4 & Vijayanath.V5
1Associate professor,2Assistant professor,3Resident, Dept of pediatrics, M R medical college, Gulbarga, Karnataka,India.
4Associate Professor, Department of Pharmacology, Navodaya Medical College, Raichur, Karnataka,India.
5Associate Professor, Department of Forensic Medicine & Toxicology, VMKV Medical College & Hospital,Salem, Tamil Nadu,India.
Abstract:- In the present generation it has been established that newborns exposed to mother’s HIV infection have a higher mortality rate than those not exposed. At the same time, some authors have shown that prematurity and low birth weight were considerably associated to morbidity and mortality in the neonatal period as well as in the first year of life. In the present study, 50 HIV seropositive women delivered newborns were considered and followed prospectively and studied the consequences of neonatal outcome in HIV positive mother in terms of mortality, morbidity and somatic growth pattern. The focus of this study is to know the demographic characteristics, load of HIV transmission from mother to child, increase the effectiveness of preventive aspects of HIV regarding mother to child transmission and also to know the neonatal outcome and complications associated. In the present study it was observed that 48% of the seropositive mothers were in the age group of 21 to 25 years most of them were illiterates and housewives.
Keywords:- Infection; Mother; Child; Transmission.
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20.Dreyfuss ML, Msamanga GI, Spiegelman D, et al. Determinants of low birth weight among HIVinfected pregnant women in Tanzania. Am J Clin Nutr 2001; 74: 814-26.
Copyright © 2013 Basavaraj M Patil et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:-
Baig Vaseem Naheed1*, Swarnkar Madhusudan2,Bhardwaj Ashok Kumar3, Singh Raghuveer4, Kewalramani Suresh5 & Soni Prashant6.
1Associate Professor,2Assistant Professor,3Professor,4Professor and Head, Department of P.S.M., Jhalawar Medical College, Jhalawar (Raj.), India.5Assistant Professor, Dept. of P.S.M., S. M. S. Medical College, Jaipur (Raj.),India. 6M.B.B.S., M.B.A., Maternal and Newborn health Manager, Save The Children, India.
Abstract: Background: HIV is the most prominent risk factor for progression of TB infection to disease causation and there is paucity of studies related to clinico-radiological profile of HIV-TB co-infection, this evoked us to do this study. Material and Methods: The present study is Hospital based cross sectional study done on two hundred HIV/AIDS patients (>15 year of age) attending ART Center of S.M.S. Medical College, Jaipur (Raj.). Results: Dual infection of HIV - TB was found in nearly one third (32.50%) of study individuals, co-infection was slightly more common in males (34.70%) than that of females (26.41%). Weakness was the almost universal (98.46%) symptom and muscle wasting was commonest (80.00%) sign, oral candidiasis was the most common (52.31%) complication. Of all the 65 HIV-TB co-infected patients, pulmonary TB was found in 18 patients (27.69%), extra-pulmonary TB in 27 (41.54%) patients, while 20 (30.76%) patients had both pulmonary & extra-pulmonary TB. upper zone infiltration & cavitatory lesion were seen in 47.37% while atypical features such as mid-lower zone infiltrate & exudative lesion were seen in 73.68% & 68.42%. Sputum smear positivity for AFB was found in 42.11% of pulmonary TB cases with HIV-TB co-infection. Most (90.77%) cases with HIV-TB co-infection had CD-4 count <200/ micro L.
Keywords: Extra-Pulmonary Tuberculosis, HIV-Tb co-infection, Pulmonary Tuberculosis.
References:-
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Copyright © 2013 Baig Vaseem N et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report & Literature review:- Radiology
Nagarajan K 1*, Muthu S2 & Sushma Nayar3
Departments of Radiology1, General Surgery2 & Pathology3, Chettinad Hospital & Research Institute, Rajiv Gandhi Salai (IT Highway) Kelambakkam, Kanchipuram Dt Tamil Nadu – 603103 India.
Abstract:- Gastro-intestinal carcinoids are common in the ileo-appendiceal region and produce typical appearance of ‘spiculated’ margins in Computed Tomography (CT). Metastasis to liver leads to systemic carcinoid syndrome. We present a case of ileal mesentric carcinoid which was initially suspected as bowel mass and review the literature to underline the importance of identifying the characteristic CT appearance in view of complications associated with biopsy and surgery of such lesions.
Key Words:- Mesentric carcinoid, Imaging, CT, Liver Metastases, Surgery, Biopsy, Complications.
References:-
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Copyright © 2013 Nagarajan K, Muthu S & Sushma Nayar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.