DocumentsDate added
Case report:-
Sneha S. Desale1, Nandkumar V. Dravid2, Dhiraj B. Nikumbh3*, Dhananjay V. Newadkar4 & Yogesh R. Tayade5
Assistant lecturer1, Prof & HOD2, Associate professor3, Professor4, Assistant lecturer5, Department of Pathology, JMF’s ACPM Medical college and hospital, Dhule, Maharashtra, India.
Abstract:- Dermatofibrosarcoma Protuberans (DFSP) is a rare, indolent,low grade soft tissue sarcoma with properties of progressive and locally infiltrative growth. Less than 5% of sarcomas appear as primary abdominal wall tumors. DFSP mostly occur over the trunk or proximal extremities. DFSP accounts for <0.01% of all malignancies and <0.1% of all the cutaneous neoplasms. DFSP over an anterior abdominal wall is a rare clinical entity. Herein, we present a case of DFSP over anterior abdominal wall in a 35 year old male, which was diagnosed on histopathology and confirmed on immunohistochemistry. DFSP is a rare dermal malignancy with a propensity to be locally aggressive but rarely metastatic. Hence proper histopathological diagnosis is always warranted in such rare tumor.
Keywords:- Soft tissue sarcoma, Dermatofibrosarcoma Protuberans,Abdominal wall.
References:-
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Copyright © 2013 Nikumbh et al.. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Clinical case report:-Orthodontics and Dentofacial Orthopedics.
Chougule Kishor Adinath1* & Shetti Shraddha Subhash2
1Professor and Post-graduate Teacher, 2Post-graduate student, Department of Orthodontics and Dentofacial Orthopedics, Tatyasaheb Kore Dental College and Research Centre, New Pargaon, Kolhapur, India.
Abstract:- A set of identical male triplets was studied. Lateral cephalograms, study models and facial photographs were taken and assessed for various traits. When all the records were assessed, two of the triplets showed more similarity than the third one, comparatively. This supports the hypothesis that heredity is not the sole controlling factor and the phenotype is inevitably the result of both genetic and environmental factors.
Keywords:- Triplets, Genetics, Inheritance, Heredity.
References:-
1.Wilcox M.A, D.F.Wyszynski et al. Emperically derived phenotypic subgroups –qualitative and quantitative trait analysis. BMC Genet 4 Suppl.1:S15.
2.Lauweryns I., Carels et al. The use of twins in dentofacial genetic research. Am .J. Orthod Dentofac Orthop 1993;103(1):33-8.
3.Mossey P.A, “The heritability of malocclusion: Part 2 The influence of genetics in malocclusion” Journal of Orthodontics Sept1999;6 (3):195-203.
4.Hunter W.S. “A study of the inheritance of craniofacial characteristics as seen in lateral cephalograms of 72 like sexed twins”. European orthodontic society report of congress, 41, 59-70.
5.Menezes et al “Genetic influences on dentition and dental arch dimensions: a study of monozygotic and dizygotic triplets” Am. J. of physical Anthropology 1974; 40( 2): 213-9.
6.Markovic & Trisovic “Monozygotic triplets with discordance for same traits” European J. of Orthod 1979; 1(3):189-92.
7.Leighton B.C., “Dental arch development in a set of triplets” European Journal of Orthodontics 1992;14:273-9.
Competent interest:- The authors declare that they have no competing interests.
Source of funding:-None.
Copyright © 2013 Chougule K Adinath & Shetti S Subhash . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:- Biosciences
Jyoti Rana1*, Pushpa Thakur1 & M.S.Thakur2
1IIHS, Himachal Pradesh University Shimla, Himachal Pradesh -171005, India.
2Department of Biosciences, Himachal Pradesh University Shimla-171005, India.
Abstract:-
The succession of necrophilous insects on Sus scrofa Linnaeus kept in two different environments viz., grassland and aquatic were investigated. The purpose of this study was to investigate the decomposition rate, insect succession, taxonomic identification and to study the life history of Chrysomya megacephala (Fabricius, 1784) on two pig carrion. Three species of Calliphoridae i.e. Chrysomya rufifacies (Maquart), Calliphora vicina Robineou-Desvoidy and Chrysomya megacephala (Fabricius) were collected from the two pig carrion. The species found to be more pronounced in both the environment was Chrysomya megacephala (Fabricius). Due to their abundance in both the environments life history has also been noted during whole decomposition. A total number of 462 specimens were collected from the grassland and 476 from the aquatic environment. The specimen collected belonged to Diptera, Coleoptera, Hymenoptera, Dermaptera and Arachnida. Insect fauna associated with aquatic environment were observed more than grassland environment.
Keywords:- Insect Succession, Decomposition, Sus scrofa.
References:-
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Copyright © 2013 M S Thakur. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article:-Oral and Maxillofacial Pathology
Lalita Jayaram Thambiah1* & Satish Kumaran P2
1Professor of Oral and Maxillofacial Pathology, Consultant Oral and Maxillofacial Pathologist,Annasamy Mudaliar General Hospital, Fraser town, Bangalore,India.
2Consultant Oral and Maxillofacial Surgeon,Annasamy Mudaliar General Hospital,Fraser town, Bangalore,India.
Abstract:- Malignant tumours which start in one part of the body tend to invade organs not directly connected with that part and develop tumours in them. Destruction of the basement membrane is the first step in tumour invasion and metastasis. The expression of collagen IV protein and the expression of mRNA of collagen IV were studied to ascertain if they correlate. Malignant tissues have a high molecular mass which specifically degrades collagen IV. Many tumourigenic cells synthesize less collagen and larger quantity of proteases including collageneases. It results in the cells becoming less dependent on extracellular matrix for growth. These factors increase their ability to invade.
Keywords:-Well-differentiated squamous cell carcinoma, metastasis, collagen IV, mRNA expression level.
References:-
1.Daniela Spano et al. “Molecular Networks that Regulate Cancer Metastasis.” Seminars in Cancer Biology. 22 (2012) 234-49.
2.Massoumeh Zargaran et al. “Immunohistochemical Evaluation of Type IV Collagen and Laminin-332 γ2 Chain Expression in Well-differentiated Oral Squamous Cell Carcinoma and Oral Verrucous Carcinoma: a New Recommended Cut-off.” Journal of Oral Pathology & Medicine (2011) 40:167-73.
3.Michio Tsuda, Yumi Yamagishi and Tsunehiko Katsunuma. “High Molecular Mass Type IV Collagen-specific Metalloprotease from Human Carcinoma Tissue.” Federation of European Biochemical Societies Vol. 232, No.1, 1988: 140-4.
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5.Kenneth J.Livak and Thomas D. Schmittgen, “Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2-∆∆CT” methods, 2001; 25, 402-8.
6.Timpl, R., Wiedmann, H., von Delden, V., Furthmayr, H and Kuhn, K.: “A Network Model for the Organization of Type IV Collagen Molecules in Basement Membranes.” Eur.J.Biochem 1981; 120:203-11.
7.Hynda K. Kleinman, Robert J. Klebe and George R. Martin. “Role of Collagenous Matrices in Adhesion and Growth of Cells.” The Journal of Cell Biology 1981;88 (March): 473-85.
Copyright © 2013 Lalita Jayaram Thambiah & Satish Kumaran P. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article:- Biochemistry
E. E. Edet1, E. David-Oku1* M.I. Akpanabiatu2, G. O. Igile1, B. Mgbeje1, G. E. Egbung1 & F.E.Uboh1
1Department of Biochemistry, University of Calabar, P.M.B. 1115, Calabar, Nigeria.
2Department of Biochemistry, University of Uyo, P.M.B. 1017, Uyo, Nigeria.
Abstract:-
The effect of Gongronema latifolium crude leaf extract (GL) on serum enzymes was assessed in male diabetic rats. The rats were gavaged with 200, 300 and 400 mgkg-1 b.wt. of GL day-1 for two weeks. Serum was investigated biochemically for AST, ALT, ALP, GGT and LDH activities. Serum ALT, ALP and LDH activities increased significantly (p< 0.001) in alloxan-induced diabetic rats treated with GL when compared to non-diabetic rats. In diabetic rats, serum GGT activity increased significantly (p< 0.05) in the treated animals, whereas serum LDH activity decreased significantly (p< 0.01) when compared to their controls. In diabetic rats also, AST: ALT ratios were higher in the treated animals when compared to the control and showed non-dose dependent decreases in serum AST, ALT, LDH and GGT activities with increased dosage of GL. In non-diabetic rats, serum ALP and LDH activities decreased significantly (p< 0.05) in the treated animals when compared to the control. There were also non-dose dependent decreases in serum AST, ALT, ALP, GGT and LDH activities with increased dosage of GL. AST: ALT ratio was high in treated animals when compared to the control and showed a non-dose dependent increase with increased dosage of GL. Moreover the AST: ALT ratio of test groups and controls of both diabetic and non-diabetic rats were higher than unity or one. The high values of AST: ALT ratio in the serum provided additional evidence for the incidence of myocardial infarction in this study. The actions of the water soluble fraction of the ethanol extract in diabetic and non-diabetic wistar rats suggest different mechanism of action of GL leaf extract.
Key words:- Alloxan-induced diabetes, Gongronema latifolium, Serum enzymes, Myocardial infarction.
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Copyright © 2013 E. David-Oku et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.