DocumentsDate added
Research article:-
Yuanqing Tu1, Feng Huang2, Saichun Wu1, Manping Li1, Jing Zeng1 & Xiaoyun Tong3*
1 Bachelor,2Ph.D, Pharmacy college of Jinan University,Guangzhou,P.R.China,510632, 3*M.D, Teaching & Research Section of Internal Medicine of Traditional Chinese Medicine, College of Clinical Medicine, Yunnan University of TCM, Kunming, P.R.China, 650021.
Abstract :- The purpose of this research is to explore the effect of ferulic acid in myocardial infarction rats induced by Isoproterenol. The rats were divided into control, model, simvastatin, ferulic acid (Low, Middle, High dose) groups. Control and model groups were orally pretreatment with saline for 21 days, Simvastatin group with simvastatin(15mg/kg), and ferulic acid with ferulic acid (10, 20 and 40mg/kg, respectively), and then all the groups were subcutaneously injected with isoproterenol except control group on 19th, 20th, 21st days at an interval of 24h to induce myocardial infarction model. Lead II electrocardiograph were observed and recorded. Cardiac marker enzymes in serum were detected. The model group rats showed increase in the level of lactate dehydrogenase, creatine kinase and malondialdehyde and decrease in the activities of superoxide dismutase. Pretreatment with ferulic acid can restore the level of marker enzyme to nearly normal. And the infarction size was also detected by TTC assay, the number of EPCs in peripheral blood was calculated by flow cytometry, the CD34+ cells and RBPJK protein in the cardiac tissue were evaluated with immunohistochemistry, the expression of Notch1 receptor and Jagged1 ligand were detected by western blotting. Pretreatment with ferulic acid can reduce the infarction size of rats and ameliorate the injury tissues. We can also observe higher percentage of EPCs in peripheral blood. Ferulic acid can up-regulates the level of Notch1 and Jagged1 compared with model group.
Key Words:- Ferulic Acid, Endothelial progenitor cells, Notch signaling pathway.
References:-
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5.Raphael K. Notch signaling[J].Cold Sring Harbor Perspectives in Biology 2013:1-4.
6.Sang-Mo Kwon, Masamichi Eguchi, Mika Wada, et al. Specific Jagged-1 Signal From Bone Marrow Microenvironment Is Required for Endothelial Progenitor Cell Development for Neovascularization. Circulation 2008; 118: 157-65.
7.Karthikeyan K, Sarala Bai BR, Niranjali Devaraj S,et al. Cardio-protective effect of grape seed proanthocyanidins on isoproterenol-induced myocardial injury in rats. Int J Cardiol 2008; 115(3):326-33.
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Copyright © 2013 Xiaoyun Tong et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
*Correspondence address:
Xiaoyun Tong M.D,
Teaching & Research Section of Internal Medicine of Traditional Chinese Medicine, College of Clinical Medicine, Yunnan University of TCM, Kunming, P.R.China, 650021.
Short communication:-
Vela Desai1, Prena Pratik1* & Rajeev Sharma1**
Affiliation:-
1Prof & HOD, 1*PG Student,1**Senior Lecturer, Department of Oral medicine and radiology(OMR),Jaipur Dental College,Dhand, Amet, Thesil,Jaipur, Rajasthan, India.
Abstract :-
Recently, “Ergonomics” is being frequently used in the profession of dentistry. Good ergonomics is essential so that work capability, efficiency and high clinical level of treatment can be maintained throughout the working life of dental professionals. The scope of ergonomics in dentistry is large. Dentistry has always been known as an uneasy occupation therefore one must take into account the serious health hazards faced by the dentists. When talking about the musculoskeletal disorders it might be assumed that the knowledge of ergonomics may be of some use.
Key Words:- Ergonomics, dentists.
References:-
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*Correspondence address:
Dr.Prena Pratik,
PG Student,
Department of Oral medicine and radiology(OMR),
Jaipur Dental College, Dhand, Amet, Thesil, Jaipur, Rajasthan, India.
Copyright © 2013 Vela Desai,Prena Pratik & Rajeev Sharma. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:- Obstetrics & Gynaecology
Abhilasha Gupta1, Aruna Verma2* & Ketaki Harit3
Professor & Head1,Lecturer2,Junior Resident3,Department of Obstetrics & Gynaecology, LLRM Medical College, Meerut,India.
Abstract:- Aims & objectives: Comparison of febrile and infectious morbidity, incidence of serious post-operative complications,maternal side-effects of drug therapy and cost-effectiveness of single shot, double shot and extended antibiotic prophylaxis in cesarean section.
Materials and methods: Patients were randomly allocated to three different groups. Group A patients were administered single shot of broad-spectrum antibiotics pre-operatively, within 30 minutes before starting the surgery. Group B patients were given a loading dose of antibiotics pre-operatively and another dose 12 hours later. Group C patients were administered antibiotics upto the 7th post-operative day.
Results & conclusion: There was no significant difference in terms of fever, post-operative infectious morbidity, and wound gaping or mean duration of hospital stay in the three regimes. There was a significant difference in side-effects of drug therapy between the three groups; maximum side-effects being seen in patients kept on extended antibiotic regime (p<0.001). Cost of treatment was minimum in single shot regime and maximum in extended regime (p<0.001). Single shot antibiotic prophylaxis can thereby be safely used instead of prolonged antibiotic therapy in patients undergoing cesarean section. There is significant improvement in maternal comfort level and reduction in cost of treatment without any increase in risk of post-operative complications.
Keywords:- Antibiotic prophylaxis, Cesarean section, Single shot.
References:-
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Copyright © 2013 Abhilasha Gupta, Aruna Verma & Ketaki Harit. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
*Correspondence address:
Dr. Aruna Verma (MD).,
Lecturer (Obs & Gynae)
R-18, Medical College Campus, LLRM Medical College, Meerut ,India.
Contact no. +91- 09997706487
Case controlled study:- Biochemistry
Sharma Priyanka1, Prasad Suvarna 2 & Tangri Nitin 3*
1,2Department of Biochemistry, 3Department of Respiratory Medicine, MM Institute of Medical Sciences, Mullana, Ambala, Haryana– India.
Abstract:-
Background:-Infertility represents a common condition nowadays, with important medical, economic and psychological implications. Traditionally, measurement of Prolactin and thyroid hormones, especially thyroid stimulating hormone (TSH) has been considered an important component of infertility workup in women. Aims: - The study was designed to evaluate the status of thyroid function in female infertility after exclusion of tubal factor and male factor infertility, and to investigate the impact of thyroid status on serum Prolactin. Method:-In this retrospective case control study, we investigated fifty (50) infertile women in the age range of 20- 40 years attending department of Biochemistry, MMIMSR, Mullana (Ambala) for hormonal evaluation from November, 2010 to October, 2011. Fifty (50) fertile women with similar age range were selected as controls. The association between thyroid dysfunction and levels of serum Prolactin was reviewed. Results: - The majority of infertile and fertile women were euthyroid and there was no significant association between Infertility & TSH (p > 0.05). Hyperprolactinemia was depicted in 32% infertile women. Prevalence of primary infertility was 76% while that of secondary infertility cases was 24%. There was a negative correlation between serum TSH and Prolactin levels in infertile subjects (p < 0.05). Conclusion: - There was higher prevalence of hyperprolactinemia with normal thyroid function in infertile patients.
Keywords:- Thyroid Stimulating Hormone (TSH), Prolactin (PRL), Hyperprolactinemia, Infertility.
References:-
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Copyright © 2013 Sharma Priyanka, Prasad Suvarna & Tangri Nitin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
*Correspondence address:
Dr. Nitin Tangri,
Department of Respiratory Medicine,
MM Institute of Medical Sciences, Mullana, Ambala ,Haryana – India.
Contact no:-+91-9729456330.
Research article:-
Nuzulia Irawati*, Jamsari and Yan Wirasti.
Affiliations:-
Department of Parasitology, Medical Faculty of Andalas University,Indonesia.
Abstract :
Aim: To know the diversity of allelic type of MSP-1 block 2 among Plasmodium falciparum isolates collected in a mountain area and a coastal area in West Sumatera, Indonesia, and compare them in a mountain and coastal area. Methods: A total of 56 P. falciparum infected blood samples, which were collected from 27 patients attending a local health facilities in South Solok district is a mountain region and 29 patients attending a local health facilities in South Coastal district is a coastal region, West Sumatera, Indonesia were used in this study. The regions flanking the highly polymorphic characters, block 2 for MSP-1, were genotyped by allele-specific nested-PCR to analyse the population diversity of parasite. Sequence analysis of the polymorphic regions of MSP-1 was also conducted to identify allelic diversity in the parasite population. Results : Diverse allelic polymorphism of MSP-1 was identified in P. falciparum isolates from a mountain area and a coastal area in West Sumatera, Indonesia,West Sumatera, Indonesia and most of the infections were determined to be mixed infections. Sequence analysis of MSP-1 block 2 revelaled that 16 different alleles for MSP-1 (3 for K1 type, 2 for MAD20 type and 2 for RO33 type) were identified. Conclusion: Extensive genetic polymorphism with diverse allele type was identified in MSP-1 in P. falciparum field isolates from a mountain area and a coastal area in West Sumatera, Indonesia. A high level of mixed infections was also observed, as was a high degree of multiplicity of infection.
Key words:-Plasmodium falciparum, MSP-1 block 2, allelic types, mountain area, coastal area.
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*Corresponding author:-
Nuzulia Irawati.,
Department of Parasitology,
Medical Faculty of Andalas University, Indonesia.
Copyright © 2013 Nuzulia Irawati, Jamsari and Yan Wirasti. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.