DocumentsDate added
Original article:-
*1Asadi-Shekaari M, 2Kalantari Pour TP, 3Namazian E, 4Arab Nejad F, 1Zangiabadi N, & 1Afarinesh Khaki MR
1Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.
2Midwifery and Nursing Faculty, Branch of Kerman, Islamic Azad University, Kerman, Iran.
3Midwifery student, Member of Student Research Committee, Kerman Medical University, Kerman, Iran.
4Medical student, Member of Student Research Committee, Kerman Medical University,
Kerman, Iran.
Abstract:
Background & objective for the study: Ischemic stroke is a major cause of death and disability in developed countries. Oxidative stress and inflammation are involved in the pathophysiology of this disease. Walnut kernels (WKs) are a highly nutritious food due to their large amount of phenolic compounds. These compounds have beneficial effects on human health due to their obvious antioxidant and anti-atherogenic properties. The aim of this study was to determine whether or not a WK diet had cerebroprotective effects on the focal ischemic brain.
Methods: Male Wistar rats were fed with equal amounts of a WK-enriched diet or a control diet. After 8 weeks of feeding, middle cerebral artery occlusion was induced for 30 min followed by 48 h reperfusion. After behavioural testing, the animals were sacrificed and their brains were removed for histological, ultrastructural, immunohistochemical and biochemical studies.
Results: The results showed that the animals which received a WK-enriched diet had a significant reduction in neuronal damage induced by ischemic reperfusion compared to the controls.
Conclusion: Our results suggest that pre-treatment with WKs reduces the severity of cerebral ischemic injury.
Key Words: Antioxidant; fatty acids; inflammation; MCAO; Walnut.
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Article citation:-
Asadi-Shekaari et al. Feeding with walnut (Juglans regia) reduces cerebral ischemic damage in rats. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 June; 31(31): 1137-1142.
Copyright © 2013 Asadi-Shekaari et al.. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:-
Geoffrey Muriira Karau1, 2*, Eliud Nyagah Mwaniki Njagi1, Alex King’ori Machocho3, Laura Nyawira Wangai4, Peter Ng’aru Kamau5 & Paul Bundi Karau6
Affiliations:- 1Department of Biochemistry and Biotechnology, Kenyatta University, P.O Box 43844-00100, Nairobi, Kenya.
2Kenya Bureau of Standards, P.O Box 54974-00200, Nairobi, Kenya.
3Department of Chemistry, Kenyatta University, P.O. Box 43844-00100, Nairobi,Kenya. 4Department of Biochemistry and Molecular Biology, Jomo Kenyatta University of Agriculture and Technology, P.O Box 62000-00200, Nairobi, Kenya.
5Research and Development Division, Mount Kenya University, P. O Box 342-01000, Thika, Kenya.
6Kenya Methodist University, School of Medicine and Health Sciences, P. O Box 267-60200, Meru, Kenya.
Abstract:-
Senna spectabilis D. C Irwin has been used as a forkloric medicine to manage diabetes mellitus by the communities in south eastern part of Kenya. The present study evaluated in-vivo hypoglycemic activity of the aqueous and ethyl acetate extracts of S. spectabilis. The study used six groups of mice each of five mice. Diabetes mellitus was induced in five groups with 10% alloxan monohydrate at a dose of 186.9 mg/kg body weight. Non-diabetic control mice was orally administered with 0.1 ml physiological saline; diabetic mice with 0.075 mg of reference drug, glibenclamide at 3 mg/kg body weight; 1.25 mg, 2.5 mg, and 5 mg leaf and stem barks aqueous and ethyl acetate extracts in 0.1 ml physiological saline for 50, 100 and 200 mg/kg body weight, and the other group of diabetic mice was given 0.1 ml physiological saline. Blood glucose level was determined after 0, 2, 4, 6 and 8 hours. S. spectabilis exhibits a significant hypoglycemic activity in both aqueous and ethyl acetate extracts. The activity is either dose dependent or independent for the leaves and stem barks extracts, respectively. The study findings validate the forkloric use of this plant among the local communities of south eastern Kenya.
Key Words: Senna spectabilis, hypoglycemic activity, diabetic BALB/c mice, ethyl acetate extract and aqueous extract.
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Copyright © 2013 Karau Muriira et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report:-
Serdar SARGIN1, Aziz ATİK1, Gökhan MERİÇ1, Ahmet Aslan2*& M.Nuri Konya2
Affiliation:-
1MD, Orthopaedics Surgeon; Balıkesir Universty, Medicine Faculty, Departmants of Orthopaedics and Traumatology. Balıkesir/TURKEY.
2MD, Orthopaedics Surgeon; Afyonkarahisar State Hospital, Departmants of Orthopaedics and Traumatology. Afyonkarahisar/TURKEY.
Abstract:- Coincidence of ipsilateral posterolateral elbow dislocation and distal radial fracture is very rare. Herein we present an 84-year-old female who had an unusual case of ipsilateral fracture of distal radius and posterolateral elbow dislocation. Closed reduction was immediately performed under sedation. A long arm cast was applied for immobilisation. In the sixth month, the patient regained full flexion-extension of the elbow and wrist, and full pronation-supination of the forearm. As we report good results of our patient, we can offer closed reduction and long arm cast for the treatment of İpsilateral posterolateral elbow dislocation and distal radial fracture.
Key Words:- Elbow dislocation, Distal radial fracture, Ipsilateral, Treatment.
References:-
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Copyright © 2013 Aslan Ahmet et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Letter to Editor
Yadavalli Guruprasad1* & Dinesh Singh Chauhan1
Affiliations:-
*1Assistant Professor,1Reader, Department of Oral & Maxillofacial Surgery AME’S Dental College Hospital & Research Centre,Raichur-584103, Karnataka, India.
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Article citation:-
Yadavalli Guruprasad & Dinesh Singh Chauhan. Hypoglycemic effect of aqueous and ethyl acetate extracts of Senna spectabilis in alloxan induced diabetic male mice. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 June; 31(31): 1245-1246.
Copyright © 2013 Yadavalli Guruprasad & Dinesh Singh Chauhan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article:-
*1Raut Mohan ,1Rajurkar Sampda,1Malkar Vilas,1Joge Umesh,2Sapkal Pravin & 1Wagh Sanjay
Affiliation:-
1Assistant Professor Department of PSM,2Assistant Professor, Department of Anesthesia, Government Medical College, Akola,Maharastra,India.
Abstract:
Background: HIV/ AIDS is one of the most urgent threat to global public health. The changing trend in the country indicates that HIV infection is spreading in two ways: From urban to rural areas and from individuals practicing high risk behavior to the general population called Type 4 pattern. Auto drivers considered to be the one of the important mediator between this two population groups and hence studied here. Methods: The present study was carried out among the 346 auto drivers in urban area of Akola during July 2012 to Dec2012. Universal followed by convenience sampling method was used for selection of study participants. The preformed semi-structured questionnaire was used to collect the information. Result and conclusion: A total 346 auto rickshaw drivers were studied. Majority 331 (95.7%) of them have heard about HIV and around 50% knew that it is STI. Of the four routs of transmission, around 50% had correct knowledge about three route of transmission but the fourth one i.e infected mother to her foetus correct knowledge was seen in only 36%. 54% auto drivers ask for new needles before injection, 5% had sex with FSW and 5% had multiple sex partners. In the present sample of Auto drivers, though majority had heard of HIV / AIDS, they didn’t have correct knowledge about transmission of HIV / AIDS and safe sex practices. Hence health education on HIV / AIDS along with safe sex and condom promotion needs to be inculcated among them.
Key Words:- HIV/AIDS, Route of transmission, Safe sex practice.
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Article citation:-
Raut et al. Knowledge Attitude and Practice regarding HIV/ AIDS among auto drivers in one of the urban area of India. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 June; 31(31): 1229-1232.
Copyright © 2013 Raut et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.