DocumentsDate added
Original article:-
Maninder Karan*1, Prerna Sarup2 & Karan Vasisht3
Affiliation:-
M. Pharm., Ph. D. 1*, M. Pharm.2, and M. Pharm., Ph. D.1, 1,2,University Institute of Pharmaceutical Sciences–UGC Centre for Advanced Studies Panjab University, Chandigarh 160014, India.
Abstract:
Raw guggulu (RG) was purified by seven different methods to get pure guggulu (PG-1 to PG-7) using triphla kasaya (PG-1), cow urine (PG-2), cow milk (PG-3), vasa swarasa (PG-4), vasa kasaya (PG-5), nirgundi swaras with haldi curna (PG-6) and water (PG-7). The guggulu purified by each method was evaluated in vitro for its antioxidant activity and in vivo for antinociceptive activity using peripheral and central models of nociception and the results were compared with raw guggulu. All the samples showed significant antioxidant activity over raw guggulu (IC50 value of 215.46 µg/ml) with IC50 values ranging from 46.87 to 156.89 µg/ml. Guggulu purified in nirgundi swaras with haldi curna showed maximum antioxidant activity at IC50 value of 29.97 µg/ml while minimum activity was shown by guggulu purified with water at IC50 value of 156.89 µg/ml which was still better over raw guggulu. All purified guggulu samples showed antinociceptive activity over raw guggulu with PG-6 exhibiting maximum activity (65.97 % in acetic acid induced writhing model and 40.53 % in tail flick model) while minimum activity of 42.77 % in acetic acid induced writhing model and 27.23 % in tail flick model was exhibited by PG-1.
Key Words:- Antinociceptive, antioxidant, raw and purified guggulu.
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Article citation:-
Maninder Karan, Prerna Sarup & Karan Vasisht. Evaluation of antioxidant and antinociceptive potential of raw and purified guggulu. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 June; 31(31): 1150-1158.
Copyright © 2013 Maninder Karan,Prerna Sarup & Karan Vasisht. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article:-
D. Lalitha Devi1*,K. Satyanarayana Murthy2 , Shaswat Kumar Patnaik3 & V. Subbi Reddy4
Affiliation:-
1Associate Professor, Department of Pharmacology, 2Professor and H.O.D, Department of Pharmacology, 3Associate Professor, Department of Anasthesiology,4Tutor,Department of Pharmacology, GSL Medical college, Rajahmundry, A.P., India.
Abstract: -
Objectives: To study the hemodynamic and respiratory effects of Propofol and Thiopentone during induction and maintenance of anaesthesia for short surgical procedures. Materials and methods: The study was conducted on 60 adult female patients of ASA grade 1 and grade 2 aged between 18- 60 years presenting for short surgical procedures in the department of obstetrics and gynaecology of GSL General Hospital during the period of January2007- October 2007. The patients were randomly divided into 2 groups. Group 1 patients received Propofol 2-2.5 mg per kg, and Group 2 patients received Thiopentone 4-6 mg per kg intravenously for the induction of anaesthesia. The pulse rate, blood pressure and respiratory rate were recorded at 1st, 5th and10th minutes respectively after induction. Presence or absence of apnoea, response of the patient to pain, perioperative evaluation for nausea and vomiting and recovery are observed. Results: In our study we have found that Propofol provided smooth and pleasant loss of consciousness.The time taken for induction of anaesthesia with both the drugs was similar and there is no statistically significant difference between the two groups. Regarding blood pressure changes, the fall in blood pressure was slightly more in Propofol group than Thiopentone which is statistically significant z=2.5(p<0.05). Recovery was very rapid and smooth in patients who received Propofol and highly significant statistically z=28.17(p<0.0001). Orientation time was less in patients receiving Propofol when compared with Thiopentone. z=30.29(p<0.0001). Incidence of nausea and vomiting is less in Propofol group. Conclusions: In this study it is concluded that Propofol is a better alternative to Thiopentone as main anaesthetic agent for short surgical procedures.
Key Words: Propofol, Thiopentone, anaesthetic agent, short surgical procedures.
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Article citation:-
D.Lalitha Devi et al. Comparative evaluation of propofol with thiopentone for short surgical procedures in a teaching hospital. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 June; 31(31): 1143-1149.
Copyright © 2013 D.Lalitha Devi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article:-
Nair Sindhu1*, Bhat Kishore2, Nayak Ramakant3, Kotrashetti Vijayalakshmi4 & Babji Deepa5
Affiliation:-
1Postgraduate student, 3Professor and Head,4Reader, 5Senior lecturer,Department of Oral Pathology and Microbiology, 2Professor and Head,Department of Microbiology, Maratha Mandal’s NGH Institute of Dental Sciences and Research Centre.Near K.S.R.P.Ground, R.S.No.47/2, Bauxite Road, Belgaum.( Karnataka), India.
Abstract:
Introduction: Mutans streptococci (MS) and Lactobacilli are well known as cariogenic oral bacteria. MS has primarily been linked with initial caries development and lactobacilli with the progression of the caries lesion. Recent research suggests that even though lactobacilli have a role in progression of dental caries, they may also act as antimicrobial agents in the oral cavity.
Aim: To assess the relationship between MS and Lactobacillus in caries-free and high caries risk individuals.
Materials & Methods: 60 subjects (Group A – 30 caries free, Group B - 30 high caries risk individuals) in the age group of 16-25 years were considered for the study. Caries-free subjects were with a DMFT = 0, while those in the high risk group had a DMFT ≥ 3 with atleast 1 active carious lesion at the time of clinical examination. Plaque samples were collected and then cultured on Mann Rogosa Sharpe agar for Lactobacilli screening and on Mitis Salivarius Bacitracin agar for MS. Samples which were positive for both MS and lactobacillus were further cultured together. The interference capacity of Lactobacillus was then checked. Statistical analysis was done using Chi square test and Spearman rank correlation coefficient.
Results: On primary culture, Group A individuals were colonized predominantly by MS while those of Group B were colonized by both micro-organisms. On co-culturing, inhibitory effect was observed only in 1 case in Group A, while in Group B, inhibitory effect was observed in 15 cases and 1 case showed absence of inhibition. Statistically significant correlation between DMF and presence of lactobacillus was also found.
Conclusion: Our study demonstrates that lactobacillus has an inhibitory effect on MS group in vitro. Slight to complete inhibition was observed in the high risk caries individuals, while caries-free individuals did not show very specific results.
Key Words: Caries; Inhibition; Lactobacilli; Mutans streptococci.
References:
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Article citation:-
Nair Sindhu et al. Effect of Lactobacillus on Mutans Streptococcus in caries-free and high caries risk individuals. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 June; 31(31): 1192-1198.
Copyright © 2013 Nair Sindhu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article:
1Akshay M Daga,*2Pankaj J Akhare,3Ajay S Saxena,4Mohit B Zamad,5Mohsin A Quazi & 6RidhiShri P Akhare
Affiliation:-
1Associate Professor,Department of Oral and Maxillofacial Surgery,V.S.P.M’s Dental College and Research Center,Digdoh Hills, Hingna,Nagpur – 440019. Maharashtra. India.
*2Associate Professor,Department of Orthodontics & Dentofacial Orthopedics,V.S.P.M’s Dental College and Research Center,Digdoh Hills, Hingna,Nagpur – 440019. Maharashtra. India.
3Associate Professor,Department of Conservative & Endodontics,SPDC Dental College and Research Center,DMIMMS, Sawangi (Meghe), Wardha.Maharashtra. India.
4 3rd Year PG,Department of Oral and Maxillofacial Surgery,V.S.P.M’s Dental College and Research Center,Digdoh Hills, Hingna,Nagpur – 440019. Maharashtra. India.
5 2nd Year PG,Department of Prostthetic & Implantology,S K Dental College and Research Center,Hingna,Nagpur – 440019.Maharashtra.India.
6 BDS,92, New Jagruti Colony,Near Friends Colony,Katol Road,Nagpur–440013.Maharashtra. India.
Abstract:
Background: Cleft surgeries in the developing world serve as not only aesthetic and functional ones but, in some cases, as life saving operations too.
Aim: To evaluate the level of awareness of cleft patients with regards to their defect and relate it to their quality of life taking internationally approved and local factors into consideration.
Settings and Design:
Random study 123 patients completed the MOS short form – 36 questionnaire to evaluate the health related quality of life along with a few other questions. The aesthetic, functional and psychological outcomes were assessed on a visual analog scale.
Results: The main cause for clefts was considered to be god’s will. 29% of the patients were not allowed to draw water from the local well and 38% were not allowed to join school before the surgery, while post surgically only 6% had the same problems. The health related quality of life questionnaire demonstrated higher scores in all subsets under the mental health criteria after cleft surgeries.
Conclusion: Where myths and beliefs are still present, the surgery not only improves the facial appearance and function, but also helps the patient to be inculcated back into the society.
Key Words: Cleft Lip and palate, Health related quality of life, Myths and beliefs, Psychological aspects, Short form questionnaire.
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Article citation:-
Akhare et al. Cleft lip and palate- Improving lives through awareness. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013, June; 31(31): 1159-1163.
Copyright © 2013 Akhare et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article:-
*1Ajay Kumar A, 2M. R.Vasanthan & 3N. Kannan
Affiliations:-
1Associate Professor, 2 Professor, 3Assistant Professor, Department of Anaesthesiology and Critical Care, Sree Balaji Medical College and Hospital (7, works road, Chromepet, Chennai – 600044), India.
Abstract:-
A surgical procedure performed on a patient admitted and discharged on the same day of surgery is an accepted and well-established practice in modern medicine today. The principal arguments in favour of this practice are minimizing cost and making hospital resources available for more number of patients, as each patient spends a shorter period in the hospital. The availability of shorter acting anaesthetic agents with better recovery profile has made general anaesthesia applicable in day case procedures. The ‘clear headedness’ of recovery enables the patients to be discharged from the hospital just a few hours after surgery. The drugs found most suitable for this technique are Propofol and Sevoflurane. The present study compares the recovery characteristics of these two drugs and their usefulness in ambulatory anaesthesia. We compared the recovery profile of 40 patients coming for surgeries lasting less than an hour. Aldrete scoring was used to assess early recovery and PADSS scoring used for assessing ‘Home Readiness’. ‘Home Readiness’ was sooner while using Sevoflurane VIMA(Volatile Induction and Maintenance Anesthesia) as compared to Propofol TIVA(Total Intravenous Anesthesia) making Sevoflurane the ideal choice for Day case surgery.
Keywords: Propofol TIVA, Sevoflurane VIMA, Recovery scores, Day case anaesthesia.
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Article citation:-
Ajay Kumar. A, M. R. Vasanthan & N. Kannan. Comparison of recovery from propofol TIVA and sevoflurane VIMA in day case surgeries. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 June; 31(31): 1214-1220.
Copyright © 2013 Ajay Kumar A, R.Uma & M. R.Vasanthan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.