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Original article:-
Maninder Karan*1, Kawal Preet 2 & Karan Vasisht3
M. Pharm., Ph. D.*1, M. Pharm.2, M. Pharm., Ph. D.3
University Institute of Pharmaceutical Sciences–UGC Centre for Advanced Studies, Panjab University, Chandigarh 160014, India.
Abstract:-
The present study assessed topical anti-inflammatory activity of different species of an indigenous drug Barleria against croton oil induced oedema in female rats. Seven different extracts viz., mother extract (methanolic, ME, prepared by maceration), hexane (HE), chloroform (CE), ethyl acetate (EAE), butanol (BE) and left aqueous (LAE) extracts obtained after partitioning of ME and total aqueous extract (TAE, prepared by maceration) of each Barleria spp. were evaluated at 200 and 400 mg/ml prepared in croton oil solution using ibuprofen as a standard. The maximum effect was observed at a dose of 200 mg/ml for all the extracts of both the species and chloroform extract of B. prionitis showed the best topical activity with 88.31 per cent inhibition of ear oedema.
Key Words: - Barleria prionitis, B. cristata, Anti-inflammatory, Topical model.
References:-
1.Robins A, Cotrans K. Acute and chronic inflammation. In: Giltman LI. Inflammation, pathologic basis of disease. VIII ed: Elsevier publisher, Chicago; 2009. p. 43-77.
2.Mitchell RN, Cotron RS. Robinson’s basic pathology, VII ed: Harcourt (India) Pvt Ltd., New Delhi; 2000. p. 33.
3.Vogel GH. Analgesic, anti-inflammatory and anti-pyretic activity. In: Vogel WH, Scholkens, BA, Sandow, J, Muller, G and Vogel, WF. Drug Discovery and Evaluation Pharmacological Assays. II ed: Springer publications, Germany; 2002. p. 725-71.
4.Goyal R, Sharma P, Singh M. Possible attenuation of nitric oxide expression in anti-inflammatory effect of Ziziphus jujuba in rat. J Nat Med. 2011; 65:514-8.
5.Tripathi KD. Prostaglandins, leukotrienes (eicosanoids) and platelet activating factor. In: Essentials of medical pharmacology. IV ed: Jaypee publishers, New Delhi; 1999. p. 210-21.
6.Hecker M, Foegh ML, Ramwell PW. The eicosanoids: prostaglandins, thromboxanes, leukotrienes and related compounds. In: Katzung BG. Basics and clinical pharmacology. XI ed: Appleton and Lange, Paramount publishers; 2009. p. 313-29.
7.Goodman A, Gillman, L. Autocoids: The theory of inflammation. In: Brunton L, Parker, K, Blumenthal, D, Buxton, L. Manual of Pharmacology and Therapeutics. III ed: Tata McGraw Hill Companies, New Delhi; 2008. p. 4301.
8.Sautebin L, Prostaglandins and nitric oxide as molecular targets for anti-inflammatory therapy. Fitoterapia. 2000; 71:S48–S57.
9.Balkwill MJ, Balkwill K. A preliminary analysis of distribution pattern in a large, pantropical genus, Barleria L. (Acanthaceae). J Biogeogr. 1998; 25:95-110.
10.Makholela T, Bank H, Balkwill K. A preliminary study of allozyme variation in three rare and restricted endemic Barleria greenii (Acanthaceae) populations. Biochem Syst Ecol. 2003; 31:141-54.
11.Anonymous. The Wealth of India, A Dictionary of Indian Raw Materials and Industrial Products. Council of Scientific and Industrial Research, New Delhi; 1948. Vol 1, p 158.
12.Hooker JD. The Flora of British India The authority of the secretary of state for India and council. Reeve and Co. Ltd; 1885. Vol IV, p. 486.
13.Shendage SM, Yadav SR. Revision of the genus, Barleria (Acanthaceae) in India. Rheedea. 2010; 20: 81-130.
14.Anonymous. The Ayurvedic Pharmacopoeia of India, Govt. of India, Ministry of Health and Family Welfare Dept of Indian System of Medicine and Homeopathy. Vol. III, Part I. I ed; 2001. p. 165-8.
15.Borthakur SK, Nath K, Gogoi P. Herbal remedies of the Nepalese of Assam. Fitoterapia. 1996; LXVII(3): 231-37.
16.Kirtikar KR, Basu BD, editors. Indian Medicinal Plants. Council of Scientific and Industrial Research, New Delhi; II ed, 1956. p. 1876-88.
17.Anonymous. Reviews on Indian Medicinal Plants. Indian Council of Medical Research, New Delhi; 2004. p. 63-82.
18.Chopra RN, Nayar SL, Chopra IC. Glossary of Indian Medicinal Plants New Delhi; 1956. p. 32-3.
19.Jain SP, Puri HS. Ethnomedicinal plants of Jaunsar-Bawar hills, Uttar Pradesh, India. J Ethnopharmacol. 1984; 12:215.
20.Pandey G. Dravyaguna Vijnana, Materia Medica Vegetable Drugs: Chaukhambha Orientalia, Part III (P-Y), Varanasi; 2004. 279-86.
21.Shastry JLN. Dravyaguna Vijnana, Study of Essential Medicinal Plants in Ayurveda. Vol II. II ed: Chaukhambha Orientalia,Varanasi; 2005. p. 884-85.
22.Banerjee D, Maji AK, Mahapatra S, Banerji P. Barleria prionitis Linn.: A review of its traditional uses, phytochemistry, pharmacology and toxicity. Res J Phytochem. 2012; 6(2):31-41.
23.Singh B, Bani S, Gupta DK, Chandan BK, Kaul A. Antiinflammatory activity of ‘TAF’ an active fraction from the plant Barleria prionitis Linn. J Ethnopharmacol. 2000; 85: 187-93.
24.Karan M, Kaur I, Chopra D, Vasisht K, inventors; Anti-inflammatory activity of the iridoid glycosides Published on 9.4.2010 with Indian Patent Application no 2182/DEL/2008.
25.Khadse CD, Kakde RB. Antiinflammatory activity of aqueous extract fractions of Barleria prionitis L. roots. Asian J Plant Sci Res. 2011; 1(2):63-8.
26.Jaiswal SK, Dubey MK, Das S, Verma AR, Vijaykumar M, Rao CV. Evaluation of flower of Barleria prionitis for anti-inflammatory and anti-nociceptive activity. Int J Pharm Bio Sci. 2010; 6(2):1-10.
27.Lehra KS, Chawla AS, Maninder KV. Chemical investigation and anti-inflammatory activity of Barleria prionitis. Indian J Nat Prod 2010; 26 (2):3-7.
28.Gambhire NM, Wankhede SS, Juvekar RA. Anti-inflammatory activity of fractions of the Barleria cristata leaves extract. Pharmacology online 2009; 2:1014-24.
29.Gambhire M, Juvekar A, Wankhede S. Evaluation of anti-inflammatory activity of methanol extract of Barleria cristata leaves by in vivo and in vitro methods. Internet J Pharmacol. 2009; 7(1).
30.Ammo SO, Finnie JF, Staden JV. In vitro pharmacological evaluation of three Barleria species. J Ethnopharmacol. 2009; 121:274-7.
31.Kawal P, Vasisht K, Karan M. Acute and sub-acute anti-inflammatory evaluation with chemical studies on two species of an indigenous drug ‘Barleria.’ J Pharm Biomed Sci. (communicated).
32.Kulkarni SK. Practical Pharmacology and Clinical Pharmacy. Vallabh Publications, New Delhi; I ed: 2008. p. 166-69.
33.Tubaro A, Delbello G, Zilli C, Della LR. The Croton oil ear test revisited. Agents Actions. 1985; 17:347-9.
34.Winter CA, Risley EA, Nuss GW. Croton oil -induced ear oedema in rat as an assay for anti-inflammatory drugs. Biol exp protocols 1998; 59:544-9.
35.Leung DYM, Harbeck R, Bina P, Reiser RF, Yang E, Norris DA, Hanifin JM, Sampson HA. Presence of IgE antibodies to Staphylococcal exotoxins on the skin of patients with atopic dermatitis. J. Clin. Invest. 1993; 92:1374-80.
Article citation:-
Maninder Karan, Preet Kawal & Karan Vasisht. Topical anti-inflammatory studies on Barleria prionitis and B. cristata. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 June; 31(31): 1164-1169.
Copyright © 2013 Maninder Karan, Kawal Preet & Karan Vasisht. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.