DocumentsDate added
Research article:-
Shyamala Viswanathan, Anagha Krishnamoorthy and Thangaraju Nallamuthu*
Affiliation:-
Centre for Advanced Studies in Botany, University of Madras, Guindy Campus, Chennai- 600 025, India.
The name of the department(s) and institution(s) to which the work should be attributed:
Centre for Advanced Studies in Botany, University of Madras.
Author’s contributions: - All author contributed equally to this paper.
Abstract:
Objective: To evaluate the in vitro antioxidant and antiproliferative activity of Ulva lactuca, Chnoospora implexa, and Chondrococcus hornemanni.
Methods: Dried seaweeds of Methanol extract of Ulva lactuca, Chnoospora implexa, and Chondrococcus hornemanni. In vitro total phenol and total flavonoid content were tested for the three different seaweeds. Antioxidant activity was determined by DPPH assay and Ferric Reducing Antioxidant Power (FRAP) assay. Antiproliferative activity was determined by 3 (4, 5– dimethylthiazole – 2-Yl), 2, 5- diphenyltetrazolium bromide (MTT) assay to determine the specificity against human breast cancer cell line (MCF-7).
Results: The highest total phenolic content was observed in C. implexa (87.0±0.04 mg GAE/g) when compare with other two different seaweeds and the total flavonoid content had showed highest activity in C. hornemanni (63.9±0.12 mg QE/ g) when compare with other two seaweeds. In vitro antioxidant activity of brown and red seaweed showed higher activity in both the assays than green seaweed. The LC 50 (Lethal concentration) of three different seaweeds was observed at 125 µg/mL concentration of the extract. The data showed that these species are a potential source of compounds for the treatment of certain cancer diseases. Therefore, finding new antiproliferative agents with low side effects could be interesting.
KeyWords: Seaweeds, Total phenol, Total flavonoid, Antioxidant, Antiproliferative and MCF-7.
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Article citation:-
Shyamala Viswanathan, Anagha Krishnamoorthy and Thangaraju Nallamuthu. In vitro antioxidant and antiproliferative activities of macro algae against MCF-7 cell line. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 July; 32(32): 1413-1424. Available at http://www.jpbms.info.
Copyright © 2013 Rohan Shanmuganathan & Indra Devi Subramaniam. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case study:-
*1Rohan Shanmuganathan & 2Indra Devi Subramaniam
Affiliation:-
1Klinik Kesihatan Serendah, Selangor, Malaysia.
2Multimedia University, Cyberjaya, Malaysia.
The name of the department(s) and institution(s) to which the work should be attributed:
Klinik Kesihatan Serendah, Hulu Selangor, Selangor, Malaysia.
Author’s contributions: - Both author contributed equally to this paper.
Abstract:
Background: The reemergence of Tuberculosis cases in Malaysia is a cause for concern. Several reasons have been attributed to this. Among these are the influxes of foreign workers, HIV and drug abuse.
Aim: To determine the socio-demographic characteristics of tuberculosis patients in Malaysia to test the veracity of the reasons attributed to the reemergence of TB cases in Malaysia. This study also examines the manifestation of the disease among Malaysians. Seven propositions were developed to be tested in this study based on literature review on the reemergence of TB cases worldwide.
Method: A total of 40 tuberculosis patients who had sought treatment at a Health Clinic during a one-year period were studied. Data was collected from their medical cards.
Results: Majority of the patients were Malaysians, males between the age of 21 to 50 years and unemployed. There did not seem to be an association between HIV positive cases and TB. Similarly there was no association between drug addiction and TB infection as majority of the patients were HIV negative and not drug users. Most of the cases were pulmonary TB. The most common symptoms were prolonged cough, weight loss and bloody sputum.
Conclusion: Propositions relating TB cases to economically productive age group, gender and poverty were supported by the findings of the study. The results did not support the propositions that reemergence of TB cases in Malaysia is due to influx of foreigners, increase in HIV positive cases, drug addiction and drug related HIV positive cases.
Key Words: Tuberculosis; HIV; drug abuse; socio-demography; Malaysia.
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Article citation:-
Rohan Shanmuganathan & Indra Devi Subramaniam. Socio-demography of tuberculosis patients in Malaysia: Case study of Klinik Kesihatan Serendah. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 July; 32(32): 1353-1361. Available at http://www.jpbms.info.
Copyright © 2013 Rohan Shanmuganathan & Indra Devi Subramaniam. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review article:-
*1Abhishek Singh Nayyar,2Mubeen Khan,3G.T.Subhas.
Affiliation:-
1Assistant Professor, Department of Oral Medicine and Radiology, Saraswati-Dhanwantari Dental College and Hospital, Parbhani, Maharashtra, India.
2Professor and Head, Department of Oral Medicine and Radiology, Government Dental College and Research Institute, Bangalore, Karnataka, India.
3Professor and Head, Department of Neurology, Bangalore Medical College and Research Institute, Bangalore, Karnataka, India.
Author’s contributions-All authors contributed equally to this paper.
Abstract:
Epilepsy is described as a chronic neurological disorder characterized by recurrent seizures of cerebral origin, presenting with episodes of sensory, motor or autonomic phenomenon with or, without loss of consciousness. Despite tremendous advances in the understanding regarding the diagnosis and management of epilepsy, phenytoin still remains the drug of choice in an effective and safer long term management of this disorder. The long term administration of phenytoin, however, has been seen to lead to a number of adverse effects including tremendous fall in the levels of folic acid leading to the onset of several related disorders, most prominently megaloblastic anemias. On the other hand, folates administered at pharmacological doses have been blamed for a decrease in the concentration of phenytoin which is severe enough to precipitate seizures. However, the use of folates as adjuvant to the routine anti-epileptic therapy to overcome such effects requires further evaluation before coming to a conclusion.
Key words: Epilepsy; chronic neurological disorder; megaloblastic anemias; phenytoin.
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Article citation:-
Abhishek Singh Nayyar, Mubeen Khan, G.T.Subhas, Rownak Khandelwal, Rahul Anand & Mohammed Imran. Phenytoin, epilepsy and folic acid interactions: Inside out. Journal of Pharmaceutical and Biomedical Sciences (J Pharm Biomed Sci.) 2013 July; 32(32): 1432-1438.Available at http://www.jpbms.info
Copyright © 2013 Abhishek Singh Nayyar, Mubeen Khan, G.T.Subhas. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:-
*1Kshitiz Ranka,2Ruchita Jain & 3Ankur Jhanwar
Affiliation:-
1Department of Surgery,Kasturba medical college, Mangalore, Karnataka, India.
2Department of Obs & gynae. S.N. Medical College, Jodhpur, Rajasthan, India.
3Department of Surgery, Kota medical college, Rajasthan, India.
Author contributions: - All authors contributed equally to this paper.
Place of study: - Department of Surgery, Kasturba medical college, Mangalore, Karnataka, India.
Abstract:
Introduction: Gastric outlet obstruction (G.O.O.) also known as pyloric obstruction is not a single entity. It is the clinical & patho-physiological consequence of any disease process that produces a mechanical impediment to gastric emptying.
Material& methods: 40 patients attending surgical out-patient department of Kasturba Medical College, Mangalore during the period of July 2008 to July 2010 of G.O.O. with chief complaints of projectile vomiting, visible gastric peristalsis or palpable distended stomach were included in this study. Cases of functional non-mechanical cause of G.O.O were excluded. Only patients of 20 years & above were included in this study. Saline load test, upper gastro-intestinal endoscopy and routine laboratory investigations done in all cases while Barium meal study was done in few cases to decide the diagnosis.
Results: Age group of 50-59 was maximum sufferer 40%, followed by age group 60-69 years (30%). Male-Female ratio was 2.3: 1. Antral carcinoma (75%) cases topped the list followed by cicatrized duodenal ulcer which was seen in 22.5% cases; only one case was due to trichobezoar.
Conclusion: This study is a clinical observational study of gastric outlet obstruction, but in vast majority of cases diagnosis can be established clinically. Males are more sufferers and antral carcinoma seems to be main causes of G.O.O. After proper diagnosis relief to patient can be given by surgical treatment. The type of procedure depends on underlying cause.
Key Words: Gastric outlet obstruction; duodenal ulcer; pyloric obstruction; antral carcinoma; trichobezoar.
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Article citation:-
Ranka Kshitiz , Jain Ruchita & Jhanwar Ankur. Gastric outlet obstruction in adults: A prospective study in tertiary care hospital of Karnataka. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013, July; 32(32): 1282-1286. Available at http://www.jpbms.info.
Copyright © 2013 Ranka Kshitiz , Jain Ruchita & Jhanwar Ankur. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article:-
VermaMadhurima1, Gupta Ritu2, Porwal K Sanjay3*, Gupta Sanjeev4 & SwarnkarMadhusudan5
Affiliation:-
1Assistant Professor, 2Associate Professor, Department of Gynecology & Obstetrics, 3Associate Professor, Department of Surgery, 4Senior Resident Department of Anaesthesia, 5Assistant Professor, Department of PSM, Jhalawar Medical College, Jhalawar, Rajasthan, India.
Abstract:
Objective: To evaluate the prevalence of pelvic pathology among patient with uterine fibroid.
Material & method: The study was carried out in indoor patient of Zanana Hospital Jaipur Rajasthan a tertiary center attached to SMS medical collage & Hospital Jaipur, Rajasthan,India.
The study was carried out over a period of 18 month.Included 7348 cases of gynaecological admission out of which 508 cases were of fibroid uterus. All cases of fibroid of uterus were studied & managed surgically & were confirmed by histopathological examination. During surgery a systematic inspection of the pelvis was carried out to know the prevalence of associated pelvic pathology other then fibroid.
Results: In present series associated pelvic pathology were present in 189 cases (37.2%).Incidence of fibroid uterus come out to be 6.8% of gynaecological admission. The most common associated pelvic pathology were PID seen in 123 (24.2%) cases, next common were adenomyosis seen with 32 cases (6.2%),simple serous cyst 25 cases (4.9%) endometrosis 6 cases (1.1%) papillary adenoma with 2 cases (0.39%) dermoidcyst associated with one case ( 0.19%) of fibroid uterus.
Key Words: Uterine leiomyoma; fibroid; adenomyosis.
References:
1. Briggs ND. Common gynaecologicaltumours. Tropical Journal of Obstetrics and Gynaecology.1995;12(12):62–71.Link
2. Evans P, Brunsell S. Uterine fibroid tumours: Diagnosis and treatment. American Family Physcian.2007;75:1503–1508.Pubmed
3. Lethaby A, Vollenhoven B. Fibroids (uterine myomatosis, leiomyomas) American Family Physcian.2005;71:1753–1756.Pubmed
Article citation:-
VermaMadhurima, Gupta Ritu, Porwal K Sanjay, Gupta Sanjeev & SwarnkarMadhusudan. To study the prevalence of pelvic pathology among patient with uterine myoma. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013, July; 32(32): 1279-1281. Available at http://www.jpbms.info.
Copyright © 2013 VermaMadhurima, Gupta Ritu, Porwal K Sanjay, Gupta Sanjeev & SwarnkarMadhusudan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.