DocumentsDate added
Review article
Rachna Jain1*, Kumud Mittal2 & Shekhar Kapoor3
Affiliation:-
1MDS, Senior lecturer, Department of Periodontics and Implantolgy, SKSS Dental College and Hospital, Ludhiana, Punjab, India
2MDS, Reader, Department of Oral Medicine and Radiology, SKSS Dental College and Hospital, Ludhiana, Punjab, India
3MDS, Associate professor, Department of Oral Medicine and Radiology, Christian Dental College and Hospital, Ludhiana, Punjab, India
Author’s contributions-
The credit for the concept and idea behind the article design goes to the first author. Collection of the whole data and the literature search has been done by all three authors. Editing of the whole manuscript has been done by first and third author.
The final refining of the script has been done by all three authors.
Corresponding Authors
Dr. Rachna Jain.
MDS, Senior lecturer, Department of Periodontics and Implantolgy, SKSS Dental college and hospital, Ludhiana, Punjab, India
Core Idea:- Aac is one of the most important periodontopathogen. Not much has been written about the virulence factors lately. So the idea of the review was to signify its virulence factors and the role it plays in causing periodontal disease.
Abstract:
Periodontitis patients are a heterogeneous group of individuals with diverse genetic backgrounds, systemic and psychological conditions and varied clinical manifestation. Evidence show that A. actinomycetemcomitans is able to elicit its own uptake into epithelial cells and its spread to adjacent cells by usurping normal epithelial cell function.
A. actinomycetemcomitans has individual factors that cause bone resorption, as well as a number of activities that elicit detrimental effects on connective tissue and the extracellular matrix. In this short review the invasiveness and the virulence of A. actinomycetemcomitans comitans are discussed. Factors that promote A. actinomycetemcomitans colonization and persistence in the oral cavity include adhesins, bacteriocins, invasins and antibiotic resistance. It can interact and adhere to all components of the oral cavity (the tooth surface, other oral bacteria, epithelial cells or the extracellular matrix). The adherence is mediated by a number of distinct adhesins that are elements of the cell surface (outer membrane proteins, vesicles, fimbriae or amorphous material).
Key words: A.actinomycetemcomitans, virulence factors, epithelial cells, periodontal disease.
References:
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Article citation:-
Rachna Jain,Kumud Mittal& Shekhar Kapoor. Virulence factors of A. actinomycetemcomitans – A review. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 September 34(34): 1693-1698.
Copyright © 2013 Rachna Jain,Kumud Mittal & Shekhar Kapoor. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
1SANNI, Momoh, *1EJEMBI, Daniel, 2EMMANUEL, T. Friday,
1ABBAH, Okpachi C. & 1OGALA, Emmanuel.
Affiliation:-
1Department of biochemistry, Kogi State University, Anyigba, Nigeria.
2Department of medical biochemistry, Kogi State University, Anyigba, Nigeria.
Author’s contributions- All authors contributed equally to this paper.
Abstract:
The effects of Chronic Administration of indomie instant noodles on the activity of alkaline phosphatase of rat small intestine were investigated. Forty eight (48) albino rats (Rattus novergicus) of average weight 210g were divided into 7 groups containing 6 rats except the 7th group which 12 rats as control; each group was further divided into equal number of males and females. Group 1 was fed with the noodle cooked and spiced, group 2 was fed with raw noodle spiced, and group 3 was fed with a mixture of the cooked and raw noodles and spiced with the seasoning. Groups 4-6 were fed in a repeated fashion as 1, 2 & 3 with the exclusion of the seasoning spice. Group 7 was fed with normal rat feed. Water was provided ad libitum. Animals were fed for thirty days and were sacrificed on the thirty first day after commencement of administration of test feed (indomie) and the organs of interest was collected and kept for analysis. The results obtained were statistically treated (p<0.05) at 95% confidence level using F-test with a positive association of consumption of indomie noodles with damage to small intestinal tissues was observed.
Key words: Indomie instant noodles; Alkaline phosphatase.
Article citation:-
Sanni et al. Effects of Chronic administration of indomie noodles on the activity of alkaline phosphatase of rat small intestine. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 September; 34(34): 1682-1687.Available at http://www.jpbms.info
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Copyright © 2013 Sanni et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Sinha Abhishek1*,Srivastava Sunita2, Mishra Anuj3, Agarwal Nitin4 & Pooja M. Sinha5
Affiliation:-
1Reader,2Senior Lecturer, 3Post graduate student, 4Professor & Head, Department of Oral Medicine and Radiology, 5Senior lecturer, Department of public health dentistry, Sardar Patel Post Graduate Institute of Dental & Medical Sciences, Raebareily Road, Lucknow, Uttar Pradesh, India.
Author’s contributions:- All the authors contributed equally to this paper.
Work attributed by: Department of Oral Medicine and Radiology, Sardar Patel Post Graduate Institute of Dental & Medical Sciences, Raebareily Road, Lucknow, Uttar Pradesh, India.
Abstract:
Background: Oral Lichen planus is a chronic inflammatory disorder that can be painful especially in erosive forms that commonly affects skin and oral mucosa. In this area different treatments have been used in symptomatic oral lichen planus (OLP), with variable results.
Aim: To compare the efficacy of aloevera and topical steroids in symptomatic treatment of Erosions and burning sensation in Erosive Lichen Planus.
Methods: A total of 10 patients with Oral Lichen Planus were randomly selected for the study and divided into two groups (A and B). The group A received aloe vera gel and group B topical steroids. The patients were under regular follow up every 2 weeks for 3 months. Clinical evaluation and pain reduction was evaluated by VAS method in group A and B. Data were evaluated statistically by using Wilcoxon signed rank test.
Results: In group A, 4 patients had complete remission and 1 patient showed good response to treatment where as in group B, 2 patients had complete remission, 2 patient showed good response and 1 patient showed no response to treatment (p<0.001), it was determined that Aloevera was stastistically significant (p<0.05) as compared to Topical Steroid at the end of treatment.
Conclusion: The topical application of Aloe vera improves the total quality of life score in patients with oral lichen planus. However, according to result of this study, the use of aloevera gel instead of steroid in treating erosive lichen planus is better and more appropriate choice.
Key words: Aloevera gel; Burning sensation; Oral lichen planus; Triamcinolone acetonide.
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Article citation:-
Sinha Abhishek,Srivastava Sunita, Mishra Anuj, Agarwal Nitin & Sinha M Pooja. Aloevera vs topical steroid in treatment of erosive lichen planus. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 September; 34(34): 1657-1662.Available at http://www.jpbms.info
Copyright © 2013 Sinha Abhishek,Srivastava Sunita, Mishra Anuj, Agarwal Nitin. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review article
Amartya De1, Gayatri Dewangan2 & Akhilesh Mishra*3
Affiliation:-
1Department of Pharmacology, R.G. Kar Medical College & Hospital, Kolkata, WBUHS, Kolkata, India.
2Department of Pharmacology & Toxicology, COVSC, Mhow, India.
3Department of Pharmacology & Toxicology, WBUAFS, Kolkata, India.
Author’s contributions:- All the author contributed equally to this paper.
*Correspondence to:-
Dr. Akhilesh Mishra, PhD INSPIRE Fellow
Department of Pharmacology & Toxicology, WBUAFS, Kolkata, India.
Email: drakhileshvet@gmail.com
Abstract:
Epidermolysis Bullosa (EB) encompasses a number of disorders characterized by recurrent blister formation as the result of structural fragility within the skin and selected other tissues. Clinical manifestations ranges widely from localized blistering of the hands and feet to generalized blistering of the skin and oral cavity and injury to many internal organs. Epidermolysis Bullosa is a group of genetically determined disease characterized by abnormal damaged of the skin and mucosa. EB varies from mild to very sever and even lethal. The mild forms are all of autosomal dominant inheritance. Traditionally, EB is classified according to skin morphology to give three major categories. In this article we discuss mainly pathophysiology, diagnosis, surgical treatment, stem cell therapy, gene therapy and targeted protein therapy to manage the disease.
Key words: Epidermolysis Bullosa; skin blistering; autosomal dominant; pathophysiology.
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Article citation:-
Amartya De, Gayatri Dewangan & Akhilesh Mishra. Epidermolysis Bullosa and its Management. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 September; 34(34): 1637-1642.Available at http://www.jpbms.info
Copyright © 2013 Amartya De, Gayatri Dewangan & Akhilesh Mishra. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
1Varsha Chaudhary, *2Bhat Kishore,3Sunil Rao,4Preeti Ingalagi & 5Manohar Kugaji
Affiliation:-
1,5Research Officer,2Professor and Head,4Sr. Lecturer, Department of Microbiology, Maratha Mandal’s NGH Institute of Dental Sciences and Research Centre, Belgaum, Karnataka, India.
3Professor and Head, Department of Microbiology, Yenepoya Medical College, Yenepoya University, Mangalore, India.
Author’s contributions: - All the authors contributed equally to this paper.
The name of the Department and Institution to which the work should be attributed:-
Department of Microbiology,
Maratha Mandal’s NGH Institute of Dental Sciences And Research Center, Near K.S.R.P .Ground, R.S.No.47/2, Bauxite Road
Belgaum. (Karnataka), India.
Abstract:
Porphyromonas gingivalis is a major member of red complex in the oral cavity and play a significant role in the progression of adult periodontitis charecterized by alveolar bone loss. Variety of methods such as culture, PCR, Microscopy etc. has been used to detect P.gingivalis but each one has distinct advantages and disadvantages. PCR assays with synthesized 16S r RNA probes enable the detection of virtually any microorganism in a plaque sample. This technique, therefore, is the most sensitive of any of the above.
Aim: To compare culture technique and PCR method to detect and quantify P.gingivalis in subgingival plaque samples in order to assess the relationship of this bacterium with periodontal status.
Materials & Methods: A total of one hundred patients with adult periodontitis and an equal number of controls were selected in an age range of 20 to 50 years and belonged to both the sexes. Sub gingival plaque samples were collected and subjected to anaerobic culture and PCR. In culture species identification was done based on biochemical reactions. The PCR was performed by using specific primers for the 16S rRNA gene of P. gingivalis and quantification was done using standard strain of P.gingivalis.
Results: Comparison was done between the results of anaerobic culture & PCR for control and chronic periodontitis patients. Statistically P value <0.001 is significant & kappa statistics demonstrated moderate agreement (K=0.554) between the above two groups. Results of culture and PCR also depicted that female were prone to chronic periodontitis than male in all the age groups.
Conclusion: The result of PCR confirms those of quantitative culture of P.gingivalis, and offers significant advantages with respect to the rapidity and sensitivity of detection of P.gingivalis in sub gingival plaque samples.
Key Words: Culture; PCR; P.gingivalis; red complex.
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Article citation:-
Varsha Chaudhary, Bhat Kishore, Sunil Rao, Preeti Ingalagi & Manohar Kugaji. Comparison of culture and PCR for detection of Porphyromonas gingivalis in patients with chronic periodontitis and healthy subjects. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 September; 34(34): 1670-1675.Available at http://www.jpbms.info
Copyright © 2013 Varsha Chaudhary, Bhat Kishore, Sunil Rao, Preeti Ingalagi & Manohar Kugaji. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.