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Research article
Aiyalu Rajasekaran1*, Ramasamy Arivukkarasu2 & Shanmugasundaram Murugesh3
Affiliation:-
1KMCH College of Pharmacy, Coimbatore- 641 048, Tamilnadu, India.
2Research scholar, SASTRA University, Thanjavur-613401, Tamilnadu, India.
3Periyar University, Salem, Tamilnadu, India.
Author’s contributions: - All the authors contributed equally to this paper.
The name of the Department and Institution to which the work should be attributed:-
KMCH College of Pharmacy, Coimbatore- 641 048, Tamilnadu, India.
Abstract:
Background: Ethno medical studies of north Gujarat (India) reveal the use of hot aqueous extract of Adenema hyssopifolium by tribal inhabitants for the treatment of diabetes, fever, stomach ache, dyspepsia and for malaria in interior part of Gujarat. Traditional siddha practitioners of Tamilnadu use this processed fortified powder of this plant, by dispensing along cumin’s for jaundice patients, two grams two times a day, advised to take this herbal powder and along with cooked fermented rice water to cure the jaundice.
Objective: The purpose of the study is to evaluate In vitro antioxidant activity of the ethanol extract of Adenema hyssopifolium to scientifically validate and support the traditional claim.
Materials and methods: In vitro assessment was carried out by DPPH, nitric oxide radicals, hydrogen peroxide and superoxide scavenging activity. Results: Ethanol extract exhibited 71%, 70% and 81% of scavenging activity in DPPH method (IC50=540 µg/mL), superoxide ((IC50=715 µg/mL) and hydrogen peroxide method ((IC50=760 µg/ml) respectively. Ascorbic acid 98% (IC50=540 µg/ml), Quercetin 85% (IC50=715 µg/ml) and Butylated hydroxy toluene 95% (IC50=640 µg/ml) were used as reference standards respectively. Total flavonoid and phenol content in ethanol extract of Adenema hyssopifolium was found to be 0.37% equivalent to Quercetin and 1.29% equivalent to Gallic acid respectively.
Conclusion: Ethanol extract showed potential antioxidant and free radical scavenging activity, which may be due to the presence of flavonoid and iridoid glycosides in the Adenema hyssopifolium extract.
Key Words: Adenema hyssopifolium; antioxidant; iridoid glycoside.
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Article citation:-
Aiyalu Rajasekaran, Ramasamy Arivukkarasu & Shanmugasundaram Murugesh. In-vitro antioxidant activity of ethanol extract of Adenema hyssopifolium G.Don. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 September; 34(34): 1676-1681.Available at http://www.jpbms.info
Copyright © 2013 Aiyalu Rajasekaran, Ramasamy Arivukkarasu & Shanmugasundaram Murugesh. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
*Malabika Misra1,Ronita Roychoudhury2,Debjani Sengupta3,Sougata Kumar Burman4,Jayeeta Mukherjee5 & Nayan Chandra Sarkar6
Affiliation:-
1Assistant professor,2,4,5,6Clinical tutor, department of Obstetrics & Gynaecology, Assistant professor, department of community medicine, College of medicine & J.N.M. Hospital, The West Bengal university of health sciences, P.O:- Kalyani, District:- Nadia-741 235,India.
Author’s contributions: - Malabika Misra towards concept, design, literature search, clinical studies, data acquisition, statistical analysis, manuscript writing and editing Ronita Roychoudhury & Debjani Sengupta helps in literature search, data analysis, manuscript editing, and writing. Sougata Kumar Burman, Jayeeta Mukherjee, Nayan Chandra Sarkar analysed, collected the data and helped in manuscript writing.
The name of the Department and Institution to which the work should be attributed:-
College of medicine & J.N.M. Hospital,The West Bengal university of health sciences,P.O:- Kalyani, Distt:- Nadia-741 235,India
Abstract:
Aims: In this study our aim is to find out the best way of delivery of baby in case of caesarean section of obstructed labor cases.
Objectives: Comparing the maternal and fetal outcome of two different methods of delivery of fetus during caesarean section of obstructed labor cases.
Method: This is a comparative study based on clinical observational findings. Following c.s. of obstructed labor cases certain maternal and fetal outcome measures were recorded. Total 122 cases were taken. According to the method of delivery of fetal head these patients were divided into two groups. There were 61 mothers in each group. Their clinical observational records regarding maternal and fetal morbidity were compared and analyzed statistically. In one technique head was delivered first with the help of an extra assistant who pushes fetal head through vagina. In the other, baby was delivered by reverse breech technique.
Result: In the 1st technique laceration of lower flap of uterine incision occurred in 12 cases, whereas in 2nd technique it happened in only 2 cases. Extension of line of incision occurred in 37 cases of caesarean section by the 1st technique. On the other hand, only 9 cases suffered extension of incision line during the delivery of baby by the 2nd technique. These two were statistically significant. Only 7 cases developed mild fever, following c.s. by push technique and 11 cases of the other group developed post-operative fever.
This is insignificant statistically. Mean time of operation in push technique was 55.7 minutes ± 9.05 minutes standard deviation, while in pull technique it is 37 minutes ± 7 minutes standard deviation. Duration of hospital stay, blood loss and these are not different significantly.
Number of foetuses needed NICU admission was significantly higher in the 1st group.
Key Words: Obstructed labor; pull vs. push technique of c.s.
References:
1.Levy R, Chernomoretz T, Appelman Z, Levin D, Or Y, Hagay ZJ.Head pushing versus reverse breech extraction in cases of impacted fetal head during Cesarean section.Eur J Obstet Gynecol Reprod Biol. 2005 Jul 1;121(1):24-6. [Pubmed]
2.Firoozeh Veisi , Maryam Zangeneh , Shohreh Malekkhosravi ,Negin Rezavand. Comparison of “Push” & “Pull”method for impacted fetal head extraction during caesarean delivery International Journal of Gynecology and Obstetrics 2012; 118 (1): 4-6.DOI:10.1016/j.ijgo.2011.12.027[Link]
3.Fasubaa OB, Ezechi OC, Orji EO, Ogunniyi SO, Akindele ST, Loto OM et al Delivery of the impacted head of the fetus at caesarean section after prolonged obstructed labour: a randomised comparative study of two methods J Obstet Gynaecol 2002 22 375–8 doi:10.1080/01443610220141290. [Pubmed][Informa heath care]
Article citation:-
Misra Malabika et al. Comparison of maternal and fetal outcome between two different ways of delivery of impacted fetal head in caesarean section of obstructed labor. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 September; 34(34): 1602-1605.Available at http://www.jpbms.info.
Short communication
*1Hinduja Dharam, 2 Muthu Karuppaiah. R, 3 MN Vishwanath, 4 Babaji Prashant & 5 DMello Kuldeep
Affiliation:
1Associate Professor, Department of Conservative Dentistry & Endodontics, Index Dental College, Indore, Madhya Pradesh, India.
2Reader, Department of Community Dentistry, Rajah Muthai Dental College, Chidamberam, Tamilnadu, India.
3Professor, Department of Orthodontics, Sharavathi Dental College, Shimoga, Karnataka, India.
4Associate Professor,Department of Pedodontics, Vyas Dental College, Jodhpur, India.
5Professor, Department of Orthodontics, Vyas Dental College, Jodhpur-342001, Rajasthan, India.
Abstract:
Nanorobotics technology is an area of science which refers to designing and building nanorobotic device ranging from 0.1 to 10 mm. This technology is used in both medicine and dentistry for tooth renaturalisation, orthodontics teeth alignment, for local anesthesia, diagnosing and treating the disease.
Key words: Nano dentistry; nano technology; nano medicine.
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Article citation:-
Hinduja D et al. Nano dentistry: A boon to dentistry. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 September; 34(34): 1654-1656. Available at http://www.jpbms.info
Copyright © 2013 Hinduja D et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
AnkolekarVrinda H1*,Quadros Lydia S2 & D’souza Antony S3
Affiliation:-
1MD Anatomy, 2M.Sc. (Medical), 3MS Anatomy, Department of Anatomy, Kasturba Medical College, Manipal University, Manipal – 576104, Karnataka, India.
Author’s contributions:- AnkolekarVrinda H contributes towards concept, design, literature search, clinical studies, data acquisition, statistical analysis, manuscript writing and editing. Quadros Lydia S helps in literature search, data analysis, manuscript editing, and writing. D’souza Antony S analysed, collected the data and helped in manuscript writing.
The name of the Department and Institution to which the work should be attributed:-
Department of Anatomy, Kasturba Medical College, Centre for Basic Sciences, Manipal University. Madhavnagar, Manipal – 576104, Karnataka, India.
Abstract:
Background: Knowledge of the coronary venous system (CVS) anatomy is an important factor before many electrophysiological procedures, such as CRT or ablations.
Aim: To study the anatomy of the coronary venous system and its tributaries in cadaveric hearts.
Methodology: Fifty-five normal formalin-fixed adult human cadaveric hearts were used in this study. The following measurements were noted: a. length of coronary sinus, b. its relation to left coronary artery, mitral valve annulus and left atrium, c. number of atrial and ventricular tributaries, d. distance and the opening angles of major tributaries from the coronary ostium, e. length and width of coronary ostium, f. Attachment of Thebesian valve.
Results:
a.Length of coronary sinus(CS) ranged from 2cm to 3.8cm, the mean being 2.8cm.
b.Relation of coronary sinus to the left coronary artery (LCA) andmitral valve annulus was above and parallel in 100% cases.
c.The number of Atrial tributariesranged from 1-2 and ventricular from 1-6.
d.The mean distance ofAnterior interventricular vein (AIV),Posterior vein of the left ventricle (PVLV),Oblique vein of left atrium (OVLA),Middle cardiac vein (MCV) from the coronary ostium was 67.5mm, 32mm, 41mm, 7mm respectively.
e.The average length and width of coronary ostium was 9mm and 13mm respectively.
f.The besian valve in 24/55 hearts was attached to the superior, right and inferior margins of the ostium. In 29/55 hearts to the inferior margin of the ostium.
Conclusion: For invasive cardiologists, knowledge about CVS anatomy could add value before and during electrophysiology procedures.
Key Words: Coronary sinus; coronary ostium; great cardiac vein; the besian valve.
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Article citation:-
AnkolekarVrinda H, Quadros Lydia S & D’souza Antony S. Morphometric and morphological variations of coronary venous system and its tributaries – An anatomical study. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 September; 34(34): 1663-1669.Available at http://www.jpbms.info
Copyright © 2013 AnkolekarVrinda H,Quadros Lydia S & D’souza Antony S. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
Eugène Sèlidji Attakpa1, 3*, Alphonse Sezan1, Bialli Seri2, Naim Akhtar Khan3
Affiliation:-
1Laboratoire de Biomembranes et Signalisation Cellulaire,Département de Physiologie Animale, Faculté des Sciences et Techniques 01 BP : 4521 Université d’Abomey Calavi Cotonou (Rép. du Bénin).
2Laboratoire de Neurosciences,Unité de Formation Biosciences 22 BP 582 Abidjan 22 Université de Cocody-Abidjan (Rép. de Côte-d’Ivoire).
3Unité Propre de Recherche de L’Enseignement Supérieur EA 4183 Lipides et Signalisation Cellulaire, Faculté des Sciences de la Vie, Université de Bourgogne, 6 Boulevard Gabriel, 21000 Dijon, (France).
Abstract:
In order to investigate the implication of docosahexaenoic acid (DHA) in T signaling, we assessed their effects on the activation of two mitogen activated protein (MAP) kinases, i.e. extracellularly-regulated kinases 1 and 2 (ERK1/ERK2) in mouse CD4+ T cells. The n-3 polyunsaturated fatty acids (PUFAs) alone failed to induce MAP kinase (MAPK) enzyme activity. To elucidate whether DHA act via protein kinase C (PKC) dependent and independent pathways, we employed their respective activators, i.e. phorbol 12-myristate 13-acetate (PMA) and anti-CD3 antibodies. DHA diminished the PMA- and anti-CD3-induced phosphorylation of ERK1/ERK2 CD4+ T cells. In the present study, PMA acts mainly via protein kinase C (PKC) whereas anti-CD3 antibodies act via PKC-dependent and–independent mechanisms. We observed that DHA inhibited PMA-stimulated PKC enzyme activity. Together these results suggest that DHA modulate ERK1/ERK2 activation upstream of MEK via PKC-dependent and independent pathways and that these actions may be implicated in DHA-induced immunosuppression. Our study shows that DHA inhibits cell cycle progression.
Key words: Mouse; CD4+ T cells; DHA, ERK.
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Article citation:-
Eugène Sèlidji Attakpa,Alphonse Sezan,Bialli Seri,Naim Akhtar Khan. Action of Docosa-Hexaenoic Acid is their interference with MAP kinase signaling in mouse CD4+ T cells. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 September; 34(34):1704-1710.Available at http: //www.jpbms.info.
Copyright © 2013 Eugène Sèlidji Attakpa,Alphonse Sezan,Bialli Seri,Naim Akhtar Khan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.