DocumentsDate added
Original article:
*1Sharma Priyanka, 2Sen Meenal, 3Yadav Rajeev, 4Sen Vandna & 5Swarnkar Madhusudan
Affiliation:
1M.B.B.S. Resident, Pathology Department, Mahatma Gandhi Medical College, Jaipur, Rajasthan, India
2M.B.B.S. Resident Gynecology & Obstetric Department, M.S. Ramaiah Medical College, Bangalore, India
3M.D. (P.S.M), Assistant Professor, P. S. M. Department, SMS Medical College, Jaipur, Rajasthan, India
4M.D. (P.S.M), Professor, P. S. M. Department, NIMS Medical College, Jaipur, Rajasthan, India
5M.D. (P.S.M) Assistant Professor, P. S. M. Department, Jhalawar Medical College, Jhalawar, Rajasthan, India
Author’s contribution:
Dr.Priyanka Sharma worked on concepts, design, clinical studies, data acquisition and statical analysis. Dr.Meenal Sen contributed towards literature survey,data acquisition and Statistical analysis analysis. Dr.Rajeev Yadav contributed towards data acquisition, Statistical analysis and manuscript editing. Dr.Vandna Sen contributed towards concepts, design, literature search and article preparation. Dr.Madhusudan Swarnkar contributed towards manuscript preparation, editing and review.
Core idea: Despite having favourable attitude towards early detection (81.42% women) of breast carcinoma only one in eight (12.85%) women knew about self breast examination(SBE), which can be used as a tool for primary prevention of breast cancer in a country like India, where majority of the population live in villages & general public can not afford sophisticated methods like screening mammography.
*Corresponding author:
Dr. Vandna Sen.
202, AWHO Colony, Jaipur-302023, Rajasthan, India
Contact No. : 9460143884
Abstract:
Background: Among Indian women cancer of breast & cervix account for nearly 60% of all the cancers. Early detection is very vital, as in early stages breast cancer treatment is easier & more successful. Objective: To assess the knowledge attitude & practice regarding breast carcinoma and socio-demographic factors affecting the knowledge in the study subjects with the attitude & practice of self-breast examination (SBE). Methodology: A descriptive study was conducted from January to March 2013 on 328 women of 21 to 65 years of age who were admitted as indoor patients in different specialty wards of Mahatma Gandhi medical colleges, Hospital, Jaipur, Rajasthan, India. Statistical Analysis: was done by percentage & proportions & Chi Square test (x2).
Result: Though 77.13% women had knowledge about different types of cancers but knowledge about breast carcinoma was present in 27.66% of women (P<0.001).Majority of these women i.e. 84.28% could link it with signs & symptoms of breast carcinoma & its risk factors (P<0.001).With the increase in the educational level & socioeconomic status there was increase in the knowledge about carcinoma. Despite 81.42% women who had favorable attitude towards early detection of carcinoma (P<0.001), only 12.85% of them knew about self-breast examination (P<0.001) & 66.66% of them were doing it themselves (P>0.05).
Conclusions: Despite 81.42% women, who had favorable attitude towards early detection of breast carcinoma, only 12.85% of them had knowledge about self-breast examination (SBE) & 66.66% of them were doing it themselves.
Key words: Breast Cancer; Self-breast examination; Mammography.
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Article citation:-
Sharma Priyanka,Sen Meenal,Yadav Rajeev,Sen Vandna, Swarnkar Madhusudan., Cross sectional study of knowledge attitude & practice (KAP) regarding breast carcinoma in women of 21 To 65 years of age in a medical college hospital, Jaipur, Rajasthan, India. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 October; 35(35):1747-1751.
Copyright © 2013 Sharma Priyanka,Sen Meenal,Yadav Rajeev,Sen Vandna, Swarnkar Madhusudan. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article:
S. I. Abbas1*; Harbi1, M.S.M.A and Gameel2, A.A
Affiliation:-
1Veterinary Research Institute, Animal Resources Research Corporation, P. O. Box 8067 (El Amarat), Khartoum, Sudan
2Faculty of Veterinary Pathology, Faculty of Veterinary Medicine University of Khartoum P.O.Box.32 Shambat, Khartoum North, Sudan
Author’s contributions- All authors contributed equally to this paper.
*Correspondence to:-
S. I. Abbas.
Veterinary Research Institute, Animal Resources Research Corporation, P. O. Box 8067 (El Amarat), Khartoum, Sudan.
Core idea : Contagious caprine pleuropneumonia (CCPP), caused by M.capricolum subsp. capri pneumoniae (Mccp; cF 38) is a fatal disease of goats in Sudan and other African, Middle Eastern and Asian countries. Beside goats, the disease constitutes a potential threat to wild ruminants in areas where it is enzootic in presence of chronic carriers. Symptoms and lesions of the disease may be confused with those seen in other mycoplasmosis of small ruminants. Diagnosis can be tentatively established from typical symptoms and necropsy findings and confirmed by identification of the causative organisms. Isolation of Mccp by conventional bacteriological methods is not always possible and more specific methods (i.e. PCR) can be used.
Abstract:
In this study 18 mycoplasma isolates were recovered from 249 samples consisted of 180 pneumonic lungs and 69 pleural fluids. The samples were collected from veterinary clinics in 6 different areas in the Sudan. With the use of biological, biochemical & serological tests the 18 isolates were completely identified to species level and accordingly catagorized to 4 different groups.
The first group consisted of two isolates of M. capricolum subsp. capricolum (Mccp), they were both recovered from the lung and pleural fluid of the same animal, the second group included 3 isolates of M. mycoides subsp. mycoides (LC type), the third group included 6 isolates of M. ovipneumoniae and the fourth group included 7 isolates of M. arginini. All lungs from which these isolates were recovered had been studied grossly and histopathologically.
Key words: Caprine-Pleuropneumonia-Mycoplasma-pathology.
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Article citation:-
S.I.Abbas, Harbi & Gameel. First reported case of pathological manifestations of natural cases of Contagious Caprine Pleuropneumonia in the Sudan from which M.capricolum subsp.capripneumoniae; M. mycoides subsp. mycoides (LC type); M. ovipneumoniae & M. arginini were isolated. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 October;35(35):1739-1746. Available at http: //www.jpbms.info
Original article
Soni Hardik K1*, Patel Vrushali V2, Vaghasiya Jitendra D2,
Patel Vandana B2, Patel Ghanshyam R1
Affiliation:-
1Vasu Research Centre, A Division of Vasu Healthcare Pvt. Ltd., 896/A, G.I.D.C., Makarpura, Vadodara – 390 010, Gujarat, India.
2Department of Pharmacology, Babaria Institute of Pharmacy, BITS Edu campus, Vadodara-Mumbai NH#8, Varnama, Vadodara – 391 240, Gujarat, India.
The name of the Department and Institution to which the work should be attributed:-
Vasu Research Centre, A Division of Vasu Healthcare Pvt. Ltd., 896/A, G.I.D.C., Makarpura, Vadodara – 390 010, Gujarat, India
Author contributions:
Soni Hardik K: Concept, design, literature search, data analysis and manuscript preparation.
Patel Vrushali V: Literature search, Experimental study, Data acquisition and Statistical analysis.
Vaghasiya Jitendra D and Patel Vandana B: Data analysis and manuscript review.
Patel Ghanshyam R: Data analysis and manuscript editing.
Core Idea: The study was initiated to evaluate safety and efficacy of anti-urolithiatic formulation developed from herbo-mineral source. Major ingredients of UCEX01 are individually well reported in Ayurvedic texts and scientific research publications for variety of activities like diuretic, anti-urolithiatic, anti-inflammatory etc. However, no such evidence was available which proves the safety and efficacy of such combination. Therefore, present study was taken up to evaluate acute toxicity and anti-urolithiatic activity of UCEX01.
*Correspondence to:
Soni Hardik K
Asst. Manager, R&D
Vasu Research Centre (A Division of Vasu Healthcare Pvt. Ltd.)
896/A, G.I.D.C., Makarpura, Vadodara-390010, Gujarat, India.
Tel.: 91-265-2657701, 2657702, Fax: 91-265-2647331
Mob.: 91-9428692240.
Abstract:
Urolithiasis is the most common urinary tract disorder with high recurrence. But, unfortunately most of its treatments are expensive or having side effects. Therefore, the search for anti-urolithiatic drugs from natural sources has been of great importance. UCEX01 is the herbo-mineral Ayurvedic formulation used for the treatment of kidney stone. But, no scientific evidences are available which proves safety and efficacy of such combination. Hence, present study was conducted to evaluate acute toxicity and anti-urolithiatic activity of UCEX01. Healthy male Wistar rats were used by dividing randomly into 4 groups. Group I was considered as normal control. Group II was as Disease control, Group III as UCEX01 treated with Therapeutic Effective Dose (TED-I) and Group IV was as UCEX01 treated with double of Therapeutic Effective Dose (TED-II). After 28th day, blood and urine sample were collected. Urine volume and pH was measured immediately. Bio-chemical parameters like calcium, phosphorus, creatinine and uric acid were estimated in serum and urine. Histopathology of kidney was also carried out. No mortality was observed during acute oral toxicity study. On basis of study data it can be concluded that the treatment of UCEX01 has significant anti-urolithiatic effect on ethylene glycol induced urolithiasis in rats. The underlying mechanism(s) of this effect is unknown however it may be attributed to its diuretic, anti-inflammatory and lowering of urinary concentrations of stone-forming elements. It can be a safe and effective remedy for the treatment of kidney stone.
Key words: UCEX01; ethylene glycol; urolithiasis; herbo-mineral Ayurvedic formulation.
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Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: Nil
Article citation:-
Soni Hardik K, Patel Vrushali V, Vaghasiya Jitendra D, Patel Vandana B, Patel Ghanshyam R. Pharmacological evaluation of Anti-urolithiatic activity of UCEX01 - A herbo-mineral ayurvedic formulation. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 October; 35(35): 1834-1839. Available at http: //www.jpbms.info.
Copyright © 2013 Soni Hardik K, Patel Vrushali V, Vaghasiya Jitendra D, Patel Vandana B, Patel Ghanshyam R. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Debasis Das1,Kanti Bhushan Choudhury2,Sita Chattapadhyay3, Sougata Kumar Burman*4,Maitreyi Bandyopadhyay5, Abhijit Bhakta6
Affiliation:-
1Associate Professor, Community Medicine, Malda Medical College, Malda, West bengal,India.
2Assistant Professor, Community Medicine, Calcutta National Medical College, Kolkata,India.
3Associate Professor, Community Medicine, I.P.G.M.E.& R, Kolkata, India
4Clinical Tutor, Department of Obstetrics & Gynaecology, College of Medicine & J N M Hospital, WBUHS, Kalyani, Nadia, India.
5Assistant Professor, Department of Microbiology, R G Kar Medical College, Kolkata,India
6Associate Professor, Department of Anatomy R S Medical College, Kolkata, India
The name of the Department and Institution to which the work should be attributed:-
I C T C Centre
I P G M E & R
Kolkata
Author contributions:
All the authors equally to this paper.
*Correspondence to:
Dr Sougata Kumar Burman
Clinical Tutor
Obstetrics & Gynaecology.
College of Medicine & J N M Hospital,WBUHS.
Kalyni, West Bengal,.India.
Mobile: 09475943811
Abstract:
Objective: Recording the profile & queries of the clients attending Integrated Counselling & Testing Centre so that this information can be used for developing preparedness of the counsellor to handle questions of the clients in clinic. Design: It is a type of cross-sectional need assessment study. Setting: Counselling centre set-up of Institute of Post Graduate Medical Education & Research, Kolkata, West Bengal. Method: All the 259 clients attending the ICTC centre during March – May’2011 were listened passively during group counselling followed by collection of selected client variable from the client records were done. Results: Among total 259 clients 36.68% were rural residents, others semi-urban or urban dwellers, 82.63% came referred from antenatal clinic & 13.51% from obstetrics & gynaecology clinic, mostly female, 97.37% in reproductive age group, mean age being 28.11±18.18 years, 7.45% illiterate & 97.3% married, 97.68% heterosexual, others being student and/or unmarried. No other risk factor like homosexuality, history of blood transfusion, history of use of infected syringe and needle in health facility found among any client. All clients are counselled, found HIV negative, 2.7% spouse tested. There are 75 different types of questions asked by 195 clients on general aspect of HIV /AIDS, transmission, prevention, treatment, tests and some unrelated areas. Among those who asked questions, 90.77percent able to comprehend the answer given by the counsellor, 58.97% found satisfied. Conclusion: To develop preparedness of the counsellor in ICTC, recording client queries is valuable.
Key words: Client, Queries; ICTC; India.
REFERENCES:
1.Operational Guidelines for Integrated Counselling and Testing Centres: National AIDS Control Organization. Ministry of Health & Family Welfare, Government of India, July 2007.
2.Olanrewjiu A M, Ola F A, Akintunde A E, Ibrahim B & Ibiyemi F. HIV voluntary counselling and testing of pregnant women in primary health care centres in Ilesa, Nigeria. The Internet Journal of Third World Medicine, 2007. Vol. 6 No. 1.
3.Pool R, Nyanzi S, Whitworth J A. Attitudes to voluntary counselling and testing for HIV among pregnant women in rural south-west Uganda. AIDS Care, 2001Oct; 13(5):605-15.
Article citation:-
Das Debasis et al. Queries of clients in integrated counselling & testing centre of a tertiary care hospital of West Bengal, India. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 October; 35(35): 1826-1829. Available at http: //www.jpbms.info.
Copyright © 2013 Das Debasis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
0riginal article
Kuldeep Kumar1*, Sandeep Punia2, Jagjit Kaur 3 and Teena Pathak 4
Affiliation:-
1Assistant Professor, 2,4Ph. D. Students, 3Research Scholar, Department of Biotechnology, M. M. Modi College, Patiala-147 001 Punjab (India)
The name of the Department and Institution to which the work should be attributed:-
Department of Biotechnology,M. M. Modi College, Patiala-147 001 Punjab (India).
Authors contributions:
Author 1 contributes towards the Concepts, Design, Literature search, Clinical studies, Experimental studies, Data acquisition, Data analysis, Manuscript preparation, editing and review. Author 2 & 4 worked in literature search, experimental studies, data acquisition and manuscript preparation. Author 3 contributes towards literature search and manuscript preparation.
*Corresponding author:
Dr. Kuldeep Kumar.
Assiatant Professor, Department of Biotechnology
Mulatni Mal Modi College, Patiala 147001, Punjab (India)
Abstract:
Aim: L-asparaginase is an enzyme of great therapeutic value and is used worldwide. Citrus limon is used for this purpose as it is a potential source of L-asparaginase. This work has been carried out to develop plant asparaginase based asparagine biosensor for leukemia. It is a novel and diagnostic biosensor for monitoring asparagine levels in leukemic patients.
Methods: Various immobilization strategies have been applied to fabricate the biosensor and improve the stability of L-asparaginase. Phenol red indicator has been coimmobilized with asparaginase from Citrus limon and color visualization approach has been optimized for varying concentrations of asparagine.
Results and conclusion: The detection limit of asparagine achieved with different immobilization techniques such as agar method, agarose method and gelatin method is 10-1 –10-10M. Immobilization with agar method is found to be more effective due to faster response time. Furthermore these immobilization techniques have been applied for the detection of asparagine in normal and leukemia serum samples.
Key Words: Biosensor; Immobilized; L-asparaginase; Leukemia.
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Article citation:-
Kumar Kuldeep, Punia Sandeep, Kaur Jagjit, Pathak Teena. Development of plant asparagine biosensor for detection of leukemia. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 October; 35(35):1796-1801.Available at http://www.jpbms.info