DocumentsDate added
Research article
Darlene Sredl*
Affiliation:-
Darlene Sredl, Ph.D., R.N.
Teaching professor, College of Nursing, University of Missouri-St Louis, One University Boulevard St. Louis, MO 63121-4400.
Corresponding author:-
Darlene Sredl, Ph.D., R.N.
Teaching professor, College of Nursing, University of Missouri-St Louis, One University Boulevard St. Louis, MO 63121-4400.
Core idea:
The paradigm is shifting! Contemporary research emphasis is on multidisciplinary modes of acquiring data. Even the emphasis of JPBMS is ‘Research across boundaries’ publishing multi-dimensional research venues. This article explores a new research methodology (Amalgamethodology) which was developed originally as a suggested research methodology unique to nursing. However, in practice, it has become clear that this methodology is well-suited to other scientific research endeavors also, particularly pharmacology.
Abstract:
Pharmacologic clinical trial research could yield far richer data by combining quantitative with qualitative methods, a process known as Amalgamethodology.
Key words: Amalgamethodology; Adaptive trial design; Pharmacodynamic Physiologically-based Pharmacodynamics (PBKP); Clinical trials Quantitative method; Qualitative method; Profile Analysis.
REFERENCES
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2.Sredl D. Amalgamethodology: A research methodology unique to nursing fostering critical thinking implications for education and practice. Journal of Applied Medical Sciences. 2013;2(1):61-73.
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5.Sredl D. Evidence-Based Nursing Practice (EBNP): A Crystalized Synthesis of Apperceptions, Beliefs, and Efforts toward EBNP Implementation among Contemporary Nurse Executives in the United States of America St. Louis: College of Nursing, University of Missouri @ St. Louis; 2005.
6.Davison ML. Addendum to "Multidimensional scaling and factor models of test and item responses.": Department of Educational Psychology, University of Minnesota;1996.
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8.Ding CS. Profile analysis: Multidimensional scaling approach. Practical Assessment, Research, and Evaluation 7(16) 2001; http://ericae.net/pare/Articles.htm, 2001.
9.Ding CS. Multidimensional Scaling Approach. Practical Assessment Research and Evaluation. 2001;7(16).
10.Davidson ML, Gasser, M., & Ding, C. Identifying major profile patterns in a population: An exploratory study of WAIS and GATB patterns. Psychological Assessment. 1996;8:26-31.
Sredl, D. Amalgamethodology: Building the Educational Evidence-Base for a Research Design Unique to the Science of Nursing. 11th Annual Nurse Educator Institute. North Arkansas Partnership for Health Education. Branson, MO March 15-15, 2011.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: Nil
Article citation:-
Darlene Sredl. Pharmacologic implications of utilizing amalgamethodology as adaptive trial design in clinical trial research methodology. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 November 35(35): 1860-1865. Available at www.jpbms.info.
Copyright © 2013 Darlene Sredl. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
Kirtilaxmi K. Benachinmardi1, *C.Panduranga2, V.Srinivasamurthy3,Sharath N Burugina4, Vani B.R5, Navaneeth. B.V6
Affiliation:-
1Tutor/Lecturer, Department of Microbiology, ESIC Medical College and PGIMSR, Rajajinagar, Bangalore-560010,India.
2Assistant Professor, Department of Pathology, ESIC Medical College and PGIMSR, Rajajinagar, Bangalore-560010,India.
3Professor and Head, Department of Pathology, ESIC Medical College and PGIMSR, Rajajinagar, Bangalore-560010.India.
4Assistant Professor, Department of Community Medicine, ESIC Medical College and PGIMSR, Rajajinagar, Bangalore-560010,India.
5Associate Professor, Department of Pathology, ESIC Medical College and PGIMSR, Rajajinagar, Bangalore-560010,India.
6Professor and Head, Department of Microbiology, ESIC Medical College and PGIMSR, Rajajinagar, Bangalore-560010,India.
Corresponding author:
Dr. C. Panduranga, M.D.,
Assistant Professor, Department of Pathology, ESIC Medical College and PGIMSR, Rajajinagar, Bangalore-560010, Karnataka, India. Contact no:-+91 9480710942
Abstract:
Back ground: Dengue viral infection is one of the common arboviral infections in tropical and subtropical countries. Hematological examination is an essential step in the management of these patients and in few cases it can give a clue to the underlying diseases. Hence this study was undertaken at a tertiary care hospital to document the hematological changes in acute dengue fever.
Materials and Methods: This a prospective study conducted between April to September 2013. Simultaneously the blood samples were subjected for serological examination for NS1 antigen and IgM antibody by ELISA and hematological examination by autoanalyser.
Results: A total of 150 serologically proven cases of dengue cases were observed during the study period. 21.3% were less than 12 years and 78.75% were more than twelve years of age. Male to female ratio was 1.34. Thrombocytopenia was the most common change observed in 79%. Under 12 years 25% patients showed increase HCT, 62.5% had leucopenia, 18.8% had neutropenia and 80% showed atypical lymphocytes. Above 12 years haematocrit increase was seen in 3% of male and 2% of female patients, 55 % had decreased total count, 29.5% had neutropenia and 90% showed presence of atypical lymphocytes.
Conclusion: Thrombocytopenia is the most common hematological change followed by leucopenia, neutropenia and presence of atypical lymphocytes. Hematological changes are more reflected in children than in adults.
Key words: Dengue fever; thrombocytopenia; neutropenia; leucopenia; NS1 antigen.
Article citation:
Kirtilaxmi K. Benachinmardi,C.Panduranga,V.Srinivasamurthy,Sharath N Burugina,Vani B.R,Navaneeth. B.V. Hematological profile in acute dengue infection: A study at tertiary care teaching hospital. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 November 36(36):1866-1870. Available at www.jpbms.info.
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Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: Nil
Copyright © 2013 C.Panduranga. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Sakthibalan M1*, Nileshraj G1, Sawadkar MS2, Shanmugam M3
Affiliation:-
1Post Graduate,2Head of the Department, Department of Pharmacology, Sri Manakula Vinayagar Medical College and Hospital (SMVMCH), Pondicherry University, Pondicherry, India
3Head of the Department, Department of General Medicine, Sri Manakula Vinayagar Medical College and Hospital (SMVMCH), Pondicherry University, Pondicherry, India
Author’s contributions- All the authors contributed equally to this paper
The name of the department(s) and institution(s) to which the work should be attributed:
Sri Manakula Vinayagar Medical College and Hospital (SMVMCH), Pondicherry University, Pondicherry, India
Corresponding author:-
Dr. MurugesanSakthibalan.
Post Graduate, Department of Pharmacology,
Sri Manakula Vinayagar Medical College and Hospital, Madagadipet, Pondicherry, India – 605107
Ph No: 9443627722/98843591097/0413-2643000
Fax : 0413-26433014.
Abstract:
Background: Elevated Blood pressure is an important modifiable risk factor for cardiovascular diseases.The prescribing pattern of drugs used for treating hypertension changes over time in response to changes in recommended guidelines and innovations in drug formulations. Therefore it is necessary to find out the recent trends in prescribing anti-hypertensive medications by medical practitioners in upcoming medical practice.
Aims & objectives: To evaluate the recent trends in prescribing anti-hypertensive drugs, the different combinations being prescribed and the commonly prescribed dosage of individual drugs. Methodology: This study was carried out for a 3 months’ time period. The patients selected were in the age group of 25 to 90 years, diagnosed to have mild to severe systemic hypertension and on treatment, who were attending the OPD of General Medicine, without any co morbid conditions.
Result & Conclusion: The most common anti-hypertensive agents used were; CA channel blockers (76%) followed by β blockers (29.8%),AR blockers (19.9%) & ACE inhibitors (19.3%). Of the respondents 50.29% were receiving at least 2 anti-hypertensive agents. Most common agents used in combination were CA channel blockers + β blockers (40.96%) followed by AR blockers + CA channel blockers (22.89%) & ACE inhibitors + CA blockers (19.27%). The usage of two or more anti-hypertensive agents in combination has increased in the recent years, for better control of blood pressure. Though the usage of AR blockers and ACE inhibitors have increased, the CA channel blockers and β blockers tops the list in the most commonly prescribed anti-hypertensive agents.
Key words: Anti-hypertensive; Trends; CA channel blockers; β blockers; AR blockers; ACE inhibitors.
REFERENCES
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Article citation:-
Sakthibalan M,Nileshraj G,Sawadkar MS,Shanmugam M. Recent trends in prescribing anti-hypertensives in a tertiarycare hospital. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 November 36(36): 1866-1870. Available at www.jpbms.info.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: Nil
Copyright © 2013. Sakthibalan M, Nileshraj G, Sawadkar MS, Shanmugam M.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Silpiranjan Mishra1,*, C.Krithika2, RamachandranSudarshan3,S.C.Selvamuthukumar4, Priya Ramani2, S. Uma Maheswari1
Affiliation:-
1Post graduate trainee, 2Reader, 3Senior lecture, 4Professor and HOD, Department of Oral Medicine and Radiology, Thai Moogambigai dental college, Chennai, Tamilnadu, India
Author’s contributions- All the authors contributed equally to this paper
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Oral Medicine and Radiology, Thai Moogambigai dental college, Chennai, Tamilnadu India
Corresponding author:-
Dr. Silpiranjan Mishra.
Post graduate trainee,
Department of Oral Medicine and Radiology,
Thai Moogambigai dental college, Chennai, Tamilnadu, India
Ph no: 09176174611
Abstract:
The terms ‘‘Eagle’s syndrome’’ represents a series of symptoms caused by an elongated styloid process or the mineralization of part or the entire stylohyoid ligament. The symptoms of this syndrome can be varied and so the patients can present to general physicians, Otorhinolaryngologists or Dental surgeons for management. In many cases, it may just be an incidental finding with minimal or no symptoms. Diagnosis usually depends on clinical symptoms, digital palpation in the tonsillar fossa and infiltration with anesthetic agent, but diagnosis is ultimately confirmed by radiological findings. With the advancements in three dimensional imaging, dental surgeons are more likely to encounter this syndrome in their practice and hence they need to be familiar with the clinical presentation. The treatment can be conservative or surgical depending on the underlying pathogenesis and the extent to which anatomical structures are compressed or irritated by the styloid process. This review deals with the current understanding of the etiopathogenesis, clinical features, diagnosis and management of this clinically relevant condition.
Key words: Eagle’s syndrome; styloid; Dental surgeons.
Article citation:-
Silpiranjan Mishra, C.Krithika, Ramachandran Sudarshan, S.C.Selvamuthukumar,Priya Ramani,S. Uma Maheswari. Elongated styloid process- A review. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 November 36(36): 1871-1876. Available at www.jpbms.info.
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Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: Nil
Copyright © 2013. Silpiranjan Mishra, C.Krithika, Ramachandran Sudarshan, S.C.Selvamuthukumar,Priya Ramani,S. Uma Maheswari. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Mahajan Shikhaa1,*, Pandey Rajesh2, Kaur Harnam4, Bhaskar Neeru2,
Ishaq Sheikh3, Sodhi S. Kuldeep4, Singh Jasbir4
Affiliation:-
1Assistant Professor, Department of Biochemistry, Maharishi Markandeshwar Medical College and Hospital, Kumarhatti, Solan, Himachal Pradesh, India
2Associate professor, Department of Biochemistry, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, India
3P.G. student, Department of Biochemistry, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, India
4Professor, Department of Biochemistry, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, India
The name of the department(s) and institution(s) to which the work should be attributed:
1.Department of Biochemistry, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, India
2.Department of Biochemistry, Maharishi Markandeshwar Medical College and Hospital, Kumarhatti, Solan, Himachal Pradesh, India
Corresponding author:-
Dr. Shikhaa Mahajan.
Assistant Professor,
Department of Biochemistry, Maharishi Markandeshwar Medical College and Hospital, Kumarhatti, Solan, Himachal Pradesh, India.
Phone number: +91-8059931702, +91-9467630796.
Abstract:
Background: Subclinical hypothyroidism is defined as elevated serum TSH and normal total T4 and T3 levels.
Aim: Evaluate burden of SCH in apparently healthy rural subjects residing in and around village Mullana in Haryana, India.
Settings and design: Community based Prospective Cross-sectional study was conducted in rural setting of Haryana. 500 subjects were selected randomly by planned systematic simple random sampling method.
Material and Methods: Serum T3, T4 and TSH were estimated by ELISA. Two grades of SCH: grade II and III were created based on the value of TSH. An individual was said to be in grade II of SCH when serum TSH value was between 6.0–12.0 µIU/ml and in grade III of SCH when serum TSH value was >12.0 µIU/ml. Logistic Model was built by using the of Forward Wald criterion.
Statistical analysis used: The count and percentages were calculated for each group by entering the data in SPSS version 12 [SPSS v12 (SPSS Inc, Chicago, IL)]. Bar charts and tables were prepared in microsoft excel 2007 software program.
Results: Out of 500 apparently healthy subjects, 12.2% were SCH positive with 10% males and 14.4% females. SCH was more in females than males. Predominance of grade II subjects. Logistic Model showed if serum T4 of any individual is known, we can find out whether he/she is SCH positive or negative.
Conclusions: High occurrence of SCH especially in women suggests that thyroid hormone estimation should be considered during routine evaluation in asymptomatic people especially in a susceptible population
Key words: Thyroid; Thyroid stimulating hormone; Thyroxine; Triiodothyronine; Subclinical hypothyroidism.
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Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
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Copyright © 2013. Mahajan Shikhaa, Pandey Rajesh, Kaur Harnam, Bhaskar Neeru, Ishaq Sheikh, Sodhi S. Kuldeep, Singh Jasbir. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.