DocumentsDate added
Original article
Saurabh K. Deo1,*, Rajesh Pandey2, Jasbir Singh2, Kuldip S. Sodhi2
Affiliation:-
1Ph. D. Student, 2Professor, Department of Biochemistry, MM Institute of Medical Sciences and Research, Mullana, Ambala, Haryana, India
Author’s contributions:- Author 1 & 2 contributed towards concepts, design, literature survey, data acquisition, manuscript editing and preparation.
Author 3 & 4 contributed in Design, literature search, clinical studies, data acquisition and analysis.
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Biochemistry, MM Institute of Medical Sciences and Research, Mullana, Ambala, Haryana, India
Corresponding author:-
Mr. Saurabh K. Deo.
Department of Biochemistry, MM Institute of Medical Sciences and Research, Mullana, Ambala, Haryana, India
Abstract:
Glycosylation, the attachment of sugar moieties to proteins, is a post-translational modification (PTM) that provides greater proteomic diversity than other PTM. Various glycosyltransferases catalyze the reactions. However, nonenzymatic protein glycation is a complex cascade of reactions yielding a heterogeneous class of compounds, collectively termed advanced glycation end products (AGE). Nonenzymatic glycation of macromolecules, especially proteins leading to their oxidation is increased in diabetes mellitus and plays an important role in associated complications of the disease. The amount of AGE on a protein has been found to be dependent on the inherent reactivity of specific amino groups as determined by their microenvironment, the glucose concentration, and the half-life of the protein. The initial Schiff base adducts formed from glucose and lysine and N-terminal amino-acid residues rearrange to form fructosamine. Fructosamine degradation and the direct reaction of α-oxoaldehydes with protein form many AGE. AGE and other ligands interact with their receptors, i.e. receptor for AGE (RAGE), localized to a variety of tissues. This interaction triggers diverse signaling pathways that converge on the activation of critical transcription factors and the initiation of a local inflammatory reaction that, when prolonged, results in cellular dysfunction affecting various tissues. The possible outcomes include retinopathy, neuropathy, nephropathy, angiopathy, Alzheimer’s disease, cardiomyopathy, metastasis etc.
Key words: Glycation; glycosylation; advanced glycation end products; diabetes mellitus; complications.
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Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: Nil
Article citation:-
Saurabh K. Deo, Rajesh Pandey, Jasbir Singh, Kuldip S. Sodhi. Protein glycation: Biochemical-clinical correlations. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 December 37(37): 1942-1947. Available at www.jpbms.info.
Copyright © 2013 Saurabh K. Deo, Rajesh Pandey, Jasbir Singh, Kuldip S. Sodhi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report and literature review
Ahmet Aslan1,*,Mehmet Nuri Konya1, Serdar Sargın2
Affiliation:-
1MD, Orthopaedics Surgeon; Afyonkarahisar State Hospital, Departmants of Orthopaedics and Traumatology. Afyonkarahisar/TURKEY.
2MD, Orthopaedics Surgeon; Balıkesir Universty, Medicine Faculty, Departmants of Orthopaedics and Traumatology. Balıkesir/TURKEY.
The name of the department(s) and institution(s) to which the work should be attributed:
Afyonkarahisar State Hospital,
Departmants of Orthopaedics and Traumatology. Afyonkarahisar/TURKEY.
*Corresponding author:-
Ahmet Aslan: MD,
Orthopaedics Surgeon; Afyonkarahisar State Hospital, Departmants of Orthopaedics and Traumatology. Afyonkarahisar/TURKEY.
Tel:+905056462411
Abstract:
Percutaneous trigger finger releasing has been reported as a safe, effective and quick procedure, but most surgeons convert percutaneous releasing to an opened method because of residual triggering. In this article, we aimed to present an unusual case with trigger finger who underwent percutaneous releasing and afterwards opened revision surgery because of recurrence, in attribution to current literature. The patient was a 51 year-old diabetic female with pain in the middle finger of right hand and had trigger finger. Percutaneous releasing was performed by using the tip of a 18-gauge needle at the outpatient room under local anaesthesia. Theree months after percuteneous surgery, the patient reapplied to the hospital because of recurrent triggering of the finger. A secondary procedure by using opened releasing surgery method with A1 pulley was performed to fix the residual or recurrent triggering occured after the initial percutaneous surgical procedure. The patient recovered completely after the second surgery and turned back to her normal life. No complications were observed at 6 month- follow-up examinations. In patients with trigger finger, opened revision surgery is needed when the triggering relapse after percutaneous releasing. The ganglion involvement should always be kept in mind because the ganglion at the level of the metacarpal head of the flexor tendon under A1 pulley can be trapped and this is one of the very rare cause of trigger finger as it is in this case.
Key words: Trigger; Finger; Digits; Treatment; Surgical; Release; Percutaneous.
REFERENCES
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Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: Nil
Article citation:
Ahmet Aslan,Mehmet Nuri Konya,Serdar Sargın. Revision Surgery after percutaneous release of the A1 pulley for surgical treatment of trigger finger: An unusual case and brief review of literature. Journal of pharmaceutical and biomedical sciences (J Pharm Biomed Sci.) 2013 December 37(37): 1960-1963. Available at www.jpbms.info.
Copyright © 2013 Ahmet Aslan,Mehmet Nuri Konya,Serdar Sargın. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.