DocumentsDate added
Original article
Preetinder Singh1,*,Yash Paul Dev Sharma2,Priyanka Singla3,Nitin Khuller1,Aman Bhatia1
Affiliation:-
1Associate Proffesor,2 Professor & Head,3PG Student, (Periodontology and Oral Implantology) SDD Hospital and Dental College, Barwala (Haryana), India
The name of the department(s) and institution(s) to which the work should be attributed:
Periodontology and Oral Implantology, SDD Hospital and Dental College, Barwala (Haryana) India
*Corresponding author:-
Dr. Preetinder Singh,MDS
Associate. Professor (Periodontology and Oral Implantology) SDD Hospital and Dental College, Barwala (Haryana), India
Contact number: +91-9915652946.
Abstract:
The increased rate and severity of periodontal destruction appear to be the result of the release and activation of increased quantities of inflammatory and tissue destructive molecules such as prostaglandins, cytokines, and matrix metalloproteinases (MMPs). Subantimicrobial dose doxycycline (SDD) has been shown to be an effective inhibitor of MMPs, especially collagenase. Aim and objective: To evaluate the adjunctive benefits of SDD along with surgical management of patients with the generalized aggressive periodontitis. Methods and material: Twenty subjects with aggressive generalized periodontitis received subgingival debridement along with conventional flap surgery and plus 6 months of adjunctive subantimicrobial doxycycline (SDD). Periodontal status was monitored at baseline, and at 1, 3 and 6 months after periodontal surgery. Results: The mean of baseline gingival index and on recall 3 came out to be clinically significant (p<0.05). The mean value of probing depth at baseline and that on recall 3 came out to be statistically significant (p<0.05) thus suggesting that there was considerable reduction in probing depth after conventional flap surgery along with SDD. The mean value of CAL at baseline and at recall 3 was clinically significant (p<0.05) thus suggesting that there was significant gain in CAL after conventional flap surgery along with SDD.
Conclusion: SDD can be used as a beneficial adjunct in the treatment of patients with aggressive periodontitis.
Keywords: Subantimicrobial dose doxycycline; Aggressive Periodontitis; Host Modulation.
REFERENCES
1.Newman, Takei, Klokkevold, Carranza; Clinical Periodontology; 10th Edition: Elseveir.
2.Page RC, Kornman KS. The pathogenesis of human periodontitis: An introduction. Periodontol 2000 1997; 14: 9- 11.
3.Pihlstrom BL. Periodontal risk assessment, diagnosis and treatment planning. Periodontol 2000 2001; 25: 37-58.
4.Greenstein G. Periodontal response to mechanical nonsurgical therapy: A review. J Periodontol 1992; 63: 118- 130.
5.Quirynen M, Mongardini C, De Soete M, et al. The role of chlorhexidine in the one-stage full-mouth disinfection treatment of patients with advanced adult periodontitis. Long-term clinical and microbiological observations. J Clin Periodontol 2000; 27: 578-589.
6.Caton JG, Ciancio SG, Blieden TM, et al. Treatment with subantimicrobial dose doxycycline improves the efficacy of scaling and root planing in patients with adult periodontitis. J Periodontol 2000; 71: 521-532.
7.Emingil G, Atilla G, Sorsa T, Luoto H, Kirilmaz L, Baylas H. the effect of adjunctive low dose doxycycline therapy on clinical parameters and gingival crevicular fluid matrix metalloproteinase 8 levels in chronic periodontitis. J Periodontol 2004; 75: 106-115.
8.Preshaw PM, Hefti AF, Novak MJ, Michalowicz BS, Pihlstrom BL, Schoor R et al. subantimicrobial dose doxycycline enhances the efficacy of scaling and root planing in chronic periodontitis: A multicentre Trial. J Periodontol 2004; 75: 1068- 1076.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: None
Article citation:
Preetinder Singh,Yash Paul Dev Sharma,Priyanka Singla,Nitin Khuller,Aman Bhatia. Efficacy of subantimicrobial dose Doxycycline as an adjunct to surgical therapy in patients suffering from aggressive periodontitis. J Pharm Biomed Sci 2014; 04(01): 29-33. Available at www.jpbms.info.
Copyright © 2014 Preetinder Singh,Yash Paul Dev Sharma,Priyanka Singla,Nitin Khuller,Aman Bhatia. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original research
Phani Kumar Sarkar1,*, Tapan Majumder2,Umakanta Acharjee3
Affiliation:-
1Associate Professor, Department of Ophthalmology, Agartala Government Medical College & GBP Hospital, Agartala, Tripura,India
2Associate Professor, Department of Microbiology, Agartala Government Medical College & GBP Hospital, Agartala, Tripura,India
3PGT, Department of Ophthalmology, Agartala Government Medical College & GBP Hospital, Agartala, Tripura,India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Ophthalmology, Agartala Government Medical College & GBP Hospital, Agartala, Tripura,India
Department of Microbiology, Agartala Government Medical College & GBP Hospital, Agartala, Tripura,India
*Corresponding author:-
Dr. Phani Kumar Sarkar.
Associate Professor, Department of Ophthalmology, Agartala Government Medical College & GBP Hospital, Agartala, Tripura,India
Abstract:
Background: Mycotic ocular keratitis continues to be an important cause of ocular morbidity, particularly in agricultural communities of the developing world. Etiology is considered to be multifactorial. Corneal blindness due to Infective Keratitis accounts for 20- 30 % of blindness in developing countries of the world. This study was undertaken to evaluate the mode of presentation along with fungal profile of corneal infections in study subjects.
Methods: Study subjects are subjected to corneal scrapings under aseptic conditions from each ulcer. The scraping material was examined by preparing 10% KOH mount and Gram staining and then inoculated directly onto Sabouraud's dextrose agar, sheep's blood agar, chocolate agar, in a row of C-shaped streaks.
Results: A total of 45 patients were examined, Out of which 42 presented on the first visit with eye pain, followed by 40 patients (88.88%) with watering. All 45 patients had epithelial defect on fluorescence staining which were centrally placed in 53.33%, paracentral in 28.88% and 17.77% in the periphery. 40 patients had Circumciliary congestion, 12 patients (26.66%) had multiple satellite lesions, 10 patients (22.22%) had hypopyon and 3 patients (6.66%) had immune rings. The predominant isolate was Aspergillus species--14 cases (70%) followed by Scopolariopsis--3 cases (15%), Candida--2 cases (10%), Scedosporium--1 cases (5%). Out of 45 subjects 30 were males, 15 were females. 20 cases (44.44%) were reported positive for fungus by microscopy and culture. Male outnumbered the females, ratio being 4:1. 35% cases were between the age group 41 to 50 years. 14 patients (70%) were agriculturists by occupation. 17 patients (85%) gave a definite history of trauma by vegetative materials. 8 patients (40%) were diabetics under medication. 16 cases (80%) reside in the villages
Conclusion: Keratomycosis in young male adults established as an important cause of ocular morbidity, in the rural areas, involved in outdoor and agricultural activity, leading to grave economic consequences. Early, meticulous examination of corneal scrapings by direct microscopy, and timely institution of antifungal therapy may limit ocular morbidity and its disastrous sequelae among these patients.
Keywords: Aspergillus; Hypopyon; Keratomycosis; Sabouraud’s dextrose agar.
REFERENCES
1.Thomas PA. Current perspectives on ophthalmic mycoses. Clin Microbiol Rev.2003; 16:730-97.
2.Verenkar MP, Subhangi B, Pinto MJW. A study of mycotic keratitis in Goa. Ind Jour of Medi Micro 1998; 16:58-60.
3.Dutta L C, Dutta Nitin K. Modern Ophthalmology vol 1. 3rd ed. New Delhi: Jaypee; 2005.
4.Khurana A K . Comprehensive Ophthalmology. 5th ed. New Delhi: New age international limited; 2012.
5.Sridhar MS, Sharma S, Gopinathan U, et al. Anterior chamber tap: diagnostic and therapeutic indications in the management of ocular infections. Cornea. 2002;21:718-722.
6.Gaudio PA, Gopinathan U, Sangwan V, Hughes TE. Polymerase chain reaction based detection of fungi in infected corneas. Br J Ophthalmol 2002; 86:755–760.
7.Krachmer, Mannis, Holland. Cornea fundamentals, diagnosis and management, Vol 1 . 2nd ed. China: Elsevier Mosby; 2005.
8.Polack FM, Kaufman HE, Newmark E. Keratomycosis. Medical and surgical treatment. Arch Ophthalmol. 1971 Apr;85(4):410–416.
9.Prashant G, Gullapalli N. Corneal Ulcers: diagnosis and management. Community Eye Health. 1999;12:21–23.
10.Bharathi M J, Ramakrishnan R, Vasu S, Meenakshi R, Palaniappan R. Epidemiological characteristics and laboratory diagnosis of fungal keratitis. A three-year study. Indian J Ophthalmol 2003;51:315-21.
11.Arora U, Gill P K, Chalotra S. Fungal Profile of Keratomycosis. Bombay Hospital Journal, 2009 ;51(3), 325-327.
12.Kumari N, Xess A, Shahi SK. A study of keratomycosis: our experience. Indian J Pathol Microbiol :2002 Jul;45(3):299-302.
13.Nath R, Baruah S, Saikia L, Devi B, Borthakur AK, Mahanta J. Mycotic corneal ulcers in upper Assam, Indian J Ophthalmol. 2011 Sep-Oct;59(5):367-71.
14.Tanure MA, Cohen EJ, Sudesh S, Rapuano CJ, Laibson PR. Spectrum of fungal keratitis at Wills Eye Hospital, Philadelphia, Pennsylvania. Cornea. 2000;19(3):307–312.
15.Gopinathan U, Garg P, Fernandes M, et al. The epidemiological features and laboratory results of fungal keratitis: a 10-year review at a referral eye care center in south India. Cornea. 2002; 21:555-559.
16.Gill P K, Devi P. Keratomycosis –A retrospective study from a North Indian tertiary care institute. Journal of Indian Academy of clinical medicine 2011; 12(4): 271-273.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: None
Phani Kumar Sarkar,Tapan Majumder,Umakanta Acharjee. Preoperative ibuprofen administration for the treatment of post operative periodontal surgical pain: A double-blind placebo-controlled study. J Pharm Biomed Sci 2014; 04(01): 34-40. Available at www.jpbms.info.
Copyright © 2014 Phani Kumar Sarkar,Tapan Majumder,Umakanta Acharjee.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article:
Dr.Sarat Kumar Behera1,*,Dr.Umakanta Tripathy1 ,Sudeep Kumar Patra2, Princejeet Sarangi3
Affiliation:-
Intensive Care Unit, Hi-Tech Medical College & Hospital, Pandra, Rasulgarh, Bhubaneswar, Odisha,India
The name of the department(s) and institution(s) to which the work should be attributed:
Hi-Tech Medical College & Hospital, Pandra, Rasulgarh, Bhubaneswar, Odisha,India
*Corresponding author:-
Dr Sarat Kumar Behera,
Intensive Care Unit, Hi-Tech Medical College & Hospital, Pandra, Rasulgarh, Bhubaneswar, Odisha, India
Abstract:
Background and aims: In this article we report our experience with outcomes of serious OP insecticide poisonings and its intensive care management.
Subjects and methods: A cross sectional, retrospective, observational, descriptive, study on fifty eight patients with history of Organophosphorus compound poisoning who were admitted to the Intensive care unit during august 2010 to July 2013, were selected and nature of the compound, time duration between consumption and admission with clinical features were noted. Patients were selected according to Inclusion and Exclusion Criteria. The blood samples were taken immediately and sent for estimation of serum cholinesterase level before doing any intervention. The patients were managed in ICU with Pralidoxime infusion, atropine bolus and drip, adequate level of atropinization was maintained and if required with mechanical ventilation. The chi-square test was used for statistical analysis. Data are presented as mean ± standard deviation.
Results: Out of fifty eight (58) patients 60 % were male and 40% were female. All the cases were due to ingestion of organ phosphorus agents with suicidal intensions. The most frequent clinical signs were meiosis, change in mental status, hyper salivation, agitation and fasciculation. All of the patients received atropine. Atropine was administered till atropinisation and the average total atropine dose was 0.02-0.08 mg/kg per hour. Pralidoxime was given for 5-7 days and the average dose was 500mg/hour. Mortality rate is very low i.e. only 2% with the management of OP poisoning patient in ICU. Mechanical ventilator is being given to 30% of the patients as they were aspirating and oxygen saturation was decreased to less than 90%. The main reason of patient death due to OP poisoning is respiratory failure.
Conclusions: OP insecticide poisoning is a serious condition that needs rapid diagnosis and treatment. Since respiratory failure is the major reason for mortality, careful monitoring, appropriate management and early recognition of this complication may decrease the mortality rate among these patients.
Keywords: Thyroid hormones; Fasting, non fasting; Diagnosis; Subclinical hypothyroidism.
REFERENCES
1.Aygun D.Diagnosis in an acute organophosphate poisoning: report of three interesting cases and review of the literature. Eur J Emerg Med 2004; 11:55-8.
2.Darren M, Roberts C. Management of acute organophosphorus pesticide poisoning. BMJ 2007; 334:629.
3.Lee EC.Clinical manifestations of sarin nerve gas exposure. JAMA 2003;290:659-62.
4.Ong S,Leng Y K. Suicidal behaviour in Kuala Lumpur, Malaysia. In: Peng KL, Tseng W, editors. Suicidal behaviour in the Asia-Pacific region. Singapore: Singapore University Press; 1992. pp. 144–75.
5.Aghanwa HS. Attempted suicide by drug overdose and by poisoningestion methods seen at the main general hospital in Fiji islands: A comparative study. Gen Hosp Psychiatry. 2001;23:266–71. [PubMed: 11600168]
6.Senanayake N, De Silva HJ, Karalliedde L. A scale to assess severity in organophosphorus intoxication: POP scale. Hum Exp Toxicol 1993; 12:297-9.
Article citation:
Sarat Kumar Behera,Sudeep Kumar Patra,Princejeet Sarang. Critical care management of organ phosphorus poisoning in a tertiary care hospital of Odisha,India. J Pharm Biomed Sci 2014; 04(01): 61-66. Available at www.jpbms.info.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: None.
Sarat Kumar Behera, Sudeep Kumar Patra, Princejeet Sarangi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report
Changala. Praveen*, Rampure M. Dilip, Bandi S. Gurushantappa, Chinthala. Ellareddy
Affiliation:-
General Medicine, Mamata Medical College, 4-2-161, Rotary Nagar, Khammam-507002, Andhra Pradesh, India
The name of the department(s) and institution(s) to which the work should be attributed:
Mamata Medical College, 4-2-161, Rotary Nagar, Khammam-507002, Andhra Pradesh, India
*Corresponding author:-
Dr. Changala. Praveen.
PG, General Medicine, Mamata Medical College, 4-2-161, Rotary Nagar, Khammam-507002, Andhra Pradesh, India
Core idea: Leptospirosis is an acute febrile illness which is a zoonotic disease, here we report a young man presented with fever, decreased urine output and was not responding to treatment, whose initial workup showed deranged renal and liver parameters along with thrombocytopenia and subsequently he showed positive result for leptospira microagglutination test. He improved in subsequent days after putting on Inj. Ceftriaxone. This case report shows the importance of considering Leptospirosis in every case of acute febrile illness.
Abstract:
Leptospirosis is a zoonotic disease. Clinical hallmark of leptospirosis include jaundice, renal injury, splenomegaly, fever and refractory shock. In this report we present a 25 year old male presented to emergency department with fever and kidney injury.
Case presentation:
A 25 year old male agricultural laborer presented with fever, decreased urine output. His initial workup showed deranged renal parameters and liver function tests along with leukocytosis and thrombocytopenia. A microagglutination test for leptospira showed positive result. Subsequently the patient recovered after a course of intravenous antibiotics.
Conclusion: Leptospirosis should be considered in the diagnosis of every patient who presents with acute febrile illness.
Keywords: Leptospirosis;Fever; Kidney injury.
REFERENCES
1.Joseph M.Vinetz, Harrison’s Principles Of Internal Medicine; Infectious Diseases,2012 18th Edition; Chapter 171: 1392-1396.
2.Loganathan N, Shivakumar S, RavishankarD.Co-infection of Malaria andLeptospirosis – A Study of 48 cases (Abstract).62nd Annual Conference ofAssociation of Physicians of India. 2007.Goa.
3.Edwards GA, Domm BM: Leptospirosis.Med Times 1966, 94(9):1086-1095.II PubMed Abstract.
4.VelineniS,Asuthkar S, Umabala P et al. Serological evaluation of leptospirosis in Hyderabad,Andhra Pradesh: A retrospective hospital – based study. Indian J MedMicrobiol. 2007; 25:24-27
5.Debnath C, Pal NK, Pramanik AK et al. A serological study of leptospirosis among hospitalized jaundice patients in around Kolkata.. Indian J Med Microbiol.2005; 23:68.
6.Shivakumar S. Leptospirosis in Chennai- Changing clinical Profile. J. Assoc Phys
India 2006,54:964-965.
7.Panaphut T, Domrongkitchaiporn S, Vibhagool A, Thinkamrop B, Susaengrat W. Ceftriaxone compared with sodium penicillin g for treatment of severe leptospirosis. Clin Infect Dis. 2003; 36:1507-13.
8.Sethi S, Sood A, Pooja, Sharma S, Sengupta C, Sharma M. Leptospirosis in northern India: A clinical and serological study. Southeast Asian J Trop Med Public Health. 2003; 34:822–5.
Article citation:
Changala. Praveen, Rampure M. Dilip, Bandi S. Gurushantappa, Chinthala. Ellareddy. A rare case report on leptospirosis in Khammam, Andhra Pradesh, India. J Pharm Biomed Sci 2014; 04(01): 45-47. Available at www.jpbms.info.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: None
Copyright © 2014 Changala. Praveen, Rampure M. Dilip, Bandi S. Gurushantappa, Chinthala. Ellareddy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original research
Preetinder Singh1,Yash Paul Dev2,Shivani Rathore3,*,Nitin Khuller1,Sumit Kaushal4
Affiliation:-
1,Associate Professor, 2Professor & Head, 3PG Student,4Assistant Professor (Periodontology and Oral Implantology),SDD Hospital and Dental College, Barwala (Haryana) India
The name of the department(s) and institution(s) to which the work should be attributed:
Periodontology and Oral Implantology, SDD Hospital and Dental College, Barwala (Haryana) India
*Corresponding author:-
Dr. Shivani Rathore,
PG Student (MDS),
(Periodontology and Oral Implantology) SDD Hospital and Dental College, Barwala (Haryana) India
Abstract:
Twenty chronic periodontitis patients, aged 35-60 years, were taken in a randomized double blind study. Aims and Objectives: To assess the effect of preoperative ibuprofen administration on the post operative periodontal surgical pain. Materials and Methods: The study consisted of ten chronic periodontitis, indicated for full mouth surgery. In each patient, two quadrants (mandibular) were considered for periodontal surgery after thorough scaling and root planing. The patients were given ibuprofen before 3rd quadrant surgery and placebo before the surgery for 4th quadrant. All patients gave verbal informed consent to participate in the study before anesthesia and surgery. The VAS score were recorded for each patient immediately after and 2 hours post operatively. Statistical analysis: data were analyzed using the student t test. Results: Results indicated that preoperative treatment with ibuprofen significantly reduced initial pain intensity of operative and post operative pain as compared with placebo. No adverse reactions related to preoperative medication were observed. Conclusions: The results of this study showed that 400 mg ibuprofen administered immediately before periodontal surgery was effective for alleviating the operative and post operative painful sequelae.
Keywords: Ibuprofen; operative pain; pain/prevention and control; periodontal surgery.
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Preetinder Singh,Yash Paul Dev,Shivani Rathore,Nitin Khuller,Sumit Kaushal. Preoperative ibuprofen administration for the treatment of post operative periodontal surgical pain: A double-blind placebo-controlled study. J Pharm Biomed Sci 2014; 04(01): 41-44. Available at www.jpbms.info.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: None
Copyright © 2014 Preetinder Singh,Yash Paul Dev,Shivani Rathore,Nitin Khuller,Sumit Kaushal. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.