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Case report
S. H. Arif1, S. S. Ahmad1, Kafil Akhtar2,*, R. S. Chana3
Affiliation:-
1Professor,2Associate Professor,Department of Pathology, 3Professor,Department of Surgery, J. N. Medical College, A. M. U. Aligarh (UP):202002,India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Pathology,
J. N. Medical College, A. M. U. Aligarh (UP): 202002, India
Author contributions: All the authors contributed equally to this paper.
*Corresponding author:
Dr. Kafil Akhtar.
Associate Professor, Department of Pathology,
J. N. Medical College, A. M. U. Aligarh (UP): 202002, India
Abstract:
Cystic partial differentiated nephroblastoma (CPDN) is rare multilocular cystic lesion of kidney having low malignant potential. It is differentiated from multilocular cystic disease of kidney by the presence of partially or well differentiated renal element or renal balstemal cell in the septa of the locules of the cyst. It is treated with partial nephrectomy with 100% survival rate but chance of recurrence is high and therefore regular follow up is necessary. CPDN occurs in children of less than 2 years of age but adult cannot be spared. We report an unusual case of CPDN in a nine year old female who presented with abdominal lump for a period of 2 months.
Keywords: Cystic partial differentiated nephroblastoma; Cystic lesion of kidney; Female.
Article citation:
S. H. Arif, S. S. Ahmad Kafil Akhtar, R. S. Chana. Cystic partially differentiated nephroblastoma – a rare entity – a case report. J Pharm Biomed Sci 2014; 04(01): 58-60. Available at www.jpbms.info.
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Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: None
Copyright © 2014 S. H. Arif,S. S. Ahmad,Kafil Akhtar, R. S. Chana. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Bansal Sangeeta A1,*, Bansal Vinita A2
Affiliation:-
1Associated Professor, Department of Anesthesiology, 2Associate Professor, Department of Obstetrics and Gynecology, Index Medical College and Research Centre Indore, India.
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Anesthesiology,
Index Medical College and Research Centre Indore, Madhya Pradesh, India
*Corresponding author:-
Dr. Sangeeta Bansal-Agarwal
401, Gold Residency, 7/2 Manoramaganj, Indore- 452001, India
Contact: +91-98260-15819
Abstract:
Background: Hysterectomies are associated with visceral and somatic pain. To get good perioperative pain relief various adjuvant are tried. Aim of our study was to find effects of low dose of intrathecal Clonidine as adjuvant to Bupivacaine in hysterectomies.
Material and methods: In a prospective randomized, double blind controlled trial, sixty patients were divided equally, randomly between two groups. Group I received 3.5 ml Bupivacaine 0.5% with 0.3 ml of normal saline. Group II received 3.5 ml Bupivacaine 0.5% with 0.3ml, 45 µg of Clonidine. Onset, duration of sensory and motor block, number of Diclofenac injection in first operative day along with haemodynamic, sedation, nausea, vomiting, shivering and other side effects were measured using f-test and t-test in data analysis package of the Microsoft Excel.
Results: Onset of sensory and motor block were comparable in two groups. There was significant increase in the duration of sensory block in Group II (in Group I was 186 minutes as compared to 206.8 minutes in Group II) (P value < 0.01). Similarly significant increase in duration of motor block in Group II (Group I was 208 minutes as compared to 240 minutes in Group II) (P value <0.03). Significant sedation was found in Group II (P value < 0.0001). Besides this all other parameters were comparable in two groups.
Conclusions: Low dose intrathecal Clonidine (45 µg) added to hyperbaric Bupivacaine increases duration and quality of block in hysterectomies with good sedation level and no side effects.
Keywords: Bupivacaine; Clonidine, Hysterectomy; Subarachnoid block.
REFERENCES
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Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: Department of Anesthesiology, Index Medical College Indore (M P).
Article citation:-
Bansal Sangeeta A,Bansal Vinita A. Efficacy of intrathecal Clonidine in perioperative pain relief in Hysterectomies. J Pharm Biomed Sci 2014; 04(01): 09-13. Available at www.jpbms.info.
Copyright © 2014 Bansal Sangeeta A, Bansal Vinita A. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article:
Dr.Sarat Kumar Behera1,*,Dr.Umakanta Tripathy1 ,Sudeep Kumar Patra2, Princejeet Sarangi3
Affiliation:-
Intensive Care Unit, Hi-Tech Medical College & Hospital, Pandra, Rasulgarh, Bhubaneswar, Odisha,India
The name of the department(s) and institution(s) to which the work should be attributed:
Hi-Tech Medical College & Hospital, Pandra, Rasulgarh, Bhubaneswar, Odisha,India
*Corresponding author:-
Dr Sarat Kumar Behera,
Intensive Care Unit, Hi-Tech Medical College & Hospital, Pandra, Rasulgarh, Bhubaneswar, Odisha, India
Abstract:
Background and aims: In this article we report our experience with outcomes of serious OP insecticide poisonings and its intensive care management.
Subjects and methods: A cross sectional, retrospective, observational, descriptive, study on fifty eight patients with history of Organophosphorus compound poisoning who were admitted to the Intensive care unit during august 2010 to July 2013, were selected and nature of the compound, time duration between consumption and admission with clinical features were noted. Patients were selected according to Inclusion and Exclusion Criteria. The blood samples were taken immediately and sent for estimation of serum cholinesterase level before doing any intervention. The patients were managed in ICU with Pralidoxime infusion, atropine bolus and drip, adequate level of atropinization was maintained and if required with mechanical ventilation. The chi-square test was used for statistical analysis. Data are presented as mean ± standard deviation.
Results: Out of fifty eight (58) patients 60 % were male and 40% were female. All the cases were due to ingestion of organ phosphorus agents with suicidal intensions. The most frequent clinical signs were meiosis, change in mental status, hyper salivation, agitation and fasciculation. All of the patients received atropine. Atropine was administered till atropinisation and the average total atropine dose was 0.02-0.08 mg/kg per hour. Pralidoxime was given for 5-7 days and the average dose was 500mg/hour. Mortality rate is very low i.e. only 2% with the management of OP poisoning patient in ICU. Mechanical ventilator is being given to 30% of the patients as they were aspirating and oxygen saturation was decreased to less than 90%. The main reason of patient death due to OP poisoning is respiratory failure.
Conclusions: OP insecticide poisoning is a serious condition that needs rapid diagnosis and treatment. Since respiratory failure is the major reason for mortality, careful monitoring, appropriate management and early recognition of this complication may decrease the mortality rate among these patients.
Keywords: Thyroid hormones; Fasting, non fasting; Diagnosis; Subclinical hypothyroidism.
REFERENCES
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Article citation:
Sarat Kumar Behera,Sudeep Kumar Patra,Princejeet Sarang. Critical care management of organ phosphorus poisoning in a tertiary care hospital of Odisha,India. J Pharm Biomed Sci 2014; 04(01): 61-66. Available at www.jpbms.info.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: None.
Sarat Kumar Behera, Sudeep Kumar Patra, Princejeet Sarangi. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Preetinder Singh1,*,Yash Paul Dev Sharma2,Priyanka Singla3,Nitin Khuller1,Aman Bhatia1
Affiliation:-
1Associate Proffesor,2 Professor & Head,3PG Student, (Periodontology and Oral Implantology) SDD Hospital and Dental College, Barwala (Haryana), India
The name of the department(s) and institution(s) to which the work should be attributed:
Periodontology and Oral Implantology, SDD Hospital and Dental College, Barwala (Haryana) India
*Corresponding author:-
Dr. Preetinder Singh,MDS
Associate. Professor (Periodontology and Oral Implantology) SDD Hospital and Dental College, Barwala (Haryana), India
Contact number: +91-9915652946.
Abstract:
The increased rate and severity of periodontal destruction appear to be the result of the release and activation of increased quantities of inflammatory and tissue destructive molecules such as prostaglandins, cytokines, and matrix metalloproteinases (MMPs). Subantimicrobial dose doxycycline (SDD) has been shown to be an effective inhibitor of MMPs, especially collagenase. Aim and objective: To evaluate the adjunctive benefits of SDD along with surgical management of patients with the generalized aggressive periodontitis. Methods and material: Twenty subjects with aggressive generalized periodontitis received subgingival debridement along with conventional flap surgery and plus 6 months of adjunctive subantimicrobial doxycycline (SDD). Periodontal status was monitored at baseline, and at 1, 3 and 6 months after periodontal surgery. Results: The mean of baseline gingival index and on recall 3 came out to be clinically significant (p<0.05). The mean value of probing depth at baseline and that on recall 3 came out to be statistically significant (p<0.05) thus suggesting that there was considerable reduction in probing depth after conventional flap surgery along with SDD. The mean value of CAL at baseline and at recall 3 was clinically significant (p<0.05) thus suggesting that there was significant gain in CAL after conventional flap surgery along with SDD.
Conclusion: SDD can be used as a beneficial adjunct in the treatment of patients with aggressive periodontitis.
Keywords: Subantimicrobial dose doxycycline; Aggressive Periodontitis; Host Modulation.
REFERENCES
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Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: None
Article citation:
Preetinder Singh,Yash Paul Dev Sharma,Priyanka Singla,Nitin Khuller,Aman Bhatia. Efficacy of subantimicrobial dose Doxycycline as an adjunct to surgical therapy in patients suffering from aggressive periodontitis. J Pharm Biomed Sci 2014; 04(01): 29-33. Available at www.jpbms.info.
Copyright © 2014 Preetinder Singh,Yash Paul Dev Sharma,Priyanka Singla,Nitin Khuller,Aman Bhatia. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.