DocumentsDate added
Case report
Renu Nagar
Affiliation:-
Head of Biochemistry & Point of Care Testing, Al Ain Hospital, UAE.
The name of the department(s) and institution(s) to which the work should be attributed:
Al Ain Hospital, UAE.
*Corresponding author:-
Dr. Renu Nagar.
Head of Biochemistry & Point of Care Testing, Al Ain Hospital, UAE.
Abstract:
A woman receiving Levo-Dopa for Parkinson’s disease for last five years was re-evaluated as a result of reflex testing for Vitamin D & Parathyroid hormone (PTH) in laboratory. She was found to have Primary Hyper-Parathyroidism presenting as Parkinsonism. Patient recovered soon after her Parathyroidectomy. Hyper-parathyroidism is not a recognized cause of Parkinsonism. The case highlights the significance re-evaluation of Levo-Dopa resistant cases of Parkinson’s disease, Reflex testing in lab & Collaborative Care in hospitals.
Keywords: Hyperparathyroidism; Parathyroid hormone, PTH; Parkinsonism; Parkinson’s disease; Reflex testing; Collaborative care.
REFERENCES
1.Youanes NA, Shafagoij Y, Khatib F, Ababneh M. Laboratory screening for hyperparathyroidism. Clin Chim Acta 2005; 353:1-12.
2.Kearns AE, Thompson GB: Medical and surgical management of hyperparathyroidism. Mayo Clin Proc 2002; 77:87-89.
3.Joynt. Clinical Neurology, 1998; Ch. 38, p 39-42.
4.Kovacs CS, Howse DC, Yendt ER. Reversible Parkinsonism induced by hypercalcemia and primary hyperparathyroidism.Arch Intern Med. 1993 May 10; 153(9):1134-1136.
5.Hirooka Y, Yuasa K, Hibi K, Ishikawa A, Sobue G, Naruse T, Mitsuma T. Hyperparathyroidism associated with Parkinsonism. Intern Med. 1992 Jul; 31(7):904-907.
Article citation:-
Renu Nagar. A case of Hyperparathyroidism misdiagnosed as Parkinson’s disease. J Pharm Biomed Sci 2014; 04 (01): 01-03. Available at www.jpbms.info.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: Nil
Copyright © 2014 Renu Nagar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
Manoj Kumar Jindal1,*,Dr. Manish Upadhyay2
Affiliation:-
1Department of Chemistry, CEC Durg, C.G. India
2Department of Chemistry of C. V. Raman University, Bilaspur, C.G. India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Chemistry, CEC Durg, C.G. India
*Corresponding author:-
Manoj Kumar Jindal.
Assistant Professor, Department of Chemistry, CEC Durg, C.G. India
Abstract:
Water is an essential constituent for all type of life on Earth. In Present study, quality of Drinking Water, were determined in December 2013 from near J.P. Cement Industry Sector Area Bhilai Chhattisgarh, India. The result showed that in Ground Water of this area contain low Hardness and amount of Alkalinity was found to be high. Bicarbonate Alkalinity was found to be 270 mg/l. and also analyzed Water Quality parameters pH, TDS, Chloride, DO, BOD, Temporary Hardness, Permanent Hardness, Carbonate Alkalinity, Calcium and Magnesium. Amount of Total Dissolved Solid was found to be 732 ppm. And Dissolved Oxygen 25.6 ppm and BOD remain 4.48 ppm.
Keywords: Ground Water; Water Quality; Parameters.
Article citation:-
Manoj Kumar Jindal, Dr.Manish Upadhyay. Analysis of drinking water quality of ground water near industrial area in Bhilai Chhattisgarh, India. J Pharm Biomed Sci 2014; 04(01): 22-24. Available at www.jpbms.info.
REFERENCES
1.Verma S., Thakur B and Das S. To Analyse the Water Sample of Pond Located Near Nandani Mines in Durg District Chhattisgarh, India. JPBMS 2012, 22(19).
2.Vinod Jena , Satish Dixit and Sapana Gupta. Comparative study of ground water by physicochemical parameters and water quality index. Der Chemica Sinica, 2012; 3(6):1450-1454.
3.Wu-yuan Jia, Chuan-rong Li, Kun Qin & Lin Liu. Testing and Analysis of Drinking Water Quality in the Rural Areas of High-tech District in Tai’an City. Journal of Agriculture Science 2010;2(3).
4.Parihar S.S., Kumar Ajit, Kumar Ajay, Gupta R. N. , Pathak Manoj, Shrivastav Archana and Pandey A.C. Physico-chemical and Microbiological Analysis of Underground Water in and Around Gwalior City, MP, India.Research Journal of Recent Sciences 2012;1(6):62-65.
5.Mohammad Mehdi Heydari, Ali Abasi, Seyed Mohammad Rohani and Seyed Mohammad Ali Hosseini. Correlation Study and Regression Analysis of Drinking Water Quality in Kashan City, Iran Middle- East journal of Scientific Research 2013; 13 (9):1238-1244.
6.Patil P.N. Sawant. D.V, Deshmukh. R.N. physic-chemical parameters for testing of water- A review. 2012 International Journal of Environmental Sciences 2012;3(3):1194-1207.
7.Yuvaraj .D, Alaguraja .P .Sekar, M, Muthuveerran.P.Manivel .M. Analysis of Drinking water problem in Coimbatore City Corporation, Tamilnadu, India using Remote Sensing and GIS tools. International Journal of Environmental Science Volume 2010; 1(1):71-76.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: None.
Copyright © 2013 Manoj Kumar Jindal, Dr. Manish Upadhyay. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Brief Communication
Harpreet Kaur1,*, Shalini Gupta2
Affiliation:-
1Assistant Professor,2Associate Professor, Department. of Biochemistry, Gian Sagar Medical College and Hospital, Ram Nagar, Rajpura, Distt. Patiala, Punjab, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Biochemistry, Gian Sagar Medical College and Hospital, Ram Nagar, Rajpura, Distt. Patiala, Punjab, India
*Corresponding author:-
Dr. Harpreet Kaur.
Assistant Professor, Department of Biochemistry, Gian Sagar Medical College and Hospital, Ram Nagar, Rajpura, Distt. Patiala, Punjab, India
Contact number: +91-9915022170
Abstract:
Thyroid function tests are designed to distinguish hyperthyroidism and hypothyroidism from the euthyroid state. Thyroid stimulating hormone (TSH) in the body follows a circadian rhythm, i.e., it follows a 24-hour cycle with regular fluctuations. TSH is nadir in the late afternoon and peak at midnight. As subclinical hypothyroidism diagnosis can be missed if serum sample for thyroid hormones is estimated in an afternoon and it is a risk factor for various diseases, so an early morning fasting sample should be preferred choice of estimation.
Keywords: Thyroid hormones; Fasting; Non fasting; Diagnosis; Subclinical hypothyroidism.
Harpreet Kaur, Shalini Gupta. Diagnostic significance of serum thyroid hormones level estimation in early morning fasting sample. J Pharm Biomed Sci. 2014; 04(01):55-57. Available at www.jpbms.info.
REFERENCES
1.Brabant G, Prank K, Ranft U, Schuermeyer Th, Wagner TOF, Hauser H, et al. Physiological regulation of circadian and pulsatile TSH secretion in normal man and woman. J Clin Endocrinol Metab. 1990; 70(2):403–7.
2.Weeke J and Gundersen HJ. Circadian and 30 minutes variations in serum TSH and thyroid hormones in normal subjects. Acta Endocrinol 1978; 89: 659-672.
3.Scobbo RR, VonDohlen TW, Hassan M and Islam S. Serum TSH variability in normal individuals: the influence of time of sample collection The West Virginia Medical Journal 2004; 100(4):138-142.
4.Sviridonova MA, Fadeyev VV, Sych YP and Melnichenko GA. Clinical significance of TSH circadian variability in patients with hypothyroidism. Endocr Res. 2013; 38 (1), 24-31.
5.Bandyopadhyay D, Goel P, Baruah H and Sharma D. Fasting or random: which venous blood sample is better for thyroid testing? J. Adv Researches in Biol Scienc.2012; 4(4): 275-278.
6.Biondi B and Cooper DS. The clinical significance of subclinical thyroid dysfunction. Endocr Rev 2008; 29: 76-131.
7.Ochs N, Auer R, Bauer DC, Nanchen D, Gussekloo J, Cornuz J et al., Meta-analysis: subclinical thyroid dysfunction and the risk for coronary heart disease and mortality. Ann Intern Med 2008; 148: 832-845.
8.Tian L, Song Y, Xing M, Zhang W, Ning G, Li X et al., A novel role for thyroid-stimulating hormone: up-regulation of hepatic 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase expression through the cyclic adenosine monophosphate/protein kinase A/cyclic adenosine monophosphate-responsive element binding protein pathway. Hepatology 2010; 52: 1401-1409.
9.Xing Wanjia, Wang Chenggang, Wang Aihong, Yang Xiaomei, Zhao Jiajun, Yu Chunxiao et al., Lipids in Health and Disease 2012; 11: 44-47.
10.Ruhla S, Weickert MO, Arafat AM, et al. A high normal TSH is associated with the metabolic syndrome. Clin Endocrinol (Oxf ) 2010; 72: 696-701.
11.Oh JY, Sung YA and Lee HJ. Elevated thyroid stimulating hormone levels are associated with metabolic syndrome in euthyroid young women. Korean J Intern Med 2013; 28: 180-186.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: None.
Copyright © 2014 Harpreet Kaur, Shalini Gupta. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original research
Phani Kumar Sarkar1,*, Tapan Majumder2,Umakanta Acharjee3
Affiliation:-
1Associate Professor, Department of Ophthalmology, Agartala Government Medical College & GBP Hospital, Agartala, Tripura,India
2Associate Professor, Department of Microbiology, Agartala Government Medical College & GBP Hospital, Agartala, Tripura,India
3PGT, Department of Ophthalmology, Agartala Government Medical College & GBP Hospital, Agartala, Tripura,India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Ophthalmology, Agartala Government Medical College & GBP Hospital, Agartala, Tripura,India
Department of Microbiology, Agartala Government Medical College & GBP Hospital, Agartala, Tripura,India
*Corresponding author:-
Dr. Phani Kumar Sarkar.
Associate Professor, Department of Ophthalmology, Agartala Government Medical College & GBP Hospital, Agartala, Tripura,India
Abstract:
Background: Mycotic ocular keratitis continues to be an important cause of ocular morbidity, particularly in agricultural communities of the developing world. Etiology is considered to be multifactorial. Corneal blindness due to Infective Keratitis accounts for 20- 30 % of blindness in developing countries of the world. This study was undertaken to evaluate the mode of presentation along with fungal profile of corneal infections in study subjects.
Methods: Study subjects are subjected to corneal scrapings under aseptic conditions from each ulcer. The scraping material was examined by preparing 10% KOH mount and Gram staining and then inoculated directly onto Sabouraud's dextrose agar, sheep's blood agar, chocolate agar, in a row of C-shaped streaks.
Results: A total of 45 patients were examined, Out of which 42 presented on the first visit with eye pain, followed by 40 patients (88.88%) with watering. All 45 patients had epithelial defect on fluorescence staining which were centrally placed in 53.33%, paracentral in 28.88% and 17.77% in the periphery. 40 patients had Circumciliary congestion, 12 patients (26.66%) had multiple satellite lesions, 10 patients (22.22%) had hypopyon and 3 patients (6.66%) had immune rings. The predominant isolate was Aspergillus species--14 cases (70%) followed by Scopolariopsis--3 cases (15%), Candida--2 cases (10%), Scedosporium--1 cases (5%). Out of 45 subjects 30 were males, 15 were females. 20 cases (44.44%) were reported positive for fungus by microscopy and culture. Male outnumbered the females, ratio being 4:1. 35% cases were between the age group 41 to 50 years. 14 patients (70%) were agriculturists by occupation. 17 patients (85%) gave a definite history of trauma by vegetative materials. 8 patients (40%) were diabetics under medication. 16 cases (80%) reside in the villages
Conclusion: Keratomycosis in young male adults established as an important cause of ocular morbidity, in the rural areas, involved in outdoor and agricultural activity, leading to grave economic consequences. Early, meticulous examination of corneal scrapings by direct microscopy, and timely institution of antifungal therapy may limit ocular morbidity and its disastrous sequelae among these patients.
Keywords: Aspergillus; Hypopyon; Keratomycosis; Sabouraud’s dextrose agar.
REFERENCES
1.Thomas PA. Current perspectives on ophthalmic mycoses. Clin Microbiol Rev.2003; 16:730-97.
2.Verenkar MP, Subhangi B, Pinto MJW. A study of mycotic keratitis in Goa. Ind Jour of Medi Micro 1998; 16:58-60.
3.Dutta L C, Dutta Nitin K. Modern Ophthalmology vol 1. 3rd ed. New Delhi: Jaypee; 2005.
4.Khurana A K . Comprehensive Ophthalmology. 5th ed. New Delhi: New age international limited; 2012.
5.Sridhar MS, Sharma S, Gopinathan U, et al. Anterior chamber tap: diagnostic and therapeutic indications in the management of ocular infections. Cornea. 2002;21:718-722.
6.Gaudio PA, Gopinathan U, Sangwan V, Hughes TE. Polymerase chain reaction based detection of fungi in infected corneas. Br J Ophthalmol 2002; 86:755–760.
7.Krachmer, Mannis, Holland. Cornea fundamentals, diagnosis and management, Vol 1 . 2nd ed. China: Elsevier Mosby; 2005.
8.Polack FM, Kaufman HE, Newmark E. Keratomycosis. Medical and surgical treatment. Arch Ophthalmol. 1971 Apr;85(4):410–416.
9.Prashant G, Gullapalli N. Corneal Ulcers: diagnosis and management. Community Eye Health. 1999;12:21–23.
10.Bharathi M J, Ramakrishnan R, Vasu S, Meenakshi R, Palaniappan R. Epidemiological characteristics and laboratory diagnosis of fungal keratitis. A three-year study. Indian J Ophthalmol 2003;51:315-21.
11.Arora U, Gill P K, Chalotra S. Fungal Profile of Keratomycosis. Bombay Hospital Journal, 2009 ;51(3), 325-327.
12.Kumari N, Xess A, Shahi SK. A study of keratomycosis: our experience. Indian J Pathol Microbiol :2002 Jul;45(3):299-302.
13.Nath R, Baruah S, Saikia L, Devi B, Borthakur AK, Mahanta J. Mycotic corneal ulcers in upper Assam, Indian J Ophthalmol. 2011 Sep-Oct;59(5):367-71.
14.Tanure MA, Cohen EJ, Sudesh S, Rapuano CJ, Laibson PR. Spectrum of fungal keratitis at Wills Eye Hospital, Philadelphia, Pennsylvania. Cornea. 2000;19(3):307–312.
15.Gopinathan U, Garg P, Fernandes M, et al. The epidemiological features and laboratory results of fungal keratitis: a 10-year review at a referral eye care center in south India. Cornea. 2002; 21:555-559.
16.Gill P K, Devi P. Keratomycosis –A retrospective study from a North Indian tertiary care institute. Journal of Indian Academy of clinical medicine 2011; 12(4): 271-273.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: None
Phani Kumar Sarkar,Tapan Majumder,Umakanta Acharjee. Preoperative ibuprofen administration for the treatment of post operative periodontal surgical pain: A double-blind placebo-controlled study. J Pharm Biomed Sci 2014; 04(01): 34-40. Available at www.jpbms.info.
Copyright © 2014 Phani Kumar Sarkar,Tapan Majumder,Umakanta Acharjee.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report
Changala. Praveen*, Rampure M. Dilip, Bandi S. Gurushantappa, Chinthala. Ellareddy
Affiliation:-
General Medicine, Mamata Medical College, 4-2-161, Rotary Nagar, Khammam-507002, Andhra Pradesh, India
The name of the department(s) and institution(s) to which the work should be attributed:
Mamata Medical College, 4-2-161, Rotary Nagar, Khammam-507002, Andhra Pradesh, India
*Corresponding author:-
Dr. Changala. Praveen.
PG, General Medicine, Mamata Medical College, 4-2-161, Rotary Nagar, Khammam-507002, Andhra Pradesh, India
Core idea: Leptospirosis is an acute febrile illness which is a zoonotic disease, here we report a young man presented with fever, decreased urine output and was not responding to treatment, whose initial workup showed deranged renal and liver parameters along with thrombocytopenia and subsequently he showed positive result for leptospira microagglutination test. He improved in subsequent days after putting on Inj. Ceftriaxone. This case report shows the importance of considering Leptospirosis in every case of acute febrile illness.
Abstract:
Leptospirosis is a zoonotic disease. Clinical hallmark of leptospirosis include jaundice, renal injury, splenomegaly, fever and refractory shock. In this report we present a 25 year old male presented to emergency department with fever and kidney injury.
Case presentation:
A 25 year old male agricultural laborer presented with fever, decreased urine output. His initial workup showed deranged renal parameters and liver function tests along with leukocytosis and thrombocytopenia. A microagglutination test for leptospira showed positive result. Subsequently the patient recovered after a course of intravenous antibiotics.
Conclusion: Leptospirosis should be considered in the diagnosis of every patient who presents with acute febrile illness.
Keywords: Leptospirosis;Fever; Kidney injury.
REFERENCES
1.Joseph M.Vinetz, Harrison’s Principles Of Internal Medicine; Infectious Diseases,2012 18th Edition; Chapter 171: 1392-1396.
2.Loganathan N, Shivakumar S, RavishankarD.Co-infection of Malaria andLeptospirosis – A Study of 48 cases (Abstract).62nd Annual Conference ofAssociation of Physicians of India. 2007.Goa.
3.Edwards GA, Domm BM: Leptospirosis.Med Times 1966, 94(9):1086-1095.II PubMed Abstract.
4.VelineniS,Asuthkar S, Umabala P et al. Serological evaluation of leptospirosis in Hyderabad,Andhra Pradesh: A retrospective hospital – based study. Indian J MedMicrobiol. 2007; 25:24-27
5.Debnath C, Pal NK, Pramanik AK et al. A serological study of leptospirosis among hospitalized jaundice patients in around Kolkata.. Indian J Med Microbiol.2005; 23:68.
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India 2006,54:964-965.
7.Panaphut T, Domrongkitchaiporn S, Vibhagool A, Thinkamrop B, Susaengrat W. Ceftriaxone compared with sodium penicillin g for treatment of severe leptospirosis. Clin Infect Dis. 2003; 36:1507-13.
8.Sethi S, Sood A, Pooja, Sharma S, Sengupta C, Sharma M. Leptospirosis in northern India: A clinical and serological study. Southeast Asian J Trop Med Public Health. 2003; 34:822–5.
Article citation:
Changala. Praveen, Rampure M. Dilip, Bandi S. Gurushantappa, Chinthala. Ellareddy. A rare case report on leptospirosis in Khammam, Andhra Pradesh, India. J Pharm Biomed Sci 2014; 04(01): 45-47. Available at www.jpbms.info.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: None
Copyright © 2014 Changala. Praveen, Rampure M. Dilip, Bandi S. Gurushantappa, Chinthala. Ellareddy. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.