DocumentsDate added
Research article
Nisha Bindu Murali *, Murugadoss, R.Vidhya, S.Karthik, Sateesh
Affiliation:-
Department of Anaesthesia, Chennai Medical College and Research Center,IRUNGALUR, TRICHY-621105 Tamilnadu,India
The name of the department(s) and institution(s) to which the work should be attributed:
Chennai Medical College Hospital and Research Centre, Irungalur, Trichy-621105 Tamilnadu, India
*To whom it corresponds:-
Dr.Nisha Bindu Mural.
Senior resident,
Chennai Medical College Hospital and Research Centre, Irungalur, Trichy-621105 Tamilnadu, India
Core idea: The main purpose of this study was to find the effect of systemic hypertension in blood-brain-barrier and indirectly csf-albumin levels. And its contribution as a predictor of Stroke in the future which mostly occurs due to disruption of BBB .
Abstract:
Aim: To compare the Cerebrospinal fluid Albumin levels in normal patients and patients with systemic hypertension and hence to analyse the effect of systemic hypertension in the blood-brain-barrier. Materials and methods: The study was conducted in Chennai Medical College Hospital and Research Center, Irungalur, Trichy from May to June 2013. Hospital ethical committee approval was attained and informed written consent was also obtained from all patients participating in the study. All patients fulfilling inclusion and exclusion criteria were included in the study. Both hypertensive and normal patients undergoing sub-umbilical surgeries under subarachnoid block were included in the study after obtaining informed consent. 49 patients in each group, Group A included patients with systemic hypertension on treatment and Group B were normal patients without any co-morbid conditions. Under strict aseptic precautions lumbar puncture was done using 25 G Quincky needle and 0.5ml of CSF was collected in a sterile container and send for biochemical analysis. Patients who had traumatic tap were excluded from the study. CSF -albumin levels were calculated by immunodensitometric method and then were statistically analyzed using Chi-square test and Students–t Test.
Results: Demographic data was analyzed using Chi-Square test and found that there was not any statistical significance. While, CSF albumin levels in normal group was 137.25 ± 28.77 while it was 289.41 ± 54.05 in hypertensive group .This difference was statistically significant.
Discussion: The albumin in the blood reaches CSF through the process of diffusion1. This restricted exchange of materials between blood and perivascular and extravascular fluid is done through the blood-brain barrier in the central nervous system. Disruption of tight junctions in the BBB is the hallmark of not only many CNS pathology but also systemic diseases7. One such diseases is systemic hypertension which brings about inflammatory changes in the body including neuro-inflammation. This not only causes disruption of BBB but also increases the Para cellular permeability i.e. bends without breaking them.
This cellular change in the BBB due to hypertension may increase its permeability to albumin which in turn increases the CSF albumin levels. In our study, CSF albumin level was higher in hypertensive group compared to normal patients. This difference was statistically significant. This difference signifies the changes occurring in the BBB in hypertensive individuals which could lead to stroke in the future. Weather CSF albumin levels could be used as a predictor of stroke and its relation to years of hypertensive state are to be analyzed in our next study.
Key words: CSF Albumin levels; Blood-Brain-Barrier (BBB); Diffusion.
REFERENCES
1.W. A. Bonadio, L. Stanco, R. Bruce, D. Barry, and D. Smith,“Reference values of normal cerebrospinal Fuid composition in infants ages 0 to 8 weeks,”Pediatric Infectious Disease Journal 1992;11(7):589–591, .
2.C. E. Johanson, J. A. Duncan, P. M. Klinge, T. Brinker, E. G.Stopa, and G. D. Silverberg, “Multiplicity of cerebrospinal fluid functions: new challenges in health and disease,” Cerebrospinal Fluid Research 2008;(5): 10.
3.E. M. Carmona-Calero, H. Perez-Gonzalez, I. Martinez-Pena y Valenzuela et al., “Effect of the arterial hypertension and captopril treatment on the angiotensin II content in the subfornical organ. A study in SHR rats,” Histology and Histopathology.2005: 20(1): 135–138.
4.E. M. Carmona-Calero, I. Gonzalez-Marrero, M. Castaneyra-Martin et al., “Hypertension effects on p73 expression in the rat circumventricular organs and cerebrospinal fluid,” World Journal of Neuroscience, 2012; 2(2);68–73.
5.I. Gonzalez-Marrero, E. M. Carmona-Calero, P. Fernandez-Rodriguez et al., “Expression of certain proteins in the subfornical organ and cerebrospinal fluid of spontaneously hypertensive rats,” Histology and Histopathology.2007; 22(12):1371–1378.
6.M. R. Del Bigio, “Hydrocephalus-induced changes in the composition of cerebrospinal fluid,” Neurosurgery. 1989;25(3):416–423.
7.H. Al-Sarraf, F. Ghaaedi, and Z. Redzic, “Time course of hyperosmolar opening of the blood-brain and blood-CSF barriers in spontaneously hypertensive rats,” Journal of Vascular Research,vol. 2007;44(2): 99–109.
8.Habgood MD, Sedgwick JE, Dziegielewska KM, Saunders NR A developmentally regulated blood-cerebrospinal fluid transfer mechanism for albumin in immature rats. J Physiol.1992; Oct 456:181-92.
9.Ibrahim Gonzalez-Marrero,Leandro Castaneyra-Ruiz ,Juan M. GonzalezToledo, “ High Blood Pressure Effects on the Blood to Cerebrospinal Fluid Barrier and Cerebrospinal Fluid Protein Composition:A Two-Dimensional Electrophoresis Study in Spontaneously Hypertensive Rats” International Journal of Hypertension, Volume 2013 (2013), Article ID 164653,2013.
10.I. Gonzalez-Marrero, L. Castaneyra-Ruiz, J. M. Gonzalez-Toledo et al., “High blood pressure effects on the brain barriers and choroid plexus secretion,” Neuroscience & Medicine.2012;3(1);60–64.
11.Huber JD, Egleton RD, Davis TP Molecular physiology and pathophysiology of tight junctions in the blood-brain barrier. Trends Neurosci . 2001; 24(12):719-25.
12.D. Carnevale, G. Mascio, M. A. Ajmone-Cat et al., “Role of neuroinflammation in hypertension-induced brain amyloid pathology,” Neurobiology of Aging. 2012;33(1):205.e19–205.e29.
13.I. Gonzalez-Marrero, L. Castaneyra-Ruiz, J. M. Gonzalez-Toledo et al., “High blood pressure effects on the brain barriers and choroid plexus secretion,” Neuroscience & Medicine. 2012; 3(1):60–64.
Article citation:
Nisha Bindu Murali, Murugadoss, R.Vidhya, S.Karthik, Sateesh. A comparative study of the cerebrospinal fluid -albumin levels in normal patients and in patients with systemic hypertension. J Pharm Biomed Sci 2014; 04(02): 118-121. Available at www.jpbms.info.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Nisha Bindu Murali, Murugadoss, R.Vidhya, S.Karthik, Sateesh . This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:
Debasis Das1,Sougata Kumar Burman2,*,Prasanta Kumar Das3,Debjyoti Santra4,
Mousumi Basu5,Arnab Kumar Mondal6
Affiliation:-
1Debasis Das, Associate Professor, Community Medicine, Malda Medical College, Malda, West Bengal, India.
2Sougata Kumar Burman, Clinical Tutor, Gynae & Obstetrics, College of Medicine & J.N.M Hospital, WBUHS, Kalyani, Nadia, India.
3Prasanta Kumar Das, Associate Professor, Psychiatry Medicine, Medical College, Kolkata, India.
4Debjyoti Santra, Associate Professor, Gynae & Obstetrics, B.S. Medical College, Bankura, West Bengal, India.
5Mousumi Basu, Associate Professor, Community Medicine, I.P.G.M.E & R, Kolkata, West Bengal, India.
6Arnab Kumar Mondal, Assistant Professor, Microbiology, Malda Medical College, West Bengal, India.
The name of the department(s) and institution(s) to which the work should be attributed:
1. Community Medicine, Malda Medical College, Malda, West Bengal, India.
2. Gynae & Obstetrics, College of Medicine & J.N.M Hospital, WBUHS, Kalyani, Nadia, India.
3. Psychiatry Medicine, Medical College, Kolkata, India.
4. Gynae & Obstetrics, B.S. Medical College, Bankura, West Bengal, India.
5. Community Medicine, I.P.G.M.E& R, Kolkata, West Bengal, India.
*To whom it corresponds:-
Dr Sougata Kumar Burman.
Clinical Tutor,Dept of Obs & Gynae, College of Medicine & J N M Hospital, WBUHS, Kalyani, Nadia.
Address: - Shivam, 4 no P L Chatterjee Lane, Krishnagar, Nadia, India.
Mobile no -91-9475943811
Abstract
Though item examination has immense importance in undergraduate medical curriculum, often the objectives, basis of giving marks are poorly understood by the students. Moreover, the students may have preferences regarding methodology of the examinations. The current study is being planned to assess perception on item examination amongst undergraduate medical students. Methodology: It is a cross-sectional descriptive, observational study, conducted among 6th semester batch of M.B.B.S students of the session 2011-1012 at Institute of Post Graduate Medical Education & Research, Kolkata. All the 75 students attended in a routine lecture class were filled up a pre-designed, pre-tested anonymous questionnaire. Analysis was done in Excel workbook of Microsoft Office software package in computer. Result: Among 75 (75.76%) participant of 6th Semester students 24(32%) have idea about how teachers put marks in the item examinations. 63(84%) students know that marks of item examinations are added to the final university examinations. 59(78.67%) wanted items to be held in teacher’s chamber, more no. wanted on Monday (43(57.33%)) & Friday (19(25.33%)), 43(57.33%) prefer afternoon & 32(42.67%) favour forenoon, expected duration of holding 14.4±20.34minutes, 47(62.67%) wanted item one by one & 28(37.33%) in groups. Students also gave opinion about attempt in item examination, displaying marks, contribution of marks to university examination and perceived benefit.
Conclusion: Item examination should be planned based on perception and opinion of student to get maximum benefit.
Keywords: Item examination; Perception; M.B.B.S students; Kolkata.
REFERENCES
1.Rules & Regulations of MBBS Examination, available at www.thewbuhs.org: last assessed on 12.12.2013.
2.Thomas P, Hoon O P. Perception of Students towards the Examination Questions at the Faculty of Medicine and Health Science, University Malaysia Sarawak. Education for Health. 2008; 21(1):1-3.
3.Mohammad J et al. A Survey of Medical Students’ Perceptions of the Quality of their Medical Education upon Graduation. Annals Academy of Medicine Singapore. 2008; 37(12):1012-8.
Article citation:
Debasis Das,Sougata Kumar Burman,Prasanta Kumar Das,Debjyoti Santra,Mousumi Basu et al. A study of perception of 6th semester M.B.B.S. students of institute of post graduate medical education & research, Kolkata about item examinations. J Pharm Biomed Sci 2014; 04(02): 122-126. Available at www.jpbms.info.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Debasis Das,Sougata Kumar Burman,Prasanta Kumar Das,Debjyoti Santra,Mousumi Basu et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:
Srinivas K1,*, Syamala2, Sunitha Tadi3, Sai Krishna P4, Viswa Teja Nallam5, Santhosh Kumar P6
Affiliation:-
1Department of Pharmacology, Andhra Medical College, KGH,Visakhapatnam, Andhra Pradesh, India.
2Department of Pharmacology, Andhra Medical College, KGH,India
3Department of Pharmaceutical Biotechnology, Andhra University, Andhra Pradesh, India
4,5,6 Yalamarty College of Pharmacy, Andhra Pradesh, India
The name of the department(s) and institution(s) to which the work should be attributed:
1. Department of Pharmacology, Andhra Medical College, KGH,Visakhapatnam, Andhra Pradesh, India
2. Department of Pharmaceutical Biotechnology, Andhra University, Andhra Pradesh, India
3. Yalamarty College of Pharmacy, Andhra Pradesh, India
Authors contribution: All the authors contributed equally to this paper.
*To whom it corresponds:-
Dr. K.Srinivas,
Department of Pharmacology,
Andhra Medical College, King George Hospital, Visakhapatnam, Andhra Pradesh, India.
Contact no:- +91-9912811005+91-9912811005
Abstract:
Aim: Despite the tremendous increase in health care and research, little awareness is available about self-medication in developing countries like India. This study mainly aims to determine the prevalence of self-medication practices among students of Pharmacy and Engineering colleges in Visakhapatnam district with reasons and some suggestions.
Purpose: The main purpose of the study is to assess the knowledge, awareness and perception of self-medication practice with a view to observe the irrational usage of Non- Prescription drugs (OTC drugs) among the under graduate students.
Materials and methods: Data related to this study was collected by a pre-tested questionnaire prepared in English regarding self-medication. This was a descriptional study conducted by selecting students among students from pharmacy and engineering background. The prevalence of self-medication was reported in percentage.
Results: The prevalence of self-medication practice was found to be high among pharmacy students when compared to engineering students.
Conclusion: Over the years there has been an appreciable increase in the manufacture, sales and promotion of OTC products in India and on the other view irrational use of self-medication is also increasing among the public especially younger generation like students. Thus to prevent the adverse effects of self-medication it is essential to create awareness and educate the public about responsible self- medication and develop a nationalized list of OTC drugs.
Keywords: Over the counter drugs (OTC); prescription drugs; Self-medication.
REFERENCES
1.Responsible self-care and self-medication; A World-wide survey of consumers, 2006.
2.Mohmmad Salim T.K, Self-medication with OTC drug, Scholars Research Library. 2011; 3(1): 91-98.
3.Afolabi A.O., “Factors influencing pattern of self-medication in adult Nigerian population”, Anals of African medicine. 2008;7(3): 120-127.
4.Girma Belachew Gutema, “Self-medication practices among health science students: Case of Mekelle University” Journal of Applied Pharmaceutical Sciences. Dec-2011, ISSN-22311-3354, www.japsonline.com.
5.David.E.Webber, PhD, Director of WSMI, 3rd WSMI/ILAR/ANDI Latin American Conference, Oct2009.
6.Organisation of Pharmaceutical Producers of India, Business Monitor International 2010, www.Indianstat.com.
7.PHARMACEUTICALS, Indian Brand Equity Foundation, August 2013. www.ibef.org.
8.Supriya Guptha; “Emerging Indian OTC Markets” Apeejay Journal of Management Sciences and technology. 2013; 1(1):25-29.
9.Pran Gopal Sahah,; ‘Indian OTC Market Opportunities and Challenges” Global Research Analysis.2013; 2(10). ISSN2277-8160.
10.Sonam Jain, “Concept of Shelf Medication”. International Journal of Pharmaceutical and Biological Archives. 2011;2(3);831-836, 10th June 2011.
11.Mary F Dallman, “Chronic stress and comfort foods; Self-medication and abdominal obesity”. Brain, Behaviour and Immunity.2005; (19): 275-280. 29th Jan, 2005.
12.Rohit K Verma, Lalit Mohan, Manisha Pandey. Evaluation of self medication among professional students in North India: proper statutory drug control must be implemented. Asian J Pharm Clin Res. 2010; 3 (1): 60-64.
13.Pankaj Jain. Statistical Study on self-medication pattern in Haryana, India. Indo Global Journal of Pharmaceutical Sciences, 2012; 2(1); 21-35.
14.Suleiman Ibrahim Sharif. Evaluation of self-medication among Pharmacy students. American Journal of Pharmacology and Toxicology, 2012;7(4):135-140.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: None
Article citation:
Srinivas K,Syamala, Sunitha Tadi, Sai Krishna P, Viswa Teja Nallam, Santhosh Kumar P. Self-medication practices among students of engineering and pharmacy colleges in visakhapatnam district,Andra Pradesh,India. J Pharm Biomed Sci 2014; 04(02): 127-132. Available at www.jpbms.info
Copyright © 2014 Srinivas K,Syamala, Sunitha Tadi, Sai Krishna P, Viswa Teja Nallam, Santhosh Kumar P. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case Report
Vishwajit.Rampratap.Chaurasia1,*,Vinaykumar.S.Masamatti1,Veerendra.M.Uppin1,Lokesh D Kumar2
Affiliation:-
1Department of Conservative Dentistry & Endodontic, KLE’S Dental College, Belgaum, Karnataka, India
2Department of Periodontics, SRM Dental College, Chennai, Tamil Nadu, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Conservative Dentistry & Endodontic, KLE’S Dental College, Belgaum, Karnataka, India
Department of Periodontics, SRM Dental College, Chennai, Tamil Nadu, India
*Corresponding author:-
Dr.Vishwajit.Rampratap.Chaurasia.
Department of Conservative Dentistry & Endodontic, KLE’S Dental College, Belgaum, Karnataka, India
Abstract
With the increasing number of clinical reports of aberrant root canal morphological variations of root and root canal system, it is very important from clinician’s point of view to be aware of the variable anatomy present in a tooth. This case report describes endodontic management of four canalled and three rooted mandibular first molar.
Keywords: Anatomical variations; Radix entomolaris; three rooted mandibular molar; Endodontic treatment.
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2.Schumacher C. Endodontic treatment of a mandibular first moalr with radix entomolaris: a case report. ENDO(Lond Engl) 2008;2(4):301-304.
3.Calberson FL, Moor RJD, Deroose CA. The radix entomolaris and premolars: clinical approach in Endodntics. JOE 2007;33:58-63.
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6.De Moor RJ, Deroose CA, Calberson FL. The radix wntomolaris in mandibular first molars:an endodontic challenge. Int Endod J2004;37:789-99.
7.Rakesh Rajan R, Senthil Kumar, Mohan Kumar NS, Karunakaran JV. Elusive canals in Endodontics. J Indian Acad Dent Spec. 2011;2:37-42.
8.Gluskin AH, Peters CI, Ming Wong RD, Ruddle CJ. In: Ingle, Bakland, Baumgartner, editors. Ingle’s Endodontics. 6th ed. Netherlands: BC Decker Publishers; 2008. p. 1088-161.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Article citation: Vishwajit.Rampratap.Chaurasia, Vinaykumar.S.Masamatti, Veerendra.M.Uppin, Lokesh D Kumar. Radix enteromolaris: A case report on endodontic management of a mandibular first molar with three roots. J Pharm Biomed Sci 2014; 04(02): 133-136. Available at www.jpbms.info.
Copyright © 2014 Vishwajit Rampratap. Chaurasia, Vinaykumar S. Masamatti, Veerendra.M.Uppin, Lokesh D Kumar. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original Article
Thalquotra Mohit 1,*, Pandey Rajesh2, Singh Jasbir2, Agrawal B.K.3, Sodhi K.S.2
Affiliation:-
1P.G. student, Department of Biochemistry, MMIMSR, Mullana, Ambala, Haryana, India
2Professor, Department of Biochemistry, MMIMSR, Mullana, Ambala, Haryana, India
3Professor, Department of Medicine, MMIMSR, Mullana, Ambala, Haryana, India
The name of the department(s) and institution(s) to which the work should be attributed:
1. Department of Biochemistry, MMIMSR, Mullana, Ambala, Haryana, India
2. Department of Medicine, MMIMSR, Mullana, Ambala, Haryana, India
*To whom it corresponds:-
Mohit Thalquotra.
P.G. student, Department of Biochemistry, MMIMSR, Mullana, Ambala, Haryana,India
Mobile:+91-8221033642+91-8221033642
Abstract
Context: Chronic kidney disease (CKD) is a worldwide health problem with an increasing incidence and prevalence. Abnormalities in the structure and function of the thyroid gland and in the metabolism and plasma concentration of thyroid hormones are common in patients with CKD.
Aims: In view of variability of thyroid function tests reported in patients with CKD in previous studies, a prospective study of thyroid profile was performed in patients with CKD.
Setting and design: Prospective cross sectional study in rural setting of Haryana.
Materials and Methods: Total number of 30 patients with CKD on conservative management who were admitted to Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala during the period January 2013-January 2014 were selected in this prospective study. There were two groups (30 patients and 30 controls). Serum T3, T4 and TSH were evaluated in the subjects of both the groups and compared.
Statistical analysis: By SPSS version 12 [SPSS v12 (SPSS Inc., Chicago, IL)].
Results: 23.33% of the uremic patients kept on conservative treatment or on regular hemodialysis showed significant reduction of serum T3 and T4 in comparison to the control group. However, the level of TSH did not show significant alterations.
Conclusions: Thyroid dysfunction merits attention for the better management of CKD patients.
Keywords: Chronic kidney disease, Hemodialysis, Triiodothyronine (T3), Thyroxine (T4), Thyroid stimulating hormone (TSH).
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6.Bargman JM,SKorecki K. Chronic kidney disease. In: Longo DL, Fauci AS, Kasper DL. Harrison’s Principles of Internal Medicine, Vol. 2, 18th edn., 2011; McGraw Hill, London, pp. 2289-2313.
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12.Czernichow P, Dauzet MC, Broyer M, Rappaport R. Abnormal TSH, PRL and GH response to TSH releasing factor in chronic kidney failure. J Clin Endocrinol Metab 1976; 43: 630–637.
13.Spaulding SW, Gregerman RI. Free thyroxine in serum by equilibrium dialysis: Effects of dilution, specific ions and inhibitors of binding. J Clin Endocrinol Metab 1972;34: 974–982.
14.Zoccali C, Tripepi G, Cutrupi S, Pizzini P, Mallamaci F. Low triiodothyronine: A new facet of inflammation in end-stage kidney disease. J Am Soc Nephrol 2005;16: 2789–2795.
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Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Article citation:
Thalquotra Mohit ,Pandey Rajesh, Singh Jasbir, Agrawal B. K., Sodhi K.S. Evaluation of thyroid profile in patients with chronic kidney disease. J Pharm Biomed Sci 2014; 04(02): 143-147. Available at www.jpbms.info.
Copyright © 2014 Thalquotra Mohit, Pandey Rajesh, Singh Jasbir, Agrawal B. K., Sodhi K.S. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.