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Original article
Singla K 1,*, Sodhi KS 2, Pandey R 2, Singh J 2, Sharma P3
Affiliation:-
1 Post graduate student, Department of Biochemistry, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, India.
2Professor, Department of Biochemistry, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, India.
2Professor and Head of Department, Department of Biochemistry, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, India.
3Ph.D student, Department of Biochemistry, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, India.
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Biochemistry, Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, India.
Authors contribution: All the authors contributed equally to this paper.
*Corresponding author:-
Dr. Kusum Singla,
Post Graduate Student,
Department of Biochemistry,
Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala, India.
Email address: dockusumairan@gmail.com
Phone number: +91-9034933995.
Abstract:
Aim: The present study was undertaken to evaluate the role of cystatin C as an early biomarker of renal impairment in type 2 diabetes mellitus (T2DM) before the onset of microalbuminuria.
Materials and methods: For the present hospital based cross-sectional study, a total number of 30 normoalbuminuric, T2DM patients for more than 5 years of duration in the age group of 30 years and above were selected. Serum and urine cystatin C estimation along with calculation of estimated glomerular filtration rate (eGFR) using Chronic Kidney Disease Epidemiology (CKDEPI) and Modification of Diet in Renal Disease (MDRD) equations was performed.
Results: There was no statistical difference in the mean serum and urine cystatin C levels among males and females (p>0.05). Receiver operating characteristic (ROC) curve analysis of eGFR calculated using MDRD and CKDEPI showed the overall accuracy of 63% with sensitivity and specificity of 70% and 60% respectively. ROC analysis of urine cystatin C predicted sensitivity and specificity of 50% each.
Conclusion: Serum cystatin C estimation is a useful approach for early detection of renal impairment in T2DM. This would help in reducing the burden of chronic kidney disease (CKD) related morbidity and mortality.
Keywords: Chronic kidney disease, Cystatin C, diabetes mellitus, normoalbuminuria.
Singla K ,Sodhi KS, Pandey R,Singh J,Sharma P. The utility of serum cystatin C in the diagnosis of early diabetic nephropathy. J Pharm Biomed Sci 2014; 04(02): 84-87. Available at www.jpbms.info.
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Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: Financial grant from Indian Council of Medical Research, New Delhi.
Copyright © 2014 Singla K ,Sodhi KS,Pandey R,Singh J,Sharma P. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
HG Hamza1,*, A I Saleh1, Z K Mohammed1, H A Ngadda2
Affiliation:-
1Department of Biochemistry, Faculty of Science, University of Maiduguri. PMB 1069, Maiduguri, Nigeria
2Department of Histopathology, College of Medical Sciences, University of Maiduguri. PMB 1069, Maiduguri, Nigeria
The name of the department(s) and institution(s) to which the work should be attributed:
University of Maiduguri. PMB 1069, Maiduguri, Nigeria
*Corresponding author:
Dr HG Hamza.
Department of Biochemistry. Faculty of Science University of Maiduguri, PMB 1069 Nigeria
Abstract:
The present study aims at investigating the chemopreventive potentials of water extract of traditional medicinal plant, Detarium microcarpum against mycotoxin induced hepatic and renal damage in rats. The result of the study revealed that the mycotoxin ingested animal showed drastic weight loss, induced liver and kidney damage through elevating marker enzymes and serological variables. However, administration of 750 mg/kg body weight of the water extract of Detarium microcarpum effectively ameliorated the deviation caused by liver and kidney damage in response to mycotoxin ingestion. Pathological examination of the liver and kidney tissues also supported the biochemical findings. From the current investigation it can be concluded that supplementation of plant extract was beneficial in modulating the alteration induced in liver, kidney and serum variables of rats under the effect of mycotoxin.
Keywords: Mycotoxins; Deterium microcarpum; Chemopreventive potentials.
HG Hamza, A I Saleh, Z K Mohammed, H A Ngadda. Effect of aqueous extract of detarium microcarpum (Guill&Sperr) on mycotoxin- induced tissue damage in albino rats. J Pharm Biomed Sci 2014; 04(02): 92-99. Available at www.jpbms.info.
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Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: None
Copyright © 2014 HG Hamza, A I Saleh, Z K Mohammed, H A Ngadda. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:
Ezissi Anthony I*, Ezejindu Damian N ,Ejimofor Obioma C
Affiliation:-
Department of Anatomy, College of Health sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Anatomy, College of Health sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria.
*Corresponding author:-
Ezissi Anthony I.
Department of Anatomy, College of Health sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
Phone no: - +2348065931492+2348065931492
Abstract:
The present study is aimed at studying the histological changes that might occur at the liver as a result of consumption of yaji – a Nigerian meat sauce with complex mixtures of spices and additives. The study was prompted by the reports of cytotoxicity and excitotoxicity of some of its spices and additive constituents. Twenty wistar rats of an average weight of 215g were used for the study and were divided into 4 groups of 5 rats in each group. Group A served as the control and received 71g of normal feed (growers mash), while the experimental groups B, C, D received 71g of normal feed with 5g, 10g and 15g of yaji respectively. The animals were sacrificed after 60 days (2 months) of administration of yaji. The results showed that the consumption of yaji in small amount had no effects on the histological appearance of the liver. But a large/excessive consumption of yaji induced mild distortions of histological liver appearance which includes mild central vein hypertrophy, increased cellularity and increase in vascularity with signs of edema.
Keywords: Yaji; Body weight; Liver weight; Suya.
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Article citation:
Ezissi Anthony I,Ezejindu Damian N.,Ejimofor Obioma C. A Study on the Histological Effects of Consumption of Yaji on the Liver of Wistar Rats. J Pharm Biomed Sci 2014; 04(02): 106-112. Available at www.jpbms.info.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Ezissi Anthony I,Ezejindu Damian N.,Ejimofor Obioma C. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Olayode Olusina S1(MSc), Azubuike Chukwuemeka P1,* (PhD), Igwilo Cecilia I1 (PhD)
Affiliation:-
1Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Lagos, P.M.B.12003, Lagos, Nigeria
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Lagos, P.M.B.12003, Lagos, Nigeria
*Corresponding author:-
Azubuike Chukwuemeka P.
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Lagos, P.M.B.12003, Lagos, Nigeria
Email: cazubuike@unilag.edu.ng Phone no: +234-8033618556+234-8033618556
Abstract:
The security and purity of low density polyethylene packaged water for human consumption during their shelf life was studied.
Assessment of protective ability of thin film polyethylene packaging material of twelve brands of sachet water randomly obtained in Mushin area of Lagos state was carried out by challenging the samples with Escherichia coli, methyl violet solution and dual purpose kerosene (DPK) respectively to estimate the extent it protects the content (water) from being contaminated by microorganisms, solute and vapour.
Five of the twelve brands (41.7%) were contaminated with microorganisms most likely during production. A brand was contaminated with Escherichia coli while another one with Schistosoma spp. Three other brands were contaminated with Shigella spp. Microbiological challenge test result indicated presence of challenge organism in one brand within two weeks and in three brands at fourth week. At third day of exposure to DPK, eight brands had smell and tastes of DPK, all the brands were permeated by DPK at seventh day of exposure. Only one brand was penetrated by dye (methyl violet) at first week of immersion and five other brands at fourth week of immersion.
The study shows the need for the improvement of the quality of the packaging materials for sachet water and the also the need to reduce its shelf life.
Keywords: Challenge test, Escherichia coli, Low Density Polyethylene and packaged water.
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Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Source of support: None.
Article citation:
Olayode Olusina S,Azubuike Chukwuemeka P,Igwilo Cecilia I.Assessment of the effects of low density polyethylene packaging materials on the content of sachet water marketed in Mushin Local Government Area, Lagos, Nigeria. J Pharm Biomed Sci. 2014; 04(02):100-105. Available at www.jpbms.info.
Copyright © 2014Olayode Olusina S,Azubuike Chukwuemeka P,Igwilo Cecilia I.This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original Article
Thalquotra Mohit 1,*, Pandey Rajesh2, Singh Jasbir2, Agrawal B.K.3, Sodhi K.S.2
Affiliation:-
1P.G. student, Department of Biochemistry, MMIMSR, Mullana, Ambala, Haryana, India
2Professor, Department of Biochemistry, MMIMSR, Mullana, Ambala, Haryana, India
3Professor, Department of Medicine, MMIMSR, Mullana, Ambala, Haryana, India
The name of the department(s) and institution(s) to which the work should be attributed:
1. Department of Biochemistry, MMIMSR, Mullana, Ambala, Haryana, India
2. Department of Medicine, MMIMSR, Mullana, Ambala, Haryana, India
*To whom it corresponds:-
Mohit Thalquotra.
P.G. student, Department of Biochemistry, MMIMSR, Mullana, Ambala, Haryana,India
Mobile:+91-8221033642+91-8221033642
Abstract
Context: Chronic kidney disease (CKD) is a worldwide health problem with an increasing incidence and prevalence. Abnormalities in the structure and function of the thyroid gland and in the metabolism and plasma concentration of thyroid hormones are common in patients with CKD.
Aims: In view of variability of thyroid function tests reported in patients with CKD in previous studies, a prospective study of thyroid profile was performed in patients with CKD.
Setting and design: Prospective cross sectional study in rural setting of Haryana.
Materials and Methods: Total number of 30 patients with CKD on conservative management who were admitted to Maharishi Markandeshwar Institute of Medical Sciences and Research, Mullana, Ambala during the period January 2013-January 2014 were selected in this prospective study. There were two groups (30 patients and 30 controls). Serum T3, T4 and TSH were evaluated in the subjects of both the groups and compared.
Statistical analysis: By SPSS version 12 [SPSS v12 (SPSS Inc., Chicago, IL)].
Results: 23.33% of the uremic patients kept on conservative treatment or on regular hemodialysis showed significant reduction of serum T3 and T4 in comparison to the control group. However, the level of TSH did not show significant alterations.
Conclusions: Thyroid dysfunction merits attention for the better management of CKD patients.
Keywords: Chronic kidney disease, Hemodialysis, Triiodothyronine (T3), Thyroxine (T4), Thyroid stimulating hormone (TSH).
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Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Article citation:
Thalquotra Mohit ,Pandey Rajesh, Singh Jasbir, Agrawal B. K., Sodhi K.S. Evaluation of thyroid profile in patients with chronic kidney disease. J Pharm Biomed Sci 2014; 04(02): 143-147. Available at www.jpbms.info.
Copyright © 2014 Thalquotra Mohit, Pandey Rajesh, Singh Jasbir, Agrawal B. K., Sodhi K.S. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.