DocumentsDate added
Review Article:
Fuyong Jiao1,*, Xiangyang Guo2, Xianpeng Yan3, Li Wei4
Affiliation:-
1Professor, Department of Pediatrics the Shaanxi Provincial People's Hospital of Xi,an Jiaotong Univeristy, Xi,an China
2Assistant Professor, Section of pediatric Neurology, Dept. of Pediatrics the Shaanxi Provincial People's Hospital of Xi,an Jiaotong Univeristy, Xi,an China
3Department of Pediatrics the Shaanxi Provincial People's Hospital of Xi,an Jiaotong Univeristy, Xi,an China
4Department of Pediatrics the Shaanxi Provincial People's Hospital of Xi,an Jiaotong Univeristy, Xi,an China
The name of the department(s) and institution(s) to which the work should be attributed:
Section of pediatric Neurology, Department of Pediatrics, 3rd affiliated hospital, Xi,an Jiaotong University, Xi,an, China
*To whom it corresponds:
Fuyong Jiao.
Prof. and Head
Dept. of Pediatrics the Shaanxi Provincial People's Hospital of Xi,an Jiaotong Univeristy, Xi,an China
President of China Society for Prevention of Child Abuse and Neglect
Executive councilor of International Society for Prevention of Child Abuse and Neglect ( ISPCAN )
Phone: ( 86) 029 -85368194, 85521331ext2361(O)
Mail Add: No.256 youyi West Rd. Xi,an 710068 China
jiaofy@yeah.net
Abstract:
Tourette syndrome is an inherited neuropsychiatric disorder with onset in childhood, characterized by multiple motor tics and at least one vocal tic. As the diagnostic threshold and assessment methodology have moved towards recognition of milder cases, the prevalence increase gradually. Males are more likely than females to express tics. The exact cause of TS is unknown, but environmental insults interact with genetic or other risk factors to engender the specificity suggested by neuropathological findings. The treatment of TS focuses on identifying and helping the individual manage the most troubling or impairing symptoms. Knowledge, education and understanding are uppermost in management plans. New studies on large prospective cohorts of patients of different age and the identification of reliable biomarkers or environmental insults are needed.
Keywords: Tourette syndrome; environmental insults; gene; supportive environment.
REFERENCES
1.Singer HS. Tourette syndrome and other tic disorders. Handb Clin Neurol. 2011;100:641–57.
2.Robertson MM.Gilles de la Tourette syndrome: the complexities of phenotype and treatment. Br J Hosp Med . 2011;72(2):100–7.
3.Leckman JF, Zhang H, Vitale A, et al. Course of tic severity in Tourette syndrome: the first two decades. Pediatrics. 1998;102 (1 Pt 1):14–19.
4.Du JC, Chiu TF, Lee KM, et al. Tourette syndrome in children: an updated review. Pediatr Neonatol. 2010 Oct;51(5):255–64.
5.Swain JE, Scahill L, Lombroso PJ, et al. Tourette syndrome and tic disorders: a decade of progress. J Am Acad Child Adolesc Psychiatry. 2007;46(8):947–68.
6.Scahill L, Williams S, Schwab-Stone M, et al. Disruptive behavior problems in a community sample of children with tic disorders. Adv Neurol. 2006;99:184–90.
7.Bloch MH, Leckman JF. Clinical course of Tourette syndrome. J Psychosom Res. 2009 Dec;67(6):497–501.
8.Bloch M, State M, Pittenger C. Recent advances in Tourette syndrome. Curr. Opin. Neurol. 2011 Apr;24(2):119–25.
9.Lombroso PJ, Scahill L. Tourette syndrome and obsessive–compulsive disorder. Brain Dev. 2008 Apr;30(4):231–37.
10.Robertson MM. The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 1: the epidemiological and prevalence studies. J Psychosom Res. 2008 Nov;65(5):461–72.
11.Cohen DJ, Jankovic J, Goetz CG, (eds). Advances in neurology, Tourette syn58drome. Lippincott, Williams & Wilkins, Philadelphia, PA. 2001.
12.Abuzzahab FE, Anderson FO. Gilles de la TS syndrome; international registry. Minnesota Medicine. 1973 Jun;56(6):492–96.
13. Scahill L. Epidemiology of Tic Disorders. Medical Letter: 2004 Retrospective Summary of TS Literature. Tourette Syndrome Association. Thefirst page (PDF), is available at archive.org without subscription. Retrieved on June 11, 2007.
14.Zohar AH, Apter A, King RA et al. Epidemiological studies. In Leckman JF, Cohen DJ. TS Syndrome—Tics, Obsessions, Compulsions: Developmental Psychopathology and Clinical Care. John Wiley & Sons, Inc., New York. 1999:177–92.
15.Coffey BJ, Park KS. Behavioral and emotional aspects of Tourette syndrome. Neurol Clin. 1997 May;15(2):277–89.
16.Zinner SH.Tourette disorder. Pediatr Rev. 2000;21(11):372–83.
17.Hawley, JS. Tourette Syndrome. eMedicine (June 23, 2008). Retrieved on August 10, 2009.
18.Stern JS, Burza S, Robertson MM. Gilles de la TS syndrome and its impact in the UK. Postgraduate Medicine Journal. 2005 Jan;81(951):12–19.
19.Leckman JF. TS syndrome. Lancet. 2002 Nov 16;360(9345):1577–86.
20.Denckla MB. Attention-deficit hyperactivity disorder (ADHD) comorbidity: a case for "pure" Tourette syndrome?. J Child Neurol. 2006 Aug;21(8):701–3.
21.Denckla MB. Attention deficit hyperactivity disorder: the childhood co-morbidity that most influences the disability burden in Tourette syndrome. Adv Neurol. 2006;99:17–21.
22.Robertson MM. The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 2: tentative explanations for differing prevalence figures in GTS, including the possible effects of psychopathology, aetiology, cultural differences, and differing phenotypes. J Psychosom Res. 2008 Nov;65(5):473–86.
23.Walkup, JT, Mink, JW, Hollenback, PJ, (eds). Advances in Neurology, Tourette syndrome. Lippincott, Williams & Wilkins, Philadelphia, PA. 2006;99:xv.
24.O'Rourke JA, Scharf JM, Yu D, et al. The genetics of Tourette syndrome: A review. J Psychosom Res. 2009 Dec;67(6):533–545
25.Mejia NI, Jankovic J. Secondary tics and tourettism. Rev Bras Psiquiatr. 2005;27(1):11–17.
26.van de Wetering BJ, Heutink P. The genetics of the Gilles de la Tourette syndrome: a review. J Lab Clin Med. 1993 May;121(5):638–45.
27.Tourette Syndrome: Frequently Asked Questions. Tourette Syndrome Association. Retrieved on December 29, 2011.
28. Black, KJ. Tourette Syndrome and Other Tic Disorders. eMedicine (March 22, 2006). Retrieved on June 27, 2006.
29.Swerdlow, NR. Tourette Syndrome: Current Controversies and the Battlefield Landscape. Curr Neurol Neurosci Rep. 2005, 5:329–31.
30.Pauls DL, Towbin KE, Leckman JF, et al. Gilles de la TS syndrome and obsessive–compulsive disorder. Evidence supporting a genetic relationship. Arch Gen Psychiatry. 1986 Dec;43(12):1180–82.
31.Miguel EC, do Rosario-Campos MC, Shavitt RG, et al. The tic-related obsessive–compulsive disorder phenotype and treatment implications. Adv Neurol. 2001;85:43–55.
32.Peterson BS, Cohen DJ. The treatment of TS Syndrome: multimodal, developmental intervention. J Clin Psychiatry. 1998;59 Suppl 1:62–72.
33.Harris K, Singer HS. Tic disorders: neural circuits, neurochemistry, and neuroimmunology. J Child Neurol. 2006;21(8):678-89.
34.Leckman JF, Bloch MH, Smith ME, et al. Neurobiological substrates of Tourette's disorder, J Child Adolesc Psychopharmacol. 2010 ;20(4):237-47
35.Mazzone L,Yu S,Blair C,et al. An FMRI study of frontostriatal circuits during the inhibition of eye blinking in persons with Tourette syndrome. Am J Psychiatry.2010,167(3 ):341-9.
36.Albin RL, Young AB, Penney JB. The functional anatomy of basal ganglia disorders. Trends Neurosci. 1989,12(10):366-375.
37.Mink J. W. The basal ganglia and involuntary movements:Impaired inhibition of competing motor patterns. Arch. Neurol. 2003; 60,1365–1368.
38.Mink J.W. Basal ganglia dysfunction in Tourette’s syndrome:a new hypothesis. Pediatr. Neurol. 2001;25, 190–198
39.Albin RL, Mink JW. Recent advances in Tourette syndrome research. Trends Neurosci 2006; 29:175–182.
40.Stern E, Silbersweig DA, Chee KY, et al. A functional neuroanatomy of tics in Tourette syndrome. Arch Gen Psychiatry 2000; 57:741–748.
41.Peterson BS, Skudlarski P, Anderson AW, et al. A functional magnetic resonance imaging study of tic suppression in Tourette syndrome. Arch Gen Psychiatry 1998; 55:326–333.
42.Kalanithi PS, Zheng W, Kataoka Y, et al. Altered parvalbumin-positive neuron distribution in basal ganglia of individuals with Tourette syndrome. Proc Natl Acad Sci U S A 2005; 102:13307–13312.
43.Kataoka Y, Kalanithi PS, Grantz H, et al. Decreased number of parvalbumin and cholinergic interneurons in the striatum of individuals with Tourette syndrome. J Comp Neurol 2010; 518:277–291.
44.Leckman JF. Tourette’s syndrome. Lancet 2002; 360:1577–1586.
45.Whitaker AH, Van Rossem R, Feldman JF, et al. Psychiatric outcomes in low birth-weight children at age 6 years: relation to neonatal cranial ultrasound abnormalities. Arch Gen Psychiatry 1997; 54:847–856.
46.Mathews CA, Bimson B, Lowe TL, et al. Association between maternal smoking and increased symptom severity in Tourette’s syndrome. Am J Psychiatry 2006; 163:1066–1073.
47.Fagel DM, Ganat Y, Cheng E, et al. Fgfr1 is required for cortical regeneration and repair after perinatal hypoxia. J Neurosci 2009; 29:1202–1211.
48.Singer HS. Tourette’s syndrome: from behaviour to biology. Lancet Neurol 2005; 4:149–159.
49.Threlfell S, Clements MA, Khodai T, et al. Striatal muscarinic receptors promote activity dependence of dopamine transmission via distinct receptor subtypes on cholinergic interneurons in ventral versus dorsal striatum. J Neurosci 2010; 30:3398–3408.
50.Morris G, Arkadir D, Nevet A, et al. Coincident but distinct messages of midbrain dopamine and striatal tonically active neurons. Neuron 2004; 43:133–143.
51.Price RA, Kidd KK, Cohen DJ, et al. A twin study of Tourette syndrome. Arch Gen Psychiatry 1985; 42:815–820.
52.Walkup JT, LaBuda MC, Singer HS, et al. Family study and segregation analysis of Tourette syndrome: evidence for a mixed model of inheritance. Am J Hum Genet 1996; 59:684–693.
53.Kurlan R, Eapen V, Stern J, et al. Bilineal transmission in Tourette’s syndrome families. Neurology 1994; 44:2336–2342.
54.Hasstedt SJ, Leppert M, Filloux F, et al. Intermediate inheritance of Tourette syndrome, assuming assortative mating. Am J HumGenet 1995; 57:682–689.
55.Sundaram SK, Huq AM, Wilson BJ, Chugani HT. Tourette syndrome is associated with recurrent exonic copy number variants. Neurology 2010; 74:1583–1590.
56.Verkerk AJ, Mathews CA, Joosse M, et al. CNTNAP2 is disrupted in a family with Gilles de la Tourette syndrome and obsessive compulsive disorder. Genomics 2003; 82:1–9.
57.Lawson-Yuen A, Saldivar JS, Sommer S, Picker J. Familial deletion within NLGN4 associated with autism and Tourette syndrome. Eur J Hum Genet 2008; 16:614–618.
58.Ercan-Sencicek AG, Stillman AA, Ghosh AK, et al. L-histidine decarboxylase and Tourette’s syndrome. N Engl J Med 2010; 362:1901–1908.60 Leckman JF, Bloch MH, King RA, et al."Phenomenology of tics and natural history of tic disorders. Adv Neurol. 2006;99:1–16.
59.Leckman JF, Bloch MH, King RA, et al."Phenomenology of tics and natural history of tic disorders. Adv Neurol. 2006;99:1–16.61
60.Bagheri MM, Kerbeshian J, Burd L. Recognition and management of TS syndrome and tic disorders. American Family Physician. 1999; 59:2263–74.
61.The Tourette Syndrome Classification Study Group. Definitions and classification of tic disorders. Arch Neurol. 1993 Oct;50(10):1013–16.
62.Dure LS 4th, DeWolfe J. Treatment of tics. Adv Neurol. 2006;99:191–96.
63.Malone DA Jr, Pandya MM. Behavioral neurosurgery. Adv Neurol. 2006;99:241–47.
64.Jankovic J. Differential diagnosis and etiology of tics. Adv Neurol. 2001;85:15–29.
65.Cohen AJ, Leckman JF. Sensory phenomena associated with Gilles de la TS syndrome. J Clin Psychiatry. 1992 Sep; 53(9):319–23.
66.Prado HS, Rosário MC, Lee J, et al. Sensory phenomena in obsessive–compulsive disorder and tic disorders: a review of the literature. CNS Spectr. 2008;13(5):425–32.
67.Bliss J. Sensory experiences of Gilles de la Tourette syndrome.Arch Gen Psychiatry. 1980 Dec; 37(12):1343–47.
68.Kwak C, Dat Vuong K, Jankovic J. Premonitory sensory phenomenon in TS syndrome.Mov Disord. 2003 Dec;18(12):1530–33.
69.Scahill LD, Leckman JF, Marek KL. Sensory phenomena in TS syndrome. Adv Neurol.1995; 65:273–80.
70.Miguel EC, do Rosario-Campos MC, Prado HS, et al. Sensory phenomena in obsessive–compulsive disorder and TS disorder. J Clin Psychiatry. 2000 Feb;61(2):150–56.
71.Rapin I. Autism spectrum disorders: relevance to Tourette syndrome. Adv Neurol. 2001;85:89–101.
72.Spencer T, Biederman J, Harding M, et al. Disentangling the overlap between TS disorder and ADHD". J Child Psychol Psychiatry. 1998 Oct;39(7):1037–44.
73.Summary of Practice: Relevant changes to DSM-IV-TR. American Psychiatric Association. Retrieved from May 11, 2008
74.Scahill L, Erenberg G, Berlin CM Jr, et al. Tourette Syndrome Association Medical Advisory Board: Practice Committee. Contemporary assessment and pharmacotherapy of Tourette syndrome. NeuroRx. 2006 Apr;3(2):192–206.
75.Ringman JM, Jankovic J. Occurrence of tics in Asperger's syndrome and autistic disorder. J Child Neurol. 2000 Jun;15(6):394–400.
76.Jankovic J, Mejia NI. Tics associated with other disorders. Adv Neurol. 2006;99:61–68.
77.Freeman, RD. TS Syndrome: minimizing confusion. Roger Freeman, MD, blog. Retrieved on February 8, 2006.
78.Robertson MM. Tourette syndrome, associated conditions and the complexities of treatment. Brain. 2000;123 Pt 3:425–62.
79.Schapiro NA. Dude, you don't have TS: TS syndrome, beyond the tics. Pediatr Nurs. 2002; 28(3):243–46, 249–53.
80.Coffey BJ, Shechter RL. Treatment of co-morbid obsessive compulsive disorder, mood, and anxiety disorders. Adv Neurol. 2006; 99:208–21.
81.Himle MB, Woods DW, Piacentini JC. et al. Brief review of habit reversal training for tourette syndrome. J Child Neurol. 2006 Aug;21(8):719–25.
82.Woods DW, Himle MB, Conelea CA. Behavior therapy: other interventions for tic disorders. Adv Neurol. 2006; 99:234–40.
83.Pappert EJ, Goetz CG, Louis ED, et al. Objective assessments of longitudinal outcome in Gilles de la TS syndrome. Neurology. 2003 Oct 14;61(7):936–40.
84.Singer HS. TS syndrome: from behaviour to biology. Lancet Neurol. 2005 Mar;4(3):149–59.
85.Burd L, Kerbeshian PJ, Barth A, et al. Long-term follow-up of an epidemiologically defined cohort of patients with Tourette syndrome. J Child Neurol. 2001;16(6):431–37.
86.Leckman JF, Cohen DJ. TS Syndrome—Tics, Obsessions, Compulsions: Developmental Psychopathology and Clinical Care. John Wiley & Sons, Inc., New York. 1999:37.
87.Cohen DJ, Leckman JF, Pauls D. Neuropsychiatric disorders of childhood: TS syndrome as a model. Acta Paediatr Suppl 1997,422; 106–11.
88.Fuyong Jiao ,Xianpeng Yan ,Ru Xue, Jing Lin,Tourette treatment progress .China Medicine and Pharmacy. 2012;2 (23):52-54.
89.Fuyong Jiao,Li Wei,Jing Lin et al. Clincal assessment of treatment of Tourette Syndrome in Chinese children with Clonidine transdermal patch , Journal of the Polish society of Child Neurology ,2011;20 (40):15-19, 20.
90.Ya-song Du, Hua-fang Li, Alasdair Vance, Fu-yong Jiao et al .Randomized double-blind multicentre placebo-controlled clinical trial of the Clonidine adhesive patch for the treatment of tic disorders, Australian and New Zealand Journal of Psychiatry 2008; 42:807-813.
Article citation:
Jiao Fuyong,Guo Xiangyang,Yan Xianpeng,Wei Li. Update situation of Tourette syndrome. J Pharm Biomed Sci 2014; 04(04): 327-337. Available at www.jpbms.info.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Jiao Fuyong,Guo Xiangyang,Yan Xianpeng,Wei Li. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.