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Research article
Atefeh Seghatoleslam., PhD1, 2*,Narges Mashkour., MSc2,Mehdi Namavari., PhD3,Bentolhoda Azarmehr., MSc2, Mahmood Nejabat., MD4
Affiliation:-
1Histomorphometry & Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, P.O Box 71348 45794, Shiraz, Iran
3Razi Vaccine & Serum Research Institute, P.O Box 71955-367, Shiraz, Iran
4Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, P.O Box 71348 45794, Shiraz, Iran
The name of the department(s) and institution(s) to which the work should be attributed:
1. Histomorphometry & Stereology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
2. Department of Biochemistry, School of Medicine, Shiraz University of Medical Sciences, P.O Box 71348 45794, Shiraz, Iran
3. Razi Vaccine & Serum Research Institute, P.O Box 71955-367, Shiraz, Iran
4. Research Center for Traditional Medicine and History of Medicine, Shiraz University of Medical Sciences, P.O Box 71348 45794, Shiraz, Iran
Address reprint requests to
Atefeh Seghatoleslam PhD.
Department of Biochemistry
School of Medicine,
Shiraz University of Medical Sciences,
P.O Box 71348 45794, Shiraz, Iran
J Pharm Biomed Sci 2014;04(06):552-558.
Article citation:
Seghatoleslam A, Mashkour N, Namavari M, Azarmehr B, Nejabat M. The potential effects of herbal distillates with hot and cold temperament on cell metabolic activity And Growth: A Preliminary in Vitro Study. J Pharm Biomed Sci 2014;04(06):552-558. Available at www.jpbms.info
ABSTRACT
Background: Traditional Medicine has nowadays become an object of interest as it helped many people to get released of their health problems. In the south-centre of Iran, the city of Shiraz, the distillates of different plants or herbs with hot/warm and cold nature are being used traditionally as beverages for balancing human body temperament.
Objectives: To study the common beliefs about warm/hot and cold temperament at the cellular level, the effects of five plant distillates on cell metabolic activity and/or growth of two mammalian cell lines, MDCK and Vero cells, were surveyed.
Methods: For this purpose, MTT assay and doubling time determination on the cells were applied. The changes in metabolic activity and/or growth of treated cells were then compared with the control untreated cells.
Results: Data revealed the enhancement of cell metabolic activity and/or growth rate up to two times by hot-tempered distillates when compared to controls. The adverse effects were observed for cold-tempered distillates by the reduction in cell metabolic activity and/or growth up to 50%.
Conclusions: Our findings as the first in vitro study of the effect of different temperaments at cellular level could scientifically explain their properties according to common beliefs. This study could also open a new insight towards the application of hot distillates of special plants/herbs in the industrial manufacturing of cell culture media based on biological products.
KEYWORDS: Traditional Iranian Medicine (TIM); Herbal Distillates; Hot- and Cold- Temperament/Nature; MTT Assay; Doubling Time Assay.
REFERENCES
1.Behrouz R, Ourmazdi M, Reza’i P. Iran the cradle of science. 1st ed: Iran Almanac; 1993. p. 115-8.
2.Meyerhof M. Science and medicine. In: Arnold STW, Guillaume A, editors. The legacy of Islam. London: Oxford University Press; 1968.
3.Gorji A, Khaleghi Ghadiri M. History of epilepsy in Medieval Iranian medicine. Neuroscience & Biobehavioral Reviews. 2001;25(5):455-61.
4.Becka J. The father of medicine, Avicenna, in our science and culture. Abu Ali ibn Sina (980-1037)]. Casopís lékar̆ů c̆eských. 1980;119(1):17.
5.Sajadi MM, Mansouri D, Sajadi M-RM. Ibn Sina and the clinical trial. Annals of Internal Medicine. 2009;150(9):640-3.
6.Huff TE. The rise of early modern science: Islam, China and the West: Cambridge University Press; 2003.
7.Lutz PL, Boutilier RG. The rise of experimental biology: an illustrated history: Humana Press; 2002.
8.Tabei S, Masoumpour M, Asadollahi R, Sobhani N, Sajjadi S. Avicenna's viewpoints on Fever and it's comparison to modern medicine. Medical Journal of the Islamic Republic of Iran (MJIRI). 2004;18(1):79-84.
9.El Diwani R. Islamic contributions to the West. Lake Superior State University. 2005:9.
10.Tibi S. Al-Razi and Islamic medicine in the 9th Century. JRSM. 2006;99(4):206-7.
11.Acharya D. Indigenous herbal medicines: Tribal formulations and traditional herbal practices: Aavishkar Publishers; 2008.
12.Mikaili P, Shayegh J, Asghari MH, Sarahroodi S, Sharifi M. Currently used traditional phytomedicines with hot nature in Iran. Annals of Biological Research. 2011;2(5):56-68.
13.Mikaili P, Shayegh J, Asghari MH, Sarahroodi S, Sharifi M. Common Iranian traditional herbal medicine with cold nature used as infusion. Journal of American Science. 2011;7(9):87-91.
14.Amirghofran Z. Medicinal plants as immunosuppressive agents in traditional Iranian medicine. Iran J Immunol. 2010;7(2):65-73.
15.Shahabi S, Hassan ZM, Mahdavi M, Dezfouli M, Rahvar MT, Naseri M, et al. Hot and cold natures and some parameters of neuroendocrine and immune systems in traditional Iranian medicine: A preliminary study. The Journal of Alternative and Complementary Medicine. 2008;14(2):147-56.
16.Ardekani MRS, Rahimi R, Javadi B, Abdi L, Khanavi M. Relationship between temperaments of medicinal plants and their major chemical compounds. Journal of Traditional Chinese Medicine. 2011;31(1):27-31.
17.Malek S. An investigation on traditional and industrial production of rose water from Rosa damascena in Kashan area. Proceeding of the first festival of rose and rose water. 2001;26.
18.Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol methods. 1983;65(1-2):55-63.
19.Roth V. Doubling Time 2006 [cited 2012 June]. Available from: http://www.doubling-time.com/compute.php.
20.Some traditional herbal medicines, some mycotoxins, naphthalene and styrene: IARC Monographs, Volume 82, World Health Organization press; 2002.
21.Saxena M. Herbal formulation for wound healing. US Patent 20,100,178,367; 2010.
22.Foster S. Licorice - Glycyrrhiza 2009 [cited 2012 March]. Available from: http://www.stevenfoster.com/education/monograph/licorice.html.
23.Hair loss supplements. Licorice home remedies: expectorant, hair loss and hypertension [cited 2012 March]. Available from: http://www.hairlosssupplements.com/hair-care-herbal-supplements/licorice-herbal-supplement.shtml
24.Herbs at a Glance: Lavender: National Center for Complementary and Alternative Medicine (NCCAM). March 2007 [cited 2012]. 9000 Rockville Pike, Bethesda, Maryland]. Available from: http://nccam.nih.gov/health/lavender/ataglance.htm?nav=gsa.
25.Essential Oil Profile, Lavender [cited 2012 March]. Available from: http://wholesale.frontiercoop.com/AromaTraining/profiles/lavender2.html.
26.Howard M. Traditional Folk Remedies: A Comprehensive Herbal by Howard: Century; 1987.
27.Flamm G, Glinsmann W, Kritchevsky D, Prosky L, Roberfroid M. Inulin and oligofructose as dietary fiber: a review of the evidence. Critical Reviews in Food Science and Nutrition. 2001;41(5):353-62.
28.Hughes R, Rowland I. Stimulation of apoptosis by two prebiotic chicory fructans in the rat colon. Carcinogenesis. 2001;22(1):43-7.
29.Kluwer W. Chicory 2009 [cited 2012 March]. Available from: http://www.drugs.com/npp/chicory.html.
30.Hobbs C. Hawthorn For The Heart [cited 2012 March]. Available from: http://www.healthy.net/scr/article.aspx?Id=898.
31.Pittler MH, Schmidt K, Ernst E. Hawthorn extract for treating chronic heart failure: meta-analysis of randomized trials. American Journal of Medicine. 2003;114(8):665-74.
32.Kumar D, Arya V, Bhat ZA, Khan NA, Prasad DN. The genus Crataegus: chemical and pharmacological perspectives. Revista Brasileira de Farmacognosia. 2012;22:1187-200.
33.Hadjimitova V, Traykov T, Hadjieva P, Traldi P. Free Radical Scavenging Properties and LC/MS Analysis of Bulgarian Crataegus Oxycantha Fruits Ethanol Extract. The Internet Journal of Alternative Medicine. 2008;6(2).
Copyright © 2014 Seghatoleslam A, Mashkour N, Namavari M, Azarmehr B, Nejabat M. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Source of support: This study was financially supported by the office of the Vice Chancellor for Research and Technology of Shiraz University of Medical Sciences, grant no.90-01-64-3548.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclosure forms provided by the authors are available with the full text of this article at jpbms.info
Zhijian Zhang1, Qingqing Bao1,2, Guoshuai Feng1, Sha Li3,*, Jie Jiang4*
Affiliation:-
1College of Pharmacy, Jinan University, Guangzhou 510632, China
2The Children’s Hospital Zhejiang University School of Medicine, Hangzhou 310006, China
3Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China
4Dongguan Institute of Jinan University, Dongguan 523808, China
The name of the department(s) and institution(s) to which the work should be attributed:
1.College of Pharmacy, Jinan University, Guangzhou 510632, China
2.The Children’s Hospital Zhejiang University School of Medicine, Hangzhou 310006, China
3.Department of Pharmaceutics, College of Pharmacy, Jinan University, Guangzhou 510632, China
4.Dongguan Institute of Jinan University, Dongguan 523808, China
Authors contributions:
Zhijian Zhang, Qingqing Bao and Guoshuai Feng contributed equally to this work.
Address reprint requests to
Zhijian Zhang.
College of Pharmacy, Jinan University, Guangzhou 510632, China
J Pharm Biomed Sci 2014;04(06):536-544.
Article citation:
Zhang Z, Bao Q, Feng G, Li S, Jiang J. The post-treatment action of Chinonin on MPTP-induced mice model of parkinson’s disease. J Pharm Biomed Sci 2014; 04(06):536-544. Available at www.jpbms.info
ABSTRACT
To evaluate the protective effects of chinonin on Parkinson’s Disease (PD), we investigated its inhibition in MPP+-induced toxicity in SH-SY5Y cells and its post-treatment action on 1-methyl-4-phenyl- 1,2,3,6-tetrahydropyridine (MPTP)-induced C57BL/6 mice. Moreover, the possible mechanisms of action were elucidated. Male C57BL/6 mice were treated with MPTP (30 mg/kg, i.p.) once daily for 7 days and subsequently followed by chinonin (10, 20, 40 mg/kg, i.p.) injection twice a day from the 8th day for 14 days. On the 7th and 21st day, the mice were subjected to Open Field test and Cat Walk test. The impact of chinonin on tyrosine hydroxylase immunoreactivity of the substantia nigra was assessed. Meanwhile, the levels of dopamine (DA) and its metabolites, glutathione (GSH), superoxide dismutase (SOD) and malonyldialdehyde (MDA) in striatum were determined. The Results indicated that chinonin had neuroprotective effect on MPP+-induced SH-SY5Y cells cytotoxicity. In MPTP-induced PD-like C57BL/6 mice model, chinonin significantly prevented dopaminergic neuronal degeneration, dopamine depletion and oxidative stress at 20 mg/kg although the obvious improvement was not observed in MPTP-induced behavioral deficits. To conclude, the potent post-treatment action of chinonin on PD-like mice model was mainly derived from its neuroprotective and anti-oxidative activity.
KEYWORDS: Chinonin; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP); Post-treatment action; Neuroprotective effect; Anti-oxidative activity.
Source of support:
This research was supported by the Guangdong province science and technology project (2010B011000006) to Sha Li.
Science and Technology Support Project of the Ministry of Science and Technology (2013BAH08F04, China).
Guangzhou Science and Technology Project(7411851111945, China).
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research.
All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclosure forms provided by the authors are available with the full text of this article at jpbms.info
Research article:
Pawan Kumar Goel.,MD1,*,Vinod Kumwar Bhardwaj.,MD,2,Ashok Kumar.,MS,3,
Naresh Kumwar.,MD,4,Siba Das Dutta.,MD5
Affiliation:-
1Department of Community Medicine, SHKM Govt Medical College Nalhar Mewat,India.
2Department of Pharmacology, SHKM Govt Medical College Nalhar Mewat ,India
3Department of ENT,SHKM Govt Medical College Nalhar Mewat,India
4,5Department of Physiology, SHKM Govt Medical College Nalhar Mewat, India
The name of the department(s) and institution(s) to which the work should be attributed:
SHKM Govt Medical College Nalhar Mewat, India
Address reprint requests to
Dr. Pawan Kumar Goel
Associate Professor, Department of Community Medicine,
SHKM Govt. Medical College, Nalhar, District Mewat, Haryana, India
J Pharm Biomed Sci 2014;04(06):563-565.
Article citation:
Goel PK,Bhardwaj VK,Kumar A,Kumar N,Das SD. Psycho-social correlates of KAP- gap of contraceptive usage amongst slum dwellers. J Pharm Biomed Sci 2014;04(05):563-565. Available at www.jpbms.info
ABSTRACT
Background: India, despite of being the first country to start National Family Planning programme (1952) is expected to become the most populous country by surpassing China by the year 2050.The concept of “ KAP gap” was first explored in 1960’s.
Aims: To find out psycho-social reasons of non-usage of contraceptives. Material &Methods: A cross sectional study was carried out amongst 716 eligible couples residing in slums of Khalapar, (Muzaffarnagar).
Results: Twenty nine percent of couples were not using contraceptives due to psychosocial reasons. The majority (62.5%) of women were aged less than 30 years. The commonest reason was husband not interested (9.8%); maximum number of husbands were educated junior high school and above (42.9%). While the maximum number of women who were not interested were illiterate (52.9%). The majority (60.7%) of couples belong to lower socioeconomic classes (IV &V). The majority (70.6%) of women and 47.6% of men who were not interested to use contraceptives belong to lower socioeconomic classes (IV &V).
Conclusion: since a very high proportion (29.0 %) of study subjects is nonuser due to psychosocial reasons it is recommended that due attention should be paid by planners and it should be dealt with strengthening behavior change communication.
KEYWORDS: KAP gap; slum dwellers; contraceptive usage; unmet needs.
REFERENCES
1.K. Park (2000): Park's Textbook of Preventive and Social Medicine, (16th Ed.), M/s Banarasidas Bhanot, Jabalpur, p. 327.
2.Govt. of India (2000), National Population Policy 2000.Ministry of family welfare New Delhi.
3.France Donnay. Children in the tropic. Controlling fertility 1991,193-194.
4.Mishra D. and Singh H. P., Kuppuswamy’s Socioeconomic status scale – A Revision, Indian Journal of Pediatrics, Vol. 70, March 2003,
5.Census of India: Provisional population Total (paper 1991) Registrar and Census commissioner for India, New Delhi 1991.
6.Kansal A. (2004): Epidemiological correlates of fertility and contraceptive prevalence in rural population of Dehradun District. Thesis submitted for MD Community Medicine to H.N.B. Garhwal University (Unpublished).
7.Khokar A. and Gulati N. A study of never users of contraception from an urban slum of Delhi, Indian Journal of Community Medicine, Vol.XXV,No.1,Jan-Mar.2000.
Copyright © 2014 Goel PK, Bhardwaj VK, Kumar A, Kumar N, Das SD. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclosure forms provided by the authors are available with the full text of this article at jpbms.info
Research article:
Yasmin Grewal.,MPH, MDSc., BDS1,*,Rahul Datta.,MDS., BDS2,Karanpal Singh.,BDS3,
Gursimran Singh.,BDS4,Sandeep Singh.,BDS5,Parneet Kaur.,BDS6
Affiliation:-
1Reader & Head, Department of Public Health Dentistry, Rayat Bahra Dental College & Hospital, Punjab, India
2Professor& Head, Department of Oral and Maxillofacial Surgery, Rayat Bahra Dental College & Hospital, Punjab, India
3Demonstrator,Rayat Bahra Dental College & Hospital, Punjab, India
4Post Graduate student, Department of Periodontics, College of Dental Sciences, Davangere, Karnataka, India
5Consultant Dentist, Hoshiarpur, Punjab, Genesis Institute of Dental Sciences & Research, Punjab, India
6Consultant Dentist, Amritsar, Punjab, Genesis Institute of Dental Sciences & Research, Punjab, India.
The name of the department(s) and institution(s) to which the work should be attributed:
1.Rayat Bahra Dental College & Hospital, Punjab, India
2.College of Dental Sciences, Davangere, Karnataka, India
3.Punjab, Genesis Institute of Dental Sciences & Research, Punjab, India
Address reprint requests to
Yasmin Grewal.
House no. 1082
Sector 2, Panchkula – 134112,
Haryana, India or at yasmingrewal@gmail.com
J Pharm Biomed Sci 2014;04(06):532-535.
Article citation:
Grewal Y, Datta R, Singh K, Singh G, Singh S, Kaur P. Prevalence of periodontal disease in the rural population of Punjab, India. J Pharm Biomed Sci 2014;04(05):532-535. Available at www.jpbms.info
ABSTRACT
Introduction: Periodontal diseases are prevalent among adults worldwide and studies conducted in the last decade in India have indicated high national periodontal disease prevalence especially in rural areas. However, data on periodontal health status of the rural population in Punjab is scarce.
Material and methods: A descriptive cross-sectional study was conducted to assess periodontal status of 18 to 74 year old subjects in Ferozepur District. Information was collected using the WHO oral health assessment form and the Community Periodontal Index (CPI) guidelines.
Results: A Total of 340 subjects were screened. Dental calculus was found to be the most prevalent finding with 38.5% (n=131) of the population affected. Progressive periodontal disease indicated by shallow and/or deep periodontal pockets was observed in 23.8% (n=81) of the total sample.
Conclusion: An increase in awareness of dental diseases on a community level along with better availability of health care facilities would be beneficial in reducing the prevalence of periodontal diseases.
KEYWORDS: CPI; Oral hygiene; Periodontal status; Rural; India; Punjab.
Ethical approval:
Permission to conduct the study was obtained from-
Genesis Institute of Dental Sciences & Research, Ferozepur, Punjab, India
Affiliated to Baba Farid University of Health Sciences, Faridkot, Punjab, India
REFERENCES
1.Rozier RG. Dental Public Health. In Wallace RB ed, Public Health and Preventive Medicine, Washington; Prentice Hall International Inc 1998:1091-112.
2.Marsh PD, Bradshaw DJ. Dental Plaque as a Biofilm. J Ind Microbiol 1995;15(3):169-75.
3.Gambhir RS, Sogi GM, Veeresha KL, Sohi RK, Randhawa A, Kakar H. Dental health status and treatment needs of transport workers of a northern Indian city: A cross- sectional study. J Nat Sc Biol Med 2013;4:451-56.
4.Kumar PR, John J. Assessment of periodontal status among dental fluorosis subjects using community periodontal index of treatment needs. Indian J Dent Res 2011;22:248-51.
5.Agarwal V, Khatri M, Singh G, Gupta G,
Marya CM, Kumar V et al. Prevalence of periodontal diseases in India. J Oral Health Comm Dent 2010;4(Spl):7-16.
6.Kadanakuppe S, Bhat PK. Oral health status and treatment needs of Iruligas at Ramanagara District, Karnataka, India. West Indian Med J. 2013;62(1):73-80.
7.Philip B, Chithresan K, Vijayaragavan VS, Maradi A. Prevalence of periodontal diseases among the adult tribal population in Nilgiris- an epidemiological study. Int J Pub Health Dent 2013;4(1):8-12.
8.The Indian Express. Lack of hygiene and awareness plagues the dental health of rural people of Punjab. Available at: www.indianexpress.com/story-print/599388/. Accessed April 3rd 2010.
9.Oral Health Survey - Basic Methods Geneva: World Health Organization 1997: 25-28.
10.Shah CS. An epidemiological study in Gujarat by community periodontal index of treatment needs (CPITN). Annals and Essences of Dentistry 2010;2(4):30-32.
11.Singh GP, Soni BJ. Prevalence of periodontal diseases in urban and rural areas of Ludhiana, Punjab. Indian J Community Med. 2005;30:128–29.
12.Singh A, Agarwal V, Tuli A, Khattak BP. Prevalence of chronic periodontitis in Meerut: A cross‑sectional survey. J Indian Soc Periodontol 2012;16:529-32.
13.Philip B, Chithresan K, Vijayaragavan VS, Maradi A. Prevalence of periodontal diseases among the adult tribal population in Nilgiris- an epidemiological study. Int J Pub Health Dent 2013;4(1):8-12.
14.Rooban T, Rao A, Joshua E, Ranganathan K. Dental and oral health status in drug users in Chennai, India: A cross sectional study. J Oral MaxilloFacial Pathol. 2008;12:16–21.
15.Vandana KL, Reddy SM. Assessment of periodontal status in dental fluorosis subjects using community periodontal index of treatment needs. Indian J Dent Res. 2007;18:67–71.
16.Jacob P, Shaju, Zade RM, Das M. Prevalence of periodontitis in the Indian population: A literature review. J Indian Soc Periodontol.2011 Jan-Mar;15(1):29–34.
17.Sood M. A study of epidemiological factors influencing periodontal diseases in selected areas of district Ludhiana, Punjab. Indian J Community Med. 2005;30:70–1.
18.Megalamanegowdru J, Ankola AV, Vathar J, Vishwakarma P, Dhanappa KB, Balappanavar AY. Periodontal health status among permanent residents of low, optimum and high fluoride areas in Kolar District, India. Oral Health Prev Dent. 2012;10(2):175-83.
19.Jayakrishnan R, Sarma PS, Thankappan KR. Prevalence of periodontal disease among adults in Trivandrum District, Kerala, India. Malaysian Dent J 2005;26(2):97-104.
20.Doifode VV, Ambadekar NN, Lanewar AG. Assessment of oral health status and its association with some epidemiological factors in population of Nagpur, India. Indian J Med Sci. 2000;54:261–69.
Copyright © 2014 Grewal Y, Datta R, Singh K, Singh G, Singh S, Kaur P. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclosure forms provided by the authors are available with the full text of this article at jpbms.info
Case Report
Ajay K Yadlapalli 1,*, Veeranjaneyulu P2, Krishna Santosh B3,Haseena Md4, Asif Mahajan5
Affiliation:-
1Ajay K Yadlapalli, Assistant Professor, Department of ENT, 2Veeranjaneyulu P, Professor & Head, Department of ENT,3Krishna Santosh B, Senior Resident, Department of ENT,4Haseena Md, Junior Resident, Department of ENT,5Asif Mahajan, Junior Resident, Department of ENT, GSL Medical College, Rajanagaram, Rajahmundry, Andhra Pradesh–533 296,India
The name of the department(s) and institution(s) to which the work should be attributed:
GSL Medical College, Rajanagaram, Rajahmundry, Andhra Pradesh – 533 296, India
Author’s contributions
All of the authors drafted, revised the article and approved the final version.
*To whom it corresponds:
Dr. Ajay Kumar Yadlapalli,
Assistant Professor, Department of ENT,
GSL Medical College, Rajanagaram, Rajahmundry
Andhra Pradesh – 533 296, India
Contact no: +91-9966526322
Abstract: Laryngeal tuberculosis is a rare form of extrapulmonary tuberculosis (TB) caused by Mycobacterium tuberculosis.
It has been estimated that laryngeal TB accounts for less than 1% of all TB cases and may present as a primary infection or secondary to pulmonary tuberculosis.
Due to uncommon clinical presentations and lack of clinical suspicion, laryngeal TB is frequently confused with other laryngeal diseases such as chronic laryngitis and laryngeal carcinoma.
Here we present a case of a 32yr old male, daily labourer with laryngeal tuberculosis secondary to pulmonary tuberculosis. The approach to diagnosis and the treatment was presented followed by discussion on clinico-pathological features of laryngeal tuberculosis and the importance of its early diagnosis.
Keywords: Antituberculous agents; carcinoma; Dysphonia; laryngeal tuberculosis; mycobacterium tuberculosis; stridor; vocal cords.
REFERENCES
1.Ismael Kassim, Ray CG (editors) (2004). Sherris Medical Microbiology (4th ed.). McGraw Hill. ISBN 0-8385-8529-9.
2.Scott-Brown’’s Otolaryngology; 6th edition; volume 5; pg no 5/5/14-5/5/15.
3.Changing trends in clinical manifestations of laryngeal tuberculosis Jung-eun et al; The Laryngoscope; Volume 110; Issue 11; pg no. 1950-1953; November 2000.
4.Case report: Acute tuberculous laryngitis presenting as acute epiglottitis El Beltagi Ah etal Indian journal Radial Imaging 2011, October 21st; Volume 4; pg no.284-286.
5.Tuberculosis, S.K.Sharma , A. Mohan 1st edition : 2001 page no : 288–292.
6.Kulkarni Neeta et al., Epidemiological and clinical study of ENT tuberculosis reported that the commonest presenting feature in all the patients was hoarseness. J Laryngol Otol. 2001; 115(7):555-558.
7.Rajat Bhatia et al., Tubercular laryngitis: case series, Indian J. Otolaryngol. Head Neck Surg.(October–December 2008) 60:331–334.
8.Khan KA, Khan NA, Maqbood M, Otorhinolaryngological Manifestation of Tuberculosis, JK science, July-september 2002;4(3):115-118.
9.Galletti F et al., Laryngeal tuberculosis: considerations on the most recent clinical and epidemiological data and presentation of a case report, Acta Otorhinolaryngol Ital. 2000 Jun;20(3):196-201.
10.Varshney S, Hasan SA. Clinico – Histopathological study of Laryngeal Biopsies. SDMH Journal.1995;19:140–141.
11.Anil Mehndiratta et al., Primary tuberculosis of larynx, Ind J Tub 1997;44:211-212.
12.Keyvan Kiakojuri, Mohammad Reza Hasanjani Roushan, Laryngeal tuberculosis without pulmonary involvement : Caspian J Intern Med. 2012;3(1):397-399.
Article citation:
Yadlapalli AK, Veeranjaneyulu P, Krishna SB,Haseena Md, Mahajan A, Laryngeal Tuberculosis: A Rare Case Report. J Pharm Biomed Sci 2014; 04(06):497-501.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Yadlapalli AK,Veeranjaneyulu P,Krishna SB,Mahajan A, This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.