DocumentsDate added
Original article:
Sadredin Rasi Hashemi 1, Hamid Noshad1,*, Hesam Rasul Amini²
Affiliation:-
1Chronic kidney Disease Research center, Tabriz University of Medical Sciences, Tabriz, Iran.
2Faculty of Medicine, Tabriz University of Medical sciences, Tabriz, Iran
The name of the department(s) and institution(s) to which the work should be attributed:
1.Chronic kidney Disease Research center, Tabriz University of Medical Sciences, Tabriz, Iran.
2.Faculty of Medicine, Tabriz University of Medical sciences, Tabriz, Iran
Address reprint requests to
Hamid Noshad.
Chronic kidney disease Research center, Tabriz university of medical sciences, Tabriz, Iran, Tel:+984113298247, Fax: +984113373966, Mobile: +989143115927.
Article citation:
Hashemi SR,Noshad H.Amini HR. Effect of hemodialysis with High-Flux filters on control of hyperphosphatemia in patients with end stage renal disease. J Pharm Biomed Sci. 2014; 04(09):737-742. Available at www.jpbms.info
ABSTRACT
Background: Hyperphosphatemia (HP) is one of the most important electrolyte disturbances in patients with end stage renal disease (ESRD). Its treatment is essential for controlling of Hyperparathyroidism, vessel calcifications and cardiovascular mortality. Current studies, evaluates the effect of high-flux hemodialysis on resistant hyperphosphatemia (HP) in ESRD patients.
Methods: Forty hemodialyzed patients with resistant HP were enrolled in a clinical trial study conducted at Tabriz University of medical sciences, Tabriz, Iran during February to October 2012. The eligible participants were randomly allocated to High and Low-flyx groups based on random block procedure produced by Random Allocation Software (RAS). All patients hemodialyzed for two months with the same filters (high efficienct). High-Flux (R60) filter in case group (n=20) and low-flux (R6) was used in the control group (n=20). Laboratory data and HD efficiency (KT/V) were compared before and at the end of the study. Quantitative values are compared by in depended student t-test and before-after values compared by paired t-test. Qualitative values compared by chi-square test and p-value less than 0.05 considered significant.
Results: There were significant differences in cholesterol, triglyceride, albumin and phosphate levels between both High-flux and Low-flux group and serum phosphate level diminished significantly in High-flux group (p=0.01,p=0.01,p=0.03,p=0.004 respectively).There was not any significant difference in HD efficacy between both groups (P=0.16).
Conclusion: High-Flux filter can reduce serum phosphate levels and improve lipid profile in ESRD patients with resistant hyperphosphatemia.
KEYWORDS: Hemodialysis; Hyperphosphatemia; High-Flux filter.
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Copyright © 2014 Hashemi SR.,Noshad H.,Amini HR. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Competing interest / Conflict of interest: None
Review article:
Mwahib Sid Ahmed Mohamed Osman Aldosh*
Affiliation:-
Assistant Professor, Radiological Sciences Department Applied Medical College - Najran University- Kingdom of Saudi Arabia
The name of the department(s) and institution(s) to which the work should be attributed:
Radiological Sciences Department Applied Medical College - Najran University- Kingdom of Saudi Arabia
Address reprint requests to
Dr. Mwahib Sid Ahmed Mohamed Osman Aldosh ,Ph.D
Assistant Professor, Radiological Sciences Department Applied Medical College-Najran University- Kingdom of Saudi Arabia
Article citation:
Mwahib A. Applications of Nanoparticles in Biomedical. J Pharm Biomed Sci. 2014;04(09):743-750. Available at www.jpbms.info
ABSTRACT
The application of nanomaterials for cancer therapy and for early diagnosis of pathologies has received considerable attention in recent years. Particularly in the field of biomedical with extensive applications. The wide interdisciplinary world of Nanoscience was experiencing a strong development during the last years. One exciting topic is the possibility of using nanoscale materials for biomedical applications. The application of nanotechnology to medicine, known as nanomedicine, concerns the use of precisely engineered materials at this length scale to develop novel therapeutic and diagnostic modalities. Recent improvements in engineering at the nanoscale level have lead to the development of a variety of new, novel nanoscale platforms (quantum dots, nanoshells, gold nanoparticles, paramagnetic nanoparticles, carbon nanotubes), which currently are under development and has profoundly studied. The emerging roles of these wide variety of applications, in biomedical imaging and therapeutic are the focus of this research, in addition to describing how nanoparticles can be used for targeted imaging and delivery of therapeutic agents and identify and discuss strategies to circumvent barriers to intratumoral delivery of nanoparticles.
KEYWORDS: Nanoparticles; applications; magnetic resonance imaging; cancer therapy; diagnostic imaging; drug deliver.
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Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclosure forms provided by the authors are available with the full text of this article at jpbms.info
Copyright © 2014 Mwahib A. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Niraj Kumar Biswas1,*,Parimal H Patel2,Hitesh R Ahir3,Purvi H Kothadia3,Alka B Nerurkar4
Affiliation:-
1Associate Professor, 2Assistant Professor, 3Tutor,4Professor and Head, Department of Microbiology, GMERS Medical College, Valsad, Gujarat, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Microbiology, GMERS Medical College, Valsad,Gujarat, India
Address reprint requests to
Dr.Niraj KUmar Biswas.
Associate Professor, Department of Microbiology, GMERS Medical College, Valsad, Gujarat, India
Article citation:
Biswas NK,Patel PH,Ahir HR,Kothadia PH,Nerurkar AB. Bacteriological profile of Urinary tract infection and its antibiotic susceptibility at tertiary care Hospital, Valsad, Gujarat,India. J Pharm Biomed Sci. 2014; 04(09):751-754. Available at www.jpbms.info
ABSTRACT
Objective:This study was done to find out the common bacteria causing UTI and to determine the antibiotic susceptibility pattern of the urinary pathogens in patients attending a tertiary care hospital in Valsad, Gujarat.
Material and Methods: In duration of January to July 2014, 179 urine samples were collected from patients of suspected UTI, Collected samples were inoculated on sheep Blood agar, Mac Conkey agar and Nutrient agar and incubated at 37°C by using standard method and antibiotic susceptibility test were performed by Kirby Bauer disc diffusion method.
Results: 76(42.45%) samples were found to be positive in a culture in which 60 (78.95%) were gram negative, 13(17.10%) were Gram positive and 3 (3.95%) were candida spp. Maximum number of organisms isolated were E.coli, followed by Klebsiella sp., Pseudomonas sp. Enterococcus sp, Candida and other organisms. Isolated organisms show more resistance to commonly used antibiotics.
Conclusion: Gram negative bacilli are the commonly isolated organisms in UTI and E.coli is most common of them. An isolated organism shows more resistance to commonly used antibiotics.
KEYWORDS: UTI; Antibiotic susceptibility; urinary pathogens.
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Copyright © 2014 Biswas NK,Patel PH,Ahir HR,Kothadia PH,Nerurkar AB. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Competing interest / Conflict of interest: None
Original article
Mervat A. Ahmed1, Mona A. Mohamed2,*, Maha G. Soliman1,Yasmine H. Abd El-Naby3
Affiliation:-
1Zoology Department, 2Biochemistry division, 3Chemistry Department, Faculty of Science, Al-Azhar University for Girls, Egypt
3Military Clinics, Cairo, Egypt
The name of the department(s) and institution(s) to which the work should be attributed:
Faculty of Science, Al-Azhar University for Girls, Egypt
Address reprint requests to
Mona A. Mohamed.
Biochemistry division, Faculty of Science, Al-Azhar University for Girls, Egypt
Article citation:
Ahmed MA, Mohamed MA, Soliman MG, Abd Al-Naby YH. Monitoring The Expression Of Some Cell Adhesion Molecules And Serum Levels Of IL-6 And TNF-α In Irradiated Rats Treated With Wheat Germ Oil, Zinc And Bone Marrow. J Pharm Biomed Sci. 2014; 04(09):755-762. Available at www.jpbms.info
ABSTRACT
Background: Both radiotherapy and chemotherapy exert damaging effects on normal tissues in cancer patients and, consequently, induce an immune response in these tissues. Ionizing radiation in interaction with living cells causes a variety of changes depending on type of exposure, absorbed dose, duration of exposure, interval after exposure and also susceptibility of tissues. Aim: The present work was designed to evaluate the amelioration of serum IL-6 and TNF-α, in addition to expression of ICAM-1 and VCAM-1 genes in hepatic tissue of rats exposed to gamma radiation and treated with wheat germ oil and/or zinc sulfate individually or in combination with bone marrow transplanted cells.
Results: Exposure of rats to 5 Gy γ-rays (single dose) caused elevation in serum levels of MDA and IL-6, in addition to hepatic mRNA levels of ICAM-1 and VCAM-1 (62.2, 1.84-, 3.2- and 5.2- fold, respectively). On the other hand, levels of reduced glutathione and TNF-α were significantly lowered. Although administration of WG and Zn (either individually or in combination) improved the studied serum parameters, their levels were significantly different from control values. While hepatic mRNA levels of the adhesion molecules returned to near the control levels. Conclusion: Wheat germ oil and zinc in combination with bone marrow cells can be used as radioprotectors to improve the inflammatory status and disturbances in immune response induced by radiation.
Keywords:
KEYWORDS: Adhesion molecules; Inflammation; IL-6; Radiation; TNF-α.
Competing interest / Conflict of interest: None
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Copyright © 2014 Ahmed MA, Mohamed MA, Soliman MG, Abd Al-Naby YH. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Competing interest / Conflict of interest: None
Original article:
Ofem E. Ofem1, Victor U. Nna1,*, Victor O. Oka1, Archibong N. Archibong1, Stella C. Bassey2
Affiliation:-
1Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, P.M.B. 1115, Calabar, Cross River State, Nigeria
2Department of Nutrition and Dietetics, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, P.M.B. 1115, Calabar, Cross River State, Nigeria
The name of the department(s) and institution(s) to which the work should be attributed:
Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, P.M.B. 1115, Calabar, Cross River State, Nigeria
Address reprint requests to
Victor U. Nna
Department of Physiology, Faculty of Basic Medical Sciences, College of Medical Sciences, University of Calabar, P.M.B. 1115, Calabar, Cross River State, Nigeria
Article citation:
Ofem OE, Nna VU, Oka VO, Archibong AN, Bassey SC. Vitamin C and E Supplementation Reverses Alterations in Haematological Indices Induced by High Salt Loading in Rats. J Pharm Biomed Sci. 2014; 04(09):763-768. Available at www.jpbms.info
ABSTRACT
Background: High salt intake has been linked with deleterious effects on the body, especially on arterial blood pressure and red blood cell hemolysis. Since vitamins C & E are acclaimed anti-oxidant vitamins, their ameliorating effects on the menace of high salt loading is suggestive. This study therefore seeks to investigate the impact of vitamin C & E supplementation on haematological indices in high salt loaded rats.
Methodology: Twenty four male albino Wistar rats weighing 180 - 200 g were divided into 4 groups (n = 6) as follows; control (fed with normal rat chow + drinking water), control + vitamin C and E group (10mg/100g bw vitamin C and 83.8mg/100g bw vitamin E, in addition to control diet), salt – fed (SF) group (8% NaCl diet + 1% NaCl drinking water), salt – fed treated (SF + Vitamin C & E) group (8% NaCl diet + 1% drinking water in addition to 10mg/100g bw vitamin C and 83.8mg/100g bw vitamin E). After 42 days of treatment, the animals were sacrificed and blood samples collected through cardiac puncture for measurement of haematological indices.
Results: Red blood cell (RBC) count, white blood cell (WBC) count, packed cell volume (PCV), mean corpuscular haemoglobin concentration (MCHC), red cell distribution wide-standard deviation (RDW-SD) and red cell distribution wide-coefficient of variation (RDW-CV) were significantly (P<0.05) higher in SF group compared with control. RDW-SD and RDW-CV were significantly (P<0.05) lower in SF + Vitamin C & E group compared with SF group. Haemoglobin concentration was significantly (P<0.05) lower in the SF + Vitamin C & E group compared with SF group. Neutrophils count was significantly (P<0.05) increased in SF + Vitamin C & E group compared with control, Vitamin C & E and SF group.
Conclusion: Vitamin C & E supplementation reversed the changes in RBC and RBC indices occasioned by high salt loading, but potentiated the effects of high salt loading on WBC and platelet indices in rats.
KEYWORDS: Platelets; red blood cells; salt; vitamin C; vitamin E; white blood cells.
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Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript