DocumentsDate added
Original article:
Kapil Srivastava1,*, Anil Bidwai2, Dhiraj Srivastava3, Ramesh Thanna4
Affiliation:-
1Ex Post Graduate Student, 2Professor,3MD,Assistant Professor, 4Msc,Department of Biochemistry, Index Medical College, Indore, Madhya Pradesh, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Biochemistry, Index Medical College, Indore, Madhya Pradesh, India
Address reprint requests to
Dr. Kapil Srivastava.
Kamaleshwar colony, Dabra, Gwalior ,Madhya Pradesh, India or at kapilgrmc@gmail.com
Article citation:
Srivastava K,Bidwai A,Shrivastava D,Thanna R. A study to assess lipid profile values in atheroscerotic patients of different age and sex groups. J Pharm Biomed Sci. 2014;04(09):A1-A7. Available at www.jpbms.info
ABSTRACT
Background: Atherosclerosis, also called hardening or blockage of the arteries, is a very common condition affecting the arteries, the thick-walled, high-pressure blood vessels that carry fresh oxygen-rich blood from the heart to the rest of the body.
Atherosclerosis occurs more frequently in men than in women. There have been studies that show the sex gap in plaque prevalence is strongly influenced by age. Objectives: Estimation of serum lipid profile in normal–male, female–healthy controls and atherosclerosis patients (male & female).
Comparison above biochemical parameters between normal male healthy control and male atherosclerosis patients (30 – 50 year & 51 – 70 year) Methodology: A Total of 53 patients full filing exclusion and inclusion criteria’s were included in the study group and 50 ages matched male and female healthy individual control groups during the period one year. Blood samples were collected from the patients and male and female healthy individual controls. This blood used for separation of serum. Serum used for estimation of lipid profile.
Results: There is significant difference in the biochemical parameters values between normal male and female healthy controls and male and female Atherosclerosis patients. There is no significant difference in the vales of serum cholesterol in both male and female atherosclerotic patients.
Conclusion: The present study hereby concludes that in comparison to normal healthy controls, atherosclerotic patients have higher serum values of TC, LDL, and TG and lower values of HDI cholesterol.
KEYWORDS: Atherosclerosis, Lipid Profile, Atherosclerotic diseases
REFERENCES
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Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Original article
Rajyalakshmi Gunti1* †.MD,Durga Rani Arava2.MD,K .VenkataRamana3,†.MBBS,DNB,DMRD
Affiliation:-
1Assistant Professor, Department of Microbiology, Rangaraya Medical College, GGH Campus, Kakinada, Andhrapradesh, India-533001.
†Consultant, Swathi Imaging and Diagnostics, Kakinada, Andhrapradesh, India-533001.
2Assistant professor, Department of Microbiology, Rangaraya Medical College, GGH Campus, Kakinada, Andhrapradesh, India-533001.
3Assosciate professor, Department of Radiology, KIMS, Amalapuram, Kakinada, Andhrapradesh, India-533001.
†Technical director and Consultant, Swathi Imaging and Diagnostics, Kakinada, Andhrapradesh, India-533001.
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Microbiology, Rangaraya Medical College, GGH Campus, Kakinada, Andhrapradesh, India-533001.
Swathi Imaging and Diagnostics, Kakinada, Andhrapradesh, India-533001.
Address reprint requests to
Dr. G. RAJYALAKSHMI,MD
Assistant professor, Department of Microbiology, Rangaraya Medical College, GGH Campus, Kakinada, Andhrapradesh, India-533001
Article citation:
Gunti R, Arava DR, Ramana KV. Prevalence of extended spectrum β-Lactamases among Escherichia coli And Klebsiella Pneumoniae in and around Kakinada, Andhrapradesh, India. J Pharm Biomed Sci. 2014; 04(09):773-775. Available at www.jpbms.info
ABSTRACT
Extended spectrum β–lactamases (ESBLs) continue to be a major problem worldwide conferring resistance to the expanded spectrum cephalosporins. As no data is available in this area an attempt was made to know the prevalence of ESBL producers among Escherichia coli and Klebsiella pneumoniae in and around Kakinada. A total of 469 Escherichia coli and 80 Klebsiella pneumoniae were studied over a two year period from March 2012 to February 2014. ESBL production was identified in 73.1% of E.coli and 58.8% of K.pneumoniae. As a large number of isolates were found to be ESBL producers in the present study, continued monitoring of drug resistance is recommended for proper disease management.
KEYWORDS: Extended spectrum β–lactamases; Escherichia coli; Klebsiella pneumoniae.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
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Copyright © 2014 Gunti R, Arava DR, Ramana KV. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Mervat A. Ahmed1, Mona A. Mohamed2,*, Maha G. Soliman1,Yasmine H. Abd El-Naby3
Affiliation:-
1Zoology Department, 2Biochemistry division, 3Chemistry Department, Faculty of Science, Al-Azhar University for Girls, Egypt
3Military Clinics, Cairo, Egypt
The name of the department(s) and institution(s) to which the work should be attributed:
Faculty of Science, Al-Azhar University for Girls, Egypt
Address reprint requests to
Mona A. Mohamed.
Biochemistry division, Faculty of Science, Al-Azhar University for Girls, Egypt
Article citation:
Ahmed MA, Mohamed MA, Soliman MG, Abd Al-Naby YH. Monitoring The Expression Of Some Cell Adhesion Molecules And Serum Levels Of IL-6 And TNF-α In Irradiated Rats Treated With Wheat Germ Oil, Zinc And Bone Marrow. J Pharm Biomed Sci. 2014; 04(09):755-762. Available at www.jpbms.info
ABSTRACT
Background: Both radiotherapy and chemotherapy exert damaging effects on normal tissues in cancer patients and, consequently, induce an immune response in these tissues. Ionizing radiation in interaction with living cells causes a variety of changes depending on type of exposure, absorbed dose, duration of exposure, interval after exposure and also susceptibility of tissues. Aim: The present work was designed to evaluate the amelioration of serum IL-6 and TNF-α, in addition to expression of ICAM-1 and VCAM-1 genes in hepatic tissue of rats exposed to gamma radiation and treated with wheat germ oil and/or zinc sulfate individually or in combination with bone marrow transplanted cells.
Results: Exposure of rats to 5 Gy γ-rays (single dose) caused elevation in serum levels of MDA and IL-6, in addition to hepatic mRNA levels of ICAM-1 and VCAM-1 (62.2, 1.84-, 3.2- and 5.2- fold, respectively). On the other hand, levels of reduced glutathione and TNF-α were significantly lowered. Although administration of WG and Zn (either individually or in combination) improved the studied serum parameters, their levels were significantly different from control values. While hepatic mRNA levels of the adhesion molecules returned to near the control levels. Conclusion: Wheat germ oil and zinc in combination with bone marrow cells can be used as radioprotectors to improve the inflammatory status and disturbances in immune response induced by radiation.
Keywords:
KEYWORDS: Adhesion molecules; Inflammation; IL-6; Radiation; TNF-α.
Competing interest / Conflict of interest: None
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Copyright © 2014 Ahmed MA, Mohamed MA, Soliman MG, Abd Al-Naby YH. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Competing interest / Conflict of interest: None
Review article:
Mwahib Sid Ahmed Mohamed Osman Aldosh*
Affiliation:-
Assistant Professor, Radiological Sciences Department Applied Medical College - Najran University- Kingdom of Saudi Arabia
The name of the department(s) and institution(s) to which the work should be attributed:
Radiological Sciences Department Applied Medical College - Najran University- Kingdom of Saudi Arabia
Address reprint requests to
Dr. Mwahib Sid Ahmed Mohamed Osman Aldosh ,Ph.D
Assistant Professor, Radiological Sciences Department Applied Medical College-Najran University- Kingdom of Saudi Arabia
Article citation:
Mwahib A. Applications of Nanoparticles in Biomedical. J Pharm Biomed Sci. 2014;04(09):743-750. Available at www.jpbms.info
ABSTRACT
The application of nanomaterials for cancer therapy and for early diagnosis of pathologies has received considerable attention in recent years. Particularly in the field of biomedical with extensive applications. The wide interdisciplinary world of Nanoscience was experiencing a strong development during the last years. One exciting topic is the possibility of using nanoscale materials for biomedical applications. The application of nanotechnology to medicine, known as nanomedicine, concerns the use of precisely engineered materials at this length scale to develop novel therapeutic and diagnostic modalities. Recent improvements in engineering at the nanoscale level have lead to the development of a variety of new, novel nanoscale platforms (quantum dots, nanoshells, gold nanoparticles, paramagnetic nanoparticles, carbon nanotubes), which currently are under development and has profoundly studied. The emerging roles of these wide variety of applications, in biomedical imaging and therapeutic are the focus of this research, in addition to describing how nanoparticles can be used for targeted imaging and delivery of therapeutic agents and identify and discuss strategies to circumvent barriers to intratumoral delivery of nanoparticles.
KEYWORDS: Nanoparticles; applications; magnetic resonance imaging; cancer therapy; diagnostic imaging; drug deliver.
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Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclosure forms provided by the authors are available with the full text of this article at jpbms.info
Copyright © 2014 Mwahib A. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article:
Delgado, E.A.D.1, Fonseca JR., J.H.2, Gibertoni, F.2, Beretta, A.L.R.Z3,*
Affiliation:-
1Student-Specialization in Clinical Analysis University Center Hermínio Ometto (UNIARARAS) Araras, S.P.
2Masters Student - Graduate Program - Biomedical Sciences Center Hermínio Ometto (UNIARARAS), Araras, S.P.
3* Doctor-teacher of the Graduate Program in Biomedical Sciences, University Center Hermínio Ometto (UNIARARAS), Araras, SP, Brasil
The name of the department(s) and institution(s) to which the work should be attributed:
Microbiological Research Laboratory, Av. Dr. Maximiliano Baruto, 500 Jd. Universitário. 13607-339 - Araras – SP – Brasil
Address reprint requests to
Ana Laura Remédio Zeni Beretta
Microbiological Research Laboratory, Av. Dr. Maximiliano Baruto, 500 Jd. Universitário. 13607-339 - Araras – SP – Brasil
Article citation:
Delgado, E.A.D., Fonseca JR., J.H., Gibertoni, F., Beretta, A.L.R.Z. Biosafety and the tuberculosis in units of health. J Pharm Biomed Sci. 2014; 04(09):769-772. Available at www.jpbms.info
ABSTRACT
Tuberculosis is an infectious disease of worldwide extent, caused by Mycobacterium tuberculosis and its transmission has always been a frequent concern in healthcare services. With the growth of strains resistant to first-line antituberculosis drugs and the emergence of Acquired Immune Deficiency Syndrome have made this more intense concern.
Objectives: Through exploratory study of articles and books published in the databases LILACS, MEDLINE, thesis database, aimed to identify the risks of health professionals for the occurrence of pulmonary tuberculosis and demonstrate the behaviors of these biosafety professionals exposed to M. tuberculosis.
Results: Due to the large number of infected people and the high risk of movement of persons affected by the disease, biosecurity should function as an effective ally, through action plans and control in health care institutions.
Conclusion: Based on the data, the study suggests that health professionals are at risk because of the limitations found with regard to preventive measures, especially the delayed diagnosis of tuberculosis. It is extremely important to implement biosecurity measures in health facilities, as well as the investigation of pulmonary tuberculosis, since these professionals are unaware of the occupational risks.
KEYWORDS: Pulmonary tuberculosis, health professionals, occupational risk; Biosafety.
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Copyright © 2014 Delgado, E.A.D., Fonseca JR., J.H., Gibertoni, F., Beretta, A.L.R.Z. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript