DocumentsDate added
Original article
Roohi sharma1,*, Rani Walia1, Shafiqa Aslam1, Parveen Gupta2
Affiliation:-
1Department of Pharmacology, Maharishi Markandeshwar Institute of Medical Science & Research, Mullana, Ambala, Haryana, India
2Department of Medicine, Markandeshwar Institute of Medical Science & Research, Mullana, Ambala, Haryana, India
The name of the department(s) and institution(s) to which the work should be attributed:
1.Department of Pharmacology, Maharishi Markandeshwar Institute of Medical Science & Research, Mullana, Ambala, Haryana, India
2.Department of Medicine, Markandeshwar Institute of Medical Science & Research, Mullana, Ambala, Haryana, India
Address reprint requests to
Roohi Sharma.
Department of Pharmacology, Maharishi Markandeshwar Institute of Medical Science & Research, Mullana, Ambala, Haryana, India
Article citation:
Sharma R, Walia R, Aslam S,Gupta P. A comparative study of rheumatoid arthritis management with combination of methotrexate with hydroxychloroquine and sulfasalazine with hydroxychloroquine. J Pharm Biomed Sci. 2014;04(10):898-903. Available at www.jpbms.info
ABSTRACT
Rheumatoid arthritis, a chronic, systemic, inflammatory autoimmune disease, has as its primary target the synovial tissues. Increased stiffness early in the morning is often a prominent feature of the disease and typically lasts for more than an hour. When the disease is unchecked, it leads to substantial disability, which can make even simple tasks such as writing difficult, because joint damage can get worse, even when pain and swelling are relieved.
Objectives: To Compare the efficacy and safety of methotrexate and hydroxychloroquine and sulfasalazine and hydroxychloroquine in treatment of patients suffering from Rheumatoid Arthritis.
Research Design & Methods: Sixty(60) patients were included in this prospective, randomized, single blind comparative study and were divided into two groups. First group (Group A) consisted of thirty(30) patients that treated with MTX 7.5 mg once a week and HCQ 200 mg OD. The second group (Group B) consisted of thirty (30) patients were given SSZ 500 mg twice a day and HCQ 200 mg once daily. Assessment of efficacy of drug therapy was done via Clinical parameter which included Visual Analogue Scale and laboratory parameter comprised of ESR, LFTs & RFTs.
Results: There was a significant reduction in VAS in Group A as compared to Group B. There was a reduction in ESR levels in the both groups. No clinical noteworthy hematological and renal abnormalities were noted during treatment.
Conclusion: Methotrexate and hydroxychloroquine combination is more efficacious and equally safe and tolerable, like sulfasalazine and hydroxychloroquine thus suggestive of better quality of life in patients suffering from RA.
KEYWORDS: Rheumatoid arthritis, methotrexate; hydroxychloroquine; sulfasalazine; visual analogue scale; erythrocyte sedimentation rate.
REFERENCES
1.Kasper DL, Fauci AS, Longo DL et al. Rheumatoid Arthritis. Harrison’s Principles of Internal Medicine. McGraw Hill. 2008; (17):2083-2092.
2.Majithia V, Geraci SA, Swan JT et al. Rheumatoid arthritis diagnosis and management. Am J Med. 2007:120 (11):936-939.
3.Krishan J. Document on Rhuematoid arthritis. An approach to Early to Early Arthrits. Available at http://pn.lifehugger.com/doc/459 .[Accessed on 22/09/12]
4.Boland EW, Headley NE. Results of long-continued cortisone administration in rheumatoid arthritis. Calif Med. 1951; 74 (63): 416-423.
5.Smolen JS, Landewe R, Breedveld FC. Management of rheumatoid arthritis with synthetic and biological disease- modifying antirheumatic drugs. Ann Rheum Dis. 2010; 69:964-965.
6.Wasserman AM. Diagnosis and Management of Rheumatoid Arthritis. American Family Physician. 2011; 84 (11):1245-1252.
7.Deighton C, O’ Mahony R, Tosh J, Turner C, Rudolf M. Management of rheumatoid arthritis. British Medical Journal. 2009; 338:710-712.
8.Weinblatt ME. Rheumatoid arthritis: more aggressive approach improves outlook. Cleve Clin J Med. 2004; 71(5):409-413.
9.Borigini MJ, Paulus HE. Innovative treatment approaches for rheumatoid arthiritis. Combination therapy.ClinRheumatol. 1995; 9(4):689-710.
10.Westergren A "Diagnostic tests: the erythrocyte sedimentation rate range ". Triangle 3 (1): 20–5. PMID 13455726
11.Gaujoux-Viala C, Smolen JS, Landewé R, a randomized controlled trials of up to 1889 patients comparing monotherapy with LEF versus MTX. Pub med. 2011.
12.Trnavský K, Gatterová J, Lindusková M et al. Efficacy and toxicity of methotrexate (MTX) monotherapy versus MTX combination therapy with non-biological disease-modifying antirheumat ic drugs in rheumatoid arthritis: a systematic review and meta-analysis. Z Rheumatol. 1993; 52(5):292-6.
Source of support: None
Competing interest / Conflict of interest:
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Sharma R, Walia R, Aslam S, Gupta P. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Dilip. M. Rampure, M.D; V.R.B. Kumar Surapureddy*, M.B.B.S; G. Rajasekharappa
Affiliation:-
Department of General Medicine, Mamatha General Hospital, Giri Prasad Nagar,Khammam. 507001, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of General Medicine, Mamatha General Hospital, Giri Prasad Nagar, Khammam. 507001, India
Address reprint requests to
Dr.V.R.B. Kumar Surapureddy.
Department of General Medicine, Mamatha General Hospital, Giri Prasad Nagar, Khammam. 507001, India
Article citation:
Rampure DM, Surapureddy VRB.K, Rajasekharappa G. A Comparative evaluation of stroke in diabetics and non diabetics. J Pharm Biomed Sci. 2014;04(10):894-897. Available at www.jpbms.info
ABSTRACT
The World Health Organization (WHO) definition of stroke is: “rapidly developing clinical signs of focal (or global) disturbance of cerebral function, with symptoms lasting 24 hours or longer or leading to death, with no apparent cause other than of vascular origin”. Diabetes is an independent risk factor for stroke. It is associated with a 2- to 3-fold increase in the risk of stroke. Our study aims to study and compare the incidence, clinical presentation and outcome of stroke in diabetics and non diabetics. It is a prospective case control observational study conducted over a period of six months. 80 patients with stroke were included in the study (40 diabetics and 40 non diabetics). The study population was selected randomly. We found that the mean age of incidence in Diabetic stroke patients was 55±9.93 and in Non-Diabetic stroke patients was 58.92±13.26. The mean blood sugar on admission in diabetic group was 214.85 ± 76.0 compared with 132.28 ± 42.37 in non-diabetic group. Hemorrhagic strokes were more frequent in the non diabetics and ischemic strokes in the diabetic stroke groups. Diabetic stroke patients had a longer duration of hospital stay with 7.82± 4.65 days as compared to non diabetics with 5.92±4.80 days. We conclude that Stroke in diabetes differs from that of stroke in non-diabetics with respect to age, stroke type, stroke severity and outcome. Hyperglycemia at stroke onset is associated with higher risk of poor outcome.
KEYWORDS: Diabetes; Stroke.
REFERENCES
1.WHO MONICA Project Investigators. The World Health Organization MONICA Project (Monitoring trends and determinants in cardiovascular disease). J Clin Epidemiol 41, 105-114. 1988.
2.http://stroke.ahajournals.org/lookup/doi/10.1161/STR.0b013e318296aeca
3.Barrett-Connor E, Khaw KT. Diabetes mellitus: an independent risk factor for stroke? Am J Epidemiol. 1988;128:116 –123
4.Henrich JB, Horwitz RI. The contributions of individual factors to thromboembolic stroke. J Gen Intern Med. 1989;4:195–201.
5.Umpierrez GE, Issacs SD, Bazargan N, You X, Thaler LM, Khitabchi AE. Hyperglycemia an independent marker of in hospital mortality in patients with undiagnosed diabetes. J of Clin Endo & Metabol, 2002; 87:3978-3982.
6.Kamel A, Azim HA, Aziz SA, Ghaffar A, Okeely AE.Cerebral infarction in diabetes mellitus:A comparative study of diabetic and non-diabetic ischemic stroke.Egypt J. Neurol. Psychiat. Neurosurg., 2006, 43(1): 167-177.
7.Candelise L, Landi G, Boccardi E, Orazio EN. Prognostic significance of hyperglycemia in acute stroke. Arch Neurol 1985; 42:661-3.
8.Weir CJ, Murray GD, Dyker AG , Lees KR. Is hyperglycemia an independent predictor of poor outcome after acute stroke. Results of a long term follow up study. Br Medical J 1997; 314:1303-6.
9.Bruno A, Biller J, Adams HP Jr, Clarke WR, Woolson RF, Williams LS, et al. Acute blood glucose level and outcome from ischemic stroke. Neurology 1999; 52:280-84.
10.Umpierrez GE, Issacs SD, Bazargan N, You X, Thaler LM, Khitabchi AE. Hyperglycemia an independent marker of in hospital mortality in patients with undiagnosed diabetes. J of Clin Endo & Metabol, 2002; 87:3978-3982.
11.Parsons MW, Barber PA, Desmond PM, Baird TA, Darby DG, Byrnes G, et al. Acute hyperglycemia adversely affects stroke outcome. A magnetic resonance imaging and spectroscopy. Ann Neurol 2002; 52:20-8.
12.Kushner M, Nencini P, Reivich M, Rango M, Jamieson D, Fazekas F, et al. Relation of hyperglycemia early in ischemic brain infarction to cerebral anatomy metabolism and clinical outcome. Ann Neurol 1990; 29:129-134.
13.Hamilton MG, Tranmer BI, Auer RN. Insulin reduction of cerebral infarction due to transient focal ischemia. J Neurosurg. 1995;82:262–268.
14.48. Carter AM. Inflammaton,thrombosis and acute coronary syndromes. Diab Vasc Dis Res 2005; 2:113-121.
15.Wass CT, Lanier WL. Glucose modulation of ischemic brain injury review and clinical recommendations. Maya Clin Proc 1996; 71:801-812.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Rampure DM, Surapureddy VRB.K, Rajasekharappa G. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Natalie Plaks*, Karin Joubert, Katijah Khoza-Shangase
Affiliation:-
Department of Speech pathology and Audiology, University of the Witwatersrand, Johannesburg, South Africa
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Speech pathology and Audiology, University of the Witwatersrand, Johannesburg, South Africa
Address reprint requests to
Natalie Plaks.
Department of Speech pathology and Audiology, University of the Witwatersrand, Johannesburg, South Africa
Article citation:
Plaks N,Joubert K,Khoza-Shangase K. Hearing loss in the South African closed head injured population: two to five years post onset. J Pharm Biomed Sci. 2014; 04(10):839-851. Available at www.jpbms.info
ABSTRACT
The current study aimed at describing auditory function within the closed head injured (CHI) population of South Africa, two to five years post head injury. A non-probability purposive sampling strategy was used to recruit 30 participants with a confirmed CHI from two neuro-rehabilitation centres within the Johannesburg area. Audiological testing was performed in a sound proof booth at the University of the Witwatersrand Speech and Hearing Clinic (USHC) following ethical approval. All equipment used in the study had been recently calibrated. The study made use of a non-experimental, descriptive, cross-sectional design to describe the auditory functioning of 30 individuals with CHI. Results: Findings from the basic audiological test battery and the audiological auditory brainstem response (ABR) revealed hearing function within normal limits for all participants Although basic audiometry indicated normal hearing, otoacoustic emissions (OAEs) were absent in five participants, and neurodiagnostic ABR measures revealed abnormalities on 14 participants’ neurodiagnostic ABR recordings. Conclusion: For accurate assessment of the integrity of the auditory pathway following CHI, current findings highlight the importance of utilizing more objective and sensitive measures during the assessment. Current findings also indicate that if overt hearing loss occurs in CHI, it can be temporary and tends to dissipate during the post-traumatic period, as evidenced in the current study.
KEYWORDS: Auditory Brainstem Response (ABR); Audiological Assessment; Closed Head Injury (CHI); Hearing Loss; Otoacoustic Emissions (OAE’s).
REFERENCES
1.Bergemalm, P.O.(2003). Progressive hearing loss after a closed head injury: A predictable outcome. Journal of Otolaryngology, 123(3):836-845.
2.Marshall, L.F. Sadler, G.R. & Bowers, S.A.(1981) Head Injury. San Diego: The Central Nervous System Injury Foundation.
3.Heitger, M.H., Jones. R.D., Dalrymple-Alford, J.C., Frampton, C.M., Ardagh, M.W. & Anderson, T.J. (2006). Motor deficits and recovery during the first year following mild closed head injury. Brain Injury, 20(8):807-824.
4.Naugle, R.I.(1990) Epidemioloy of traumatic brain injury in adults. In E.D. Bigler (Ed) Traumatic brain Injury: mechanisms of damage, assessment, intervention and outome (pp. 69-103). Austin Texas: Pro Ed
5.Bergemalm, P.O. & Borg, E.(2001). Long-term objective and subjective audiologic consequences of closed head injury. Journal of Otolaryngology, 121(1), 724–734
6.Jennett, B. & McMillan, R. (1981). Epidemiology of head injury. British Medicine Journal, 282(1), 101-104.
7.Brown, A.W., Malec, J.F., Diehl, N.N., Englander, J. & Cifu D.X.(2007). Impairment at rehabilitation admission and 1 year after moderate-to-severe traumatic brain injury: A prospective multi-centre analysis. Brain Injury, 21(7):673 – 680.Texas: Pro Ed 8. Odebode, T.O., Ademola-Popoola, D.S., Ojo, T.A. & Ayanniyi, A.A.(2005). Ocular and Visual Complications of Head Injury. Eye,19(3):561–566.
9.Statistics SouthAfrica(2010). Statistical release PO302 Mid-year estimates. http://www.statssa.gov.za/ Accessed 9 March 2011
10.Mellergard, P. & Mathiesen, T.(1998). Head injuries. In: P. Mellergard, & T. Matheson (Eds.), Basic neurosurgery (pp.15-48). Lund: Studentlitteratur.
11.Bergemalm, P.O., Hennerdal, S., Persson, B., Lyxell, B. & Borg, E.(2009). Perception of the acoustic environment and neuroimaging findings: A report of six cases with a history of closed head injury. Journal of Laryngology, 129(5):801 – 808
12.Podoshin, L. & Fradis, M.(1975). Hearing loss after head injury. Journal of Otolaryngology, 101(1),15-18.
13.Mignon, M., Schminky, A., Jane, A. & Baran, M. (2000). Central Auditory Processing Disorders: An overview of assessment and management practices. Massechusettes: Teaching research division of Western Oregon University
14.Sanjay, M.K., Naresh, P.K. & Ashis, P.(2010). Audiological deficits after closed head injury. The Journal of Trauma: Injury, Infection, and Critical Care,68(1):13-18.
15.Ylvisaker, M. & Gioia, G.A.(2002). Cognitive rehabilitation: organization, memory and language. Aspen: Aspen Publishers Inc.
16.Pope, D. & Bruce, N.(2008). Quantitative methods for health research: A practical interactive guide to epidemiology and statistics. Sussex: John Wiley & Sons.
17.Durrheim, K. (2006). Basic quantitative analysis. In: M.T. Blanche, K. Durrheim & D. Painter, Research in practice: Applied methods of social sciences (pp. 24-26). Cape Town: University of Cape Town Press.
18.Silman, S. & Silverman, C.A.(1991). Auditory diagnosis: Principles and applications. San Diego: Academic Press
19.Roeser, R.J., Valente, M. & Hosford-Dunn, H. (2002). Diagnostic procedures in the professionof audiology, in Audiology Diagnosis. In R.J. Roeser, M. Valente & H. Hosford-Dunn . Audiology Diagnosis (pp 125 -134). New York: Thieme Medical Publishers.
20.Rappaport, J. & Provencal, C.(2002). Neuro-otology for Audiologists. In Katz (Ed.), Handbook of Clinical Audiology (5th ed). (pp. 9-32). Baltimore: Lippinicott Williams & Wilkins.
21.Hall, J. (2007). New handbook of auditory evoked responses. Boston: Pearson Education.
22.Debonis, D.A. & Donohue, C.L.(2004). Survey of Audiology: Fundamentals for audiologists and health professionals. Boston, U.S.A.: Pearson Education Inc.
23.Ratcliff, J.J., Greenspan, A.I., Goldstein, F.C., Stringer, A.Y., Bushnik. T., Hammond, F.M.,et.al. (2007). Gender and traumatic brain injury: Do the sexes fare differently? Brain Injury,21(10):1023 – 1030.
24.Hood, L.J.(1998). Clinical applications of the auditory brainstem response. New York:Thomas Delmar Learning
25.Kehrle, H.M., Granjeiro, R.C., Sampaio, A.L., Bezerra, R., Almeida, V.F. & Oliveira, C.A.(2008). Comparison of auditory brainstem response results in normal-hearing patients with and without tinnitus. Journal of Otolaryngology Head and Neck Surgery,134(6):647-51.
26.Wennmo, C. & Svensson, C.(1989). Temporal bone fractures. Journal of Otolaryngology, 463(3):379–383.
27.Collinson, S.L., Meyyappan, A. & Rosenfeld, J.V.(2009).Injury and recovery: Severe amnestic syndrome following traumatic brain injury. Brain Injury, 23(1):71–76.
28.Sinninger, Y. & Starr, A.(2001). Auditory Neuropathy: A new perspective on hearing disorders. San Diego:Singular Publishing
29.Bellis, T.J. (1997). Assessment and management of central auditory processing disorders in the educational setting: From science to practice. San Diego: Singular Publishing
30.Bergemalm, P. & Lyxell, B.(2005). Appearances are deceptive? Long-term cognitive and central auditory sequalae from closed head injury. International Journal of Audiology, 44(2):176-205.
31.Meyers, J., Roberts, R., Bayless, J., Volkert, K., & Evitts, P.(2002). Dichotic listening:Expanded norms and clinical application. Archives of Clinical Neuropsychology, 17:79–90.
Copyright © 2014 Ofem OE, Nna VC,Oka VO,Archibong AN,Bassey SC. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Research article
Shenoy Poornima1, Hemavathi1,*, Sarmah Pooja1,¥,R Sharvani1,¥
Affiliation:-
1Professor, Department of Microbiology,1,* Professor & HOD, Department of Microbiology, 1,¥Assistant Professor, Department of Microbiology, Sapthagiri Institute of Medical Sciences & Research Centre, Bangalore-90,India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Microbiology, Sapthagiri Institute of Medical Sciences & Research Centre, Bangalore-90,India
Address reprint requests to
Dr Hemavathi,
Professor & HOD, Department of Microbiology, Sapthagiri Institute of Medical Sciences & Research Centre, Chikkasandra, Hesarghatta Main Road, Bangalore-560090,India
Article citation:
Poornima S, Hemavathi,Pooja S, Sharvani R. Current trend in transfusion transmitted infections among blood donors: a three year retrospective study. J Pharm Biomed Sci. 2014;04(10):914-919. Available at www.jpbms.info
ABSTRACT
Introduction: The problem of Transfusion Transmitted Infections is proportional to the prevalence of the infections in the blood donors, so it is mandatory to screen Hepatitis B and C, HIV, syphilis and malaria. As the focus of this year’s World Blood Donor Day campaign is "Safe blood for saving mothers”, a cross sectional retrospective study was undertaken to determine the sero-prevalence of the above diseases among the voluntary and replacement donors and to correlate the findings with age and sex.
Materials & Methods: Data was collected from the hospital blood bank records and was analyzed. A total of 8688 units of blood were tested for HIV (p24 antigen and HIV 1 & 2 antibodies by 4th generation ELISA), HBV and HCV (ELISA), syphilis by RPR test confirmed by TPHA and malaria by immunochromatographic test.
Results: Out of a total of 8688 units of blood tested, 6968 (80.20%) were from replacement & 1720 (19.20%) were from voluntary donors; with a preponderance of males (97.79%) to females (2.21%). Overall sero-prevalence was 0.37%, 0.94% and 0.37% for HIV, HBV and HCV respectively; 0.12% were reactive for syphilis. Two (0.02%) units showed dual infection with HIV and HCV. There was an increased prevalence of HIV, HBV, HCV and syphilis among replacement donors compared to the voluntary donors. None of the samples were positive for malaria.
Conclusions: Strict criteria for donor selection, health education coupled with sensitive screening tests are the possibilities of reducing Transfusion Transmitted Infections.
KEYWORDS: Age; Replacement donors; Sex; Transfusion transmitted infections; Voluntary donors.
REFERENCES
1.Wideman F.K. (ed). Technical Manual. American Association of Blood Banks. Aglington, USA, 1985, pp. 325-44.
2.Mudassar Zia, Emmanuel C Besa, Ronald A Sacher, Francisco Talavera.Transfusion- transmitted diseases. http://emedicine.medscape.com/article/1389957-overview#aw2aab6b5, (Accessed 25 April 2014 , Updated June 5, 2012).
3.Choudhury N,Transfusion Transmitted Infections: how many more? Asian J Transfus Sci.2010; 4:71-2.
4.National AIDS Control Organisation, Department of AIDS Control; 2009. Computerized Management Information System Bulletin; pp. 15–86. 74. http://aidsdatahub.org/en/india-reference-library/item/12112-annual-cmis-bulletin-2008-09-national-aids-control-organisation-india-2010.
5.Gharehbaghian A. An Estimate of Transfusion-Transmitted Infection Prevalence in General Populations. Hepat Mon: 2011; 11(12): 1002-1003.
6.Radhiga ST, Armugam P, Kalpana S and Natarajan M. Pattern of transfusion infections in past ten years among voluntary blood donors in Chennai- cross sectional study. IOSR J of Pharmacy and biological sciences: 2012; 2 (1): 01-04.
7.Ahmed Z, Umaru N, Sreesha K. Sero-prevalence of Transfusion- Transmitted Infections among blood donors in Mangalore. Medical Innovatica: 2012; 1 (2): 24-27.
8.Arora D, Arora B, Khetarpal A Sero-prevalence of HIV, HBV, HCV and syphilis in blood donors in Southern Haryana. Indian J Patho Microbiol: 2010; 53: 308-309
9.Bhawani Y, RaghavaRao P, Sudhakar V. Prevalence of transfusion transmissible infections among blood donors in a tertiary care hospital of Andhra Pradesh. Biology and Medicine: 2010; 2 (4): 45-48.
10.Attaullah S, Kahn S, and Kahn J. Trend of Transfusion- Transmitted Infections frequency in blood donors: provide a road map for its prevention and control. J of Translational Medicine: 2012; 10 (1): 20
11.Pallavi P, Ganesh CK, Jayashree K, Manjunath GV. Sero-prevalence and trends in Transfusion- Transmitted Infections among blood donors in a university hospital blood bank: a 5 year study. Indian J Hematol Blood Transfusion: 2011;27(1:1-6.
12.Gupta R, Singh B, Singh DK, Chugh M. Prevalence and trends in Transfusion- Transmitted Infections in a regional blood transfusion centre. Asian J Transfuse Sci: 2011;5:177-8
13.Chandra T, Kumar A, Gupta A. Prevalence of Transfusion-Transmitted Infections in
blood donors: an Indian experience. Tropical Doctor:39(3):152-154/
14.Saha SK, Banik RK, Saha MR, Habiullah M, Al Mahtab M. Prevalence of transfusion transmitted infection in healthy blood donors in Sir Samiullah Medical College, Dhaka, Bangladesh..Eurasian J Of Hepato Gastroenterology: 2011; 1 (2) : 68-70.
15.Buseri FI, Muhibi MA, Jeremiah ZA. Seroepidemiology of Tranfusion Transmissible infectious diseases among blood donors in Osogbo, Southwest Nigeria. Blood Transfus: 2009; 7:293-9.
16.A Karuru J W , Lule G N , Joshi M, Anzala O. Prevalence of HCV and HIV HCV co-infection among volunteer blood donors and VCT clients. East Afr Med J: 200; 82(4):166-9.
17.Agarwal N, Dubey U ,Agarwal A, Jaiswal R. Hepatitis B or Hepatitis C: The bigger threat in multiple infected HIV positive blood donors. Journal Of Clinical And Diagnostic Research:2011; 5:766-768.
18.Sethi B, Kumar S, Butola KS, Mishra JP, Kumar Y. Sero-prevalence pattern among blood donors in a tertiary health care centre. Internet J of Medical Update: 2014; 9(1):10-15.
19.Wang JEH. A study on the epidemiology of Hepatitis C among blood donors in Singapore. J Public Health Med: 1995; 17(4): 387-391.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Poornima S,Hemavathi,Pooja S,Sharvani R. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Barnabas,B.B1,*. M. Sc.; Gana, J1. M. Sc..; Daniel, A.A1. M. Sc.; Gbate, M1. M. Sc.
and Akanbi, Y.N.T2.HND
Affiliation:-
1lecturer,Science Laboratory Technology Department, 2Technologist, Chemical Engineering Technology Department, The Federal Polytechnic, P. M. B. 55, Bida, Niger State Nigeria
The name of the department(s) and institution(s) to which the work should be attributed:
Science Laboratory Technology Department, Federal Polytechnic, Bida, Niger State
Address reprint requests to
BARNABAS, B. B
Science Laboratory Technology Department, Federal Polytechnic, Bida, Niger State
Article citation:
Barnabas, BB; Gana, J; Daniel, AA. Gbate, M.and Akanbi, YNT. Antihelminthic Study of A Local Medicinal Plant(Canarium Shweifurthii) On Infected Rabbits. J Pharm Biomed Sci.2014;04(10):856-860. Available at www.jpbms.info
ABSTRACT
Anti helminthic activity of local medicinal plant - Canarium schweinfurthii were studied on infected rabbits for a period of 12 weeks.
Aim: The increasing complexity in synthetic manufactured drugs manufacture and worldwide toxicity associated with these drugs and the relative tolerance as well as the demand for natural products has justified the need for the study on Canarium schwenfurthii. Materials and Method: Rabbits weighing 800g averagely were infected with Ascaris ova and divided into groups, A, B, C, D and E that served as the positive control-(no infection). Groups A, B, and C were each treated with crude ethanolic extract of bark, root, leaves of Canarium schweinfurthii respectively, while group D, was treated with a patented drug ketrax. Stool microscopy that included count of Ascaris ova, weight monitoring and haematological test were carried out on the infected rabbits.
The different parts of the plant were percolated in absolute ethanol and left for 7 days in a foil-corked conical flasks and each shaken intermittently together. After the 7 days of percolation, the mixtures were filtered paper separately. Results: The results showed that the bark, fruit and leaves had 98%, 95% and 98% deparasitization as against 99% deparasitization effect for ketrax. The percentage deparasitization of the extract was not statistically significant P>0.05. The haematological test indicates an increase in absolute eosinopil count during the active phase of the parasite infection. The body weight of the animals also increased consistently as treatment with the extracts and the patented drug were administered. Conclusion: The extracts compared favourably in its antihelminthic activity with the patented drug - ketrax and thus could serve as an alternative to ketrax in the treatment of Ascaris infection. However, since the toxicity of the extracts was not part of this current study; there is need for further study on the possible drug – host interactions and possible toxicity on the mammalian host.
KEYWORDS: Canarium schweinfurthii; Anti helminthic activity; medicinal plant.
REFERENCES
1.Alexandra, A. (1980). Proceedings of the second International congress on the plants. Haridard foundation press Pakistan, 38 – 39.
2.Centre for Disease Control and Preservation (2004). How common is Ascariasis, National center for infections diseases, division of parasitic disease, USA.
3.Chan, L.; Bundy, D. A. P. and Kan, S. P. (1994). Aggregation and predisposition to Ascaris lumbricoides and Trichuris trichura at the familiar level. Trans Royal Soc. Tro. Med. & Hyg, 88, 46-48.
4.Chesbrough Monica (2004). District Laboratory Practice in Tropical Countries 6th edition Cambridge University press 222-229.
5.Das, P.N. and Thakuria, B.N (1974). Antihelminthic effect of garlic (Alum sativum) against Ascaris galli vectoll assem. 14 47-52.
6.Da Silva, N., Montressor, A and Savioli, L (2003). Soil transmitted helminthic infections updating the global picture working paper 12 – 15.
7.Forester, J.E, Scoh, M.E., Bundy, D.A.PM, and Golden , M.H.N. (1998).Clustering of Ascaris lumbricoides and Trichuris trichura infection within households, Transaction of the Royal Society of Tropical Medicine and Hygiene 82,282-6(11):915.
8.Gerald, D S. (1998). Essentials of Parasitology (4th edition) Longman group limited.U.K.24-76.
9.Hadju, V., Stephenson, L.S., Abadi, K., Mohammad, H.O., Bowman, D.D., and Parker, R.S. (1998). Improvement of Growth, Appetite, and sound physical activity in helminth infected school boys six month after a single dose of alendazole. Asia Pacific Journal of Clinical Nutrition 7, 170176.
10.Hasswell- elkins, M.R. Elkins, D. and Anderson E.M. (1989). The influence of individual, social group and household factors in the distribution of Ascaris lumbricoides within a community and implications for Control Strategies Parasitology 98, 125-134.
11.Kan. S.P, Guyatt, H. C. and Bundy, D.A.P. (1989). Geohelminth infection of children from rural plantation and urban slums in Malaysia, Transaction of the Royal Society of Tropical Medicine and Hygiene 83,817-820.
12.Lorcain, P. O. and Holland, C. V. (2000). The public health importance of Ascaris lumbricoides, Parasitology, 121, 551-571.
13.Mann, A., Muhammad, G. and Abdulkadir, N.U. (2003). Medicinal and Economic Plants of Nupe Land 1st Edition Jude – Evans Books and Publication, Bida 212-213.
14.Sauders, W.B. (996). Morrison’s Tropical Disease Good-cook 12th edition 1374.
15.Sharrif, Z.V.(2001). Modern Herbal Therapy for Common Ailment, Natural Series. Published by spectrum books ibadan 1 9-12.
16.Wong, M.S ., Bundy, D.A.P., and Golden, M.H.N. (1988). Quantitative Assessment of Geophageous Behaviours a potenctial source of exposure to Geohelminth infection. Transacton of the Royal Society of Tropical Medicine and Hygiene, 82 621-625.
17.Akerejola, O.O., Schillborn Van Veen T.W. and Njoku, C.O., (1999) Ovine and Caprine diseases in Nigeria a review of economic losses. Bull. Anim. Hlth Prod. Afr. 27: 65-70.
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