DocumentsDate added
Original article
Sireesha Srinivasa Rao1, Srinivas Rao Kuna2, Siva Kumar Chennam Setty3,*
Affiliation:-
1Associate Professor Psychiatry, Institute of mental health (IMH), Hyderabad, Telangana, India
2Civil Surgeon specialist, Department of Orthopedics, ESI Hospital, Sanathnagar, Hyderabad, Telangana, India
3Assistant Professor, Psychiatry, Institute of Mental Health (IMH), Hyderabad, Telangana, India
The name of the department(s) and institution(s) to which the work should be attributed:
1.Psychiatry, Institute of mental health (IMH),Hyderabad, Telangana,India
2.Department of Orthopedics, ESI Hospital, Sanathnagar, Hyderabad, Telangana, India
Address reprint requests to
Sireesha Srinivasa Rao.
Associate Professor Psychiatry, Institute of Mental Health, Yerragadda, Hyderabad, Telangana, India
Article citation:
Rao SS, Kuna SR, Setty SKC. A cross sectional study of psychiatric and physical morbidity among community dwelling urban elderly adults in Hyderabad, India J Pharm Biomed Sci. 2014; 04(11):1014-1024. Available at www.jpbms.info
ABSTRACT
Background and objectives: Age is an important determinant of psychiatric illness. The overall prevalence of mental and behavioural disorders tends to increase with age due to normal ageing of brain, deteriorating physical health and cerebral pathology .Disorders such as depression, anxiety, cognitive and psychotic disorders have a high prevalence among elderly. This study was planned to assess the prevalence and pattern of psychiatric morbidity, medical morbidities, sociodemographic factors associated.
Method: Cross-sectional study where urban elderly subjects were selected by random sampling technique, those who met inclusion criteria were assessed on MMSE,GHQ-30,MINI-plus,GDRS, and Modified Kuppuswamy scale for assessment of socioeconomic status.
Results: The prevalence of psychiatric morbidity amongst urban elderly was found to be 26% ,less in comparison to those reported in earlier studies from India. However the pattern of different disorders was found to be similar. Psychiatric morbidity was found to be more in female gender (76.9%), young old age group (61.52%), literates (84.59%), widowed /unmarried/single (61.52%), middle (38.21%) and low socioeconomic status (38.21%), nuclear families (69.12%). The Current study found statistically a significant association between psychiatric morbidity and age (p value=0.01), literacy (p value=0.02), marital status (p value=0.02), socioeconomic status (p value=0.02) and type of family (p value=0.02). 66.14% of elderly with psychiatric morbidity were found to have hypertension.
Conclusion: Larger studies carried over a longer period of time are recommended for future research. Geriatric clinics will prove helpful in early diagnosis of mental illness.
KEYWORDS: Elderly adults; psychiatric morbidity; physical illness.
REFERENCES
1.Anderson RJ, Freedland KE, Clouse RE, Lustman PJ.2001.The prevalence of comorbid depression in elderly adults with diabetes: a meta analysis. Diabetes Care. 24(6):1069-78.
2.Banker K, Prajapathi B and Kedia G.2011.Study of health profile of residents of geriatric home in Ahmedabad district. National Journal of community Medicine.2:378-82.
3.Banthia JK ,editor.2001.Census of India series I. NewDelhi: Controller of Publications. Appraisal of age data;p99.
4.Barua A, Ghosh MK, Kar N, Basilio MA. Sociodemographic factors of geriatric depression Indian J Psychological medicine. Med know publication obtained from www.science open.com /document vid/ 543be2a2 91d1-443-9315-6 searched on 3.9.2014.
5.Biswas SS, Gupta R, Vanjare HA, Bose S, Patel JA,Selvarajan 2009. Depression in elderly in Vellore, South India: the use of a two question screen. Int Psychogeriatr.21:369-71.
6.Carney RM . 2003. Depression as a risk factor for mortality after acute myocardial infarction. Am J Cardiology. 92(11):1277-81
7.Census of India .2011. Available from: http: //en.Wikipedia.org/wiki 2011 -census of India, Accessed on May 16th, 2014.
8. Chowdhary A,Rasania SK.2008. A community based study of psychiatric disorders among elderly living in Delhi .The Internet Journal of Health.7 (1).
9.Cole MG,Dendukuri N.2004.The feasibility and effectiveness of brief intervention to prevent depression in older subjects : a systemic review. Int J Geriatr Psychiatry.19:1019-25.
10.Desai A, Gross berg G. 2003. Differential diagnosis of psychotic disorders in the elderly: In Cohen CI editor. Schizophrenia in to later life: treatment, research and policy
Washington DC. American Psychiatric publishing, INC p55-78.
11.Folstein MF, Folstein SE, Mc Hugh PR.Mini-Mental status examination (MMSE).1975.A practical method for grading the cognitive state of the patients for the clinicians. J Psychiatr Res.12:189-98.
12.Goldberg DP. 1992.The detection of psychiatric illness by questionnaire. Maudsley monograph 21.London Oxford University press.
13.Jain RK ,Aras RY. 2007.Depression in geriatric population in urban slums in Mumbai. Indian J of Public Health.15:112-3.
14.Joshi K, Kumar R, Avasthi A.2003. Morbidity profile and its relationship with disability and psychological distress among elderly in Northern India. International J Epidemiology.32:978-87.
15.Lesperance F,Frasure-Smith N,Talajic M,Bourassa MG.2002.Five year riskof cardiac mortality in relation to initial severity and one year changes in depression symptoms after MI.Circulation.105(9):1049-53.
16.Levine JB . 1996. Psychological predictors of subsequent medical care among patients admitted with cardiac disease. J Cardio Pulmon Rehabil.16(2):109-16.
17.Mental health and ageing .ICMR bulletin 21;5:49-54.
18.Nandi PS, Banerji G, Mukherjee SP, Nandi S,Nandi DN.1997. A study of Psychiatric morbidity of elderly population of a rural community in West Bengal. Indian J Psychiatry.39:122-9.
19.Park editon.2011. Medicine and Social Sciences.Text book of Preventive and Social Medicine.21st edition: Jabalpur. In: Banarasi Das. Bhanot publishers.p 638-40.
20.Rajan SI .2003.Demography of ageing. In: Dey AB,editor Ageing in India: Situational analysis and planning in future. Ministry of health and family welfare-Govt of India Geneva: WHO.p 3-11.
21.Rajkumar S, Kumar S, Thara R. 1997. Prevalence of dementia in a rural setting: a report from India.Int J Geriatr Psychiatry.12:702-7.
22.Rajkumar AP, Thangadurai P, Senthil Kumar P.2009. Nature and prevalence and factors associated with depression among elderly in a rural south Indian community. International Psycho geriatrics.21:372-8.
23.Ritchie K ,Artero S, Beluche I .2004. Prevalence of DSM -IV Psychiatric disorder in French elderly population. Br J Psychiatry.184:147-52.
24.Seby K, Chaudhary S, Chakraborthy R .2011. Prevalence of psychiatric and Physical morbidity in urban geriatric population. Indian J Psychiatry .53:121-7.
25.Shaji K Arun kishore NR, Lal KP, Pinto C, Trivedi JK.2004. Better mental health care for older people in India. Indian J Psychiatry.46:367-72.
26.Sheehan DV, Lecrubier Y, Sheehan KH, Amorim P, Janavs J, Weiler ET.1998 .The Mini-International Neuropsychiatric interview (MINI): The development and validation of a structured diagnostic Psychiatrici interview for DSM-IV and ICD-10 .J Clin Psychiatry.20:22-23.
27.Simonsick EM, Wallace RB, Blazer DG, Berkman LF . 1995. Depressive symptomatology and hypertension-associated morbidity and mortality in older adults. Psychosomatic med.57(5):427-35.
28.Tiwari S, Tripathi R . 2009. Neuropsychiatric morbidity amongst urban and rural elderlies in Northern India: Report from a community based epidemiological study. Int Psychogeriatr. 21(Suppl 2):s136.
29.Tiwari SC.2000. Gero Psychiatric morbidity in rural northern India: Implications for the future. Int Psychogeriatr.12:35-48.
30.Tiwari SC, Srivastava G, Tripathy.2013. Prevalence of psychiatric morbidity amongst the community dwelling rural older adults in North India. Indian J Med Res .138:504-14.
31.Vas CJ,Raj Kumar S, Tanya kitpisal R,Chandra V.2001. Alzheimer's disease: The Brain killer NewDelhi : WHO; p50.
32.Venkoba Rao A, Madhavan T. 1982. GeroPsychiatric morbidity survey in a semiurban area near Madhurai. Indian J Psychiatry. 24:258-62.
33.Yesavage JA, Brink TL, Rose TL, Lum O, Huang V,Adey M. 1983.Development and validation of a geriatric depression rating scale .A preliminary report. J Psychiatr Res.17:37-49.
34.Zayas E, Grossberg T. 1998. The treatment of psychosis in late life. J Clin Psychiatry.59:5-12.
Copyright © 2014 Rao SS, Rao SK, Chennamsetty SK. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript
Case report
Madhuri J Patil*
Affiliation:-
1Assistant Professor, Department of Obstetrics and Gynecology ,Vasantrao Naik Government Medical College,Yavatmal, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Obstetrics and Gynecology ,Vasantrao Naik Government Medical College,Yavatmal, India
Address reprint requests to
Dr.Madhuri J Patil.
Assistant Professor, Department of Obstetrics and Gynecology, Vasantrao Naik Government Medical College, Yavatmal, India
Article citation:
Patil MJ. Acute presentation of heterotopic pregnancy with tubal rupture following spontaneous conception. J Pharm Biomed Sci. 2014; 04(11):1007-1010. Available at www.jpbms.info
ABSTRACT
Background: Heterotopic pregnancy carries a significantly higher maternal mortality and morbidity due to rupture of ectopic gestation. Hence, early diagnosis and management is crucial. Incidence in the general population is increased due to increased incidence of pelvic inflammatory diseases. The five common clinical signs of heterotopic pregnancy are abdominal pain, adnexal mass, signs of peritoneal irritation, hypovolumic shock, and uterine fundus larger than menstrual date. Therefore, for early diagnosis of Heterotopic pregnancy a holistic approach and thorough pelvic ultrasound is crucial to reduce mortality and morbidity in such cases.
KEYWORDS: Heterotopic pregnancy; intrauterine; laparotomy ultrasound.
REFERENCES
1.Sumeet N Baheti, K Jayakrishanan. Heterotopic pregnancy in a natural conception: International journal of infertility and fetal medicine 2010;1:41-43.
2.Derek A, Beyer M, Daniel A, Domesic M D. Heterotopic pregnancy in emergency diagnostic challenge.OBG Management 2002;14:10.
3.Tng Chang Kwok, George Morgan. Think heterotopic: A case report of heterotopic Pregnancy detected on through ultrasonography. Journal of medical cases 2012;3(5):326-28.
4.Govindarajan M J, Rajan B. Heterotopic pregnancy in natural conception. Journal of human reproductive science 2008;(1);37-38.
5.Karim Ibn Majdoub Hassani, Abderrahim El Bouazzaoui, Mohammod O Khatouf, and Khalid Mazaz. Heterotopic pregnancy a diagnosis we should suspect more often. Journal of emergencies, trauma and shock 2010;3(3):304.
6.Sameer Umranikar, Aarti Umranikar, Junaid Rafi, et al. Acute presentation of a heterotopic pregnancy following spontaneous conception: case report. Cases journal 2009,2.9369. doi:10.1186/1757-1626-2-9369:1-4.
7.Barrenetxea G, Barinaga Rementeria L, Lopez de Larruzea A, Agirregoikoa J A, Mandiola M, Carbonero K. Heterotopic pregnancy: two cases and a comparative review. Fertil Steril 2007;87(2):417 e419-415.
8.Bignardi T, Alhamdan D, Condous G. Is ultrasound the new gold standard for the diagnosis of ectopic pregnancy. Semin Ultrasound CT MR 2008;29(2):114-20.
9.Sue Yazaki Sun, Edward Araujo junior, Julio Elito junior, Liliam Cristine Rolo. Diagnosis of heterotopic pregnancy using ultrasound and MRI in the first trimester pregnancy: A case Report. Case Reports in Radiology 2012;Article ID 317592:1-3.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript
Copyright © 2014 Patil MJ. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
HG Hamza*, Z K Mohammed, A A Adullahi and T B Kingimi
Affiliation:-
Department of Biochemistry, Faculty Science University of Maiduguri, PMB 1069 Maiduguri, Nigeria
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Biochemistry, Faculty Science University of Maiduguri, PMB 1069 Maiduguri, Nigeria
Address reprint requests to
Dr.HG Hamza
Department of Biochemistry, Faculty Science University of Maiduguri, PMB 1069 Maiduguri, Nigeria
Article citation:
Hamza HG, Mohammed ZK, Adullahi AA, Kingimi TB. Antioxidant potentials of crude extracts of Gueirra sengalensis Leaves on CCL4 induced oxidative stress in Albino rat. J Pharm Biomed Sci. 2014; 04(11):941-945. Available at www.jpbms.info
ABSTRACT
Background: There is increasing recognition that many of today’s diseases are due to the “oxidative stress” that results from an imbalance between the formation and neutralization of reactive molecules such as reactive oxygen species(ROS) and reactive nitrogen species (RNS).
Aim: The main objective of the present study was to evaluate the antioxidant activity of Gueirra senegalensis leaves, a plant which is routinely used in ethonomedicinal practice for the treatment and management of most common ailments in this part of the world.
Methods: The anti oxidative effect of extracts of Guierra senegalensis (500mg per kgbodyweight) on carbon tetrachloride induce oxidative stress in rats was tested using spectrophotometric method to measure rate of decomposition of H2O2 and estimation of thiobarbituric acid reducing substance. The extracts effects were compared with standard drug (Silymarin 140mg per kg body weight).
Results: CCl4 intoxication induced a marked increase in TBARS level (P<0.05) and a significant reduction of catalase activity (P<0.05), the extract at the dose of 500mg per kg body weight significantly (P<0.05) ameliorated the deviation caused by CCl4 induced oxidative stress.
Conclusion: The results of the present study indicate that the aqueous and ethanolic extracts of G. senegalensis showed protective abilities against CCl4 induced oxidative stress in rats.
KEYWORDS: Antioxidant; Gueirra senegalensis; Oxidative stress.
REFERENCES
1.Aebi,H. (1974). Methods in enzymatic analysis, New York Acadamic press,2:674-684.
2.Bors W, Heller W, Michel C, Saran M: Flavonoids as antioxidants: Determination of radical-scavenging efficiencies. Methods Enzymol 1990;186:343-355.
3.Braca A, Sortino C, Politi M, Morelli I, Mendez J: Antioxidant activity of flavonoids from Licania licaniaeflora. J Ethnopharmacol. 2002; 79:379-381.
4.Coker, H B, Adesegun, AS and Sofodiya M O (2008) Phytochemical screening of bioactive agents in medicinal plants. In: A Text book of Medicinal Plants from Nigeria 1st ed. University of Lagos Press, Lagos Nigeria pp 209-217.
5.Gurib-Fakim A: Medicinal plants: Traditions of yesterday and drugs of tomorrow. Mol Aspects Med. 2006; 27:1-93.
6.Hazra B, Biswas S, Mandal N. Antioxidant and free radical scavenging activity of Spondias pinnata. BMC Complement Altern Med 2008; 8:63-72.
7.Hewawasan R.P,Jayatilaka K.A.P.W, Pathirana C and Mudduka L.K.B Hepatoprotective effects of Epaltes divaricata extract on carbon tetrachloride induced hepatotoxicity in mice. Indian J. Med.Res.2004; 120:30-34.
8.Houghton PJ. The role of plants in traditional medicine and current therapy. J Altern Complement Med. 1995; 1:131-143.
9.Husain SR, Cillard J, Cillard P: Hydroxyl radical scavenging activity of flavonoids. Phytochemistry. 1987; 26:2489-2491.
10.Lai HY and Kim KH: Blechnum orientale Linn - a fern with potential as antioxidant, anticancer and antibacterial agent. BMC Complement Altern Med.2010; 10:15-22.
11.Leeuwenburgh, C. and Ji., L.L.. Arch. Biochem. Biophys.1995; 316:941-949.
12.Nagulendran KR, Velavan S, Mahesh R, Begum VH. In vitro antioxidant activity and total polyphenolic content of Cyperus rotundus rhizomes. E- J Chem. 2007;4:440-449.
13.Nwafor, P. A and HG Hamza.. Antidiarrhoeal and Anti-Inflammatory Effects of Methanolic Extract of Guiera senegalensis Leaves in Rodents. Journal of Natural Remedies,(2007);7(1):72-79
14.Shettima, A Y, Karumi Y, Tijjani M.A and Sodipo OA Phytochemical and antidiarrhoel properties of ethyl acetate root extract of Guierra senegalensis JF Gmel via oral route. J. Chem.Pharm.Res. 2012;4(10):4604-46-12.
15.Silva, O., and Gomes, E.T, Guieranone A, a Naphthyl Butenone from the Leaves of Guiera senegalensis with antifungal Activity. J. Nat. Prod.2003; 66(3):447–449.
16.Somboro, A.A. et al. An ethnobotanical and phytochemical study of the African medicinal plant Guiera senegalensis J. F. Gmel. Journal of Medicinal Plants Research.2011; 5(9):16391651.
17.Zailani, S B and Ahmed, A H(2008) Phytochemical screening and diversity of uses of medicinal plant in Nigeria: in A Text book of medicinal plant from Nigeria.1st ed. University of Lagos Press, Lagos Nigeria pp43-85.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Hamza HG, Mohammed ZK, Adullahi AA, Kingimi TB. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report
Shiddalingesh Salimath* Janaki Torvi. R., S G S Rajesh Reddy .V.
Affiliation:-
Department of Pharmacology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Pharmacology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India
Address reprint requests to
Dr.Shiddalingesh Salimath.
Department of Pharmacology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India
Article citation: Salimath S, Torvi. RJ, Reddy SGS Rajesh V. Doxycycline Induced fixed drug eruption. J Pharm Biomed Sci. 2014; 04(11):1011-1013. Available at www.jpbms.info
ABSTRACT
Fixed drug eruption (FDE) represents the most common cutaneous adverse drug reaction in Indian patients, accounting for 30% of all cutaneous adverse drug reactions. More than 100 drugs, including Doxycycline have been implicated in causing FDEs. The most common drugs causing FDE are Antibiotics (trimethoprim sulfamethoxazole, tetracycline, penicillin, and erythromycin), followed by Nonsteroidal Anti-Inflammatory Drugs (NSAIDs; Diclofenac Sodium, Aspirin, Naproxen, and Ibuprofen). One large study of 450 patients revealed male to female ratio for FDE is 1:1.1. This is a case of 29year old male patient presenting to skin OPD with complaints of erythematous skin rashes associated with burning & itching sensation. The patient stated that these lesions had appeared within a few hours of taking a single dose of oral Doxycycline 500mg for a hordeolum externum. A diagnosis of FDE to Doxycycline was made and the patient was told to stop the offending agent and was started on oral antihistamines (Tab cetrizine) and topical steroid cream (mometasone). FDE from doxycycline is a rare occurrence. When it does occur, it is often misdiagnosed. Physicians should be aware of this condition in order to prevent future recurrences as it causes a lot of cosmetic and physical discomfort to the patient.
KEYWORDS: Fixed drug eruption; doxycycline.
REFERENCES
1.Patel RM, Marfatia YS. Clinical study of cutaneous drug eruptions in 200 patients. Indian J Dermatol Venerol Leprol.2008;74:430.
2.Lee AY. Fixed drug eruptions. Incidence, recognition, and avoid¬ance. Am J Clin Dermatol. 2000; 1:277-85.
3.Breathnach SM. Drug reactions.In:Burns T, Breathnach S, Cox N, Griffi ths C,editors.Rook’s Textbook of Dermatology. 8th ed.,Oxford: Blackwell Science; 2010.p.28-177.
4.Mahaboob A, Haroon TS, Drugs causing fixed drug eruptions: a study of 450 cases. Int J Dermatol. Nov 1998;37(11):833-8.
5.MacDougall C, Chambers HF. Protein synthesis inhibitors and miscellaneous antibacterial agents. In:Brunton LL, Chabner BA, Knollmann BC,editors.Goodman & gilman's the pharmacological basis of therapeutics.12thed.New York: Mcgraw-Hill; 2006 .p.1521-1526. 6.Pai VV, Bhandri P, Kikkeri NN, Athanikar SB, Sori T. Fixed drug eruption to fluconazole: a case report and review of literature.Indian J Pharmacol.2012;44:643-5.
7.Malkarnekar SB, Naveen L. Fixed drug eruption due to clarithromycin. J Res Pharm Pract. 2013;2:169-171.
8.Lim WS, Kim DH, Jin SY, Choi YS, Lee SH, Huh HJ, et al. A case of fixed drug eruption due to doxycycline and erythromycin present in food.Allergy Immunol Res 2013;5(5):337-339.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © Salimath S,cTorvi. RJ, Reddy SGS Rajesh V. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Sharmila 1 MD (OBG), Sendhil Coumary.A1* MD, DNB, MNAMS (OBG), Lopamudra B John1† MD, DNB (OBG), Seetesh Ghose 1¥ MD, FICOG
Affiliation:-
1Assisstant Professor, *1Professor, 1†Associate Professor, 1¥Professor And Head Of Department, Department Of Obstetrics And Gynaecology, Mahatma Gandhi Medical College And Research Institute Pillaiyarkuppam Puducherry- 607402, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Obstetrics and Gynaecology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India
Address reprint requests to
Dr. Sendhil Coumary. A,
Department of Obstetrics and Gynaecology, Mahatma Gandhi Medical College And Research Institute, Pillaiyarkuppam, Puducherry, India-607402
Article citation:
Sharmila ,Coumary SA,John LB,Ghose S. Effectiveness of Intravenous Iron Sucrose among SouthIndian Antenatal Women. J Pharm Biomed Sci. 2014; 04(09):936-940. Available at www.jpbms.info
ABSTRACT
Objectives: The study aims to evaluate the safety and efficacy of intravenous iron sucrose among south indian antenatal women with moderate iron deficiency anaemia in the second trimester not responding to oral iron.
Methods: The study was a prospective interventional study conducted in the department of obstetrics and gynaecology at MGMCRI, Pondicherry, South India. During a study period of 18 months starting from December 2011, a total of 61 antenatal women were included in the study. 32 received intravenous iron sucrose in divided doses, as they did not respond well to oral iron. Haemoglobin, PCV and serum ferritin were measured before and after intra venous sucrose. The results were tabulated and analysed.
Results: After oral iron therapy the mean haemoglobin was 8.97 ± 0.80 gm%, the mean PCV was 28.16 ± 2.6, and the mean serum ferritin was 13.32 ± 2.49 micrograms respectively. After IV iron sucrose therapy the mean haemoglobin was 10.15 ± 0.36, the mean PCV was 31.5± 2.10 and the mean serum ferritin was 44.09± 7.02 respectively. There was a statistically significant difference in the rise of mean haemoglobin, PCV and serum ferritin after therapy with iron sucrose. There were no significant side effects related to intravenous iron sucrose therapy.
Conclusion: Iron sucrose is safe and effective without any serious side effects in correcting the iron deficiency anemia in pregnancy among those who are not responding or intolerant to oral iron.
KEYWORDS: Iron sucrose; iron deficiency anemia; antenatal women.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
REFERENCES
1.Nutritional anemia during pregnancy in non industrialised countries in Progress in Obstetrics and Gynaecology 15. Studd J, Tan S L, Frank A. Chervenak. 2003; 8 (1): 103-121.
2.Aykut Barut, Mehmet Harma Intravenous iron treatment for iron deficiency anemia in pregnancy. J Turkish-German Gynecol Assoc 2009;10: 109-15
3.Alhossain A. Khalafallah, Amanda E. Dennis Iron deficiency anemia in pregnancy and postpartum : pathophysiology and effect of oral versus intravenous iron therapy. Journal of pregnancy Volume 2012 doi:10.1155/2012/630519
4.Arnoff GR, Bennett WM, Blumenthal S et al. Iron sucrose in hemodialysis patients: safety of replacement and maintenance regimens. Kidney Int 2004;66:1193-98
5.Ragip A Al, Unlubilgin E, Kandemir O, Yalvac S, Cakir L, and Haberal A. Intravenous versus oral Iron in the treatment of anemia in pregnancy. The American College of Obstetricians and Gynaecologists, 2005; 106(6) : 1335-40.
6.Naz N, Mashoori R G, Zehra T, Chaudhry A, Laghari J. Intravenous Iron Sucrose versus oral iron in treatment of iron deficiency anemia in pregnancy. Medical Channel 2008 Mar ; 14(1): 55-58.
7.Shafi D, Purandare SV, Sathe AV. Iron deficiency anemia in pregnancy: intravenous versus oral route. J Obstet Gynaecol India. 2012 Jun;62(3):317-21. doi: 10.1007/s13224-012-0222-0. Epub 2012 Aug 1.
8.Deepti S, Sunetra I, Sindhu B, Amreen S. Effectiveness of Intravenous Iron Sucrose in Management Of Iron Deficient Anemia of Pregnancy at Rural Hospital Set Up. Journal of Obstetrics and Gynaecology of India 2012 Apr; 62(2): 154-157.
Copyright © 2014 Sharmila ,Coumary SA,John LB,Ghose S. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.