DocumentsDate added
Review article
Preetinder Singh1,*.,MDS, Ayushi Gandotra2.,BDS
Affiliation:-
1Associate Professor (Periodontology and Oral Implantology) SDD Hospital and Dental College, Barwala, Panchkula (Haryana), India
2Research Associate, Private Practice, Chandigarh,India
The name of the department(s) and institution(s) to which the work should be attributed:
Periodontology and Oral Implantology, SDD Hospital and Dental College, Barwala, Panchkula (Haryana), India
Address reprint requests to
Dr. Preetinder Singh, MDS
Associate Professor (Periodontology and Oral Implantology) SDD Hospital and Dental College, Barwala, Panchkula(Haryana), India
Article citation:
Singh P, Gandotra A. Strategic occupational hazards affecting dental profession and its management: A review. J Pharm Biomed Sci. 2014; 04(11):995-1000. Available at www.jpbms.info
ABSTRACT
Occupational diseases are diseases arising from or out of activity in the workplace. It is resulting from exposure to physical, chemical, biological, psychosocial or ergonomics factors in the workplace. The presence of these factors in the workplace is essential for occupational diseases to occur; e.g.,exposure to lead in the workplace will leads to lead poisoning, and presence of silica in the workplace will cause silicosis. It must be recognized, however, that other factors, such as individual susceptibility, characteristics of exposure to those substances (example duration of exposure, concentration of substance, and condition of the substance) does have a role in the developing of occupational diseases. Occupational diseases of dentistry have, in general, received scant attention. The chief cause of this is lack of awareness among occupational dental physicians. Exposure to various chemical substances is one of the causes of occupation-related dental disorders. The present review aims to focus the attention of dental physicians towards this important problem.
KEYWORDS: occupational hazards; dentistry; biohazards; occupational diseases.
REFERENCES
1.Scott, S., De Rossi, D.M.D., Martin, S., Greenberg, D.D.S.: Intraoral contact allergy: a literature review and case reports, J. Am. Dent. Assoc., Vol. 129, pp. 14351-1441, 1998.
2.Guin, J.D.: Eyelid dermatitis from methacrylates used for nail enhacement. Contact Dermatitis, Vol. 39,pp. 312-313, 1998.
3.Fowler, J.F.: Late patch test reaction to acrylates in a dental worker, Am. J. Contact Dermat., Vol. 10, pp.224-225, 1999.
4.Lonnroth, E.C., Shahnavaz, H.: Use of polymer materials in dental clinics. Swed. Dent. J., Vol. 21, pp.149-150, 1997.
5.Bentley CD, Burkhart NW, Crawford JJ: Evaluating spatter and aerosol contamination during dental procedures. J Am Dent Assoc. 1994; 125:579-584.
6.Nimmo A, Werley MS, Martin JS, Tansy MF: Particulate inhalation during the removal of amalgam restorations. J Prosthet Dent. 1990;63:228-233.
7.Lan, Fu JS. Undue absorption of lead among children. A new look at an old problem. New Eng J Med. 1972; 266: 702-10.
8.International Lobour Organization (ILO). Encyclopedia of occupational health and safety. 3rd ed. Geneva: ILO. 1983;1408-10.
9.Johansson AK. On dental erosion and associated factors. Swed Dent J Suppl. 2002;1–77.
10.Darby ML, Walsh MM, editors. Dental hygiene theory and practice. 1st ed. Philadelphia; WB Saynders Company. 1994. p. 335-365.
11.Charpin D, Vervolet D: Epidemiology of immediate-type allergic reactions to latex. Clin Rev Allergy 1993, 11, 385-390.
12.Fisher AA: Contact urticaria and anaphylactoid reaction due to cornstarch surgical glove powder. Contact Dermatitis. 1987;16:244-245.
13.Turjanamaa K, Alenius H, Mäkinen-Kiljunen S, Reunala T, Palosuo T: Natural rubber latex allergy. Allergy. 1996;51:593-602.
14.Tarlo SM, Sussman G, Contala A, Swanson MC: Control of airborne latex by use of powder-free gloves. J Allergy Clin Immunol1994, 93, 985-989.
15.Pretorius, E., Bester, M.J.: What every healt worker should know: the allergic potentional of surgical gloves. Southern African Journal of Epidemiology and Infection, Vol. 15, pp. 43-45, 2000.
16.Rustemayer, T., de Groot, J., von Blomberg, B.M.: Cross-reactivity paternsof contact-sensitizing methacrylates, Toxikology & Applied Pharmacology., Vol. 148, pp. 83-90, 1998.
17.Kanerva, L., Estalender, T., Jolanki, R., Alanko, K.: False-negative patch test reactions due to a lower concentration of a patch test substances then declared, Contact Dermatitis, Vol. 42, pp. 289-291, 2000.
18.Davis MS: Variations in patients’ compliance with doctors’ orders: analysis of congruence between survey responses and results of empirical investigations. J Med Educ 1966; 41:1037-1048.
19.Hulka BS, Cassel JC, Kupper LL, Burdette JA: Communication, compliance, and concordance between physicians and patients with prescribed medications. Am J Public Health 1976, 66, 847-853.
20.Turgut R, Krüger W: Psychosozialer Ansatz für die Motiveerung zu praventivem Zahngesundheitsverhalten. Dtsch Zahnarztl Z 1982;37: 569-571.
21.Corah NL, O’Shea RM, Bissell GD: The dentist - patient relationship: perceptions by patients of dentist behavior in relation to satisfaction ond anxiety. J Am Dent Assoc. 1985;111(3):443-446.
22.Corah NL, O’Shea RM, Bissell GD: The dentist - patient relationship: mutual perceptions and behaviours. J Am Dent Assoc 1986;113(2):253-255.
23.Gale EN, Carlsson SG, Eriksson A, Jontell M: Effects of dentist’s behavior on patient’s attitudes. J Am Dent Assoc 1984, 109, 3, 444-446.
24.Simon JF, Peltier B, Chambers D, Dower J: Dentists troubled by the administration of anesthetic injections: long-term stresses and effects. Quintessence Int 1994, 25, 641-646.
25.Rankin J, Harris M: A comparision of stress and coping in male and female dentists. J Dent Pract Admin 1990, 7, 166-172.
26.Lussi A, Hellwig E, Zero D, Jaeggi T. Erosive tooth wear: diagnosis, risk factors and
prevention. Am J Dent. 2006 Dec;19(6):319-25.
27.Zero DT, Lussi A. Erosion--chemical and biological factors of importance to the dental practitioner. Int Dent J. 2005;55(4 Suppl 1):285-90.
28.Meurman JH, ten Cate JM. Pathogenesis and modifying factors of dental erosion. Eur J Oral Sci. 1996 Apr;104(2(Pt 2)):199-206.
29.Vanuspong W, Eisenburger M, Addy M. Cervical tooth wear and sensitivity: erosion,softening and rehardening of dentine; effects of pH, time and ultrasonication. J Clin Periodontol. 2002 Apr;29(4):351-7.
30.Jarvinen V, Rytomaa I, Meurman JH. Location of dental erosion in a referred population. Caries Res. 1992;26(5):391-6.
31.Rundcrantz BL, Johnsson B, Moritz U: Cervical pain and discomfort among in dentist. Epidemiological, clinical and therapeutic aspects. Part 1. A survey of pain and discomfort. Swed Dent J. 1990;14:71-80.
32.Rundcrantz BL, Johnsson B, Moritz U: Pain and discomfort in the musculoskeletal system among dentists. A prospective study. Swed Dent J. 1991;15: 219-228.
33.Rundcrantz BL, Johnsson B, Moritz U, Roxendal G: Cervicobrachial disorders in dentists. A comparison between two kinds of physiotherapeutic interventions. Scand J Rehabil Med. 1991;23:11-17.
34.Milerad E, Ekenvall L: Symptoms of the neck and upper exteremities in dentitists. Scand J Work Environ Health 1990;16:129-134.
35.Ostrem CT: Carpal tunnel syndrome. A look at causes, symptoms, remedies. Dent Teamwork 1996; 9:11-15.
36.Best Practice Guidelines for Occupational Safety and Health in DENTAL THERAPY PRACTICE, Auckland Regional Dental Service, Waitemata District Health Board, August 2001.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Singh P, Gandotra A. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report
Madhuri J Patil*
Affiliation:-
1Assistant Professor, Department of Obstetrics and Gynecology ,Vasantrao Naik Government Medical College,Yavatmal, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Obstetrics and Gynecology ,Vasantrao Naik Government Medical College,Yavatmal, India
Address reprint requests to
Dr.Madhuri J Patil.
Assistant Professor, Department of Obstetrics and Gynecology, Vasantrao Naik Government Medical College, Yavatmal, India
Article citation:
Patil MJ. Acute presentation of heterotopic pregnancy with tubal rupture following spontaneous conception. J Pharm Biomed Sci. 2014; 04(11):1007-1010. Available at www.jpbms.info
ABSTRACT
Background: Heterotopic pregnancy carries a significantly higher maternal mortality and morbidity due to rupture of ectopic gestation. Hence, early diagnosis and management is crucial. Incidence in the general population is increased due to increased incidence of pelvic inflammatory diseases. The five common clinical signs of heterotopic pregnancy are abdominal pain, adnexal mass, signs of peritoneal irritation, hypovolumic shock, and uterine fundus larger than menstrual date. Therefore, for early diagnosis of Heterotopic pregnancy a holistic approach and thorough pelvic ultrasound is crucial to reduce mortality and morbidity in such cases.
KEYWORDS: Heterotopic pregnancy; intrauterine; laparotomy ultrasound.
REFERENCES
1.Sumeet N Baheti, K Jayakrishanan. Heterotopic pregnancy in a natural conception: International journal of infertility and fetal medicine 2010;1:41-43.
2.Derek A, Beyer M, Daniel A, Domesic M D. Heterotopic pregnancy in emergency diagnostic challenge.OBG Management 2002;14:10.
3.Tng Chang Kwok, George Morgan. Think heterotopic: A case report of heterotopic Pregnancy detected on through ultrasonography. Journal of medical cases 2012;3(5):326-28.
4.Govindarajan M J, Rajan B. Heterotopic pregnancy in natural conception. Journal of human reproductive science 2008;(1);37-38.
5.Karim Ibn Majdoub Hassani, Abderrahim El Bouazzaoui, Mohammod O Khatouf, and Khalid Mazaz. Heterotopic pregnancy a diagnosis we should suspect more often. Journal of emergencies, trauma and shock 2010;3(3):304.
6.Sameer Umranikar, Aarti Umranikar, Junaid Rafi, et al. Acute presentation of a heterotopic pregnancy following spontaneous conception: case report. Cases journal 2009,2.9369. doi:10.1186/1757-1626-2-9369:1-4.
7.Barrenetxea G, Barinaga Rementeria L, Lopez de Larruzea A, Agirregoikoa J A, Mandiola M, Carbonero K. Heterotopic pregnancy: two cases and a comparative review. Fertil Steril 2007;87(2):417 e419-415.
8.Bignardi T, Alhamdan D, Condous G. Is ultrasound the new gold standard for the diagnosis of ectopic pregnancy. Semin Ultrasound CT MR 2008;29(2):114-20.
9.Sue Yazaki Sun, Edward Araujo junior, Julio Elito junior, Liliam Cristine Rolo. Diagnosis of heterotopic pregnancy using ultrasound and MRI in the first trimester pregnancy: A case Report. Case Reports in Radiology 2012;Article ID 317592:1-3.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript
Copyright © 2014 Patil MJ. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Case report
Shiddalingesh Salimath* Janaki Torvi. R., S G S Rajesh Reddy .V.
Affiliation:-
Department of Pharmacology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Pharmacology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India
Address reprint requests to
Dr.Shiddalingesh Salimath.
Department of Pharmacology, Karnataka Institute of Medical Sciences, Hubli, Karnataka, India
Article citation: Salimath S, Torvi. RJ, Reddy SGS Rajesh V. Doxycycline Induced fixed drug eruption. J Pharm Biomed Sci. 2014; 04(11):1011-1013. Available at www.jpbms.info
ABSTRACT
Fixed drug eruption (FDE) represents the most common cutaneous adverse drug reaction in Indian patients, accounting for 30% of all cutaneous adverse drug reactions. More than 100 drugs, including Doxycycline have been implicated in causing FDEs. The most common drugs causing FDE are Antibiotics (trimethoprim sulfamethoxazole, tetracycline, penicillin, and erythromycin), followed by Nonsteroidal Anti-Inflammatory Drugs (NSAIDs; Diclofenac Sodium, Aspirin, Naproxen, and Ibuprofen). One large study of 450 patients revealed male to female ratio for FDE is 1:1.1. This is a case of 29year old male patient presenting to skin OPD with complaints of erythematous skin rashes associated with burning & itching sensation. The patient stated that these lesions had appeared within a few hours of taking a single dose of oral Doxycycline 500mg for a hordeolum externum. A diagnosis of FDE to Doxycycline was made and the patient was told to stop the offending agent and was started on oral antihistamines (Tab cetrizine) and topical steroid cream (mometasone). FDE from doxycycline is a rare occurrence. When it does occur, it is often misdiagnosed. Physicians should be aware of this condition in order to prevent future recurrences as it causes a lot of cosmetic and physical discomfort to the patient.
KEYWORDS: Fixed drug eruption; doxycycline.
REFERENCES
1.Patel RM, Marfatia YS. Clinical study of cutaneous drug eruptions in 200 patients. Indian J Dermatol Venerol Leprol.2008;74:430.
2.Lee AY. Fixed drug eruptions. Incidence, recognition, and avoid¬ance. Am J Clin Dermatol. 2000; 1:277-85.
3.Breathnach SM. Drug reactions.In:Burns T, Breathnach S, Cox N, Griffi ths C,editors.Rook’s Textbook of Dermatology. 8th ed.,Oxford: Blackwell Science; 2010.p.28-177.
4.Mahaboob A, Haroon TS, Drugs causing fixed drug eruptions: a study of 450 cases. Int J Dermatol. Nov 1998;37(11):833-8.
5.MacDougall C, Chambers HF. Protein synthesis inhibitors and miscellaneous antibacterial agents. In:Brunton LL, Chabner BA, Knollmann BC,editors.Goodman & gilman's the pharmacological basis of therapeutics.12thed.New York: Mcgraw-Hill; 2006 .p.1521-1526. 6.Pai VV, Bhandri P, Kikkeri NN, Athanikar SB, Sori T. Fixed drug eruption to fluconazole: a case report and review of literature.Indian J Pharmacol.2012;44:643-5.
7.Malkarnekar SB, Naveen L. Fixed drug eruption due to clarithromycin. J Res Pharm Pract. 2013;2:169-171.
8.Lim WS, Kim DH, Jin SY, Choi YS, Lee SH, Huh HJ, et al. A case of fixed drug eruption due to doxycycline and erythromycin present in food.Allergy Immunol Res 2013;5(5):337-339.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © Salimath S,cTorvi. RJ, Reddy SGS Rajesh V. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
Babafemi, E. O.1, David, O. M.1, Oluduro, A. O.2 and Famurewa, O.1,*
Affiliation:-
1Department of Microbiology University of Ado-Ekiti, Nigeria.P.M.B.5363, Ado-Ekiti, Nigeria.
2Department of Microbiology, ObafemiAwolowo University, Ile-Ife, Nigeria
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Microbiology, Ekiti State University, Ado-Ekiti, Nigeria, P.M.B. 5363, Ado-Ekiti, Nigeria
Department of Microbiology, Obafemi Awolowo University, Ile-Ife, Nigeria
Address reprint requests to
Famurewa, O.
Department of Microbiology Ekiti State University, Ado-Ekiti, Nigeria P.M.B. 5363, Ado-Ekiti, Nigeria
Article citation: Babafemi EO, David OM, Oluduro AO, Famurewa O. Epidemiology of methicillin-resistant Staphylococcus aureus among hospitalized patients and apparently healthy individuals in Ekiti and Ondo States, Nigeria. J Pharm Biomed Sci. 2014; 04(11):1025-1030. Available at www.jpbms.info
ABSTRACT
The incidence of methicillin-resistant Staphylococcus aureus (MRSA) in hospitalized patients and apparently healthy individuals was investigated in two western states of Nigeria using standard microbiological methods. One thousand and two hundred non-repeat isolates of S. aureus were recovered from the subjects. At varying degrees the isolates were resistant to cotrimoxazole (54.8%), augmentin (36.9%), pefloxacin (35.9%), gentamycin (28.3%), erythromycin (24.9%), vancomycin (10.3%), ofloxacin (5.2%) and ciprofloxacin (0.3%). One hundred and fifty six (13.0%) were resistant to methicillin out of which 4.8% and 8.2% were from healthy individuals and patients respectively. There was no correlation between prevalence of MRSA and age or sex (p < 0.05). There was no correlation between the antibiotic resistance pattern in MRSA from healthy volunteers and patients (P < 0.05). A total of 9.0%, 12.2% and 21.2% of the MRSA were resistant to 3, 4 and 5 antibiotics respectively. Antibacterial activities of five biocides examined using agar diffusion method showed that 38.5%, 53.2%, 59.6%, 61.5% and 71.8% of the MRSA were not inhibited by Izal®, Morigad®, Septol®, Dettol® and Purit® respectively, at concentrations two times higher than the in-use concentration. This finding points to the fact that MRSA occurs among patients and in the communities in the study areas, which calls for a public health concern and awareness.
KEYWORDS: Hospital-acquired MRSA; community acquired MRSA; biocides, epidemiology; multiple antibiotic resistance.
REFERENCES
1.Abraham B, Jacob G, Pablo Y, Nechawa P, Nurith P, Ronif T, Hannah S, Klaris R, Miriam S, Francis S. Community acquired MRSA in institutionalized adults with development disabilities. Emerg Infect Dis. 2002; 8:966-969.
2.Adeleke SI, Asani MO. Urinary tract infection with children with nephritic syndrome in Kano, Nigeria. Ann Afr Med. 2009; 8:38-41.
3.Ahmed MO, Elramalli AK, Amri SG, Abuzweda AR, Abouzeed YM. Isolation and screening of methicillin-resistant Staphylococcus aureus from health workers in Libyan hospitals. East Meditrr Health J. 2012; 18(1):37-42.
4.Ako-Nai AK, Ogunniyi AD, Lamikanra A, Torimiro SE. The characterisation of clinical isolates of Staphylococcus aureus in Ile-Ife, Nigeria. J Med Microbiol. 1991; 34:109-112.
5.Akujobi CN, Ilo IA, Egwuatu CC, Ezeanya CC. Prevalence of methicillin-resistant Staphylococcus aureus (MRSA) among healthcare workers in a tertiary institution in Nigeria. Orient J Med. 2013; 25(3-4):82-87.
6.Anyanwu NCJ, Abdullahi IO, Ameh JB, Ella EE. Molecular detection of PVL, msrA genes and antibiotic susceptibility pattern of staphylococcus aureus from skin and soft tissue infections in Zaria, Nigeria. Scient J Microbiol. 2013: 2(2):43-52.
7.Ateba NU, Schaumburg F, Adegnika AA, Kosters K, Möller T, Fernandes JF, Alabi A, Issifou S, Becker K, Grobusch MP, Kremsner PG, Lell B. Epidemiology and population structure of Staphylococcus aureus in various population groups from a rural and semi urban area in Gabon, Central Africa. Acta Trop. 2012; 124:42-47.
8.Boyce JM. MRSA in hospitals and long term care facilities: microbiology, epidemiology and preventive measures. Infect Contr Hos Epidemiol. 2005; 13:725-734.
9.Castillo JA, Clapes P, Infante MR, Comas J, Manresa A. Comparative study of the antimicrobial activity of bis-(N{alpha}-caproyl-L-arginine)-1,3-propanediamine dihydrochloride and chlorhexidinedihydrochloride against Staphylococcus aureus and Escherichia coli. J Antimicrob Chemother. 2006; 57:691-698.
10.Choi SC, Chow SY, Afra A. Nasal carriage of Staphylococcus aureus among healthy adults. J Microbiol Immunal Infect. 2006; 39:458-464.
11.Chopra I. Bacterial resistance to disinfectants, antiseptics and toxic metal ions. Soc Appl Bacteriol Tech Ser. 1991; 27:45-64.
12.CLSI. Performance Standards for Antimicrobial Disk Susceptibility Tests; Approved Standard—Eleventh Edition. M02-A11 32(1) Replaces M02-A10. 2012; 29(1).
13.Craig EZ, Bryon C, Mark AM, James EL, Adam A, Bruce KB. Community-acquired methicillin-resistant Staphylococcus aureus among Military Recruits. Emerg Infect Dis. 2004; 10:941-943.
14.David OM, Fakayode IB, Famurewa O. Evaluation of the anti-enterococcal activity of disinfectants and medicated soaps on vancomycin-resistant Enterococcus faecalis strains. Ann Res Rev Biol. 2014; 4(3):509-519.
15.David OM, Ayeni D, Fakayode IB, Famurewa O. Evaluation of antibacterial properties of various hand sanitizers wipes used for cosmetic and hand hygiene purposes in Nigeria. Microbiol Res Inter. 2013; 1(2): 22-26.
16.El-Mahmood AM, Doughari JH. Bacteriological examination of some diluted disinfectants routinely used in the Specialist Hospital Yola, Nigeria. Afr. J. Pharm Pharmacol. 2009; 3:185-1909.
17.Esan CO. Molecular studies of resistant Staphylococcus aureus in Ekiti and Ondo States, Nigeria. Ph.D Thesis. University of Ado-Ekiti, Nigeria. 2011.
18.Fawole MO, Oso BA. Laboratory Manual of Microbiology. Spectrum Books Limited, Ibadan. 2001; 127.
19.Fayyaz M, Mirza IA, Ahmed Z, Abbasi SA, Hussain A and Ali S. (). In vitro susceptibility of chloramphenicol against methicillin-resistant Staphylococcus aureus. J Coll Physic Surg Pak. 2013; 23(9): 637-640.
20.Fraise AP. Biocide abuse and antimicrobial resistance – A cause for concern? J Antimicrob Chemother. 2002; 49:1-12
21.Ghebremedhin B, Olugbosi MO, Raji AM, Layer F, Bakare RA, Konig B, Konig W. Emergence of a community-associated methicillin-resistant Staphylococcus aureus with unique resistance profile in Southwest of Nigeria. J Clin Microbiol. 2009; 47: 2975-2980.
22.Gilbert P, McBain AJ. Potential impact of increased use of biocides in consumer products on prevalence of antibiotic resistance. Clin Microbiol Rev. 2003; 16:189-208.
23.Holt JG, NR Krieg, PHA Sneath, JT Staley, and ST Williams. Bergey’s Manual of Determinative Bacteriology, 9th Edn. Williams & Wilkins, Baltimore. 1994.
24.Karpanen TJ, Worthington T, Hendry ER, Conway BR, Lambert PA. Antimicrobial efficacy of chlorhexidine digluconate alone and in combination with eucalyptus oil, tea tree oil and thymol against planktonic and biofilm cultures of Staphylococcus epidermidis. J Antimicrob Chemother. 2008; 325:1-6.
25.Kejela T, Bacha K. Prevalence and antibiotic susceptibility pattern of methicillin-resistant Staphylococcus aureus (MRSA) among primary school children and prisoners in Jimma Town, Southwest Ethiopia. Ann Clin Microbiol Antimicrob. 2013: 24: 12:11
26.Kesah C, Redjeb S.B., Odugbemi T.O., Boye C.S-B., Dosso M., NdinyaAchola J.O., Koulla-Shiro S, Benbachir M., Rahal K., Borg M (2003). Prevalence of methicillin-resistant Staphylococcus aureus in eight African hospitals and Malta. Clin.Microbiol. Infect. 9:153-156.
27.Kluytmans J, van Belkum A, Verbrugh H (1997). Nasal carriage of Staphylococcus aureus: epidemiology, underlying mechanisms, and associated risks. Clin Microbiol Rev. 10 (3): 505–20.
28.Kolman1, S, Arielly H, Paitan Y. Evaluation of single and double-locus real-time PCR assays for methicillin-resistant Staphylococcus aureus (MRSA) surveillance. BMC Res Notes. 2010; 3:110
29.Kumurya AS. Loss of the mecA gene during storage of methicillin-resistant Staphylococcus aureus isolates in Northwestern Nigeria. J Public Health Epidemiol. 2013; 5(10):410-415.
30.Little-John TG, Paulsen IT, Gillespie MT, Tennent JM, Midgley M, Jones IG. Substrate specificity and energetic of antiseptic and disinfectant resistance in Staphylococcus aureus. FEMS Letters. 1992; 95:259-266.
31.Monecke S, Ruppelt A, Wendlandt S, Schwarz S, Slickers P, Ehricht R, Jäckel SC. Genotyping of Staphylococcus aureus isolates from diseased poultry. Vet Microbiol. 2013; 162: 806-812.
32.Nadjia B, Mebrouk K. Phenotypic and genotypic characterization of Staphylococcus aureus agents of dairy cows’ mastitis in Algeria. J Appl Sci Res. 2013; 9(1):86-93.
33.Noguchi N, Nakaminami H, Nishijima S, Kurokawa I, So H, Sasatsu M. Antimicrobial agent of susceptibilities and antiseptic resistance gene distribution among methicillin-resistant Staphylococcus aureus isolates from patients with impetigo and staphylococcal scalded skin syndrome. J Clin Microbiol. 44: 2119-2125.
34.Noguchi N, Suwa J, Narui K, Sasatsu M, Ito T, Hiramatsu K, Song JH. Susceptibilities to antiseptic agents and distribution of antiseptic-resistance genes qacA/B and smr of methicillin-resistant Staphylococcus aureus isolated in Asia during 1998 and 1999. J Med Microbiol. 2005; 54:557-565.
35.Nwakwo BOK, Abdulhadi S, Magagi A, Ihesiulor G. Methicillin resistant Staphylococcus aureus and their antibiotic susceptibility pattern in Kano, Nigeria. Afr J Clin Experim.Microbiol. 2010; 11(1):1595-689.
36.Ebrahimi A, Ghasemi M, Ghasemi B. Some Virulence Factors of Staphylococci Isolated From Wound and Skin Infections in Shahrekord, IR Iran. Jundishapur J Microbiol. 2014; 7(4):1-5.
37.Obajuluwa AF, Onaolapo JA, Oyi AR, Olayinka BO. Susceptibility profile of methicillin-resistant Staphylococcus aureus (MRSA) Isolates to antibiotics and methanolic extracts of parkia biglobosa (Jacq) Benth. Brit J Pharma Res. 2013; 3(4):587-596.
38.Odetoyin WB, Aboderin AO, Ikem RT, Kolawole BA, Oyelese AO. Asymptomatic bacteriuria in patients with diabetes mellitus in Ile-Ife, South-West, Nigeria. East Afr Med J. 2008; 85:18-23.
39.Olutiola PO, Famurewa O, Sonntag H-G. An Introduction to General Microbiology.Hygiene-Institut Der Universitat Heidelberg Federal Republic of Germany. 2001; 267.
40.Onemu OS, Ophori EA. Prevalence of multi-drug resistant Staphylococcus aureus in clinical specimens obtained from patients attending the University of Benin Teaching Hospital, Benin City, Nigeria. J Nat Sci Res. 2013; 3(5):154-159.
41.Onochie CC, Chukwudi A, Alo MN, Onwa NC, Okonkwo EC and Afiukwa FN. Bacteriological examination of computer keyboards and mouse devices and their susceptibility patterns to disinfectants. Amer J Microbiol. 2013; 4(1):9-19.
42.Pallin DJ, Egan DJ, Pelletier AJ, Espinola JA, Hooper DC, Camargo CA. Increased US Emergency Department visits for skin and soft tissue infections, and changes in antibiotic choices, during the emergence of community-associated methicillin- resistant Staphylococcus aureus. Ann Emerg Med. 2008; 51:291-298.
43.Popovich KJ, Weinstein RA, Hota B. Are community-associated methicillin- resistant Staphylococcus aureus (MRSA) strains replacing traditional nosocomial MRSA strains? Clin Infect Dis. 2008; 46:787-794.
44.Price CS, Williams A, Philips G, Dayton M, Smith W, Morgan S. Staphylococcus aureus nasal colonization in pre-operative orthopaedic out patients. Clin Orthop Relat Res. 2008; 466:2824-2847.
45.Ramdani-Bouguessa N, Bes M, Meugnier H, Forey F, Reverdy ME, Lina G, Vandenesch F, Tazir M, Etienne J. Detection of methicillin-resistant Staphylococcus aureus strains resistant to multiple antibiotics and carrying the Panton-Valentine leukocidin genes in an Algiers hospital. Antimicrob Agents Chemother. 2006; 50:1083-1085.
46.Sheikh AF, Mehdinejad M. Identification and determination of coagulase-negative Staphylococcus species and antimicrobial susceptibility pattern of isolates from clinical specimens. Afri J Microbiol Res. 2012; 6(8):1669-1674.
47.Shittu AO, Lin J, Kolawole DO. Antimicrobial susceptibility patterns of Staphylococcus aureus and characterization of MRSA in Southwestern Nigeria. Wounds. 2006; 18:77-84
48.Shittu AO, Lin J. Antimicrobial susceptibility pattern and characterization of clinical isolates of Staphylococcus aureus in Kwazulu-Natal province of South Africa. BMC Infect Dis 2006; 6:188-192.
49.Smith TL, Pearson ML, Wilcox KR. Emergence of Vancomycin resistance in Staphylococcus aureus. NEJM. 1999; 340:493-501.
50.Tula MY, Azih AV, Okojie RO. Antimicrobial susceptibility pattern and plasmid-mediated antibacterial resistance in Staphylococcus aureus and coagulase-negative staphylococci (CoNS). Amer J Res Com. 2013; 1(9):149-166.
51.Weber DJ, Rutala WA, Sickbert-Bennett EE. Outbreaks associated with contaminated antiseptics and disinfectants. Antimicrob Agents Chemother. 2007; 51:4217-4224.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © Babafemi EO, David OM, Oluduro AO, Famurewa O. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Research article
Reyadh Jassim Abbas1,*,May Al- Sabbagh1, Dr Hassan Mohammed Abbas Altemmi2, Dr Monewer3
Affiliation:-
1Department of Clinical Pharmacy, College of Pharmacy, University of Baghdad, Baghdad Iraqi
2Ph.D Clinical Pharmacy, Medical City Baghdad, Baghdad Iraq, 3MSC Oncology Medical City Baghdad, Iraq
The name of the department(s) and institution(s) to which the work should be attributed:
1Department of Clinical Pharmacy, College of Pharmacy, University of Baghdad, Baghdad Iraqi
Address reprint requests to
Reyadh Jassim Abbas
Department of Clinical Pharmacy, College of Pharmacy, University of Baghdad, Baghdad Iraqi
Article citation:
Abbas RJ, Sabbagh-Al M, Altemmi Abaas HM, Monewer. The possible protective effect of melatonin in Iraqi breast cancer patients taking chemotherapy. J Pharm Biomed Sci. 2014; 04(11):1001-1006. Available at www.jpbms.info
ABSTRACT
Breast cancer is the most common cancer that lead to death in the world. The most common type of breast cancer is ductal carcinoma. Chemotherapy that used in the treatment of breast cancer is associated with adverse effects like cardio toxicity, especially with doxorubicin use, due to increase free radical formation like reactive oxygen species. To evaluate the protective effect of melatonin in Iraq breast cancer taking chemotherapy, 40 volunteers, 10 normal subjects served as control, 30 volunteers were divided into two groups randomly first 10 patient named group A taking only chemotherapy without melatonin. The second 20 patient named group B taking melatonin + chemotherapy. In the current study, we measured serum malondialdehyde (MDA), liver function test (ALT, AST and TSB) and cardiac enzyme (CPK and LDH). The results showed that chemo therapy increase serum MDA, AIT, AST, CPK, LDH and reduction in serum TSB. Patients who taking extra supplement with melatonin (group B) showed normalized of these biochemical parameters. Melatonin has a role in protecting against toxicity that produced by chemotherapy.
KEYWORDS: Breast cancer; Chemotherapy; melatonin.
REFERENCES
1.American cancer society . Breast cancer . Fact and Figure 2009. American cancer society, Atlanta, GA2009.
2.Iraq cancer registry, 2010,p28.
3.Wood, WC et at. Malignant tumor of breast in ;devitant,Hellman editor.Cancer principle and practice of oncology 7th edition , Philadelphia Pa. Lippincott william and Wilkins, pp77-1415.
4.Chu, E et al . Cancer chemotherapy.In; Katzung BG,editor. Basic and clinical pharmacology, 9th edition . Mc Graw-Hill, pp: 898-930.
5.Stefulj J et al. Gene expression of the key enzymes of melatonin synthesis in extrapineal tissues of the rat. J Pineal Res. 2001;30:243–247.
6.Ackermann K et al. Melatonin synthesis in the human pineal gland .BMC neuroscience. 2007; 8supp1:p2.
7.Pieri C. Melatonin peroxyl radical scavenger more effective than vit. E Life sci. 55(15): PL 271-6.
8.Reitman and frankel. As cited by Bio Merieux kit (france). Am J Clin Path.1957;28:56 .
9.Tietz N.W. text book of clinical chemistry 3rd ed. (1999):1133-1137.
10.Buege, JA, Austa SD. Method enzymol. 1978;51:302-310.
11.Sharhar S. et al. Antioxidant intake and status, and oxidative stress in relation to breast cancer risk: A case-control study. Asian Pac. J. Cancer Prev. 2008;9:343–349.
12.Wiseman H, Halliwell B. Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J. 1996;313:17-29.
13.A.Nath et al. Elevated lipid peroxidation in breast cancer patients, Journal of pharmacy and biological sciences (JPBS),2001;9(4):17-21.
14.Shaoyu Zhou,et al. Doxorubicin–induce persistent oxidative stress to cardiac myocytes.2001;121:(3):151-157.
15.Ganiyu Oboh et al . Cyclophosphamide- induced oxidative stress in brain. Experimental and Toxicologic Pathology.2014;66(8):351-406.
16.Satoshi Numazawa et al. Possible Involvement of Oxidative Stress in 5-Fluorouracil-Mediated myelosuppression in mice. Basic & Clinical Pharmacology & Toxicology.2011;108(1):40–45.
17.Qi W, Reiter RJ, Tan DX, et al. Inhibitory effects of melatonin on ferric nitrilotriacetate-induced lipid peroxidation and oxidative DNAdamage in the rat kidney. Toxicology.1999;139:81–91.
18.Bateman JR, et al. 5-Fluorouracil given once weekly: comparison of intravenous and oral administration. Cancer. 1971;28:907-913.6
19.Paul D. King et al.Hepatotoxicity of Chemotherapy, The Oncologist.2001;6:162-176.p163.
20.Meredith MJ, Reed DJ. Depletion in vitro of mitochondrial glutathione in rat hepatocytes and enhancement of lipid peroxidation by Adriamycin and 1,3 chloroethyl-nitrosurea (BCNU). Biochem Pharmacol 1983;32:1383-1388.
21.Deepa PR, Varalakshmi P. Protective effect of low molecular weight heparin on oxidative injury and cellular abnormalities in adriamycin-induced cardiac and hepatic toxicity. Chemico-Biological Interactions. 2003;146:201-210.
22.Dr. Mustafa Ghazi Alabbassi. Melatonin Ameliorates Hepatic Damage Induced by Cyclophosphamide in rat.
23.Bahir Abdul Razzaq Mshemish et al . Effect of Silymarin against CAF protocol Hepatotoxicity, AJPS, 2011, Vol. 9, No.1.
24.Khalid A Al-Khazragi FRCP. Studying the Effect of Silymarin Against Hepatotoxicity Induced by CAF Protocol in Breast Cancer Women. Iraqi Medical Journal , Volume 56, Number 2, December 2010, ISSN 0304-4564.
25.Kamal Adel Amin,et al . Impact of Breast Cancer and Combination Chemotherapy on Oxidative Stress, Hepatic and Cardiac Markers, Sep 2012:15(3);306-312.
26.Ayça Bilginoğlu, M.D et al. Protective effect of melatonin on adriamycin-induced cardiotoxicity in rats. Arch Turk Soc Cardiol 2014; 42(3):265-273.
27.Pai VB, Nahata MC. Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention. http://www.nlm.nih.gov. Drug Saf. 2000 Apr;22(4):263-170.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Abbas RJ, Sabbagh-Al M, Altemmi Abaas HM, Monewer. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.