DocumentsDate added
Original article
Gulati Deepti1* and Goyal Pallavi2
Affiliation:-
1Senior Lecturer, 2Graduate, Department of Biotechnology, Dolphin (PG) Institute of Biomedical & Natural Sciences, Dehra Dun-248007, Uttarakhand, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Biotechnology, Dolphin (PG) Institute of Biomedical & Natural Sciences, Dehra Dun-248007, Uttarakhand, India
Address reprint requests to
Deepti Gulati,
House No. 5/12/3, Prem Nagar, Dehra Dun, Uttarakhand-248007,India
Article citation: Gulati D, Goyal P. Identification and multiple drug resistance of bacteria Isolated from soil samples collected from pharmaceutical industrial Area. J Pharm Biomed Sci. 2014; 04(11):984-994. Available at www.jpbms.info
ABSTRACT
The present study was aimed to determine Multiple-Drug Resistance among the isolated bacterial populations. The antibiotic sensitivity test was performed against 8 different antibiotics for the 16 bacterial strains isolated from Industrial area, Selaqui, Dehra Dun. All the strains were identified by Gram staining and Biochemical tests. They included; Pseudomonas sp., Bacillus sp., Klebsiella sp., Proteus sp., Staphylococcus sp., Streptococcus sp. and Enterococcus sp. The antibiotics used in the study were Penicillin (10μg), Neomycin (30μg), Cefotaxime (10μg), Rifampicin (2μg), Streptomycin(10μg), Cotrimoxazole(25μg),Amoxicillin(10μg) and Ciprofloxacin (10μg). Most of the isolates were found to be resistant to Rifampicin and Penicillin. 62.5% of the isolates were found to be resistant to Rifampicin, 56.25% to Penicillin, 12.5% to Neomycin, 12.5% to Cotrimoxazole, 6.25% to Streptomycin, 6.25% to Amoxycillin and 6.25% to Ciprofloxacin. None of the isolates was found to be resistant to Cefotaxime. The results of the study showed Rifampicin to be the least effective medicine and Cefotaxime to be the most effective medicine.
KEYWORDS: Antibiotic sensitivity; Multiple-drug resistance; Pharmaceutical effluent.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
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Copyright © Gulati D,Goyal P. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Review article
Preetinder Singh1,*.,MDS, Ayushi Gandotra2.,BDS
Affiliation:-
1Associate Professor (Periodontology and Oral Implantology) SDD Hospital and Dental College, Barwala, Panchkula (Haryana), India
2Research Associate, Private Practice, Chandigarh,India
The name of the department(s) and institution(s) to which the work should be attributed:
Periodontology and Oral Implantology, SDD Hospital and Dental College, Barwala, Panchkula (Haryana), India
Address reprint requests to
Dr. Preetinder Singh, MDS
Associate Professor (Periodontology and Oral Implantology) SDD Hospital and Dental College, Barwala, Panchkula(Haryana), India
Article citation:
Singh P, Gandotra A. Strategic occupational hazards affecting dental profession and its management: A review. J Pharm Biomed Sci. 2014; 04(11):995-1000. Available at www.jpbms.info
ABSTRACT
Occupational diseases are diseases arising from or out of activity in the workplace. It is resulting from exposure to physical, chemical, biological, psychosocial or ergonomics factors in the workplace. The presence of these factors in the workplace is essential for occupational diseases to occur; e.g.,exposure to lead in the workplace will leads to lead poisoning, and presence of silica in the workplace will cause silicosis. It must be recognized, however, that other factors, such as individual susceptibility, characteristics of exposure to those substances (example duration of exposure, concentration of substance, and condition of the substance) does have a role in the developing of occupational diseases. Occupational diseases of dentistry have, in general, received scant attention. The chief cause of this is lack of awareness among occupational dental physicians. Exposure to various chemical substances is one of the causes of occupation-related dental disorders. The present review aims to focus the attention of dental physicians towards this important problem.
KEYWORDS: occupational hazards; dentistry; biohazards; occupational diseases.
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Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Singh P, Gandotra A. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Neelam Sharma1,*, Anshul Jhanwar2
Affiliation:-
1Assistant Professor, Department of Obstetrics & Gynecology, Jhalawar medical college, Jhalawar, Rajasthan, India
2Assistant Professor, Department of Pharmacology, Jhalawar medical college, Jhalawar, Rajasthan, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Obstetrics & Gynecology, J.L.N. medical college, Ajmer, Rajasthan, India
Address reprint requests to
Dr. Anshul Jhanwar.
III/2,Doctor’s residence, Medical College Campus, Jhalawar, Rajasthan, India (Pin-326001)
Article citation:
Sharma N, Jhanwar A. To study the effect of Mifepristone-Misoprostol combination for first trimester abortion in cases with previously scarred uterus. J Pharm Biomed Sci 2014; 04(08):930-935. Available at www.jpbms.info
ABSTRACT
Introduction: In India to deal with unwanted pregnancy in the scarred uterus is thorny situation, since the caesarian section rate is increasing. Although most widely used method for terminating pregnancy is dilatation and evacuation but it increases morbidity and mortality by causing uterine perforation, serious hemorrhage and shock. Therefore medical abortion offers an advantageous alternative to surgical abortion.
Material and methods: Total one hundred and fifty patients were selected for the present prospective study and were divided randomly into two equal groups after fulfilling the inclusion and exclusion criteria. Both groups were given 200 mg Mifepristone followed by 800 µg Misoprostol after 48 hours. Group 1 consist of patients with previously scarred uterus. Group 2 consisted of patients with previously non-scarred uterus.
Results: Mean period of gestation in group 1 was 43.48 days and in group 2 was 43.81 days. Mean gravidity in group 1 was 3.24 and in group 2 was 3.17.Mean parity in group 1 was 2.2 while in group 2 was 2.14.Efficacy of procedure which was determined by the number of complete abortions in the group (92% in group 1 and 93.3% in group2.Minor side effects were seen in 21 % patients of group 1 as compared to 28% in group 2.
Conclusion: Both the groups who underwent medical abortion with mifepristone-misoprostol combination were found to be comparable in terms of efficacy, safety and acceptability for termination of pregnancy of gestational age upto 49 days.
KEYWORDS: Mifepristone, Misoprostol, Scarred uterus, Lower segment cesarean section.
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8.Sun H,Wu S,Xu H et. Al.The potential of Ru 486 for medical termination of pregnancy: An acceptability and feasibility study. J Repro Med (China). 1995; 4(3):749-75.
9.Coyaji K,Etul B,Krishna U,Otiv S, Ambardekar S,Bopardikar A: Mifepristone abortion outside the urban research hospital setting in India.Lancet,2001;357:120-22.
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16.J Xu, Chen H. Termination of early pregnancy in scarred uterus with mifepristone and misoprostol. IJOG.72 (2001):245-51.
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patients and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Disclosure forms provided by the authors are available with the full text of this article at jpbms.info
Copyright © 2014 Sharma N, Jhanwar A. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
Sharmila 1 MD (OBG), Sendhil Coumary.A1* MD, DNB, MNAMS (OBG), Lopamudra B John1† MD, DNB (OBG), Seetesh Ghose 1¥ MD, FICOG
Affiliation:-
1Assisstant Professor, *1Professor, 1†Associate Professor, 1¥Professor And Head Of Department, Department Of Obstetrics And Gynaecology, Mahatma Gandhi Medical College And Research Institute Pillaiyarkuppam Puducherry- 607402, India
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Obstetrics and Gynaecology, Mahatma Gandhi Medical College and Research Institute, Puducherry, India
Address reprint requests to
Dr. Sendhil Coumary. A,
Department of Obstetrics and Gynaecology, Mahatma Gandhi Medical College And Research Institute, Pillaiyarkuppam, Puducherry, India-607402
Article citation:
Sharmila ,Coumary SA,John LB,Ghose S. Effectiveness of Intravenous Iron Sucrose among SouthIndian Antenatal Women. J Pharm Biomed Sci. 2014; 04(09):936-940. Available at www.jpbms.info
ABSTRACT
Objectives: The study aims to evaluate the safety and efficacy of intravenous iron sucrose among south indian antenatal women with moderate iron deficiency anaemia in the second trimester not responding to oral iron.
Methods: The study was a prospective interventional study conducted in the department of obstetrics and gynaecology at MGMCRI, Pondicherry, South India. During a study period of 18 months starting from December 2011, a total of 61 antenatal women were included in the study. 32 received intravenous iron sucrose in divided doses, as they did not respond well to oral iron. Haemoglobin, PCV and serum ferritin were measured before and after intra venous sucrose. The results were tabulated and analysed.
Results: After oral iron therapy the mean haemoglobin was 8.97 ± 0.80 gm%, the mean PCV was 28.16 ± 2.6, and the mean serum ferritin was 13.32 ± 2.49 micrograms respectively. After IV iron sucrose therapy the mean haemoglobin was 10.15 ± 0.36, the mean PCV was 31.5± 2.10 and the mean serum ferritin was 44.09± 7.02 respectively. There was a statistically significant difference in the rise of mean haemoglobin, PCV and serum ferritin after therapy with iron sucrose. There were no significant side effects related to intravenous iron sucrose therapy.
Conclusion: Iron sucrose is safe and effective without any serious side effects in correcting the iron deficiency anemia in pregnancy among those who are not responding or intolerant to oral iron.
KEYWORDS: Iron sucrose; iron deficiency anemia; antenatal women.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
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Copyright © 2014 Sharmila ,Coumary SA,John LB,Ghose S. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Original article
HG Hamza*, Z K Mohammed, A A Adullahi and T B Kingimi
Affiliation:-
Department of Biochemistry, Faculty Science University of Maiduguri, PMB 1069 Maiduguri, Nigeria
The name of the department(s) and institution(s) to which the work should be attributed:
Department of Biochemistry, Faculty Science University of Maiduguri, PMB 1069 Maiduguri, Nigeria
Address reprint requests to
Dr.HG Hamza
Department of Biochemistry, Faculty Science University of Maiduguri, PMB 1069 Maiduguri, Nigeria
Article citation:
Hamza HG, Mohammed ZK, Adullahi AA, Kingimi TB. Antioxidant potentials of crude extracts of Gueirra sengalensis Leaves on CCL4 induced oxidative stress in Albino rat. J Pharm Biomed Sci. 2014; 04(11):941-945. Available at www.jpbms.info
ABSTRACT
Background: There is increasing recognition that many of today’s diseases are due to the “oxidative stress” that results from an imbalance between the formation and neutralization of reactive molecules such as reactive oxygen species(ROS) and reactive nitrogen species (RNS).
Aim: The main objective of the present study was to evaluate the antioxidant activity of Gueirra senegalensis leaves, a plant which is routinely used in ethonomedicinal practice for the treatment and management of most common ailments in this part of the world.
Methods: The anti oxidative effect of extracts of Guierra senegalensis (500mg per kgbodyweight) on carbon tetrachloride induce oxidative stress in rats was tested using spectrophotometric method to measure rate of decomposition of H2O2 and estimation of thiobarbituric acid reducing substance. The extracts effects were compared with standard drug (Silymarin 140mg per kg body weight).
Results: CCl4 intoxication induced a marked increase in TBARS level (P<0.05) and a significant reduction of catalase activity (P<0.05), the extract at the dose of 500mg per kg body weight significantly (P<0.05) ameliorated the deviation caused by CCl4 induced oxidative stress.
Conclusion: The results of the present study indicate that the aqueous and ethanolic extracts of G. senegalensis showed protective abilities against CCl4 induced oxidative stress in rats.
KEYWORDS: Antioxidant; Gueirra senegalensis; Oxidative stress.
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Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript.
Copyright © 2014 Hamza HG, Mohammed ZK, Adullahi AA, Kingimi TB. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.