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Original article
Sireesha Srinivasa Rao1, Srinivas Rao Kuna2, Siva Kumar Chennam Setty3,*
Affiliation:-
1Associate Professor Psychiatry, Institute of mental health (IMH), Hyderabad, Telangana, India
2Civil Surgeon specialist, Department of Orthopedics, ESI Hospital, Sanathnagar, Hyderabad, Telangana, India
3Assistant Professor, Psychiatry, Institute of Mental Health (IMH), Hyderabad, Telangana, India
The name of the department(s) and institution(s) to which the work should be attributed:
1.Psychiatry, Institute of mental health (IMH),Hyderabad, Telangana,India
2.Department of Orthopedics, ESI Hospital, Sanathnagar, Hyderabad, Telangana, India
Address reprint requests to
Sireesha Srinivasa Rao.
Associate Professor Psychiatry, Institute of Mental Health, Yerragadda, Hyderabad, Telangana, India
Article citation:
Rao SS, Kuna SR, Setty SKC. A cross sectional study of psychiatric and physical morbidity among community dwelling urban elderly adults in Hyderabad, India J Pharm Biomed Sci. 2014; 04(11):1014-1024. Available at www.jpbms.info
ABSTRACT
Background and objectives: Age is an important determinant of psychiatric illness. The overall prevalence of mental and behavioural disorders tends to increase with age due to normal ageing of brain, deteriorating physical health and cerebral pathology .Disorders such as depression, anxiety, cognitive and psychotic disorders have a high prevalence among elderly. This study was planned to assess the prevalence and pattern of psychiatric morbidity, medical morbidities, sociodemographic factors associated.
Method: Cross-sectional study where urban elderly subjects were selected by random sampling technique, those who met inclusion criteria were assessed on MMSE,GHQ-30,MINI-plus,GDRS, and Modified Kuppuswamy scale for assessment of socioeconomic status.
Results: The prevalence of psychiatric morbidity amongst urban elderly was found to be 26% ,less in comparison to those reported in earlier studies from India. However the pattern of different disorders was found to be similar. Psychiatric morbidity was found to be more in female gender (76.9%), young old age group (61.52%), literates (84.59%), widowed /unmarried/single (61.52%), middle (38.21%) and low socioeconomic status (38.21%), nuclear families (69.12%). The Current study found statistically a significant association between psychiatric morbidity and age (p value=0.01), literacy (p value=0.02), marital status (p value=0.02), socioeconomic status (p value=0.02) and type of family (p value=0.02). 66.14% of elderly with psychiatric morbidity were found to have hypertension.
Conclusion: Larger studies carried over a longer period of time are recommended for future research. Geriatric clinics will prove helpful in early diagnosis of mental illness.
KEYWORDS: Elderly adults; psychiatric morbidity; physical illness.
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Copyright © 2014 Rao SS, Rao SK, Chennamsetty SK. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript
Research article
Wisam R. Hassan1,*,Haydar F. AL-Tukmagi1,Osamah T. Muslim2
Affiliation:-
1Department of Clinical Pharmacy, College of Pharmacy, University of Baghdad, Baghdad, Iraq
2Department of Gastroenterology and Hepatology ,AL-Diwaniya Teaching Hospital, College of Medicine, University of AL-Qadisyia, AL-Qadisyia, Iraq
The name of the department(s) and institution(s) to which the work should be attributed:
1.Department of Clinical Pharmacy, College of Pharmacy, University of Baghdad, Baghdad, Iraq
2.Department of Gastroenterology and Hepatology,AL-Diwaniya Teaching Hospital, College of Medicine, University of AL-Qadisyia, AL-Qadisyia, Iraq
Address reprint requests to
Wisam R. Hassan.
Department of Clinical Pharmacy, College of Pharmacy, University of Baghdad, Baghdad, Iraq
Article citation:
Hassan WR, Al-Tukmagi HF, Muslim OT. Efficacy of a 10 Days course of levofloxacin based therapy after Failure of sequential therapy for Helicobacter pylori infection in Iraqi Patients. J Pharm Biomed Sci. 2014; 04(11):1031-1038. Available at www.jpbms.info
ABSTRACT
Helicobacter pylori (H. Pylori) is one of the most important risk factors of Peptic ulcer disease (PUD) and gastric cancer. The success rate of triple therapy (TT) has been declined during the last decade , sequential therapy (ST)has been proposed as an alternative to the TT regimen. A 10 days levofloxacin-based therapy(LBT) constitutes an encouraging second-line strategy after failure of ST.
The aim of this study was to establish the efficacy and tolerability of LBT after failure of (ST), also measuring the cumulative eradication rate of both regimens.
A prospective, open-label randomized clinical trial on 86 patients who had active H. Pylori infection with various gastrointestinal symptoms. The second line LBT was given after failure of the first line ST, bacterial eradication was examined 4-8weeks after treatment by using a fecal antigen test (FAT). The result was 20 patients after ST failure, only 19 patients enrolled to take LBT. The eradication rate(ER) of per-protocol and intention-to-treat for second line was 84.21% (16/19, 95% C.I 68%-100.1%) for both genders without significant difference (p=0.76) between males and females, cumulative eradication rates were 94.86% and 95.95% for both intention-to-treat and per-protocol, respectively. Compliance to the second line was 100% and adverse effects were mostly mild (36.84%) to moderate (10.56%), with little sever (5.26%) that had no effect on completion of treatment. It is concluded that a 10 days levofloxacin based therapy constitutes an encouraging second line regimen after failure of sequential therapy, with a high compliance and low adverse effects and yield a high cumulative eradication rate in clinical practice.
KEYWORDS: H. Pylori; levofloxacin; sequential therapy.
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Source of support: None
Competing interest / Conflict of interest
The author(s) have no competing interests for financial support, publication of this research, patents and royalties through this collaborative research. All authors were equally involved in discussed research work. There is no financial conflict with the subject matter discussed in the manuscript
Copyright © 2014 Hassan WR, Al-Tukmagi HF, Muslim OT. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.